DNA-directed RNA polymerase III subunit RPC3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACE2_LEIMA

TriTrypDb:

LmjF.02.0680 , LMJLV39_270033000 , LMJSD75_270033000

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	5
GO:0005666	RNA polymerase III complex	4	5
GO:0030880	RNA polymerase complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	5
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	5
GO:0140513	nuclear protein-containing complex	2	5
GO:0140535	intracellular protein-containing complex	2	5
GO:1902494	catalytic complex	2	5
GO:1990234	transferase complex	3	5

Expansion

Sequence features

E9ACE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACE2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003677	DNA binding	4	5
GO:0003697	single-stranded DNA binding	5	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.597
CLV_NRD_NRD_1	318	320	PF00675	0.398
CLV_NRD_NRD_1	358	360	PF00675	0.483
CLV_NRD_NRD_1	39	41	PF00675	0.750
CLV_PCSK_KEX2_1	25	27	PF00082	0.624
CLV_PCSK_KEX2_1	318	320	PF00082	0.398
CLV_PCSK_KEX2_1	358	360	PF00082	0.483
CLV_PCSK_KEX2_1	39	41	PF00082	0.747
CLV_PCSK_PC7_1	22	28	PF00082	0.459
CLV_PCSK_SKI1_1	100	104	PF00082	0.565
CLV_PCSK_SKI1_1	143	147	PF00082	0.445
CLV_PCSK_SKI1_1	171	175	PF00082	0.330
CLV_PCSK_SKI1_1	197	201	PF00082	0.516
CLV_PCSK_SKI1_1	221	225	PF00082	0.378
CLV_PCSK_SKI1_1	290	294	PF00082	0.412
CLV_PCSK_SKI1_1	304	308	PF00082	0.275
CLV_Separin_Metazoa	187	191	PF03568	0.437
DEG_APCC_DBOX_1	14	22	PF00400	0.442
DEG_APCC_DBOX_1	170	178	PF00400	0.326
DEG_Nend_UBRbox_2	1	3	PF02207	0.526
DEG_SPOP_SBC_1	53	57	PF00917	0.509
DOC_CKS1_1	1	6	PF01111	0.478
DOC_CYCLIN_RxL_1	301	310	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	68	74	PF00134	0.493
DOC_MAPK_gen_1	197	205	PF00069	0.365
DOC_MAPK_gen_1	219	228	PF00069	0.385
DOC_MAPK_MEF2A_6	136	144	PF00069	0.320
DOC_MAPK_MEF2A_6	304	311	PF00069	0.375
DOC_USP7_MATH_1	160	164	PF00917	0.391
DOC_USP7_MATH_1	189	193	PF00917	0.484
DOC_USP7_MATH_1	199	203	PF00917	0.317
DOC_USP7_MATH_1	255	259	PF00917	0.512
DOC_USP7_MATH_1	54	58	PF00917	0.496
DOC_USP7_MATH_1	82	86	PF00917	0.547
DOC_WW_Pin1_4	250	255	PF00397	0.561
DOC_WW_Pin1_4	335	340	PF00397	0.626
DOC_WW_Pin1_4	358	363	PF00397	0.564
DOC_WW_Pin1_4	87	92	PF00397	0.613
LIG_14-3-3_CanoR_1	15	21	PF00244	0.535
LIG_14-3-3_CanoR_1	221	227	PF00244	0.400
LIG_14-3-3_CanoR_1	318	322	PF00244	0.397
LIG_14-3-3_CanoR_1	323	328	PF00244	0.417
LIG_AP2alpha_1	178	182	PF02296	0.392
LIG_BRCT_BRCA1_1	360	364	PF00533	0.464
LIG_BRCT_BRCA1_1	89	93	PF00533	0.575
LIG_Clathr_ClatBox_1	306	310	PF01394	0.368
LIG_FHA_1	189	195	PF00498	0.483
LIG_FHA_1	223	229	PF00498	0.478
LIG_FHA_1	33	39	PF00498	0.545
LIG_FHA_1	48	54	PF00498	0.550
LIG_FHA_1	97	103	PF00498	0.524
LIG_FHA_2	156	162	PF00498	0.381
