LeishMANIAdb
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Gamma-glutamyl phosphate reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Gamma-glutamyl phosphate reductase-like protein
Gene product:
gamma-glutamyl phosphate reductase-like protein
Species:
Leishmania major
UniProt:
E9ACD7_LEIMA
TriTrypDb:
LmjF.02.0630 , LMJLV39_020011500 , LMJSD75_020011600
Length:
659

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACD7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACD7

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 5
GO:0006520 amino acid metabolic process 3 5
GO:0006560 proline metabolic process 6 5
GO:0006561 proline biosynthetic process 7 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0008652 amino acid biosynthetic process 4 5
GO:0009058 biosynthetic process 2 5
GO:0009064 glutamine family amino acid metabolic process 5 5
GO:0009084 glutamine family amino acid biosynthetic process 6 5
GO:0009987 cellular process 1 5
GO:0016053 organic acid biosynthetic process 4 5
GO:0018130 heterocycle biosynthetic process 4 5
GO:0019752 carboxylic acid metabolic process 5 5
GO:0043436 oxoacid metabolic process 4 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0044249 cellular biosynthetic process 3 5
GO:0044281 small molecule metabolic process 2 5
GO:0044283 small molecule biosynthetic process 3 5
GO:0046394 carboxylic acid biosynthetic process 5 5
GO:0046483 heterocycle metabolic process 3 5
GO:0055129 L-proline biosynthetic process 5 5
GO:0071704 organic substance metabolic process 2 5
GO:1901360 organic cyclic compound metabolic process 3 5
GO:1901362 organic cyclic compound biosynthetic process 4 5
GO:1901564 organonitrogen compound metabolic process 3 5
GO:1901566 organonitrogen compound biosynthetic process 4 5
GO:1901576 organic substance biosynthetic process 3 5
GO:1901605 alpha-amino acid metabolic process 4 5
GO:1901607 alpha-amino acid biosynthetic process 5 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity 5 7
GO:0016491 oxidoreductase activity 2 11
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4 11
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 148 150 PF00675 0.694
CLV_NRD_NRD_1 333 335 PF00675 0.442
CLV_NRD_NRD_1 36 38 PF00675 0.452
CLV_NRD_NRD_1 395 397 PF00675 0.432
CLV_NRD_NRD_1 59 61 PF00675 0.470
CLV_NRD_NRD_1 643 645 PF00675 0.481
CLV_NRD_NRD_1 8 10 PF00675 0.540
CLV_PCSK_KEX2_1 148 150 PF00082 0.694
CLV_PCSK_KEX2_1 333 335 PF00082 0.442
CLV_PCSK_KEX2_1 36 38 PF00082 0.452
CLV_PCSK_KEX2_1 395 397 PF00082 0.432
CLV_PCSK_KEX2_1 59 61 PF00082 0.470
CLV_PCSK_KEX2_1 8 10 PF00082 0.540
CLV_PCSK_SKI1_1 37 41 PF00082 0.451
CLV_PCSK_SKI1_1 395 399 PF00082 0.432
DEG_APCC_DBOX_1 36 44 PF00400 0.442
DEG_COP1_1 219 229 PF00400 0.576
