Putative mitochondrial carrier protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania major

UniProt:

E9ACE1_LEIMA

TriTrypDb:

LmjF.02.0670 , LMJLV39_020011900 , LMJSD75_020012000

Length:

313

Annotations

LeishMANIAdb annotations

Homologous to Eukaryotic mitochondrial and chloroplast transporters for folate or nicotinic acid. Has no canonical mitochondrial target signal, only a Leishmaniid-specific C-terminal extension. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ACE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACE1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0001409	guanine nucleotide transmembrane transporter activity	6	2
GO:0005215	transporter activity	1	2
GO:0015215	nucleotide transmembrane transporter activity	4	2
GO:0015216	purine nucleotide transmembrane transporter activity	5	2
GO:0015605	organophosphate ester transmembrane transporter activity	3	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	80	82	PF00675	0.530
CLV_PCSK_KEX2_1	124	126	PF00082	0.468
CLV_PCSK_KEX2_1	45	47	PF00082	0.331
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.542
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.331
CLV_PCSK_PC7_1	120	126	PF00082	0.511
CLV_PCSK_SKI1_1	112	116	PF00082	0.477
CLV_PCSK_SKI1_1	219	223	PF00082	0.319
CLV_PCSK_SKI1_1	280	284	PF00082	0.316
CLV_PCSK_SKI1_1	292	296	PF00082	0.288
DEG_APCC_DBOX_1	167	175	PF00400	0.349
DOC_CDC14_PxL_1	287	295	PF14671	0.342
DOC_PP1_RVXF_1	290	296	PF00149	0.312
DOC_PP4_FxxP_1	149	152	PF00568	0.338
DOC_PP4_FxxP_1	36	39	PF00568	0.431
DOC_USP7_MATH_1	166	170	PF00917	0.376
DOC_USP7_MATH_1	7	11	PF00917	0.615
DOC_WW_Pin1_4	280	285	PF00397	0.323
LIG_14-3-3_CanoR_1	219	224	PF00244	0.319
LIG_AP2alpha_1	14	18	PF02296	0.554
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_Clathr_ClatBox_1	150	154	PF01394	0.307
LIG_eIF4E_1	218	224	PF01652	0.407
LIG_FHA_1	265	271	PF00498	0.386
LIG_FHA_1	281	287	PF00498	0.342
LIG_FHA_2	253	259	PF00498	0.454
LIG_FHA_2	296	302	PF00498	0.392
LIG_LIR_Apic_2	147	152	PF02991	0.338
LIG_LIR_Apic_2	33	39	PF02991	0.432
LIG_LIR_Gen_1	198	207	PF02991	0.307
LIG_LIR_Gen_1	222	232	PF02991	0.342
LIG_LIR_Gen_1	90	99	PF02991	0.443
LIG_LIR_Nem_3	121	126	PF02991	0.453
LIG_LIR_Nem_3	198	202	PF02991	0.307
LIG_LIR_Nem_3	277	282	PF02991	0.345
LIG_LIR_Nem_3	300	306	PF02991	0.346
LIG_LIR_Nem_3	90	95	PF02991	0.409
LIG_PCNA_PIPBox_1	108	117	PF02747	0.411
LIG_PCNA_yPIPBox_3	101	115	PF02747	0.519
LIG_Pex14_2	123	127	PF04695	0.358
LIG_Pex14_2	14	18	PF04695	0.495
LIG_Pex14_2	36	40	PF04695	0.434
LIG_REV1ctd_RIR_1	276	283	PF16727	0.392
LIG_REV1ctd_RIR_1	300	309	PF16727	0.405
LIG_SH2_CRK	92	96	PF00017	0.378
LIG_SH2_NCK_1	92	96	PF00017	0.491
LIG_SH2_SRC	85	88	PF00017	0.359
LIG_SH2_STAP1	92	96	PF00017	0.376
LIG_SH2_STAT5	126	129	PF00017	0.564
LIG_SH2_STAT5	211	214	PF00017	0.539
LIG_SH2_STAT5	297	300	PF00017	0.359
LIG_SH2_STAT5	85	88	PF00017	0.359
LIG_UBA3_1	150	157	PF00899	0.326
LIG_WRC_WIRS_1	275	280	PF05994	0.454
MOD_CDK_SPK_2	280	285	PF00069	0.323
MOD_CK1_1	10	16	PF00069	0.351
MOD_CK1_1	2	8	PF00069	0.663
MOD_CK2_1	252	258	PF00069	0.454
MOD_CK2_1	295	301	PF00069	0.323
MOD_CK2_1	55	61	PF00069	0.469
MOD_GlcNHglycan	1	4	PF01048	0.731
MOD_GlcNHglycan	168	171	PF01048	0.395
