Nop14-like_family_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nop14-like family, putative

Species:

Leishmania major

UniProt:

E9ACE0_LEIMA

TriTrypDb:

LmjF.02.0660 , LMJLV39_020011800 , LMJSD75_020011900

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	10
GO:0030684	preribosome	3	10
GO:0030689	Noc complex	3	2
GO:0030692	Noc4p-Nop14p complex	4	2
GO:0032040	small-subunit processome	4	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

E9ACE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACE0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0030490	maturation of SSU-rRNA	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:0022613	ribonucleoprotein complex biogenesis	4	8
GO:0042254	ribosome biogenesis	5	8
GO:0044085	cellular component biogenesis	3	8
GO:0071840	cellular component organization or biogenesis	2	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.410
CLV_C14_Caspase3-7	308	312	PF00656	0.675
CLV_C14_Caspase3-7	315	319	PF00656	0.581
CLV_NRD_NRD_1	130	132	PF00675	0.704
CLV_NRD_NRD_1	156	158	PF00675	0.613
CLV_NRD_NRD_1	260	262	PF00675	0.603
CLV_NRD_NRD_1	397	399	PF00675	0.585
CLV_NRD_NRD_1	579	581	PF00675	0.419
CLV_NRD_NRD_1	584	586	PF00675	0.419
CLV_NRD_NRD_1	865	867	PF00675	0.396
CLV_NRD_NRD_1	911	913	PF00675	0.639
CLV_PCSK_FUR_1	879	883	PF00082	0.425
CLV_PCSK_KEX2_1	130	132	PF00082	0.704
CLV_PCSK_KEX2_1	156	158	PF00082	0.613
CLV_PCSK_KEX2_1	233	235	PF00082	0.536
CLV_PCSK_KEX2_1	260	262	PF00082	0.603
CLV_PCSK_KEX2_1	397	399	PF00082	0.587
CLV_PCSK_KEX2_1	579	581	PF00082	0.419
CLV_PCSK_KEX2_1	584	586	PF00082	0.419
CLV_PCSK_KEX2_1	843	845	PF00082	0.343
CLV_PCSK_KEX2_1	851	853	PF00082	0.351
CLV_PCSK_KEX2_1	865	867	PF00082	0.333
CLV_PCSK_KEX2_1	870	872	PF00082	0.333
CLV_PCSK_KEX2_1	881	883	PF00082	0.333
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.613
CLV_PCSK_PC1ET2_1	843	845	PF00082	0.343
CLV_PCSK_PC1ET2_1	851	853	PF00082	0.351
CLV_PCSK_PC1ET2_1	870	872	PF00082	0.333
CLV_PCSK_PC1ET2_1	881	883	PF00082	0.277
CLV_PCSK_PC7_1	580	586	PF00082	0.401
CLV_PCSK_PC7_1	847	853	PF00082	0.333
CLV_PCSK_PC7_1	866	872	PF00082	0.333
CLV_PCSK_SKI1_1	11	15	PF00082	0.660
CLV_PCSK_SKI1_1	112	116	PF00082	0.670
CLV_PCSK_SKI1_1	213	217	PF00082	0.566
CLV_PCSK_SKI1_1	253	257	PF00082	0.545
CLV_PCSK_SKI1_1	266	270	PF00082	0.575
CLV_PCSK_SKI1_1	322	326	PF00082	0.621
CLV_PCSK_SKI1_1	404	408	PF00082	0.530
CLV_PCSK_SKI1_1	564	568	PF00082	0.328