DEG_Nend_Nbox_1 1 3 PF02207 0.656
DEG_SPOP_SBC_1 199 203 PF00917 0.582
DEG_SPOP_SBC_1 624 628 PF00917 0.403
DOC_CKS1_1 247 252 PF01111 0.608
DOC_CYCLIN_RxL_1 551 563 PF00134 0.325
DOC_CYCLIN_yCln2_LP_2 255 261 PF00134 0.513
DOC_CYCLIN_yCln2_LP_2 343 349 PF00134 0.410
DOC_MAPK_gen_1 330 340 PF00069 0.502
DOC_MAPK_gen_1 355 362 PF00069 0.435
DOC_MAPK_gen_1 36 43 PF00069 0.401
DOC_MAPK_MEF2A_6 355 362 PF00069 0.492
DOC_MAPK_MEF2A_6 504 512 PF00069 0.405
DOC_MAPK_MEF2A_6 633 640 PF00069 0.440
DOC_MAPK_MEF2A_6 72 79 PF00069 0.674
DOC_PP2B_LxvP_1 343 346 PF13499 0.420
DOC_PP2B_PxIxI_1 357 363 PF00149 0.423
DOC_USP7_MATH_1 139 143 PF00917 0.622
DOC_USP7_MATH_1 194 198 PF00917 0.714
DOC_USP7_MATH_1 21 25 PF00917 0.462
DOC_USP7_MATH_1 216 220 PF00917 0.688
DOC_USP7_MATH_1 29 33 PF00917 0.408
DOC_USP7_MATH_1 297 301 PF00917 0.651
DOC_USP7_MATH_1 321 325 PF00917 0.590
DOC_USP7_MATH_1 389 393 PF00917 0.514
DOC_USP7_MATH_1 417 421 PF00917 0.436
DOC_USP7_MATH_1 84 88 PF00917 0.685
DOC_USP7_MATH_1 94 98 PF00917 0.601
DOC_WW_Pin1_4 130 135 PF00397 0.692
DOC_WW_Pin1_4 143 148 PF00397 0.592
DOC_WW_Pin1_4 157 162 PF00397 0.577
DOC_WW_Pin1_4 179 184 PF00397 0.638
DOC_WW_Pin1_4 207 212 PF00397 0.635
DOC_WW_Pin1_4 246 251 PF00397 0.691
DOC_WW_Pin1_4 254 259 PF00397 0.589
DOC_WW_Pin1_4 312 317 PF00397 0.634
DOC_WW_Pin1_4 401 406 PF00397 0.392
DOC_WW_Pin1_4 71 76 PF00397 0.650
LIG_14-3-3_CanoR_1 148 154 PF00244 0.693
LIG_14-3-3_CanoR_1 198 208 PF00244 0.652
LIG_14-3-3_CanoR_1 217 226 PF00244 0.570
LIG_14-3-3_CanoR_1 333 341 PF00244 0.439
LIG_14-3-3_CanoR_1 36 40 PF00244 0.438
LIG_14-3-3_CanoR_1 395 405 PF00244 0.432
LIG_14-3-3_CanoR_1 419 427 PF00244 0.401
LIG_14-3-3_CanoR_1 448 455 PF00244 0.388
LIG_14-3-3_CanoR_1 49 55 PF00244 0.387
LIG_14-3-3_CanoR_1 504 512 PF00244 0.405
LIG_14-3-3_CanoR_1 610 617 PF00244 0.434
LIG_14-3-3_CanoR_1 633 639 PF00244 0.440
LIG_14-3-3_CanoR_1 649 658 PF00244 0.350
LIG_14-3-3_CanoR_1 8 15 PF00244 0.512
LIG_APCC_ABBA_1 496 501 PF00400 0.560
LIG_BIR_III_4 118 122 PF00653 0.656
LIG_BRCT_BRCA1_1 468 472 PF00533 0.405
LIG_Clathr_ClatBox_1 569 573 PF01394 0.413
LIG_DCNL_PONY_1 1 4 PF03556 0.647
LIG_eIF4E_1 449 455 PF01652 0.380
LIG_FHA_1 333 339 PF00498 0.580
LIG_FHA_1 372 378 PF00498 0.385
LIG_FHA_1 398 404 PF00498 0.414
LIG_FHA_1 449 455 PF00498 0.419
LIG_FHA_1 492 498 PF00498 0.558
LIG_FHA_1 504 510 PF00498 0.385
LIG_FHA_1 554 560 PF00498 0.564
LIG_FHA_1 641 647 PF00498 0.459
LIG_FHA_1 72 78 PF00498 0.672
LIG_FHA_2 233 239 PF00498 0.695
LIG_FHA_2 264 270 PF00498 0.508
LIG_FHA_2 522 528 PF00498 0.532
LIG_FHA_2 584 590 PF00498 0.451
LIG_FXI_DFP_1 499 503 PF00024 0.414
LIG_LIR_Gen_1 421 431 PF02991 0.575
LIG_LIR_Gen_1 447 457 PF02991 0.408
LIG_LIR_Gen_1 458 466 PF02991 0.345
