Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MICOS complex subunit 32, putative

Species:

Leishmania major

UniProt:

E9ACD9_LEIMA

TriTrypDb:

LmjF.02.0650 , LMJLV39_020011700 , LMJSD75_020011800

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.560
CLV_NRD_NRD_1	171	173	PF00675	0.623
CLV_NRD_NRD_1	295	297	PF00675	0.498
CLV_PCSK_KEX2_1	123	125	PF00082	0.780
CLV_PCSK_KEX2_1	171	173	PF00082	0.648
CLV_PCSK_KEX2_1	295	297	PF00082	0.425
CLV_PCSK_KEX2_1	47	49	PF00082	0.663
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.690
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.648
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.663
CLV_PCSK_SKI1_1	123	127	PF00082	0.693
CLV_PCSK_SKI1_1	182	186	PF00082	0.575
CLV_PCSK_SKI1_1	202	206	PF00082	0.292
CLV_PCSK_SKI1_1	229	233	PF00082	0.459
CLV_PCSK_SKI1_1	295	299	PF00082	0.568
CLV_PCSK_SKI1_1	47	51	PF00082	0.550
DEG_SPOP_SBC_1	25	29	PF00917	0.785
DOC_CYCLIN_RxL_1	197	207	PF00134	0.580
DOC_MAPK_DCC_7	171	181	PF00069	0.567
DOC_MAPK_gen_1	197	205	PF00069	0.564
DOC_MAPK_gen_1	80	90	PF00069	0.719
DOC_MAPK_MEF2A_6	172	181	PF00069	0.563
DOC_USP7_MATH_1	267	271	PF00917	0.707
DOC_USP7_MATH_1	30	34	PF00917	0.754
DOC_WW_Pin1_4	11	16	PF00397	0.677
DOC_WW_Pin1_4	115	120	PF00397	0.575
DOC_WW_Pin1_4	190	195	PF00397	0.606
DOC_WW_Pin1_4	5	10	PF00397	0.694
LIG_14-3-3_CanoR_1	136	140	PF00244	0.807
LIG_14-3-3_CanoR_1	182	189	PF00244	0.555
LIG_14-3-3_CanoR_1	48	56	PF00244	0.636
LIG_FHA_1	11	17	PF00498	0.775
LIG_FHA_1	191	197	PF00498	0.570
LIG_FHA_1	52	58	PF00498	0.597
LIG_FHA_2	145	151	PF00498	0.823
LIG_FHA_2	183	189	PF00498	0.574
LIG_LIR_Nem_3	219	225	PF02991	0.584
LIG_NRBOX	51	57	PF00104	0.517
LIG_PCNA_yPIPBox_3	80	88	PF02747	0.632
LIG_PDZ_Class_3	310	315	PF00595	0.589
LIG_SH2_CRK	222	226	PF00017	0.594
LIG_SH2_STAT5	224	227	PF00017	0.545
LIG_SH2_STAT5	244	247	PF00017	0.443
LIG_SH3_3	150	156	PF00018	0.770
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.618
LIG_TRAF2_1	185	188	PF00917	0.631
LIG_TRAF2_1	62	65	PF00917	0.591
LIG_WRPW_2	105	108	PF00400	0.646
MOD_CDK_SPxxK_3	190	197	PF00069	0.631
MOD_CK1_1	146	152	PF00069	0.773
MOD_CK1_1	26	32	PF00069	0.769
MOD_CK1_1	8	14	PF00069	0.796
MOD_CK2_1	144	150	PF00069	0.825
MOD_CK2_1	18	24	PF00069	0.821
MOD_CK2_1	182	188	PF00069	0.550
MOD_CK2_1	35	41	PF00069	0.675
MOD_CMANNOS	108	111	PF00535	0.643
MOD_GlcNHglycan	112	115	PF01048	0.549
MOD_GlcNHglycan	274	277	PF01048	0.721
MOD_GlcNHglycan	72	75	PF01048	0.640
MOD_GSK3_1	1	8	PF00069	0.732
MOD_GSK3_1	106	113	PF00069	0.529
MOD_GSK3_1	140	147	PF00069	0.679
MOD_GSK3_1	26	33	PF00069	0.775
MOD_GSK3_1	36	43	PF00069	0.711
MOD_GSK3_1	47	54	PF00069	0.591
MOD_N-GLC_1	18	23	PF02516	0.759
MOD_NEK2_1	1	6	PF00069	0.726
MOD_NEK2_1	217	222	PF00069	0.647
MOD_PIKK_1	144	150	PF00454	0.739
MOD_PKA_1	47	53	PF00069	0.642
MOD_PKA_2	135	141	PF00069	0.725
MOD_PKA_2	272	278	PF00069	0.657
MOD_PKA_2	47	53	PF00069	0.642
MOD_Plk_1	217	223	PF00069	0.596
MOD_Plk_1	278	284	PF00069	0.596
MOD_Plk_4	278	284	PF00069	0.635
MOD_Plk_4	300	306	PF00069	0.605
MOD_Plk_4	51	57	PF00069	0.598
MOD_ProDKin_1	115	121	PF00069	0.578
MOD_ProDKin_1	190	196	PF00069	0.605
MOD_ProDKin_1	5	11	PF00069	0.696
MOD_SUMO_for_1	231	234	PF00179	0.617
MOD_SUMO_rev_2	161	168	PF00179	0.589
MOD_SUMO_rev_2	41	49	PF00179	0.662
MOD_SUMO_rev_2	63	68	PF00179	0.654
TRG_DiLeu_BaEn_1	199	204	PF01217	0.521
TRG_DiLeu_BaEn_4	187	193	PF01217	0.635
TRG_DiLeu_BaEn_4	44	50	PF01217	0.585
TRG_ENDOCYTIC_2	222	225	PF00928	0.595
TRG_ER_diArg_1	294	296	PF00400	0.470
TRG_NLS_MonoCore_2	170	175	PF00514	0.665
TRG_NLS_MonoExtN_4	169	176	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W5	Leptomonas seymouri	52%	100%
A0A0S4JF25	Bodo saltans	24%	100%
A0A1X0NJL7	Trypanosomatidae	38%	95%
A0A3S5H512	Leishmania donovani	91%	100%
A0A422NAY0	Trypanosoma rangeli	33%	95%
A4H3F6	Leishmania braziliensis	75%	100%
A4HRR0	Leishmania infantum	91%	100%
C9ZJ49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AJM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5D620	Trypanosoma cruzi	35%	98%