CLV_PCSK_SKI1_1	572	576	PF00082	0.307
CLV_PCSK_SKI1_1	585	589	PF00082	0.307
CLV_PCSK_SKI1_1	669	673	PF00082	0.326
CLV_PCSK_SKI1_1	730	734	PF00082	0.419
CLV_PCSK_SKI1_1	758	762	PF00082	0.460
CLV_PCSK_SKI1_1	840	844	PF00082	0.368
CLV_PCSK_SKI1_1	855	859	PF00082	0.368
DEG_APCC_DBOX_1	321	329	PF00400	0.616
DEG_APCC_DBOX_1	584	592	PF00400	0.309
DEG_SPOP_SBC_1	285	289	PF00917	0.648
DEG_SPOP_SBC_1	57	61	PF00917	0.758
DEG_SPOP_SBC_1	770	774	PF00917	0.420
DEG_SPOP_SBC_1	918	922	PF00917	0.743
DOC_CKS1_1	607	612	PF01111	0.333
DOC_CYCLIN_RxL_1	260	273	PF00134	0.526
DOC_MAPK_DCC_7	425	433	PF00069	0.662
DOC_MAPK_gen_1	210	220	PF00069	0.620
DOC_MAPK_gen_1	422	430	PF00069	0.540
DOC_MAPK_gen_1	537	546	PF00069	0.347
DOC_MAPK_gen_1	584	591	PF00069	0.401
DOC_MAPK_MEF2A_6	425	433	PF00069	0.662
DOC_MAPK_MEF2A_6	540	548	PF00069	0.347
DOC_MAPK_MEF2A_6	584	591	PF00069	0.419
DOC_PP2B_LxvP_1	179	182	PF13499	0.608
DOC_PP2B_LxvP_1	665	668	PF13499	0.307
DOC_PP2B_LxvP_1	682	685	PF13499	0.307
DOC_PP2B_LxvP_1	768	771	PF13499	0.479
DOC_USP7_MATH_1	147	151	PF00917	0.748
DOC_USP7_MATH_1	25	29	PF00917	0.505
DOC_USP7_MATH_1	284	288	PF00917	0.641
DOC_USP7_MATH_1	312	316	PF00917	0.640
DOC_USP7_MATH_1	332	336	PF00917	0.574
DOC_USP7_MATH_1	412	416	PF00917	0.637
DOC_USP7_MATH_1	570	574	PF00917	0.333
DOC_USP7_MATH_1	629	633	PF00917	0.419
DOC_USP7_MATH_1	771	775	PF00917	0.351
DOC_USP7_MATH_1	919	923	PF00917	0.740
DOC_USP7_UBL2_3	904	908	PF12436	0.567
DOC_WW_Pin1_4	145	150	PF00397	0.713
DOC_WW_Pin1_4	246	251	PF00397	0.519
DOC_WW_Pin1_4	606	611	PF00397	0.333
DOC_WW_Pin1_4	724	729	PF00397	0.425
DOC_WW_Pin1_4	746	751	PF00397	0.407
DOC_WW_Pin1_4	777	782	PF00397	0.438
DOC_WW_Pin1_4	805	810	PF00397	0.346
DOC_WW_Pin1_4	88	93	PF00397	0.758
DOC_WW_Pin1_4	920	925	PF00397	0.543
LIG_14-3-3_CanoR_1	112	117	PF00244	0.507
LIG_14-3-3_CanoR_1	124	132	PF00244	0.754
LIG_14-3-3_CanoR_1	26	34	PF00244	0.602
LIG_14-3-3_CanoR_1	286	294	PF00244	0.689
LIG_14-3-3_CanoR_1	378	387	PF00244	0.577
LIG_14-3-3_CanoR_1	5	13	PF00244	0.543
LIG_14-3-3_CanoR_1	584	588	PF00244	0.342
LIG_14-3-3_CanoR_1	769	779	PF00244	0.412
LIG_14-3-3_CanoR_1	855	863	PF00244	0.425
LIG_14-3-3_CanoR_1	97	102	PF00244	0.714
LIG_Actin_WH2_2	560	578	PF00022	0.344
LIG_Actin_WH2_2	632	647	PF00022	0.419
LIG_BIR_III_2	311	315	PF00653	0.536
LIG_BIR_III_4	55	59	PF00653	0.496
LIG_BRCT_BRCA1_1	103	107	PF00533	0.742
LIG_BRCT_BRCA1_1	272	276	PF00533	0.603
LIG_BRCT_BRCA1_1	594	598	PF00533	0.333
