WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACD6_LEIMA

TriTrypDb:

LmjF.02.0620 , LMJLV39_020011400 , LMJSD75_020011500

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACD6

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	2
GO:0006448	regulation of translational elongation	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0017182	peptidyl-diphthamide metabolic process	7	2
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018202	peptidyl-histidine modification	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1900247	regulation of cytoplasmic translational elongation	8	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0052689	carboxylic ester hydrolase activity	4	2
GO:0061685	diphthine methylesterase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.771
CLV_C14_Caspase3-7	171	175	PF00656	0.544
CLV_C14_Caspase3-7	283	287	PF00656	0.750
CLV_C14_Caspase3-7	343	347	PF00656	0.539
CLV_C14_Caspase3-7	511	515	PF00656	0.518
CLV_C14_Caspase3-7	528	532	PF00656	0.384
CLV_NRD_NRD_1	145	147	PF00675	0.529
CLV_NRD_NRD_1	375	377	PF00675	0.578
CLV_NRD_NRD_1	434	436	PF00675	0.608
CLV_NRD_NRD_1	554	556	PF00675	0.447
CLV_PCSK_KEX2_1	145	147	PF00082	0.529
CLV_PCSK_KEX2_1	375	377	PF00082	0.476
CLV_PCSK_KEX2_1	434	436	PF00082	0.701
CLV_PCSK_KEX2_1	438	440	PF00082	0.697
CLV_PCSK_KEX2_1	554	556	PF00082	0.423
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.746
CLV_PCSK_PC7_1	434	440	PF00082	0.587
CLV_PCSK_SKI1_1	241	245	PF00082	0.480
CLV_PCSK_SKI1_1	393	397	PF00082	0.525
CLV_PCSK_SKI1_1	435	439	PF00082	0.498
CLV_PCSK_SKI1_1	80	84	PF00082	0.531
DEG_APCC_DBOX_1	79	87	PF00400	0.592
DEG_SCF_TRCP1_1	400	406	PF00400	0.655
DEG_SPOP_SBC_1	94	98	PF00917	0.596
DOC_CYCLIN_RxL_1	390	400	PF00134	0.531
DOC_MAPK_gen_1	390	398	PF00069	0.574
DOC_MAPK_gen_1	77	85	PF00069	0.583
DOC_MAPK_MEF2A_6	27	36	PF00069	0.526
DOC_MAPK_MEF2A_6	77	85	PF00069	0.513
DOC_PP2B_LxvP_1	457	460	PF13499	0.375
DOC_PP2B_LxvP_1	52	55	PF13499	0.538
DOC_USP7_MATH_1	267	271	PF00917	0.629
DOC_USP7_MATH_1	296	300	PF00917	0.691
DOC_USP7_MATH_1	403	407	PF00917	0.678
DOC_USP7_MATH_1	451	455	PF00917	0.613
DOC_USP7_MATH_1	495	499	PF00917	0.640
DOC_USP7_MATH_1	547	551	PF00917	0.467
DOC_USP7_MATH_1	67	71	PF00917	0.742
DOC_USP7_MATH_1	94	98	PF00917	0.649
DOC_WW_Pin1_4	194	199	PF00397	0.573
DOC_WW_Pin1_4	218	223	PF00397	0.463
DOC_WW_Pin1_4	336	341	PF00397	0.447
DOC_WW_Pin1_4	351	356	PF00397	0.499
DOC_WW_Pin1_4	54	59	PF00397	0.463
LIG_14-3-3_CanoR_1	145	153	PF00244	0.572
LIG_14-3-3_CanoR_1	27	33	PF00244	0.600
LIG_14-3-3_CanoR_1	297	304	PF00244	0.580