LIG_LIR_Gen_1	166	174	PF02991	0.328
LIG_LIR_Gen_1	227	236	PF02991	0.398
LIG_LIR_Gen_1	90	101	PF02991	0.554
LIG_LIR_Nem_3	110	115	PF02991	0.449
LIG_LIR_Nem_3	135	140	PF02991	0.380
LIG_LIR_Nem_3	166	170	PF02991	0.340
LIG_LIR_Nem_3	227	233	PF02991	0.396
LIG_LIR_Nem_3	310	314	PF02991	0.322
LIG_LIR_Nem_3	338	343	PF02991	0.452
LIG_NRBOX	301	307	PF00104	0.379
LIG_PCNA_yPIPBox_3	290	303	PF02747	0.390
LIG_Pex14_2	178	182	PF04695	0.392
LIG_REV1ctd_RIR_1	309	319	PF16727	0.360
LIG_SH2_CRK	137	141	PF00017	0.362
LIG_SH2_PTP2	167	170	PF00017	0.335
LIG_SH2_SRC	11	14	PF00017	0.456
LIG_SH2_STAP1	34	38	PF00017	0.546
LIG_SH2_STAT5	167	170	PF00017	0.463
LIG_SH2_STAT5	204	207	PF00017	0.352
LIG_SH2_STAT5	34	37	PF00017	0.546
LIG_SH3_4	105	112	PF00018	0.434
LIG_SUMO_SIM_par_1	304	310	PF11976	0.333
MOD_CDC14_SPxK_1	338	341	PF00782	0.632
MOD_CDK_SPxK_1	335	341	PF00069	0.629
MOD_CK1_1	163	169	PF00069	0.401
MOD_CK1_1	259	265	PF00069	0.645
MOD_CK1_1	32	38	PF00069	0.534
MOD_CK1_1	92	98	PF00069	0.703
MOD_CK2_1	155	161	PF00069	0.381
MOD_CK2_1	53	59	PF00069	0.531
MOD_GlcNHglycan	191	194	PF01048	0.451
MOD_GlcNHglycan	196	200	PF01048	0.425
MOD_GlcNHglycan	210	213	PF01048	0.251
MOD_GlcNHglycan	240	243	PF01048	0.582
MOD_GlcNHglycan	262	265	PF01048	0.501
MOD_GlcNHglycan	31	34	PF01048	0.522
MOD_GlcNHglycan	41	45	PF01048	0.633
MOD_GlcNHglycan	84	87	PF01048	0.524
MOD_GSK3_1	195	202	PF00069	0.437
MOD_GSK3_1	206	213	PF00069	0.450
MOD_GSK3_1	255	262	PF00069	0.506
MOD_GSK3_1	290	297	PF00069	0.406
MOD_GSK3_1	331	338	PF00069	0.442
MOD_GSK3_1	358	365	PF00069	0.472
MOD_GSK3_1	87	94	PF00069	0.678
MOD_N-GLC_1	260	265	PF02516	0.638
MOD_NEK2_1	16	21	PF00069	0.433
MOD_NEK2_1	208	213	PF00069	0.381
MOD_NEK2_1	222	227	PF00069	0.287
MOD_NEK2_2	199	204	PF00069	0.357
MOD_PIKK_1	105	111	PF00454	0.439
MOD_PK_1	323	329	PF00069	0.430
MOD_PKA_2	189	195	PF00069	0.483
MOD_PKA_2	317	323	PF00069	0.396
MOD_Plk_1	155	161	PF00069	0.381
MOD_Plk_2-3	155	161	PF00069	0.381
MOD_Plk_4	16	22	PF00069	0.602
MOD_Plk_4	163	169	PF00069	0.502
MOD_Plk_4	199	205	PF00069	0.351
MOD_Plk_4	210	216	PF00069	0.335
MOD_Plk_4	298	304	PF00069	0.347
MOD_ProDKin_1	250	256	PF00069	0.563
MOD_ProDKin_1	335	341	PF00069	0.629
MOD_ProDKin_1	358	364	PF00069	0.565
MOD_ProDKin_1	87	93	PF00069	0.608
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.374
TRG_ENDOCYTIC_2	137	140	PF00928	0.371
TRG_ENDOCYTIC_2	167	170	PF00928	0.335
TRG_ENDOCYTIC_2	340	343	PF00928	0.582
TRG_ER_diArg_1	24	27	PF00400	0.564
TRG_ER_diArg_1	317	319	PF00400	0.391
TRG_ER_diArg_1	358	360	PF00400	0.483
TRG_ER_diArg_1	38	40	PF00400	0.577
TRG_NES_CRM1_1	172	187	PF08389	0.385
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3F9	Leishmania braziliensis	83%	100%
A4HRS6	Leishmania infantum	92%	100%
V5BEQ8	Trypanosoma cruzi	36%	70%