LIG_LIR_Gen_1 482 492 PF02991 0.428
LIG_LIR_Nem_3 421 427 PF02991 0.572
LIG_LIR_Nem_3 447 452 PF02991 0.415
LIG_LIR_Nem_3 458 464 PF02991 0.356
LIG_LIR_Nem_3 482 487 PF02991 0.424
LIG_LIR_Nem_3 500 505 PF02991 0.266
LIG_LIR_Nem_3 539 545 PF02991 0.458
LIG_Pex14_2 571 575 PF04695 0.414
LIG_PTB_Apo_2 478 485 PF02174 0.406
LIG_RPA_C_Fungi 3 15 PF08784 0.505
LIG_SH2_CRK 449 453 PF00017 0.390
LIG_SH2_CRK 542 546 PF00017 0.521
LIG_SH2_NCK_1 449 453 PF00017 0.390
LIG_SH2_STAP1 341 345 PF00017 0.431
LIG_SH2_STAP1 505 509 PF00017 0.449
LIG_SH2_STAT3 465 468 PF00017 0.393
LIG_SH2_STAT5 155 158 PF00017 0.731
LIG_SH2_STAT5 270 273 PF00017 0.451
LIG_SH2_STAT5 465 468 PF00017 0.558
LIG_SH2_STAT5 505 508 PF00017 0.402
LIG_SH2_STAT5 594 597 PF00017 0.392
LIG_SH3_2 208 213 PF14604 0.623
LIG_SH3_3 159 165 PF00018 0.572
LIG_SH3_3 205 211 PF00018 0.650
LIG_SH3_3 313 319 PF00018 0.650
LIG_SH3_3 433 439 PF00018 0.400
LIG_SH3_3 74 80 PF00018 0.689
LIG_SUMO_SIM_anti_2 432 437 PF11976 0.406
LIG_SUMO_SIM_anti_2 599 606 PF11976 0.416
LIG_SUMO_SIM_par_1 373 378 PF11976 0.385
LIG_SUMO_SIM_par_1 38 46 PF11976 0.407
LIG_SUMO_SIM_par_1 494 501 PF11976 0.401
LIG_SUMO_SIM_par_1 531 541 PF11976 0.442
LIG_SUMO_SIM_par_1 634 639 PF11976 0.447
LIG_SxIP_EBH_1 445 456 PF03271 0.542
LIG_TRAF2_1 524 527 PF00917 0.396
LIG_TRAF2_1 537 540 PF00917 0.393
LIG_UBA3_1 255 263 PF00899 0.514
LIG_WRC_WIRS_1 572 577 PF05994 0.420
MOD_CDC14_SPxK_1 146 149 PF00782 0.693
MOD_CDC14_SPxK_1 210 213 PF00782 0.618
MOD_CDC14_SPxK_1 257 260 PF00782 0.524
MOD_CDK_SPK_2 143 148 PF00069 0.699
MOD_CDK_SPxK_1 143 149 PF00069 0.698
MOD_CDK_SPxK_1 207 213 PF00069 0.624
MOD_CDK_SPxK_1 254 260 PF00069 0.661
MOD_CK1_1 142 148 PF00069 0.703
MOD_CK1_1 197 203 PF00069 0.761
MOD_CK1_1 219 225 PF00069 0.708
MOD_CK1_1 361 367 PF00069 0.278
MOD_CK1_1 447 453 PF00069 0.439
MOD_CK1_1 574 580 PF00069 0.552
MOD_CK1_1 7 13 PF00069 0.517
MOD_CK1_1 87 93 PF00069 0.610
MOD_CK2_1 232 238 PF00069 0.695
MOD_CK2_1 263 269 PF00069 0.598
MOD_CK2_1 297 303 PF00069 0.584
MOD_CK2_1 417 423 PF00069 0.449
MOD_CK2_1 521 527 PF00069 0.534
MOD_CK2_1 535 541 PF00069 0.381
MOD_CK2_1 583 589 PF00069 0.448
MOD_GlcNHglycan 140 144 PF01048 0.686
MOD_GlcNHglycan 202 205 PF01048 0.694
MOD_GlcNHglycan 219 222 PF01048 0.574
MOD_GlcNHglycan 230 233 PF01048 0.600
MOD_GlcNHglycan 288 291 PF01048 0.732
MOD_GlcNHglycan 293 296 PF01048 0.706
MOD_GlcNHglycan 319 322 PF01048 0.623
MOD_GlcNHglycan 4 7 PF01048 0.587
MOD_GlcNHglycan 405 408 PF01048 0.426
MOD_GlcNHglycan 467 471 PF01048 0.404
MOD_GlcNHglycan 612 615 PF01048 0.404
MOD_GlcNHglycan 651 654 PF01048 0.458
MOD_GlcNHglycan 86 89 PF01048 0.692
MOD_GlcNHglycan 9 12 PF01048 0.515
MOD_GSK3_1 139 146 PF00069 0.680
MOD_GSK3_1 157 164 PF00069 0.543
