Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACE3_LEIMA

TriTrypDb:

LmjF.02.0690 , LMJSD75_020012200

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.651
CLV_C14_Caspase3-7	70	74	PF00656	0.543
CLV_NRD_NRD_1	171	173	PF00675	0.590
CLV_NRD_NRD_1	211	213	PF00675	0.768
CLV_NRD_NRD_1	34	36	PF00675	0.619
CLV_NRD_NRD_1	37	39	PF00675	0.667
CLV_NRD_NRD_1	391	393	PF00675	0.575
CLV_NRD_NRD_1	91	93	PF00675	0.750
CLV_PCSK_FUR_1	35	39	PF00082	0.478
CLV_PCSK_KEX2_1	170	172	PF00082	0.587
CLV_PCSK_KEX2_1	211	213	PF00082	0.768
CLV_PCSK_KEX2_1	36	38	PF00082	0.624
CLV_PCSK_KEX2_1	391	393	PF00082	0.575
CLV_PCSK_KEX2_1	91	93	PF00082	0.712
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.660
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.675
CLV_PCSK_SKI1_1	305	309	PF00082	0.440
CLV_PCSK_SKI1_1	319	323	PF00082	0.353
CLV_PCSK_SKI1_1	392	396	PF00082	0.609
CLV_Separin_Metazoa	251	255	PF03568	0.453
DEG_Nend_UBRbox_3	1	3	PF02207	0.638
DEG_SPOP_SBC_1	108	112	PF00917	0.529
DEG_SPOP_SBC_1	289	293	PF00917	0.646
DEG_SPOP_SBC_1	94	98	PF00917	0.755
DOC_MAPK_gen_1	28	34	PF00069	0.748
DOC_MAPK_gen_1	327	334	PF00069	0.508
DOC_MAPK_gen_1	436	443	PF00069	0.601
DOC_MAPK_MEF2A_6	418	425	PF00069	0.549
DOC_MAPK_NFAT4_5	418	426	PF00069	0.553
DOC_MAPK_RevD_3	21	36	PF00069	0.517
DOC_USP7_MATH_1	143	147	PF00917	0.420
DOC_USP7_MATH_1	189	193	PF00917	0.816
DOC_USP7_MATH_1	288	292	PF00917	0.601
DOC_USP7_MATH_1	41	45	PF00917	0.636
DOC_USP7_MATH_1	61	65	PF00917	0.381
DOC_USP7_UBL2_3	276	280	PF12436	0.509
DOC_WW_Pin1_4	196	201	PF00397	0.722
LIG_14-3-3_CanoR_1	254	261	PF00244	0.653
LIG_14-3-3_CanoR_1	319	325	PF00244	0.472
LIG_14-3-3_CanoR_1	400	409	PF00244	0.540
LIG_14-3-3_CanoR_1	92	100	PF00244	0.747
LIG_AP2alpha_1	71	75	PF02296	0.616
LIG_FHA_1	111	117	PF00498	0.768
LIG_FHA_1	346	352	PF00498	0.529
LIG_LIR_Apic_2	128	134	PF02991	0.431
LIG_LIR_Gen_1	48	59	PF02991	0.497
LIG_LIR_Nem_3	48	54	PF02991	0.494
LIG_NRBOX	420	426	PF00104	0.488
LIG_PCNA_yPIPBox_3	327	338	PF02747	0.598
LIG_Pex14_2	71	75	PF04695	0.616
LIG_Rb_pABgroove_1	45	53	PF01858	0.610
LIG_SH2_CRK	131	135	PF00017	0.419
LIG_SH2_STAP1	283	287	PF00017	0.618
LIG_SH3_3	210	216	PF00018	0.547
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.481
LIG_TRAF2_1	394	397	PF00917	0.591
MOD_CDK_SPxK_1	196	202	PF00069	0.794
MOD_CK1_1	109	115	PF00069	0.746
MOD_CK1_1	127	133	PF00069	0.447
MOD_CK1_1	192	198	PF00069	0.785
MOD_CK1_1	291	297	PF00069	0.610
