Gamma-glutamyl phosphate reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

gamma-glutamyl phosphate reductase-like protein

Species:

Leishmania major

UniProt:

E9ACD7_LEIMA

TriTrypDb:

LmjF.02.0630 , LMJLV39_020011500 , LMJSD75_020011600

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACD7

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	5
GO:0006520	amino acid metabolic process	3	5
GO:0006560	proline metabolic process	6	5
GO:0006561	proline biosynthetic process	7	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0008652	amino acid biosynthetic process	4	5
GO:0009058	biosynthetic process	2	5
GO:0009064	glutamine family amino acid metabolic process	5	5
GO:0009084	glutamine family amino acid biosynthetic process	6	5
GO:0009987	cellular process	1	5
GO:0016053	organic acid biosynthetic process	4	5
GO:0018130	heterocycle biosynthetic process	4	5
GO:0019752	carboxylic acid metabolic process	5	5
GO:0043436	oxoacid metabolic process	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044281	small molecule metabolic process	2	5
GO:0044283	small molecule biosynthetic process	3	5
GO:0046394	carboxylic acid biosynthetic process	5	5
GO:0046483	heterocycle metabolic process	3	5
GO:0055129	L-proline biosynthetic process	5	5
GO:0071704	organic substance metabolic process	2	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:1901362	organic cyclic compound biosynthetic process	4	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901566	organonitrogen compound biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5
GO:1901605	alpha-amino acid metabolic process	4	5
GO:1901607	alpha-amino acid biosynthetic process	5	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004350	glutamate-5-semialdehyde dehydrogenase activity	5	7
GO:0016491	oxidoreductase activity	2	11
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4	11
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.694
CLV_NRD_NRD_1	333	335	PF00675	0.442
CLV_NRD_NRD_1	36	38	PF00675	0.452
CLV_NRD_NRD_1	395	397	PF00675	0.432
CLV_NRD_NRD_1	59	61	PF00675	0.470
CLV_NRD_NRD_1	643	645	PF00675	0.481
CLV_NRD_NRD_1	8	10	PF00675	0.540
CLV_PCSK_KEX2_1	148	150	PF00082	0.694
CLV_PCSK_KEX2_1	333	335	PF00082	0.442
CLV_PCSK_KEX2_1	36	38	PF00082	0.452
CLV_PCSK_KEX2_1	395	397	PF00082	0.432
CLV_PCSK_KEX2_1	59	61	PF00082	0.470
CLV_PCSK_KEX2_1	8	10	PF00082	0.540
CLV_PCSK_SKI1_1	37	41	PF00082	0.451
CLV_PCSK_SKI1_1	395	399	PF00082	0.432
DEG_APCC_DBOX_1	36	44	PF00400	0.442
DEG_COP1_1	219	229	PF00400	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DEG_SPOP_SBC_1	199	203	PF00917	0.582
DEG_SPOP_SBC_1	624	628	PF00917	0.403
DOC_CKS1_1	247	252	PF01111	0.608