LIG_14-3-3_CanoR_1	38	43	PF00244	0.493
LIG_14-3-3_CanoR_1	439	444	PF00244	0.733
LIG_14-3-3_CanoR_1	474	481	PF00244	0.571
LIG_Actin_WH2_2	79	95	PF00022	0.504
LIG_AP2alpha_2	192	194	PF02296	0.434
LIG_BRCT_BRCA1_1	160	164	PF00533	0.502
LIG_BRCT_BRCA1_1	405	409	PF00533	0.490
LIG_FHA_1	145	151	PF00498	0.567
LIG_FHA_1	164	170	PF00498	0.581
LIG_FHA_1	219	225	PF00498	0.522
LIG_FHA_1	228	234	PF00498	0.311
LIG_FHA_1	242	248	PF00498	0.340
LIG_FHA_1	255	261	PF00498	0.431
LIG_FHA_1	29	35	PF00498	0.585
LIG_FHA_1	298	304	PF00498	0.563
LIG_FHA_1	337	343	PF00498	0.481
LIG_FHA_1	352	358	PF00498	0.380
LIG_FHA_1	451	457	PF00498	0.530
LIG_FHA_2	4	10	PF00498	0.647
LIG_FHA_2	509	515	PF00498	0.591
LIG_FHA_2	535	541	PF00498	0.667
LIG_LIR_Gen_1	309	318	PF02991	0.537
LIG_LIR_Gen_1	354	362	PF02991	0.403
LIG_LIR_Nem_3	309	315	PF02991	0.532
LIG_LIR_Nem_3	354	359	PF02991	0.408
LIG_MLH1_MIPbox_1	160	164	PF16413	0.502
LIG_NRBOX	420	426	PF00104	0.565
LIG_SH2_CRK	125	129	PF00017	0.498
LIG_SH2_CRK	312	316	PF00017	0.533
LIG_SH2_NCK_1	236	240	PF00017	0.473
LIG_SH2_NCK_1	492	496	PF00017	0.376
LIG_SH2_SRC	234	237	PF00017	0.472
LIG_SH2_SRC	362	365	PF00017	0.413
LIG_SH2_STAP1	362	366	PF00017	0.363
LIG_SH2_STAP1	471	475	PF00017	0.530
LIG_SH2_STAP1	519	523	PF00017	0.386
LIG_SH2_STAP1	552	556	PF00017	0.503
LIG_SH2_STAP1	90	94	PF00017	0.489
LIG_SH2_STAT5	234	237	PF00017	0.423
LIG_SH2_STAT5	312	315	PF00017	0.534
LIG_SH2_STAT5	356	359	PF00017	0.426
LIG_SH2_STAT5	490	493	PF00017	0.473
LIG_SH3_3	154	160	PF00018	0.460
LIG_SH3_3	187	193	PF00018	0.511
LIG_SH3_3	196	202	PF00018	0.523
LIG_SH3_3	289	295	PF00018	0.526
LIG_SH3_3	371	377	PF00018	0.494
LIG_SH3_3	501	507	PF00018	0.624
LIG_SH3_3	52	58	PF00018	0.518
LIG_SH3_3	520	526	PF00018	0.484
LIG_SH3_3	75	81	PF00018	0.697
LIG_SUMO_SIM_anti_2	363	370	PF11976	0.470
LIG_SUMO_SIM_anti_2	453	460	PF11976	0.516
LIG_SUMO_SIM_par_1	30	35	PF11976	0.389
LIG_SUMO_SIM_par_1	334	339	PF11976	0.446
LIG_SUMO_SIM_par_1	367	373	PF11976	0.522
LIG_TRAF2_1	476	479	PF00917	0.516
LIG_TRFH_1	194	198	PF08558	0.496
LIG_TYR_ITSM	352	359	PF00017	0.480
MOD_CK1_1	11	17	PF00069	0.659
MOD_CK1_1	162	168	PF00069	0.524
MOD_CK1_1	227	233	PF00069	0.476
MOD_CK1_1	272	278	PF00069	0.739
MOD_CK1_1	30	36	PF00069	0.608
MOD_CK1_1	41	47	PF00069	0.398
MOD_CK1_1	427	433	PF00069	0.593
MOD_CK1_1	57	63	PF00069	0.544
MOD_CK1_1	97	103	PF00069	0.594
MOD_CK2_1	234	240	PF00069	0.508
MOD_CK2_1	277	283	PF00069	0.704
MOD_CK2_1	3	9	PF00069	0.645
MOD_CK2_1	358	364	PF00069	0.379
MOD_CK2_1	473	479	PF00069	0.514
MOD_CK2_1	495	501	PF00069	0.612
MOD_CK2_1	547	553	PF00069	0.487
MOD_GlcNHglycan	15	18	PF01048	0.496
