Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ACD0_LEIMA

TriTrypDb:

LmjF.02.0560 , LMJLV39_020010800 , LMJSD75_020010900

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.811
CLV_C14_Caspase3-7	128	132	PF00656	0.478
CLV_C14_Caspase3-7	724	728	PF00656	0.732
CLV_C14_Caspase3-7	821	825	PF00656	0.720
CLV_NRD_NRD_1	240	242	PF00675	0.681
CLV_NRD_NRD_1	361	363	PF00675	0.774
CLV_NRD_NRD_1	383	385	PF00675	0.688
CLV_NRD_NRD_1	391	393	PF00675	0.725
CLV_NRD_NRD_1	432	434	PF00675	0.642
CLV_NRD_NRD_1	565	567	PF00675	0.774
CLV_NRD_NRD_1	597	599	PF00675	0.810
CLV_NRD_NRD_1	629	631	PF00675	0.730
CLV_NRD_NRD_1	837	839	PF00675	0.728
CLV_PCSK_FUR_1	359	363	PF00082	0.779
CLV_PCSK_KEX2_1	240	242	PF00082	0.673
CLV_PCSK_KEX2_1	359	361	PF00082	0.784
CLV_PCSK_KEX2_1	383	385	PF00082	0.679
CLV_PCSK_KEX2_1	391	393	PF00082	0.711
CLV_PCSK_KEX2_1	432	434	PF00082	0.642
CLV_PCSK_KEX2_1	564	566	PF00082	0.775
CLV_PCSK_KEX2_1	597	599	PF00082	0.810
CLV_PCSK_KEX2_1	629	631	PF00082	0.730
CLV_PCSK_KEX2_1	837	839	PF00082	0.737
CLV_PCSK_SKI1_1	332	336	PF00082	0.761
CLV_PCSK_SKI1_1	82	86	PF00082	0.632
CLV_Separin_Metazoa	493	497	PF03568	0.712
DEG_Nend_UBRbox_1	1	4	PF02207	0.568
DEG_SCF_FBW7_1	682	689	PF00400	0.830
DEG_SPOP_SBC_1	479	483	PF00917	0.640
DEG_SPOP_SBC_1	814	818	PF00917	0.749
DOC_ANK_TNKS_1	497	504	PF00023	0.792
DOC_CKS1_1	229	234	PF01111	0.740
DOC_CKS1_1	683	688	PF01111	0.829
DOC_MAPK_gen_1	734	742	PF00069	0.697
DOC_MAPK_gen_1	834	842	PF00069	0.732
DOC_PP1_RVXF_1	423	430	PF00149	0.672
DOC_PP1_RVXF_1	836	843	PF00149	0.729
DOC_PP4_FxxP_1	842	845	PF00568	0.714
DOC_USP7_MATH_1	312	316	PF00917	0.781
DOC_USP7_MATH_1	363	367	PF00917	0.693
DOC_USP7_MATH_1	434	438	PF00917	0.736
DOC_USP7_MATH_1	463	467	PF00917	0.795
DOC_USP7_MATH_1	527	531	PF00917	0.758
DOC_USP7_MATH_1	579	583	PF00917	0.586
DOC_USP7_MATH_1	651	655	PF00917	0.720
DOC_USP7_MATH_1	686	690	PF00917	0.747
DOC_USP7_MATH_1	693	697	PF00917	0.795
DOC_USP7_MATH_1	706	710	PF00917	0.514
DOC_USP7_MATH_1	712	716	PF00917	0.725
DOC_USP7_MATH_1	723	727	PF00917	0.522
DOC_USP7_MATH_1	730	734	PF00917	0.637
DOC_USP7_MATH_1	783	787	PF00917	0.788
DOC_WW_Pin1_4	141	146	PF00397	0.596
DOC_WW_Pin1_4	200	205	PF00397	0.692
DOC_WW_Pin1_4	228	233	PF00397	0.718
DOC_WW_Pin1_4	284	289	PF00397	0.646
DOC_WW_Pin1_4	332	337	PF00397	0.818
DOC_WW_Pin1_4	338	343	PF00397	0.769
DOC_WW_Pin1_4	345	350	PF00397	0.635
DOC_WW_Pin1_4	386	391	PF00397	0.794
DOC_WW_Pin1_4	47	52	PF00397	0.766
DOC_WW_Pin1_4	682	687	PF00397	0.760
LIG_14-3-3_CanoR_1	15	24	PF00244	0.760
LIG_14-3-3_CanoR_1	152	161	PF00244	0.709
