Copper transporter

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Copper transporter

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACC8_LEIMA

TriTrypDb:

LmjF.02.0540 , LMJLV39_020010600 , LMJSD75_020010700

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ACC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.620
CLV_NRD_NRD_1	138	140	PF00675	0.444
CLV_NRD_NRD_1	224	226	PF00675	0.502
CLV_NRD_NRD_1	228	230	PF00675	0.562
CLV_PCSK_FUR_1	136	140	PF00082	0.445
CLV_PCSK_FUR_1	222	226	PF00082	0.455
CLV_PCSK_KEX2_1	138	140	PF00082	0.444
CLV_PCSK_KEX2_1	203	205	PF00082	0.395
CLV_PCSK_KEX2_1	224	226	PF00082	0.502
CLV_PCSK_KEX2_1	227	229	PF00082	0.542
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.410
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.457
CLV_PCSK_PC7_1	220	226	PF00082	0.453
CLV_PCSK_SKI1_1	200	204	PF00082	0.372
CLV_PCSK_SKI1_1	275	279	PF00082	0.293
CLV_PCSK_SKI1_1	304	308	PF00082	0.567
DEG_SPOP_SBC_1	25	29	PF00917	0.461
DOC_MAPK_gen_1	200	209	PF00069	0.610
DOC_MAPK_JIP1_4	49	55	PF00069	0.293
DOC_MAPK_MEF2A_6	114	123	PF00069	0.591
DOC_MAPK_MEF2A_6	154	161	PF00069	0.293
DOC_MAPK_MEF2A_6	49	57	PF00069	0.293
DOC_PP2B_LxvP_1	22	25	PF13499	0.481
DOC_PP2B_LxvP_1	298	301	PF13499	0.385
DOC_USP7_MATH_1	241	245	PF00917	0.622
DOC_USP7_MATH_1	25	29	PF00917	0.437
DOC_USP7_MATH_1	311	315	PF00917	0.346
DOC_USP7_UBL2_3	304	308	PF12436	0.403
DOC_WW_Pin1_4	126	131	PF00397	0.652
LIG_14-3-3_CanoR_1	139	149	PF00244	0.639
LIG_14-3-3_CanoR_1	212	216	PF00244	0.644
LIG_BH_BH3_1	140	156	PF00452	0.604
LIG_BIR_II_1	1	5	PF00653	0.493
LIG_BIR_III_3	1	5	PF00653	0.493
LIG_BIR_III_4	251	255	PF00653	0.583
LIG_BRCT_BRCA1_1	197	201	PF00533	0.492
LIG_BRCT_BRCA1_1	273	277	PF00533	0.602
LIG_BRCT_BRCA1_2	197	203	PF00533	0.495
LIG_EH1_1	280	288	PF00400	0.307
LIG_eIF4E_1	17	23	PF01652	0.574
LIG_FHA_1	18	24	PF00498	0.395
LIG_FHA_1	182	188	PF00498	0.289
LIG_GBD_Chelix_1	287	295	PF00786	0.482
LIG_GBD_Chelix_1	55	63	PF00786	0.338
LIG_LIR_Gen_1	153	161	PF02991	0.458
LIG_LIR_Gen_1	51	60	PF02991	0.406
LIG_LIR_Gen_1	90	100	PF02991	0.649
LIG_LIR_Nem_3	153	159	PF02991	0.458
LIG_LIR_Nem_3	163	169	PF02991	0.289
LIG_LIR_Nem_3	198	202	PF02991	0.497
LIG_LIR_Nem_3	278	284	PF02991	0.309
LIG_LIR_Nem_3	51	57	PF02991	0.406
LIG_LIR_Nem_3	61	67	PF02991	0.195
LIG_LIR_Nem_3	83	89	PF02991	0.643
LIG_LIR_Nem_3	9	13	PF02991	0.355
LIG_LIR_Nem_3	90	95	PF02991	0.607
LIG_LYPXL_yS_3	118	121	PF13949	0.591
LIG_PCNA_PIPBox_1	270	279	PF02747	0.604