LIG_BRCT_BRCA1_1	647	651	PF00533	0.362
LIG_CSL_BTD_1	778	781	PF09270	0.425
LIG_EH_1	92	96	PF12763	0.726
LIG_EH1_1	275	283	PF00400	0.497
LIG_FHA_1	113	119	PF00498	0.601
LIG_FHA_1	127	133	PF00498	0.727
LIG_FHA_1	215	221	PF00498	0.463
LIG_FHA_1	247	253	PF00498	0.512
LIG_FHA_1	607	613	PF00498	0.357
LIG_FHA_1	636	642	PF00498	0.422
LIG_FHA_1	778	784	PF00498	0.369
LIG_FHA_1	791	797	PF00498	0.434
LIG_FHA_1	873	879	PF00498	0.235
LIG_FHA_2	185	191	PF00498	0.465
LIG_FHA_2	278	284	PF00498	0.670
LIG_FHA_2	306	312	PF00498	0.679
LIG_FHA_2	403	409	PF00498	0.516
LIG_FHA_2	440	446	PF00498	0.530
LIG_FHA_2	701	707	PF00498	0.398
LIG_FHA_2	80	86	PF00498	0.722
LIG_GBD_Chelix_1	636	644	PF00786	0.419
LIG_HP1_1	668	672	PF01393	0.419
LIG_LIR_Gen_1	383	392	PF02991	0.510
LIG_LIR_Gen_1	517	527	PF02991	0.425
LIG_LIR_Gen_1	609	619	PF02991	0.311
LIG_LIR_Gen_1	632	641	PF02991	0.342
LIG_LIR_Gen_1	880	890	PF02991	0.425
LIG_LIR_Nem_3	517	523	PF02991	0.518
LIG_LIR_Nem_3	560	566	PF02991	0.315
LIG_LIR_Nem_3	609	614	PF02991	0.318
LIG_LIR_Nem_3	632	636	PF02991	0.342
LIG_LIR_Nem_3	880	886	PF02991	0.368
LIG_MYND_3	684	688	PF01753	0.425
LIG_NRBOX	540	546	PF00104	0.419
LIG_NRBOX	635	641	PF00104	0.307
LIG_NRBOX	762	768	PF00104	0.419
LIG_PTAP_UEV_1	300	305	PF05743	0.716
LIG_SH2_CRK	883	887	PF00017	0.425
LIG_SH2_GRB2like	883	886	PF00017	0.425
LIG_SH2_SRC	590	593	PF00017	0.419
LIG_SH2_STAT5	590	593	PF00017	0.428
LIG_SH2_STAT5	633	636	PF00017	0.368
LIG_SH2_STAT5	81	84	PF00017	0.726
LIG_SH3_1	747	753	PF00018	0.419
LIG_SH3_2	781	786	PF14604	0.266
LIG_SH3_3	298	304	PF00018	0.720
LIG_SH3_3	348	354	PF00018	0.698
LIG_SH3_3	468	474	PF00018	0.725
LIG_SH3_3	604	610	PF00018	0.333
LIG_SH3_3	747	753	PF00018	0.419
LIG_SH3_3	778	784	PF00018	0.320
LIG_SH3_5	599	603	PF00018	0.307
LIG_SUMO_SIM_par_1	555	560	PF11976	0.383
LIG_TRAF2_1	237	240	PF00917	0.475
LIG_TRAF2_1	407	410	PF00917	0.491
LIG_UBA3_1	227	236	PF00899	0.608
LIG_UBA3_1	587	596	PF00899	0.419
LIG_UBA3_1	619	623	PF00899	0.285
LIG_UBA3_1	640	645	PF00899	0.419
LIG_WRC_WIRS_1	389	394	PF05994	0.612
LIG_WRC_WIRS_1	812	817	PF05994	0.385
MOD_CDC14_SPxK_1	727	730	PF00782	0.425
MOD_CDK_SPxK_1	724	730	PF00069	0.425
MOD_CDK_SPxxK_3	246	253	PF00069	0.517
MOD_CK1_1	108	114	PF00069	0.602
MOD_CK1_1	140	146	PF00069	0.712
MOD_CK1_1	292	298	PF00069	0.684
MOD_CK1_1	4	10	PF00069	0.638
MOD_CK1_1	707	713	PF00069	0.235
MOD_CK1_1	774	780	PF00069	0.478
MOD_CK2_1	184	190	PF00069	0.462