DOC_CYCLIN_RxL_1	551	563	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	255	261	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.410
DOC_MAPK_gen_1	330	340	PF00069	0.502
DOC_MAPK_gen_1	355	362	PF00069	0.435
DOC_MAPK_gen_1	36	43	PF00069	0.401
DOC_MAPK_MEF2A_6	355	362	PF00069	0.492
DOC_MAPK_MEF2A_6	504	512	PF00069	0.405
DOC_MAPK_MEF2A_6	633	640	PF00069	0.440
DOC_MAPK_MEF2A_6	72	79	PF00069	0.674
DOC_PP2B_LxvP_1	343	346	PF13499	0.420
DOC_PP2B_PxIxI_1	357	363	PF00149	0.423
DOC_USP7_MATH_1	139	143	PF00917	0.622
DOC_USP7_MATH_1	194	198	PF00917	0.714
DOC_USP7_MATH_1	21	25	PF00917	0.462
DOC_USP7_MATH_1	216	220	PF00917	0.688
DOC_USP7_MATH_1	29	33	PF00917	0.408
DOC_USP7_MATH_1	297	301	PF00917	0.651
DOC_USP7_MATH_1	321	325	PF00917	0.590
DOC_USP7_MATH_1	389	393	PF00917	0.514
DOC_USP7_MATH_1	417	421	PF00917	0.436
DOC_USP7_MATH_1	84	88	PF00917	0.685
DOC_USP7_MATH_1	94	98	PF00917	0.601
DOC_WW_Pin1_4	130	135	PF00397	0.692
DOC_WW_Pin1_4	143	148	PF00397	0.592
DOC_WW_Pin1_4	157	162	PF00397	0.577
DOC_WW_Pin1_4	179	184	PF00397	0.638
DOC_WW_Pin1_4	207	212	PF00397	0.635
DOC_WW_Pin1_4	246	251	PF00397	0.691
DOC_WW_Pin1_4	254	259	PF00397	0.589
DOC_WW_Pin1_4	312	317	PF00397	0.634
DOC_WW_Pin1_4	401	406	PF00397	0.392
DOC_WW_Pin1_4	71	76	PF00397	0.650
LIG_14-3-3_CanoR_1	148	154	PF00244	0.693
LIG_14-3-3_CanoR_1	198	208	PF00244	0.652
LIG_14-3-3_CanoR_1	217	226	PF00244	0.570
LIG_14-3-3_CanoR_1	333	341	PF00244	0.439
LIG_14-3-3_CanoR_1	36	40	PF00244	0.438
LIG_14-3-3_CanoR_1	395	405	PF00244	0.432
LIG_14-3-3_CanoR_1	419	427	PF00244	0.401
LIG_14-3-3_CanoR_1	448	455	PF00244	0.388
LIG_14-3-3_CanoR_1	49	55	PF00244	0.387
LIG_14-3-3_CanoR_1	504	512	PF00244	0.405
LIG_14-3-3_CanoR_1	610	617	PF00244	0.434
LIG_14-3-3_CanoR_1	633	639	PF00244	0.440
LIG_14-3-3_CanoR_1	649	658	PF00244	0.350
LIG_14-3-3_CanoR_1	8	15	PF00244	0.512
LIG_APCC_ABBA_1	496	501	PF00400	0.560
LIG_BIR_III_4	118	122	PF00653	0.656
LIG_BRCT_BRCA1_1	468	472	PF00533	0.405
LIG_Clathr_ClatBox_1	569	573	PF01394	0.413
LIG_DCNL_PONY_1	1	4	PF03556	0.647
LIG_eIF4E_1	449	455	PF01652	0.380
LIG_FHA_1	333	339	PF00498	0.580
LIG_FHA_1	372	378	PF00498	0.385
LIG_FHA_1	398	404	PF00498	0.414
LIG_FHA_1	449	455	PF00498	0.419
LIG_FHA_1	492	498	PF00498	0.558
LIG_FHA_1	504	510	PF00498	0.385
LIG_FHA_1	554	560	PF00498	0.564
LIG_FHA_1	641	647	PF00498	0.459
LIG_FHA_1	72	78	PF00498	0.672
LIG_FHA_2	233	239	PF00498	0.695
LIG_FHA_2	264	270	PF00498	0.508
LIG_FHA_2	522	528	PF00498	0.532
LIG_FHA_2	584	590	PF00498	0.451
LIG_FXI_DFP_1	499	503	PF00024	0.414
LIG_LIR_Gen_1	421	431	PF02991	0.575
LIG_LIR_Gen_1	447	457	PF02991	0.408
LIG_LIR_Gen_1	458	466	PF02991	0.345
LIG_LIR_Gen_1	482	492	PF02991	0.428
LIG_LIR_Nem_3	421	427	PF02991	0.572