MOD_GlcNHglycan	260	263	PF01048	0.337
MOD_GlcNHglycan	288	291	PF01048	0.342
MOD_GSK3_1	55	62	PF00069	0.444
MOD_GSK3_1	87	94	PF00069	0.423
MOD_N-GLC_1	307	312	PF02516	0.595
MOD_N-GLC_2	226	228	PF02516	0.342
MOD_NEK2_1	114	119	PF00069	0.517
MOD_NEK2_1	18	23	PF00069	0.535
MOD_NEK2_1	202	207	PF00069	0.346
MOD_NEK2_1	227	232	PF00069	0.331
MOD_NEK2_1	295	300	PF00069	0.316
MOD_NEK2_1	307	312	PF00069	0.455
MOD_NEK2_1	55	60	PF00069	0.434
MOD_NEK2_1	91	96	PF00069	0.422
MOD_NEK2_2	274	279	PF00069	0.454
MOD_PIKK_1	157	163	PF00454	0.307
MOD_PKA_2	258	264	PF00069	0.431
MOD_PKA_2	55	61	PF00069	0.553
MOD_Plk_1	10	16	PF00069	0.591
MOD_Plk_4	184	190	PF00069	0.318
MOD_Plk_4	219	225	PF00069	0.318
MOD_Plk_4	274	280	PF00069	0.440
MOD_Plk_4	50	56	PF00069	0.557
MOD_Plk_4	87	93	PF00069	0.460
MOD_ProDKin_1	280	286	PF00069	0.323
MOD_SUMO_for_1	270	273	PF00179	0.405
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.454
TRG_ENDOCYTIC_2	92	95	PF00928	0.360
TRG_ENDOCYTIC_2	96	99	PF00928	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2W5	Leptomonas seymouri	46%	88%
A0A0N1IMP5	Leptomonas seymouri	22%	93%
A0A0S4IR49	Bodo saltans	49%	95%
A0A0S4IV98	Bodo saltans	26%	100%
A0A0S4JHF7	Bodo saltans	61%	99%
A0A1X0NJD2	Trypanosomatidae	25%	100%
A0A1X0NLB0	Trypanosomatidae	60%	98%
A0A1X0NUU7	Trypanosomatidae	23%	93%
A0A1X0P6S2	Trypanosomatidae	24%	96%
A0A3R7RT89	Trypanosoma rangeli	25%	100%
A0A3S7WTS6	Leishmania donovani	25%	100%
A0A422N706	Trypanosoma rangeli	46%	90%
A0A422NAX9	Trypanosoma rangeli	63%	96%
A0A451EJK1	Leishmania donovani	96%	100%
A4H3F8	Leishmania braziliensis	85%	100%
A4HRR2	Leishmania infantum	96%	100%
A4HWR9	Leishmania infantum	25%	100%
A5DX39	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	23%	100%
B0DK57	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	26%	100%
B0G143	Dictyostelium discoideum	23%	100%
C9ZJ51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D0A9Z0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	92%
E9AJM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AQH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B2N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	93%
F1R4U0	Danio rerio	23%	99%
O74439	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
P38988	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P55851	Homo sapiens	25%	100%
P70406	Mus musculus	25%	100%
P79110	Bos taurus	21%	100%
Q03028	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q08CI8	Danio rerio	22%	100%
Q4Q5H0	Leishmania major	22%	99%
Q4QF00	Leishmania major	26%	100%
Q54B67	Dictyostelium discoideum	27%	100%
Q54FE6	Dictyostelium discoideum	24%	100%
Q55DY8	Dictyostelium discoideum	25%	100%
Q55E45	Dictyostelium discoideum	24%	100%
Q55E85	Dictyostelium discoideum	25%	91%
Q55GE2	Dictyostelium discoideum	24%	100%
Q5R5A8	Pongo abelii	25%	100%
Q6PGY3	Danio rerio	26%	87%
Q86AV5	Dictyostelium discoideum	24%	100%
Q94AG6	Arabidopsis thaliana	25%	96%
Q99297	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q9N2J1	Canis lupus familiaris	25%	100%
Q9P3T7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q9W720	Danio rerio	29%	100%
Q9W725	Cyprinus carpio	28%	100%
V5B5N3	Trypanosoma cruzi	59%	95%
V5BN90	Trypanosoma cruzi	43%	90%