MOD_GSK3_1 190 197 PF00069 0.728
MOD_GSK3_1 198 205 PF00069 0.805
MOD_GSK3_1 228 235 PF00069 0.633
MOD_GSK3_1 23 30 PF00069 0.482
MOD_GSK3_1 317 324 PF00069 0.581
MOD_GSK3_1 379 386 PF00069 0.518
MOD_GSK3_1 397 404 PF00069 0.412
MOD_GSK3_1 444 451 PF00069 0.474
MOD_GSK3_1 455 462 PF00069 0.534
MOD_GSK3_1 605 612 PF00069 0.419
MOD_GSK3_1 623 630 PF00069 0.276
MOD_GSK3_1 71 78 PF00069 0.664
MOD_GSK3_1 79 86 PF00069 0.626
MOD_GSK3_1 88 95 PF00069 0.553
MOD_N-GLC_1 605 610 PF02516 0.518
MOD_NEK2_1 190 195 PF00069 0.692
MOD_NEK2_1 2 7 PF00069 0.609
MOD_NEK2_1 28 33 PF00069 0.467
MOD_NEK2_1 383 388 PF00069 0.514
MOD_NEK2_1 390 395 PF00069 0.503
MOD_NEK2_1 455 460 PF00069 0.405
MOD_NEK2_1 571 576 PF00069 0.414
MOD_NEK2_1 623 628 PF00069 0.528
MOD_NEK2_1 640 645 PF00069 0.452
MOD_NEK2_2 297 302 PF00069 0.637
MOD_NEK2_2 379 384 PF00069 0.441
MOD_NEK2_2 94 99 PF00069 0.642
MOD_PIKK_1 543 549 PF00454 0.496
MOD_PKA_1 148 154 PF00069 0.673
MOD_PKA_2 148 154 PF00069 0.673
MOD_PKA_2 197 203 PF00069 0.679
MOD_PKA_2 2 8 PF00069 0.607
MOD_PKA_2 216 222 PF00069 0.512
MOD_PKA_2 329 335 PF00069 0.528
MOD_PKA_2 35 41 PF00069 0.448
MOD_PKA_2 358 364 PF00069 0.413
MOD_PKA_2 418 424 PF00069 0.427
MOD_PKA_2 447 453 PF00069 0.473
MOD_PKA_2 455 461 PF00069 0.484
MOD_PKA_2 48 54 PF00069 0.390
MOD_PKA_2 503 509 PF00069 0.413
MOD_PKA_2 609 615 PF00069 0.421
MOD_Plk_1 341 347 PF00069 0.425
MOD_Plk_2-3 535 541 PF00069 0.461
MOD_Plk_4 371 377 PF00069 0.433
MOD_Plk_4 379 385 PF00069 0.460
MOD_Plk_4 460 466 PF00069 0.451
MOD_Plk_4 492 498 PF00069 0.544
MOD_ProDKin_1 130 136 PF00069 0.688
MOD_ProDKin_1 143 149 PF00069 0.591
MOD_ProDKin_1 157 163 PF00069 0.576
MOD_ProDKin_1 179 185 PF00069 0.638
MOD_ProDKin_1 207 213 PF00069 0.635
MOD_ProDKin_1 246 252 PF00069 0.683
MOD_ProDKin_1 254 260 PF00069 0.587
MOD_ProDKin_1 312 318 PF00069 0.631
MOD_ProDKin_1 401 407 PF00069 0.386
MOD_ProDKin_1 71 77 PF00069 0.657
TRG_DiLeu_BaEn_1 515 520 PF01217 0.376
TRG_DiLeu_BaEn_4 540 546 PF01217 0.480
TRG_ENDOCYTIC_2 105 108 PF00928 0.636
TRG_ENDOCYTIC_2 449 452 PF00928 0.384
TRG_ENDOCYTIC_2 505 508 PF00928 0.406
TRG_ENDOCYTIC_2 542 545 PF00928 0.458
TRG_ER_diArg_1 147 149 PF00400 0.692
TRG_ER_diArg_1 356 359 PF00400 0.457
TRG_ER_diArg_1 394 396 PF00400 0.432

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ITL0 Leishmania donovani 28% 100%
A0A451EJJ7 Leishmania donovani 95% 100%
A4H3F4 Leishmania braziliensis 82% 100%
A4HKV9 Leishmania braziliensis 28% 100%
A4HRQ8 Leishmania infantum 94% 100%
A4I8D9 Leishmania infantum 28% 100%
E9AJM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B397 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q4V8 Leishmania major 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS