Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACC7_LEIMA

TriTrypDb:

LmjF.02.0530 , LMJLV39_020010500 , LMJSD75_020010600

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.643
CLV_C14_Caspase3-7	627	631	PF00656	0.650
CLV_C14_Caspase3-7	695	699	PF00656	0.718
CLV_MEL_PAP_1	62	68	PF00089	0.665
CLV_NRD_NRD_1	204	206	PF00675	0.697
CLV_NRD_NRD_1	298	300	PF00675	0.835
CLV_NRD_NRD_1	502	504	PF00675	0.760
CLV_NRD_NRD_1	599	601	PF00675	0.797
CLV_NRD_NRD_1	622	624	PF00675	0.734
CLV_NRD_NRD_1	741	743	PF00675	0.726
CLV_NRD_NRD_1	852	854	PF00675	0.777
CLV_PCSK_KEX2_1	204	206	PF00082	0.697
CLV_PCSK_KEX2_1	298	300	PF00082	0.843
CLV_PCSK_KEX2_1	499	501	PF00082	0.758
CLV_PCSK_KEX2_1	599	601	PF00082	0.795
CLV_PCSK_KEX2_1	622	624	PF00082	0.734
CLV_PCSK_KEX2_1	852	854	PF00082	0.768
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.749
CLV_PCSK_SKI1_1	129	133	PF00082	0.691
CLV_PCSK_SKI1_1	264	268	PF00082	0.637
CLV_PCSK_SKI1_1	553	557	PF00082	0.727
CLV_PCSK_SKI1_1	629	633	PF00082	0.564
CLV_PCSK_SKI1_1	769	773	PF00082	0.642
DEG_APCC_DBOX_1	204	212	PF00400	0.686
DEG_SPOP_SBC_1	146	150	PF00917	0.659
DEG_SPOP_SBC_1	388	392	PF00917	0.690
DOC_CKS1_1	18	23	PF01111	0.632
DOC_CKS1_1	360	365	PF01111	0.632
DOC_MAPK_DCC_7	204	213	PF00069	0.681
DOC_MAPK_gen_1	204	211	PF00069	0.687
DOC_MAPK_MEF2A_6	204	213	PF00069	0.681
DOC_MAPK_MEF2A_6	704	712	PF00069	0.708
DOC_PP2B_LxvP_1	153	156	PF13499	0.670
DOC_PP2B_LxvP_1	356	359	PF13499	0.691
DOC_PP4_MxPP_1	537	540	PF00568	0.672
DOC_SPAK_OSR1_1	725	729	PF12202	0.707
DOC_USP7_MATH_1	163	167	PF00917	0.730
DOC_USP7_MATH_1	169	173	PF00917	0.721
DOC_USP7_MATH_1	19	23	PF00917	0.678
DOC_USP7_MATH_1	191	195	PF00917	0.621
DOC_USP7_MATH_1	218	222	PF00917	0.664
DOC_USP7_MATH_1	29	33	PF00917	0.689
DOC_USP7_MATH_1	324	328	PF00917	0.626
DOC_USP7_MATH_1	372	376	PF00917	0.715
DOC_USP7_MATH_1	404	408	PF00917	0.674
DOC_USP7_MATH_1	430	434	PF00917	0.646
DOC_USP7_MATH_1	451	455	PF00917	0.668
DOC_USP7_MATH_1	475	479	PF00917	0.706
DOC_USP7_MATH_1	514	518	PF00917	0.619
DOC_USP7_MATH_1	564	568	PF00917	0.760
DOC_USP7_MATH_1	570	574	PF00917	0.743
DOC_USP7_MATH_1	624	628	PF00917	0.658
DOC_USP7_MATH_1	637	641	PF00917	0.546
DOC_USP7_MATH_1	670	674	PF00917	0.818
DOC_USP7_MATH_1	691	695	PF00917	0.695
DOC_USP7_MATH_1	75	79	PF00917	0.615
