TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania major

UniProt:

E9ACD3_LEIMA

TriTrypDb:

LmjF.02.0590 , LMJLV39_020011100 , LMJSD75_020011200

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACD3

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0030544	Hsp70 protein binding	4	11
GO:0031072	heat shock protein binding	3	11
GO:0051879	Hsp90 protein binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	287	289	PF00675	0.631
CLV_NRD_NRD_1	340	342	PF00675	0.588
CLV_NRD_NRD_1	393	395	PF00675	0.737
CLV_NRD_NRD_1	445	447	PF00675	0.764
CLV_NRD_NRD_1	469	471	PF00675	0.774
CLV_NRD_NRD_1	507	509	PF00675	0.497
CLV_PCSK_KEX2_1	243	245	PF00082	0.366
CLV_PCSK_KEX2_1	287	289	PF00082	0.635
CLV_PCSK_KEX2_1	339	341	PF00082	0.604
CLV_PCSK_KEX2_1	445	447	PF00082	0.764
CLV_PCSK_KEX2_1	468	470	PF00082	0.774
CLV_PCSK_KEX2_1	509	511	PF00082	0.499
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.366
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.620
CLV_PCSK_SKI1_1	102	106	PF00082	0.719
CLV_PCSK_SKI1_1	382	386	PF00082	0.697
CLV_PCSK_SKI1_1	399	403	PF00082	0.558
CLV_PCSK_SKI1_1	48	52	PF00082	0.737
CLV_PCSK_SKI1_1	510	514	PF00082	0.581
CLV_PCSK_SKI1_1	7	11	PF00082	0.558
CLV_Separin_Metazoa	412	416	PF03568	0.567
DEG_SPOP_SBC_1	173	177	PF00917	0.523
DEG_SPOP_SBC_1	308	312	PF00917	0.786
DEG_SPOP_SBC_1	96	100	PF00917	0.686
DOC_PP1_RVXF_1	107	114	PF00149	0.720
DOC_PP4_FxxP_1	105	108	PF00568	0.746
DOC_PP4_FxxP_1	477	480	PF00568	0.712
DOC_USP7_MATH_1	119	123	PF00917	0.720
DOC_USP7_MATH_1	131	135	PF00917	0.651
DOC_USP7_MATH_1	308	312	PF00917	0.774
DOC_USP7_MATH_1	322	326	PF00917	0.675
DOC_USP7_MATH_1	378	382	PF00917	0.701
DOC_USP7_MATH_1	403	407	PF00917	0.709
DOC_USP7_MATH_1	417	421	PF00917	0.666
DOC_USP7_MATH_1	458	462	PF00917	0.732
DOC_USP7_MATH_1	494	498	PF00917	0.660
DOC_USP7_MATH_1	55	59	PF00917	0.757
DOC_USP7_MATH_1	96	100	PF00917	0.711
DOC_USP7_MATH_2	488	494	PF00917	0.542
DOC_USP7_UBL2_3	395	399	PF12436	0.732
DOC_WW_Pin1_4	382	387	PF00397	0.733
DOC_WW_Pin1_4	449	454	PF00397	0.773
DOC_WW_Pin1_4	51	56	PF00397	0.717
DOC_WW_Pin1_4	86	91	PF00397	0.658
LIG_14-3-3_CanoR_1	102	108	PF00244	0.741
LIG_14-3-3_CanoR_1	220	225	PF00244	0.514
LIG_14-3-3_CanoR_1	261	266	PF00244	0.528
LIG_14-3-3_CanoR_1	287	291	PF00244	0.561
LIG_14-3-3_CanoR_1	394	398	PF00244	0.523
LIG_14-3-3_CanoR_1	423	432	PF00244	0.715
LIG_14-3-3_CanoR_1	445	454	PF00244	0.513
LIG_14-3-3_CanoR_1	468	477	PF00244	0.733
LIG_Actin_WH2_2	71	88	PF00022	0.635
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_BRCT_BRCA1_1	473	477	PF00533	0.544
LIG_FHA_1	164	170	PF00498	0.409