MOD_CK2_1	34	40	PF00069	0.602
MOD_CK2_1	402	408	PF00069	0.528
MOD_CK2_1	439	445	PF00069	0.535
MOD_CK2_1	472	478	PF00069	0.741
MOD_CK2_1	526	532	PF00069	0.368
MOD_CK2_1	700	706	PF00069	0.389
MOD_CK2_1	79	85	PF00069	0.673
MOD_CK2_1	920	926	PF00069	0.672
MOD_GlcNHglycan	103	106	PF01048	0.691
MOD_GlcNHglycan	112	115	PF01048	0.629
MOD_GlcNHglycan	139	142	PF01048	0.688
MOD_GlcNHglycan	246	249	PF01048	0.578
MOD_GlcNHglycan	27	30	PF01048	0.544
MOD_GlcNHglycan	272	275	PF01048	0.589
MOD_GlcNHglycan	291	294	PF01048	0.541
MOD_GlcNHglycan	305	308	PF01048	0.745
MOD_GlcNHglycan	414	417	PF01048	0.408
MOD_GlcNHglycan	510	513	PF01048	0.532
MOD_GlcNHglycan	616	619	PF01048	0.419
MOD_GlcNHglycan	647	650	PF01048	0.362
MOD_GlcNHglycan	697	700	PF01048	0.431
MOD_GlcNHglycan	71	74	PF01048	0.731
MOD_GlcNHglycan	773	776	PF01048	0.416
MOD_GlcNHglycan	915	918	PF01048	0.690
MOD_GlcNHglycan	99	102	PF01048	0.701
MOD_GSK3_1	1	8	PF00069	0.739
MOD_GSK3_1	106	113	PF00069	0.587
MOD_GSK3_1	122	129	PF00069	0.728
MOD_GSK3_1	136	143	PF00069	0.630
MOD_GSK3_1	266	273	PF00069	0.603
MOD_GSK3_1	285	292	PF00069	0.607
MOD_GSK3_1	295	302	PF00069	0.796
MOD_GSK3_1	30	37	PF00069	0.635
MOD_GSK3_1	412	419	PF00069	0.503
MOD_GSK3_1	508	515	PF00069	0.447
MOD_GSK3_1	528	535	PF00069	0.337
MOD_GSK3_1	700	707	PF00069	0.366
MOD_GSK3_1	770	777	PF00069	0.429
MOD_GSK3_1	855	862	PF00069	0.457
MOD_GSK3_1	913	920	PF00069	0.778
MOD_GSK3_1	97	104	PF00069	0.651
MOD_LATS_1	16	22	PF00433	0.579
MOD_N-GLC_1	135	140	PF02516	0.770
MOD_N-GLC_1	289	294	PF02516	0.686
MOD_N-GLC_1	532	537	PF02516	0.354
MOD_NEK2_1	1	6	PF00069	0.593
MOD_NEK2_1	107	112	PF00069	0.637
MOD_NEK2_1	135	140	PF00069	0.779
MOD_NEK2_1	24	29	PF00069	0.586
MOD_NEK2_1	244	249	PF00069	0.557
MOD_NEK2_1	255	260	PF00069	0.446
MOD_NEK2_1	270	275	PF00069	0.650
MOD_NEK2_1	34	39	PF00069	0.615
MOD_NEK2_1	388	393	PF00069	0.514
MOD_NEK2_1	575	580	PF00069	0.357
MOD_NEK2_1	583	588	PF00069	0.328
MOD_NEK2_1	614	619	PF00069	0.308
MOD_NEK2_1	69	74	PF00069	0.565
MOD_NEK2_1	694	699	PF00069	0.343
MOD_NEK2_1	721	726	PF00069	0.363
MOD_NEK2_1	745	750	PF00069	0.429
MOD_NEK2_1	95	100	PF00069	0.620
MOD_NEK2_2	811	816	PF00069	0.368
MOD_PIKK_1	34	40	PF00454	0.616
MOD_PIKK_1	436	442	PF00454	0.577
MOD_PIKK_1	709	715	PF00454	0.362
MOD_PIKK_1	885	891	PF00454	0.460
MOD_PKA_2	123	129	PF00069	0.638
MOD_PKA_2	25	31	PF00069	0.608
MOD_PKA_2	285	291	PF00069	0.717
MOD_PKA_2	34	40	PF00069	0.570
MOD_PKA_2	4	10	PF00069	0.584