LIG_14-3-3_CanoR_1	360	366	PF00244	0.697
LIG_14-3-3_CanoR_1	425	430	PF00244	0.692
LIG_14-3-3_CanoR_1	756	762	PF00244	0.786
LIG_14-3-3_CanoR_1	805	814	PF00244	0.777
LIG_14-3-3_CanoR_1	837	841	PF00244	0.732
LIG_BRCT_BRCA1_1	134	138	PF00533	0.612
LIG_BRCT_BRCA1_1	653	657	PF00533	0.803
LIG_eIF4E_1	155	161	PF01652	0.597
LIG_eIF4E_2	492	498	PF01652	0.672
LIG_FHA_1	154	160	PF00498	0.705
LIG_FHA_1	185	191	PF00498	0.627
LIG_FHA_1	221	227	PF00498	0.653
LIG_FHA_1	229	235	PF00498	0.638
LIG_FHA_1	48	54	PF00498	0.738
LIG_FHA_1	61	67	PF00498	0.638
LIG_FHA_1	683	689	PF00498	0.828
LIG_FHA_2	373	379	PF00498	0.654
LIG_FHA_2	786	792	PF00498	0.831
LIG_FHA_2	815	821	PF00498	0.840
LIG_Integrin_RGD_1	305	307	PF01839	0.659
LIG_LIR_Apic_2	621	627	PF02991	0.634
LIG_LIR_Apic_2	646	650	PF02991	0.751
LIG_LIR_Apic_2	839	845	PF02991	0.719
LIG_LIR_Gen_1	202	211	PF02991	0.661
LIG_LIR_Gen_1	605	614	PF02991	0.831
LIG_LIR_Gen_1	738	747	PF02991	0.626
LIG_LIR_Nem_3	135	141	PF02991	0.716
LIG_LIR_Nem_3	148	154	PF02991	0.522
LIG_LIR_Nem_3	202	208	PF02991	0.672
LIG_LIR_Nem_3	379	385	PF02991	0.766
LIG_LIR_Nem_3	605	609	PF02991	0.842
LIG_LIR_Nem_3	696	700	PF02991	0.627
LIG_LIR_Nem_3	738	742	PF02991	0.620
LIG_NRBOX	233	239	PF00104	0.637
LIG_NRBOX	85	91	PF00104	0.633
LIG_Pex14_1	151	155	PF04695	0.622
LIG_Pex14_1	431	435	PF04695	0.667
LIG_Pex14_1	534	538	PF04695	0.642
LIG_SH2_CRK	282	286	PF00017	0.635
LIG_SH2_CRK	525	529	PF00017	0.660
LIG_SH2_CRK	606	610	PF00017	0.770
LIG_SH2_CRK	697	701	PF00017	0.657
LIG_SH2_NCK_1	264	268	PF00017	0.756
LIG_SH2_NCK_1	525	529	PF00017	0.660
LIG_SH2_PTP2	371	374	PF00017	0.703
LIG_SH2_PTP2	540	543	PF00017	0.747
LIG_SH2_SRC	371	374	PF00017	0.703
LIG_SH2_SRC	492	495	PF00017	0.788
LIG_SH2_STAP1	155	159	PF00017	0.703
LIG_SH2_STAP1	282	286	PF00017	0.635
LIG_SH2_STAP1	292	296	PF00017	0.643
LIG_SH2_STAT5	139	142	PF00017	0.607
LIG_SH2_STAT5	155	158	PF00017	0.599
LIG_SH2_STAT5	205	208	PF00017	0.704
LIG_SH2_STAT5	228	231	PF00017	0.716
LIG_SH2_STAT5	273	276	PF00017	0.665
LIG_SH2_STAT5	371	374	PF00017	0.781
LIG_SH2_STAT5	540	543	PF00017	0.747
LIG_SH3_2	147	152	PF14604	0.744
LIG_SH3_2	559	564	PF14604	0.835
LIG_SH3_3	144	150	PF00018	0.635
LIG_SH3_3	204	210	PF00018	0.728
LIG_SH3_3	212	218	PF00018	0.641
LIG_SH3_3	285	291	PF00018	0.744
LIG_SH3_3	313	319	PF00018	0.716
LIG_SH3_3	384	390	PF00018	0.671
LIG_SH3_3	450	456	PF00018	0.798
LIG_SH3_3	46	52	PF00018	0.767
LIG_SH3_3	473	479	PF00018	0.783
LIG_SH3_3	554	560	PF00018	0.766
LIG_SH3_3	647	653	PF00018	0.791
LIG_SH3_3	69	75	PF00018	0.712
LIG_SUMO_SIM_par_1	372	380	PF11976	0.642
LIG_TRAF2_1	375	378	PF00917	0.651