DOC_USP7_MATH_1	760	764	PF00917	0.686
DOC_USP7_MATH_1	841	845	PF00917	0.769
DOC_USP7_MATH_1	94	98	PF00917	0.608
DOC_WW_Pin1_4	110	115	PF00397	0.743
DOC_WW_Pin1_4	147	152	PF00397	0.708
DOC_WW_Pin1_4	17	22	PF00397	0.710
DOC_WW_Pin1_4	173	178	PF00397	0.775
DOC_WW_Pin1_4	2	7	PF00397	0.785
DOC_WW_Pin1_4	287	292	PF00397	0.675
DOC_WW_Pin1_4	359	364	PF00397	0.657
DOC_WW_Pin1_4	389	394	PF00397	0.780
DOC_WW_Pin1_4	426	431	PF00397	0.730
DOC_WW_Pin1_4	498	503	PF00397	0.813
DOC_WW_Pin1_4	572	577	PF00397	0.720
DOC_WW_Pin1_4	675	680	PF00397	0.717
LIG_14-3-3_CanoR_1	423	431	PF00244	0.663
LIG_14-3-3_CanoR_1	524	528	PF00244	0.782
LIG_14-3-3_CanoR_1	599	603	PF00244	0.820
LIG_14-3-3_CanoR_1	622	632	PF00244	0.709
LIG_14-3-3_CanoR_1	725	729	PF00244	0.679
LIG_14-3-3_CanoR_1	80	85	PF00244	0.642
LIG_Actin_WH2_2	331	349	PF00022	0.632
LIG_Actin_WH2_2	509	526	PF00022	0.680
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BIR_III_2	427	431	PF00653	0.696
LIG_BIR_III_2	630	634	PF00653	0.647
LIG_BRCT_BRCA1_1	51	55	PF00533	0.545
LIG_BRCT_BRCA1_1	722	726	PF00533	0.704
LIG_eIF4E_1	203	209	PF01652	0.691
LIG_eIF4E_1	549	555	PF01652	0.721
LIG_EVH1_1	538	542	PF00568	0.665
LIG_FHA_1	13	19	PF00498	0.719
LIG_FHA_1	324	330	PF00498	0.671
LIG_FHA_1	355	361	PF00498	0.622
LIG_FHA_1	49	55	PF00498	0.735
LIG_FHA_1	529	535	PF00498	0.707
LIG_FHA_1	554	560	PF00498	0.734
LIG_FHA_1	725	731	PF00498	0.699
LIG_FHA_1	765	771	PF00498	0.662
LIG_FHA_1	826	832	PF00498	0.690
LIG_FHA_2	360	366	PF00498	0.704
LIG_FHA_2	693	699	PF00498	0.715
LIG_FHA_2	777	783	PF00498	0.622
LIG_GBD_Chelix_1	334	342	PF00786	0.631
LIG_Integrin_isoDGR_2	587	589	PF01839	0.665
LIG_LIR_Apic_2	792	798	PF02991	0.633
LIG_LIR_Gen_1	32	37	PF02991	0.684
LIG_LIR_Gen_1	340	351	PF02991	0.630
LIG_LIR_Gen_1	407	417	PF02991	0.694
LIG_LIR_Gen_1	810	820	PF02991	0.625
LIG_LIR_Nem_3	32	36	PF02991	0.684
LIG_LIR_Nem_3	340	346	PF02991	0.673
LIG_LIR_Nem_3	349	355	PF02991	0.636
LIG_LIR_Nem_3	407	413	PF02991	0.688
LIG_LIR_Nem_3	52	58	PF02991	0.546
LIG_LIR_Nem_3	673	677	PF02991	0.575
LIG_LIR_Nem_3	785	791	PF02991	0.632
LIG_LIR_Nem_3	810	815	PF02991	0.622
LIG_MYND_1	152	156	PF01753	0.658
LIG_MYND_1	536	540	PF01753	0.671
LIG_PCNA_yPIPBox_3	215	227	PF02747	0.611
LIG_PDZ_Class_2	857	862	PF00595	0.669
LIG_Rb_LxCxE_1	409	427	PF01857	0.717
LIG_RPA_C_Fungi	217	229	PF08784	0.607