MOD_PKA_2	508	514	PF00069	0.513
MOD_PKA_2	575	581	PF00069	0.370
MOD_PKA_2	583	589	PF00069	0.326
MOD_Plk_1	213	219	PF00069	0.524
MOD_Plk_1	402	408	PF00069	0.588
MOD_Plk_1	436	442	PF00069	0.601
MOD_Plk_1	570	576	PF00069	0.429
MOD_Plk_1	859	865	PF00069	0.425
MOD_Plk_2-3	277	283	PF00069	0.559
MOD_Plk_2-3	478	484	PF00069	0.608
MOD_Plk_4	147	153	PF00069	0.714
MOD_Plk_4	223	229	PF00069	0.463
MOD_Plk_4	312	318	PF00069	0.597
MOD_Plk_4	416	422	PF00069	0.504
MOD_Plk_4	629	635	PF00069	0.376
MOD_Plk_4	677	683	PF00069	0.489
MOD_ProDKin_1	145	151	PF00069	0.716
MOD_ProDKin_1	246	252	PF00069	0.517
MOD_ProDKin_1	606	612	PF00069	0.333
MOD_ProDKin_1	724	730	PF00069	0.425
MOD_ProDKin_1	746	752	PF00069	0.407
MOD_ProDKin_1	777	783	PF00069	0.438
MOD_ProDKin_1	805	811	PF00069	0.346
MOD_ProDKin_1	88	94	PF00069	0.757
MOD_ProDKin_1	920	926	PF00069	0.545
MOD_SUMO_for_1	237	240	PF00179	0.540
MOD_SUMO_for_1	835	838	PF00179	0.333
MOD_SUMO_rev_2	845	853	PF00179	0.333
TRG_DiLeu_BaEn_1	223	228	PF01217	0.555
TRG_DiLeu_BaEn_1	251	256	PF01217	0.531
TRG_DiLeu_BaEn_1	277	282	PF01217	0.492
TRG_DiLeu_BaEn_1	691	696	PF01217	0.426
TRG_DiLeu_BaEn_4	740	746	PF01217	0.425
TRG_DiLeu_BaLyEn_6	682	687	PF01217	0.419
TRG_DiLeu_BaLyEn_6	727	732	PF01217	0.354
TRG_DiLeu_BaLyEn_6	734	739	PF01217	0.279
TRG_DiLeu_BaLyEn_6	822	827	PF01217	0.333
TRG_DiLeu_BaLyEn_6	849	854	PF01217	0.368
TRG_DiLeu_LyEn_5	426	431	PF01217	0.478
TRG_ENDOCYTIC_2	633	636	PF00928	0.307
TRG_ENDOCYTIC_2	736	739	PF00928	0.307
TRG_ENDOCYTIC_2	883	886	PF00928	0.333
TRG_ER_diArg_1	130	132	PF00400	0.709
TRG_ER_diArg_1	155	157	PF00400	0.620
TRG_ER_diArg_1	259	261	PF00400	0.606
TRG_ER_diArg_1	396	398	PF00400	0.748
TRG_ER_diArg_1	583	585	PF00400	0.415
TRG_ER_diArg_1	815	818	PF00400	0.350
TRG_NLS_MonoExtN_4	232	237	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	737	741	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	818	822	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	844	848	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	855	860	PF00026	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1III2	Leptomonas seymouri	58%	100%
A0A1X0NK23	Trypanosomatidae	36%	94%
A0A3S5H513	Leishmania donovani	91%	100%
A4H3F7	Leishmania braziliensis	78%	100%
A4HRR1	Leishmania infantum	91%	100%
C9ZJ50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	97%
E9AJM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5AQ76	Trypanosoma cruzi	40%	100%