LIG_LIR_Nem_3	447	452	PF02991	0.415
LIG_LIR_Nem_3	458	464	PF02991	0.356
LIG_LIR_Nem_3	482	487	PF02991	0.424
LIG_LIR_Nem_3	500	505	PF02991	0.266
LIG_LIR_Nem_3	539	545	PF02991	0.458
LIG_Pex14_2	571	575	PF04695	0.414
LIG_PTB_Apo_2	478	485	PF02174	0.406
LIG_RPA_C_Fungi	3	15	PF08784	0.505
LIG_SH2_CRK	449	453	PF00017	0.390
LIG_SH2_CRK	542	546	PF00017	0.521
LIG_SH2_NCK_1	449	453	PF00017	0.390
LIG_SH2_STAP1	341	345	PF00017	0.431
LIG_SH2_STAP1	505	509	PF00017	0.449
LIG_SH2_STAT3	465	468	PF00017	0.393
LIG_SH2_STAT5	155	158	PF00017	0.731
LIG_SH2_STAT5	270	273	PF00017	0.451
LIG_SH2_STAT5	465	468	PF00017	0.558
LIG_SH2_STAT5	505	508	PF00017	0.402
LIG_SH2_STAT5	594	597	PF00017	0.392
LIG_SH3_2	208	213	PF14604	0.623
LIG_SH3_3	159	165	PF00018	0.572
LIG_SH3_3	205	211	PF00018	0.650
LIG_SH3_3	313	319	PF00018	0.650
LIG_SH3_3	433	439	PF00018	0.400
LIG_SH3_3	74	80	PF00018	0.689
LIG_SUMO_SIM_anti_2	432	437	PF11976	0.406
LIG_SUMO_SIM_anti_2	599	606	PF11976	0.416
LIG_SUMO_SIM_par_1	373	378	PF11976	0.385
LIG_SUMO_SIM_par_1	38	46	PF11976	0.407
LIG_SUMO_SIM_par_1	494	501	PF11976	0.401
LIG_SUMO_SIM_par_1	531	541	PF11976	0.442
LIG_SUMO_SIM_par_1	634	639	PF11976	0.447
LIG_SxIP_EBH_1	445	456	PF03271	0.542
LIG_TRAF2_1	524	527	PF00917	0.396
LIG_TRAF2_1	537	540	PF00917	0.393
LIG_UBA3_1	255	263	PF00899	0.514
LIG_WRC_WIRS_1	572	577	PF05994	0.420
MOD_CDC14_SPxK_1	146	149	PF00782	0.693
MOD_CDC14_SPxK_1	210	213	PF00782	0.618
MOD_CDC14_SPxK_1	257	260	PF00782	0.524
MOD_CDK_SPK_2	143	148	PF00069	0.699
MOD_CDK_SPxK_1	143	149	PF00069	0.698
MOD_CDK_SPxK_1	207	213	PF00069	0.624
MOD_CDK_SPxK_1	254	260	PF00069	0.661
MOD_CK1_1	142	148	PF00069	0.703
MOD_CK1_1	197	203	PF00069	0.761
MOD_CK1_1	219	225	PF00069	0.708
MOD_CK1_1	361	367	PF00069	0.278
MOD_CK1_1	447	453	PF00069	0.439
MOD_CK1_1	574	580	PF00069	0.552
MOD_CK1_1	7	13	PF00069	0.517
MOD_CK1_1	87	93	PF00069	0.610
MOD_CK2_1	232	238	PF00069	0.695
MOD_CK2_1	263	269	PF00069	0.598
MOD_CK2_1	297	303	PF00069	0.584
MOD_CK2_1	417	423	PF00069	0.449
MOD_CK2_1	521	527	PF00069	0.534
MOD_CK2_1	535	541	PF00069	0.381
MOD_CK2_1	583	589	PF00069	0.448
MOD_GlcNHglycan	140	144	PF01048	0.686
MOD_GlcNHglycan	202	205	PF01048	0.694
MOD_GlcNHglycan	219	222	PF01048	0.574
MOD_GlcNHglycan	230	233	PF01048	0.600
MOD_GlcNHglycan	288	291	PF01048	0.732
MOD_GlcNHglycan	293	296	PF01048	0.706
MOD_GlcNHglycan	319	322	PF01048	0.623
MOD_GlcNHglycan	4	7	PF01048	0.587
MOD_GlcNHglycan	405	408	PF01048	0.426
MOD_GlcNHglycan	467	471	PF01048	0.404
MOD_GlcNHglycan	612	615	PF01048	0.404
MOD_GlcNHglycan	651	654	PF01048	0.458
MOD_GlcNHglycan	86	89	PF01048	0.692
MOD_GlcNHglycan	9	12	PF01048	0.515
MOD_GSK3_1	139	146	PF00069	0.680
MOD_GSK3_1	157	164	PF00069	0.543