LIG_TRFH_1	214	218	PF08558	0.665
LIG_WRC_WIRS_1	793	798	PF05994	0.580
LIG_WW_1	270	273	PF00397	0.749
LIG_WW_3	493	497	PF00397	0.722
MOD_CDC14_SPxK_1	389	392	PF00782	0.727
MOD_CDK_SPK_2	228	233	PF00069	0.747
MOD_CDK_SPK_2	386	391	PF00069	0.560
MOD_CDK_SPxK_1	386	392	PF00069	0.719
MOD_CDK_SPxxK_3	47	54	PF00069	0.691
MOD_CK1_1	192	198	PF00069	0.758
MOD_CK1_1	25	31	PF00069	0.736
MOD_CK1_1	287	293	PF00069	0.729
MOD_CK1_1	412	418	PF00069	0.674
MOD_CK1_1	447	453	PF00069	0.713
MOD_CK1_1	530	536	PF00069	0.751
MOD_CK1_1	578	584	PF00069	0.703
MOD_CK1_1	605	611	PF00069	0.774
MOD_CK1_1	760	766	PF00069	0.736
MOD_CK1_1	775	781	PF00069	0.680
MOD_CK1_1	833	839	PF00069	0.736
MOD_CK2_1	162	168	PF00069	0.686
MOD_CK2_1	256	262	PF00069	0.767
MOD_CK2_1	29	35	PF00069	0.793
MOD_CK2_1	312	318	PF00069	0.781
MOD_CK2_1	372	378	PF00069	0.659
MOD_CK2_1	436	442	PF00069	0.668
MOD_CK2_1	578	584	PF00069	0.745
MOD_CK2_1	704	710	PF00069	0.802
MOD_DYRK1A_RPxSP_1	143	147	PF00069	0.612
MOD_GlcNHglycan	134	137	PF01048	0.609
MOD_GlcNHglycan	156	159	PF01048	0.609
MOD_GlcNHglycan	17	20	PF01048	0.715
MOD_GlcNHglycan	191	194	PF01048	0.657
MOD_GlcNHglycan	25	28	PF01048	0.754
MOD_GlcNHglycan	258	261	PF01048	0.767
MOD_GlcNHglycan	276	279	PF01048	0.445
MOD_GlcNHglycan	3	6	PF01048	0.671
MOD_GlcNHglycan	31	34	PF01048	0.723
MOD_GlcNHglycan	365	368	PF01048	0.706
MOD_GlcNHglycan	438	441	PF01048	0.714
MOD_GlcNHglycan	446	449	PF01048	0.676
MOD_GlcNHglycan	465	468	PF01048	0.810
MOD_GlcNHglycan	509	512	PF01048	0.680
MOD_GlcNHglycan	529	532	PF01048	0.681
MOD_GlcNHglycan	576	580	PF01048	0.767
MOD_GlcNHglycan	591	594	PF01048	0.617
MOD_GlcNHglycan	620	623	PF01048	0.772
MOD_GlcNHglycan	632	636	PF01048	0.667
MOD_GlcNHglycan	638	641	PF01048	0.668
MOD_GlcNHglycan	714	717	PF01048	0.758
MOD_GlcNHglycan	762	765	PF01048	0.806
MOD_GlcNHglycan	775	778	PF01048	0.838
MOD_GlcNHglycan	785	788	PF01048	0.715
MOD_GlcNHglycan	797	800	PF01048	0.614
MOD_GlcNHglycan	81	85	PF01048	0.664
MOD_GSK3_1	191	198	PF00069	0.634
MOD_GSK3_1	220	227	PF00069	0.648
MOD_GSK3_1	25	32	PF00069	0.712
MOD_GSK3_1	386	393	PF00069	0.800
MOD_GSK3_1	444	451	PF00069	0.661
MOD_GSK3_1	479	486	PF00069	0.780
MOD_GSK3_1	574	581	PF00069	0.716
MOD_GSK3_1	678	685	PF00069	0.795
MOD_GSK3_1	700	707	PF00069	0.651
MOD_GSK3_1	768	775	PF00069	0.737
MOD_GSK3_1	814	821	PF00069	0.816
MOD_GSK3_1	829	836	PF00069	0.613
MOD_N-GLC_1	693	698	PF02516	0.623
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	22	27	PF00069	0.747
MOD_NEK2_1	274	279	PF00069	0.620
MOD_NEK2_1	544	549	PF00069	0.671
MOD_NEK2_1	552	557	PF00069	0.734