LIG_FHA_1	219	225	PF00498	0.538
LIG_FHA_1	295	301	PF00498	0.655
LIG_FHA_1	41	47	PF00498	0.670
LIG_FHA_1	80	86	PF00498	0.693
LIG_FHA_2	1	7	PF00498	0.591
LIG_FHA_2	15	21	PF00498	0.510
LIG_FHA_2	310	316	PF00498	0.757
LIG_FHA_2	328	334	PF00498	0.728
LIG_FHA_2	357	363	PF00498	0.655
LIG_FHA_2	426	432	PF00498	0.621
LIG_FHA_2	82	88	PF00498	0.778
LIG_LIR_Apic_2	474	480	PF02991	0.652
LIG_LIR_Nem_3	226	232	PF02991	0.431
LIG_LIR_Nem_3	237	242	PF02991	0.343
LIG_MYND_1	463	467	PF01753	0.721
LIG_Pex14_1	228	232	PF04695	0.306
LIG_PTB_Apo_2	147	154	PF02174	0.453
LIG_RPA_C_Fungi	268	280	PF08784	0.533
LIG_SH2_CRK	52	56	PF00017	0.721
LIG_SH2_GRB2like	190	193	PF00017	0.441
LIG_SH2_NCK_1	52	56	PF00017	0.721
LIG_SH2_STAP1	165	169	PF00017	0.383
LIG_SH2_STAP1	211	215	PF00017	0.516
LIG_SH2_STAP1	252	256	PF00017	0.348
LIG_SH2_STAT3	232	235	PF00017	0.306
LIG_SH2_STAT3	368	371	PF00017	0.567
LIG_SH2_STAT5	165	168	PF00017	0.417
LIG_SH2_STAT5	197	200	PF00017	0.378
LIG_SH2_STAT5	239	242	PF00017	0.454
LIG_SH2_STAT5	397	400	PF00017	0.525
LIG_SH3_2	463	468	PF14604	0.726
LIG_SH3_3	18	24	PF00018	0.568
LIG_SH3_3	460	466	PF00018	0.705
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.430
LIG_SUMO_SIM_par_1	182	187	PF11976	0.438
LIG_SUMO_SIM_par_1	219	227	PF11976	0.498
LIG_TRAF2_1	280	283	PF00917	0.596
LIG_WW_3	465	469	PF00397	0.735
MOD_CDK_SPxxK_3	382	389	PF00069	0.527
MOD_CK1_1	117	123	PF00069	0.680
MOD_CK1_1	134	140	PF00069	0.471
MOD_CK1_1	191	197	PF00069	0.343
MOD_CK1_1	223	229	PF00069	0.461
MOD_CK1_1	292	298	PF00069	0.638
MOD_CK1_1	299	305	PF00069	0.655
MOD_CK1_1	311	317	PF00069	0.657
MOD_CK1_1	34	40	PF00069	0.699
MOD_CK1_1	422	428	PF00069	0.750
MOD_CK1_1	449	455	PF00069	0.752
MOD_CK1_1	471	477	PF00069	0.749
MOD_CK1_1	94	100	PF00069	0.761
MOD_CK2_1	176	182	PF00069	0.570
MOD_CK2_1	309	315	PF00069	0.733
MOD_CK2_1	356	362	PF00069	0.689
MOD_Cter_Amidation	337	340	PF01082	0.638
MOD_GlcNHglycan	105	108	PF01048	0.619
MOD_GlcNHglycan	133	136	PF01048	0.674
MOD_GlcNHglycan	179	182	PF01048	0.568
MOD_GlcNHglycan	186	189	PF01048	0.385
MOD_GlcNHglycan	193	196	PF01048	0.256
MOD_GlcNHglycan	341	344	PF01048	0.693
MOD_GlcNHglycan	405	408	PF01048	0.698
MOD_GlcNHglycan	419	422	PF01048	0.544
MOD_GlcNHglycan	471	474	PF01048	0.679
MOD_GlcNHglycan	492	495	PF01048	0.686
MOD_GlcNHglycan	496	499	PF01048	0.681
MOD_GlcNHglycan	65	68	PF01048	0.729
MOD_GlcNHglycan	93	96	PF01048	0.743
MOD_GSK3_1	103	110	PF00069	0.649
MOD_GSK3_1	114	121	PF00069	0.713
MOD_GSK3_1	172	179	PF00069	0.570
MOD_GSK3_1	184	191	PF00069	0.507
MOD_GSK3_1	220	227	PF00069	0.454
MOD_GSK3_1	286	293	PF00069	0.545
MOD_GSK3_1	295	302	PF00069	0.635