MOD_GSK3_1	190	197	PF00069	0.728
MOD_GSK3_1	198	205	PF00069	0.805
MOD_GSK3_1	228	235	PF00069	0.633
MOD_GSK3_1	23	30	PF00069	0.482
MOD_GSK3_1	317	324	PF00069	0.581
MOD_GSK3_1	379	386	PF00069	0.518
MOD_GSK3_1	397	404	PF00069	0.412
MOD_GSK3_1	444	451	PF00069	0.474
MOD_GSK3_1	455	462	PF00069	0.534
MOD_GSK3_1	605	612	PF00069	0.419
MOD_GSK3_1	623	630	PF00069	0.276
MOD_GSK3_1	71	78	PF00069	0.664
MOD_GSK3_1	79	86	PF00069	0.626
MOD_GSK3_1	88	95	PF00069	0.553
MOD_N-GLC_1	605	610	PF02516	0.518
MOD_NEK2_1	190	195	PF00069	0.692
MOD_NEK2_1	2	7	PF00069	0.609
MOD_NEK2_1	28	33	PF00069	0.467
MOD_NEK2_1	383	388	PF00069	0.514
MOD_NEK2_1	390	395	PF00069	0.503
MOD_NEK2_1	455	460	PF00069	0.405
MOD_NEK2_1	571	576	PF00069	0.414
MOD_NEK2_1	623	628	PF00069	0.528
MOD_NEK2_1	640	645	PF00069	0.452
MOD_NEK2_2	297	302	PF00069	0.637
MOD_NEK2_2	379	384	PF00069	0.441
MOD_NEK2_2	94	99	PF00069	0.642
MOD_PIKK_1	543	549	PF00454	0.496
MOD_PKA_1	148	154	PF00069	0.673
MOD_PKA_2	148	154	PF00069	0.673
MOD_PKA_2	197	203	PF00069	0.679
MOD_PKA_2	2	8	PF00069	0.607
MOD_PKA_2	216	222	PF00069	0.512
MOD_PKA_2	329	335	PF00069	0.528
MOD_PKA_2	35	41	PF00069	0.448
MOD_PKA_2	358	364	PF00069	0.413
MOD_PKA_2	418	424	PF00069	0.427
MOD_PKA_2	447	453	PF00069	0.473
MOD_PKA_2	455	461	PF00069	0.484
MOD_PKA_2	48	54	PF00069	0.390
MOD_PKA_2	503	509	PF00069	0.413
MOD_PKA_2	609	615	PF00069	0.421
MOD_Plk_1	341	347	PF00069	0.425
MOD_Plk_2-3	535	541	PF00069	0.461
MOD_Plk_4	371	377	PF00069	0.433
MOD_Plk_4	379	385	PF00069	0.460
MOD_Plk_4	460	466	PF00069	0.451
MOD_Plk_4	492	498	PF00069	0.544
MOD_ProDKin_1	130	136	PF00069	0.688
MOD_ProDKin_1	143	149	PF00069	0.591
MOD_ProDKin_1	157	163	PF00069	0.576
MOD_ProDKin_1	179	185	PF00069	0.638
MOD_ProDKin_1	207	213	PF00069	0.635
MOD_ProDKin_1	246	252	PF00069	0.683
MOD_ProDKin_1	254	260	PF00069	0.587
MOD_ProDKin_1	312	318	PF00069	0.631
MOD_ProDKin_1	401	407	PF00069	0.386
MOD_ProDKin_1	71	77	PF00069	0.657
TRG_DiLeu_BaEn_1	515	520	PF01217	0.376
TRG_DiLeu_BaEn_4	540	546	PF01217	0.480
TRG_ENDOCYTIC_2	105	108	PF00928	0.636
TRG_ENDOCYTIC_2	449	452	PF00928	0.384
TRG_ENDOCYTIC_2	505	508	PF00928	0.406
TRG_ENDOCYTIC_2	542	545	PF00928	0.458
TRG_ER_diArg_1	147	149	PF00400	0.692
TRG_ER_diArg_1	356	359	PF00400	0.457
TRG_ER_diArg_1	394	396	PF00400	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ITL0	Leishmania donovani	28%	100%
A0A451EJJ7	Leishmania donovani	95%	100%
A4H3F4	Leishmania braziliensis	82%	100%
A4HKV9	Leishmania braziliensis	28%	100%
A4HRQ8	Leishmania infantum	94%	100%
A4I8D9	Leishmania infantum	28%	100%
E9AJM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B397	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q4V8	Leishmania major	29%	100%