MOD_NEK2_1	575	580	PF00069	0.717
MOD_NEK2_1	618	623	PF00069	0.696
MOD_NEK2_1	717	722	PF00069	0.736
MOD_NEK2_1	772	777	PF00069	0.751
MOD_NEK2_2	659	664	PF00069	0.591
MOD_PIKK_1	651	657	PF00454	0.805
MOD_PK_1	361	367	PF00069	0.696
MOD_PK_1	399	405	PF00069	0.806
MOD_PKA_1	361	367	PF00069	0.696
MOD_PKA_1	391	397	PF00069	0.661
MOD_PKA_1	829	835	PF00069	0.831
MOD_PKA_2	1	7	PF00069	0.563
MOD_PKA_2	14	20	PF00069	0.727
MOD_PKA_2	361	367	PF00069	0.696
MOD_PKA_2	390	396	PF00069	0.667
MOD_PKA_2	412	418	PF00069	0.658
MOD_PKA_2	783	789	PF00069	0.794
MOD_PKA_2	814	820	PF00069	0.848
MOD_PKA_2	833	839	PF00069	0.534
MOD_PKB_1	359	367	PF00069	0.699
MOD_PKB_1	397	405	PF00069	0.808
MOD_Plk_1	312	318	PF00069	0.781
MOD_Plk_1	575	581	PF00069	0.714
MOD_Plk_1	693	699	PF00069	0.618
MOD_Plk_1	710	716	PF00069	0.775
MOD_Plk_1	80	86	PF00069	0.633
MOD_Plk_1	840	846	PF00069	0.819
MOD_Plk_4	224	230	PF00069	0.653
MOD_Plk_4	312	318	PF00069	0.781
MOD_Plk_4	412	418	PF00069	0.624
MOD_Plk_4	425	431	PF00069	0.588
MOD_Plk_4	530	536	PF00069	0.649
MOD_Plk_4	678	684	PF00069	0.832
MOD_Plk_4	762	768	PF00069	0.703
MOD_ProDKin_1	141	147	PF00069	0.601
MOD_ProDKin_1	200	206	PF00069	0.690
MOD_ProDKin_1	228	234	PF00069	0.714
MOD_ProDKin_1	284	290	PF00069	0.641
MOD_ProDKin_1	332	338	PF00069	0.820
MOD_ProDKin_1	345	351	PF00069	0.632
MOD_ProDKin_1	386	392	PF00069	0.796
MOD_ProDKin_1	47	53	PF00069	0.767
MOD_ProDKin_1	682	688	PF00069	0.761
MOD_SUMO_rev_2	112	121	PF00179	0.732
MOD_SUMO_rev_2	32	39	PF00179	0.797
MOD_SUMO_rev_2	824	832	PF00179	0.757
TRG_DiLeu_BaEn_4	570	576	PF01217	0.769
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.815
TRG_ENDOCYTIC_2	205	208	PF00928	0.764
TRG_ENDOCYTIC_2	282	285	PF00928	0.636
TRG_ENDOCYTIC_2	371	374	PF00928	0.781
TRG_ENDOCYTIC_2	435	438	PF00928	0.739
TRG_ENDOCYTIC_2	525	528	PF00928	0.666
TRG_ENDOCYTIC_2	606	609	PF00928	0.773
TRG_ENDOCYTIC_2	697	700	PF00928	0.656
TRG_ER_diArg_1	239	241	PF00400	0.661
TRG_ER_diArg_1	359	362	PF00400	0.784
TRG_ER_diArg_1	382	384	PF00400	0.679
TRG_ER_diArg_1	390	392	PF00400	0.713
TRG_ER_diArg_1	431	433	PF00400	0.630
TRG_ER_diArg_1	495	498	PF00400	0.724
TRG_ER_diArg_1	564	566	PF00400	0.775
TRG_ER_diArg_1	596	598	PF00400	0.812
TRG_ER_diArg_1	628	630	PF00400	0.731
TRG_ER_diArg_1	718	721	PF00400	0.698
TRG_ER_diArg_1	804	807	PF00400	0.759
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYI3	Leptomonas seymouri	42%	96%
A0A3S5H507	Leishmania donovani	92%	100%
A4H3E6	Leishmania braziliensis	73%	100%
A4HRQ1	Leishmania infantum	92%	100%
E9AJL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%