LIG_RPA_C_Fungi	829	841	PF08784	0.537
LIG_SH2_CRK	674	678	PF00017	0.572
LIG_SH2_CRK	812	816	PF00017	0.622
LIG_SH2_PTP2	410	413	PF00017	0.702
LIG_SH2_STAP1	780	784	PF00017	0.656
LIG_SH2_STAP1	812	816	PF00017	0.622
LIG_SH2_STAT5	37	40	PF00017	0.673
LIG_SH2_STAT5	410	413	PF00017	0.702
LIG_SH2_STAT5	580	583	PF00017	0.578
LIG_SH3_1	533	539	PF00018	0.670
LIG_SH3_3	1	7	PF00018	0.673
LIG_SH3_3	159	165	PF00018	0.692
LIG_SH3_3	183	189	PF00018	0.752
LIG_SH3_3	357	363	PF00018	0.647
LIG_SH3_3	533	539	PF00018	0.802
LIG_SH3_3	673	679	PF00018	0.680
LIG_SH3_3	705	711	PF00018	0.726
LIG_SUMO_SIM_anti_2	782	789	PF11976	0.670
LIG_SUMO_SIM_par_1	148	157	PF11976	0.586
LIG_TRAF2_1	419	422	PF00917	0.677
LIG_WW_2	539	542	PF00397	0.660
MOD_CDC14_SPxK_1	501	504	PF00782	0.752
MOD_CDK_SPK_2	498	503	PF00069	0.750
MOD_CDK_SPxK_1	498	504	PF00069	0.751
MOD_CDK_SPxxK_3	287	294	PF00069	0.678
MOD_CK1_1	103	109	PF00069	0.738
MOD_CK1_1	172	178	PF00069	0.710
MOD_CK1_1	2	8	PF00069	0.813
MOD_CK1_1	221	227	PF00069	0.645
MOD_CK1_1	275	281	PF00069	0.697
MOD_CK1_1	310	316	PF00069	0.748
MOD_CK1_1	320	326	PF00069	0.578
MOD_CK1_1	377	383	PF00069	0.751
MOD_CK1_1	400	406	PF00069	0.692
MOD_CK1_1	454	460	PF00069	0.568
MOD_CK1_1	517	523	PF00069	0.682
MOD_CK1_1	611	617	PF00069	0.604
MOD_CK1_1	678	684	PF00069	0.742
MOD_CK1_1	692	698	PF00069	0.633
MOD_CK1_1	731	737	PF00069	0.726
MOD_CK1_1	754	760	PF00069	0.749
MOD_CK1_1	842	848	PF00069	0.608
MOD_CK2_1	359	365	PF00069	0.700
MOD_CK2_1	453	459	PF00069	0.691
MOD_CK2_1	598	604	PF00069	0.753
MOD_CK2_1	64	70	PF00069	0.711
MOD_Cter_Amidation	497	500	PF01082	0.596
MOD_GlcNHglycan	1	4	PF01048	0.817
MOD_GlcNHglycan	102	105	PF01048	0.552
MOD_GlcNHglycan	142	145	PF01048	0.769
MOD_GlcNHglycan	193	196	PF01048	0.669
MOD_GlcNHglycan	21	24	PF01048	0.538
MOD_GlcNHglycan	258	261	PF01048	0.658
MOD_GlcNHglycan	26	29	PF01048	0.682
MOD_GlcNHglycan	309	312	PF01048	0.753
MOD_GlcNHglycan	319	322	PF01048	0.627
MOD_GlcNHglycan	326	329	PF01048	0.538
MOD_GlcNHglycan	372	375	PF01048	0.716
MOD_GlcNHglycan	376	379	PF01048	0.669
MOD_GlcNHglycan	399	402	PF01048	0.796
MOD_GlcNHglycan	406	409	PF01048	0.658
MOD_GlcNHglycan	424	427	PF01048	0.545
MOD_GlcNHglycan	439	442	PF01048	0.553
MOD_GlcNHglycan	550	553	PF01048	0.706
MOD_GlcNHglycan	561	564	PF01048	0.762