MOD_GSK3_1	307	314	PF00069	0.736
MOD_GSK3_1	31	38	PF00069	0.725
MOD_GSK3_1	378	385	PF00069	0.710
MOD_GSK3_1	399	406	PF00069	0.622
MOD_GSK3_1	415	422	PF00069	0.726
MOD_GSK3_1	454	461	PF00069	0.729
MOD_GSK3_1	490	497	PF00069	0.643
MOD_GSK3_1	51	58	PF00069	0.726
MOD_GSK3_1	61	68	PF00069	0.719
MOD_GSK3_1	74	81	PF00069	0.718
MOD_GSK3_1	91	98	PF00069	0.728
MOD_N-GLC_1	149	154	PF02516	0.463
MOD_N-GLC_1	191	196	PF02516	0.340
MOD_N-GLC_1	261	266	PF02516	0.528
MOD_N-GLC_1	40	45	PF02516	0.748
MOD_N-GLC_1	79	84	PF02516	0.729
MOD_NEK2_1	172	177	PF00069	0.529
MOD_NEK2_1	184	189	PF00069	0.443
MOD_NEK2_1	224	229	PF00069	0.563
MOD_NEK2_1	269	274	PF00069	0.463
MOD_NEK2_1	286	291	PF00069	0.592
MOD_NEK2_1	300	305	PF00069	0.680
MOD_NEK2_1	31	36	PF00069	0.645
MOD_NEK2_1	454	459	PF00069	0.699
MOD_NEK2_1	63	68	PF00069	0.671
MOD_NEK2_1	78	83	PF00069	0.538
MOD_NEK2_1	85	90	PF00069	0.687
MOD_PIKK_1	122	128	PF00454	0.772
MOD_PIKK_1	31	37	PF00454	0.749
MOD_PIKK_1	322	328	PF00454	0.745
MOD_PK_1	415	421	PF00069	0.677
MOD_PKA_1	339	345	PF00069	0.630
MOD_PKA_1	468	474	PF00069	0.753
MOD_PKA_2	224	230	PF00069	0.443
MOD_PKA_2	286	292	PF00069	0.477
MOD_PKA_2	339	345	PF00069	0.650
MOD_PKA_2	378	384	PF00069	0.672
MOD_PKA_2	393	399	PF00069	0.686
MOD_PKA_2	422	428	PF00069	0.726
MOD_PKA_2	468	474	PF00069	0.754
MOD_PKA_2	85	91	PF00069	0.785
MOD_Plk_1	114	120	PF00069	0.673
MOD_Plk_1	149	155	PF00069	0.458
MOD_Plk_1	218	224	PF00069	0.502
MOD_Plk_1	261	267	PF00069	0.532
MOD_Plk_1	356	362	PF00069	0.540
MOD_Plk_1	415	421	PF00069	0.742
MOD_Plk_4	224	230	PF00069	0.453
MOD_Plk_4	261	267	PF00069	0.462
MOD_Plk_4	393	399	PF00069	0.523
MOD_ProDKin_1	382	388	PF00069	0.731
MOD_ProDKin_1	449	455	PF00069	0.774
MOD_ProDKin_1	51	57	PF00069	0.718
MOD_ProDKin_1	86	92	PF00069	0.660
MOD_SUMO_for_1	352	355	PF00179	0.548
MOD_SUMO_rev_2	142	148	PF00179	0.466
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.491
TRG_ENDOCYTIC_2	239	242	PF00928	0.433
TRG_ER_diArg_1	286	288	PF00400	0.632
TRG_ER_diArg_1	339	341	PF00400	0.604
TRG_ER_diArg_1	376	379	PF00400	0.576
TRG_ER_diArg_1	467	470	PF00400	0.741
TRG_ER_diArg_1	507	510	PF00400	0.494
TRG_NLS_MonoCore_2	507	512	PF00514	0.556
TRG_NLS_MonoExtN_4	508	513	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0B2	Leptomonas seymouri	50%	92%
A0A1X0NJW2	Trypanosomatidae	34%	100%
A0A3S5H509	Leishmania donovani	93%	98%
A0A422NAY7	Trypanosoma rangeli	30%	100%
A4H3F0	Leishmania braziliensis	72%	98%
A4HRQ4	Leishmania infantum	93%	98%
C9ZJ44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AJM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
V5B5N7	Trypanosoma cruzi	34%	100%