MOD_CK1_1	325	331	PF00069	0.582
MOD_CK1_1	343	349	PF00069	0.434
MOD_CK1_1	448	454	PF00069	0.657
MOD_CK1_1	98	104	PF00069	0.710
MOD_CK2_1	448	454	PF00069	0.601
MOD_CK2_1	93	99	PF00069	0.548
MOD_GlcNHglycan	120	123	PF01048	0.677
MOD_GlcNHglycan	184	187	PF01048	0.767
MOD_GlcNHglycan	191	194	PF01048	0.671
MOD_GlcNHglycan	277	280	PF01048	0.558
MOD_GlcNHglycan	299	302	PF01048	0.497
MOD_GlcNHglycan	309	312	PF01048	0.485
MOD_GlcNHglycan	43	46	PF01048	0.653
MOD_GlcNHglycan	54	57	PF01048	0.598
MOD_GlcNHglycan	84	87	PF01048	0.763
MOD_GSK3_1	106	113	PF00069	0.671
MOD_GSK3_1	149	156	PF00069	0.605
MOD_GSK3_1	19	26	PF00069	0.710
MOD_GSK3_1	192	199	PF00069	0.723
MOD_GSK3_1	235	242	PF00069	0.615
MOD_GSK3_1	41	48	PF00069	0.653
MOD_GSK3_1	445	452	PF00069	0.645
MOD_GSK3_1	94	101	PF00069	0.648
MOD_N-GLC_1	340	345	PF02516	0.614
MOD_NEK2_1	118	123	PF00069	0.671
MOD_NEK2_1	154	159	PF00069	0.598
MOD_NEK2_1	307	312	PF00069	0.481
MOD_NEK2_1	322	327	PF00069	0.271
MOD_NEK2_1	50	55	PF00069	0.548
MOD_NEK2_1	62	67	PF00069	0.476
MOD_NEK2_1	84	89	PF00069	0.789
MOD_PIKK_1	345	351	PF00454	0.521
MOD_PIKK_1	400	406	PF00454	0.379
MOD_PIKK_1	62	68	PF00454	0.578
MOD_PK_1	437	443	PF00069	0.574
MOD_PKA_2	118	124	PF00069	0.585
MOD_PKA_2	189	195	PF00069	0.763
MOD_PKA_2	2	8	PF00069	0.706
MOD_PKA_2	253	259	PF00069	0.451
MOD_Plk_1	19	25	PF00069	0.664
MOD_Plk_1	239	245	PF00069	0.583
MOD_Plk_1	340	346	PF00069	0.619
MOD_Plk_1	437	443	PF00069	0.574
MOD_Plk_2-3	235	241	PF00069	0.583
MOD_Plk_4	19	25	PF00069	0.788
MOD_Plk_4	367	373	PF00069	0.620
MOD_Plk_4	437	443	PF00069	0.551
MOD_Plk_4	84	90	PF00069	0.731
MOD_ProDKin_1	196	202	PF00069	0.721
MOD_SUMO_for_1	417	420	PF00179	0.544
MOD_SUMO_rev_2	300	310	PF00179	0.470
TRG_DiLeu_BaEn_1	420	425	PF01217	0.456
TRG_ER_diArg_1	171	173	PF00400	0.629
TRG_ER_diArg_1	187	190	PF00400	0.690
TRG_ER_diArg_1	211	213	PF00400	0.708
TRG_ER_diArg_1	34	37	PF00400	0.488
TRG_ER_diArg_1	91	93	PF00400	0.704
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB8	Leptomonas seymouri	48%	77%
A0A1X0NJU7	Trypanosomatidae	30%	100%
A0A3S5H515	Leishmania donovani	91%	100%
A0A3S7X120	Leishmania donovani	91%	100%
A0A422NAX6	Trypanosoma rangeli	31%	100%
A4HG32	Leishmania braziliensis	72%	100%
C9ZJ54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ACX2	Leishmania major	99%	100%
E9AG19	Leishmania infantum	92%	100%
E9AG20	Leishmania infantum	91%	100%
E9AJN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%