MOD_GlcNHglycan	170	173	PF01048	0.622
MOD_GlcNHglycan	226	229	PF01048	0.442
MOD_GlcNHglycan	269	272	PF01048	0.657
MOD_GlcNHglycan	300	303	PF01048	0.458
MOD_GlcNHglycan	305	308	PF01048	0.330
MOD_GlcNHglycan	348	351	PF01048	0.442
MOD_GlcNHglycan	400	403	PF01048	0.653
MOD_GlcNHglycan	426	429	PF01048	0.539
MOD_GlcNHglycan	475	478	PF01048	0.577
MOD_GlcNHglycan	540	544	PF01048	0.593
MOD_GlcNHglycan	65	68	PF01048	0.742
MOD_GlcNHglycan	69	72	PF01048	0.742
MOD_GlcNHglycan	97	100	PF01048	0.741
MOD_GSK3_1	158	165	PF00069	0.540
MOD_GSK3_1	3	10	PF00069	0.645
MOD_GSK3_1	320	327	PF00069	0.589
MOD_GSK3_1	358	365	PF00069	0.392
MOD_GSK3_1	38	45	PF00069	0.348
MOD_GSK3_1	63	70	PF00069	0.707
MOD_GSK3_1	93	100	PF00069	0.584
MOD_N-GLC_1	419	424	PF02516	0.570
MOD_N-GLC_1	451	456	PF02516	0.564
MOD_NEK2_1	13	18	PF00069	0.543
MOD_NEK2_1	163	168	PF00069	0.583
MOD_NEK2_1	210	215	PF00069	0.404
MOD_NEK2_1	224	229	PF00069	0.170
MOD_NEK2_1	303	308	PF00069	0.485
MOD_NEK2_1	398	403	PF00069	0.619
MOD_NEK2_1	419	424	PF00069	0.538
MOD_NEK2_2	547	552	PF00069	0.485
MOD_PIKK_1	241	247	PF00454	0.510
MOD_PK_1	38	44	PF00069	0.546
MOD_PKA_2	144	150	PF00069	0.576
MOD_PKA_2	296	302	PF00069	0.634
MOD_PKA_2	389	395	PF00069	0.424
MOD_PKA_2	473	479	PF00069	0.581
MOD_Plk_1	137	143	PF00069	0.617
MOD_Plk_1	362	368	PF00069	0.480
MOD_Plk_1	419	425	PF00069	0.568
MOD_Plk_1	513	519	PF00069	0.487
MOD_Plk_1	8	14	PF00069	0.638
MOD_Plk_2-3	364	370	PF00069	0.524
MOD_Plk_4	159	165	PF00069	0.540
MOD_Plk_4	229	235	PF00069	0.492
MOD_Plk_4	419	425	PF00069	0.568
MOD_Plk_4	486	492	PF00069	0.523
MOD_Plk_4	513	519	PF00069	0.487
MOD_Plk_4	547	553	PF00069	0.396
MOD_ProDKin_1	194	200	PF00069	0.571
MOD_ProDKin_1	218	224	PF00069	0.454
MOD_ProDKin_1	336	342	PF00069	0.450
MOD_ProDKin_1	351	357	PF00069	0.492
MOD_ProDKin_1	54	60	PF00069	0.478
MOD_SUMO_rev_2	89	95	PF00179	0.347
TRG_DiLeu_BaEn_1	364	369	PF01217	0.396
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.441
TRG_ENDOCYTIC_2	125	128	PF00928	0.487
TRG_ENDOCYTIC_2	312	315	PF00928	0.534
TRG_ENDOCYTIC_2	356	359	PF00928	0.399
TRG_ER_diArg_1	328	331	PF00400	0.539
TRG_ER_diArg_1	374	376	PF00400	0.584
TRG_ER_diArg_1	554	556	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU3	Leptomonas seymouri	49%	100%
A0A1X0NJL9	Trypanosomatidae	29%	100%
A0A3R7NH89	Trypanosoma rangeli	30%	100%
A0A3S7WNM2	Leishmania donovani	90%	99%
A4H3F3	Leishmania braziliensis	72%	100%
A4HRQ7	Leishmania infantum	90%	99%
C9ZJ47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AJM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
V5BER3	Trypanosoma cruzi	28%	100%