LIG_PDZ_Class_3	323	328	PF00595	0.430
LIG_Pex14_2	277	281	PF04695	0.390
LIG_SH2_CRK	137	141	PF00017	0.641
LIG_SH2_CRK	156	160	PF00017	0.180
LIG_SH2_CRK	194	198	PF00017	0.289
LIG_SH2_CRK	199	203	PF00017	0.573
LIG_SH2_STAT5	194	197	PF00017	0.289
LIG_SH3_3	120	126	PF00018	0.696
LIG_SUMO_SIM_anti_2	188	193	PF11976	0.323
LIG_SUMO_SIM_anti_2	263	268	PF11976	0.626
LIG_SUMO_SIM_par_1	147	153	PF11976	0.598
LIG_SUMO_SIM_par_1	183	188	PF11976	0.289
LIG_SUMO_SIM_par_1	265	271	PF11976	0.616
LIG_SUMO_SIM_par_1	55	61	PF11976	0.338
LIG_TYR_ITIM	135	140	PF00017	0.644
LIG_TYR_ITIM	192	197	PF00017	0.289
LIG_UBA3_1	63	72	PF00899	0.289
LIG_WRC_WIRS_1	7	12	PF05994	0.338
MOD_CK1_1	129	135	PF00069	0.577
MOD_CK1_1	27	33	PF00069	0.475
MOD_CK1_1	58	64	PF00069	0.338
MOD_GlcNHglycan	10	13	PF01048	0.353
MOD_GlcNHglycan	131	134	PF01048	0.454
MOD_GlcNHglycan	209	212	PF01048	0.427
MOD_GlcNHglycan	313	316	PF01048	0.482
MOD_GlcNHglycan	35	38	PF01048	0.704
MOD_GlcNHglycan	45	48	PF01048	0.613
MOD_GlcNHglycan	64	67	PF01048	0.338
MOD_GSK3_1	125	132	PF00069	0.623
MOD_GSK3_1	181	188	PF00069	0.258
MOD_GSK3_1	207	214	PF00069	0.628
MOD_GSK3_1	23	30	PF00069	0.453
MOD_GSK3_1	271	278	PF00069	0.676
MOD_GSK3_1	58	65	PF00069	0.458
MOD_N-GLC_1	181	186	PF02516	0.458
MOD_NEK2_1	142	147	PF00069	0.661
MOD_NEK2_1	16	21	PF00069	0.653
MOD_NEK2_1	187	192	PF00069	0.338
MOD_NEK2_1	207	212	PF00069	0.624
MOD_NEK2_1	215	220	PF00069	0.602
MOD_NEK2_1	276	281	PF00069	0.390
MOD_NEK2_1	293	298	PF00069	0.436
MOD_NEK2_1	33	38	PF00069	0.382
MOD_NEK2_1	55	60	PF00069	0.338
MOD_PKA_2	207	213	PF00069	0.677
MOD_PKA_2	48	54	PF00069	0.426
MOD_Plk_4	181	187	PF00069	0.288
MOD_Plk_4	192	198	PF00069	0.371
MOD_Plk_4	48	54	PF00069	0.527
MOD_Plk_4	55	61	PF00069	0.221
MOD_ProDKin_1	126	132	PF00069	0.649
MOD_SUMO_rev_2	73	80	PF00179	0.624
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.644
TRG_ENDOCYTIC_2	118	121	PF00928	0.591
TRG_ENDOCYTIC_2	13	16	PF00928	0.390
TRG_ENDOCYTIC_2	137	140	PF00928	0.645
TRG_ENDOCYTIC_2	156	159	PF00928	0.180
TRG_ENDOCYTIC_2	194	197	PF00928	0.289
TRG_ENDOCYTIC_2	199	202	PF00928	0.573
TRG_ENDOCYTIC_2	92	95	PF00928	0.644
TRG_ER_diArg_1	137	139	PF00400	0.650
TRG_ER_diArg_1	222	225	PF00400	0.699
TRG_ER_diArg_1	228	230	PF00400	0.630
TRG_NLS_MonoExtN_4	224	231	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5IR47	Trypanosoma rangeli	38%	100%
A0A451EJI9	Leishmania donovani	95%	100%
A4HRP9	Leishmania infantum	94%	100%
E9AJL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%