MOD_GlcNHglycan	565	569	PF01048	0.719
MOD_GlcNHglycan	576	579	PF01048	0.576
MOD_GlcNHglycan	610	613	PF01048	0.710
MOD_GlcNHglycan	615	618	PF01048	0.692
MOD_GlcNHglycan	639	642	PF01048	0.595
MOD_GlcNHglycan	686	689	PF01048	0.788
MOD_GlcNHglycan	691	694	PF01048	0.733
MOD_GlcNHglycan	7	10	PF01048	0.645
MOD_GlcNHglycan	712	715	PF01048	0.699
MOD_GlcNHglycan	753	756	PF01048	0.726
MOD_GlcNHglycan	764	767	PF01048	0.741
MOD_GlcNHglycan	835	839	PF01048	0.748
MOD_GlcNHglycan	85	88	PF01048	0.720
MOD_GlcNHglycan	94	97	PF01048	0.644
MOD_GSK3_1	110	117	PF00069	0.548
MOD_GSK3_1	169	176	PF00069	0.733
MOD_GSK3_1	272	279	PF00069	0.656
MOD_GSK3_1	319	326	PF00069	0.584
MOD_GSK3_1	337	344	PF00069	0.647
MOD_GSK3_1	366	373	PF00069	0.680
MOD_GSK3_1	374	381	PF00069	0.596
MOD_GSK3_1	400	407	PF00069	0.659
MOD_GSK3_1	422	429	PF00069	0.771
MOD_GSK3_1	437	444	PF00069	0.569
MOD_GSK3_1	44	51	PF00069	0.739
MOD_GSK3_1	481	488	PF00069	0.656
MOD_GSK3_1	523	530	PF00069	0.695
MOD_GSK3_1	555	562	PF00069	0.774
MOD_GSK3_1	570	577	PF00069	0.606
MOD_GSK3_1	720	727	PF00069	0.778
MOD_GSK3_1	729	736	PF00069	0.674
MOD_GSK3_1	751	758	PF00069	0.733
MOD_GSK3_1	760	767	PF00069	0.771
MOD_GSK3_1	839	846	PF00069	0.577
MOD_GSK3_1	92	99	PF00069	0.690
MOD_LATS_1	832	838	PF00433	0.539
MOD_N-GLC_1	173	178	PF02516	0.644
MOD_N-GLC_1	24	29	PF02516	0.625
MOD_N-GLC_1	275	280	PF02516	0.651
MOD_N-GLC_1	755	760	PF02516	0.783
MOD_NEK2_1	170	175	PF00069	0.688
MOD_NEK2_1	24	29	PF00069	0.667
MOD_NEK2_1	346	351	PF00069	0.632
MOD_NEK2_1	523	528	PF00069	0.721
MOD_NEK2_1	683	688	PF00069	0.583
MOD_NEK2_2	624	629	PF00069	0.558
MOD_PIKK_1	337	343	PF00454	0.632
MOD_PIKK_1	430	436	PF00454	0.672
MOD_PIKK_1	514	520	PF00454	0.681
MOD_PIKK_1	736	742	PF00454	0.672
MOD_PKA_1	140	146	PF00069	0.792
MOD_PKA_2	221	227	PF00069	0.613
MOD_PKA_2	346	352	PF00069	0.676
MOD_PKA_2	422	428	PF00069	0.666
MOD_PKA_2	523	529	PF00069	0.785
MOD_PKA_2	598	604	PF00069	0.806
MOD_PKA_2	64	70	PF00069	0.672
MOD_PKA_2	724	730	PF00069	0.735
MOD_PKA_2	833	839	PF00069	0.540
MOD_Plk_1	466	472	PF00069	0.695
MOD_Plk_1	656	662	PF00069	0.734
MOD_Plk_1	782	788	PF00069	0.625
MOD_Plk_1	810	816	PF00069	0.623
MOD_Plk_2-3	776	782	PF00069	0.628
MOD_Plk_4	209	215	PF00069	0.673
MOD_Plk_4	29	35	PF00069	0.772
MOD_Plk_4	406	412	PF00069	0.685
MOD_Plk_4	441	447	PF00069	0.686
MOD_Plk_4	576	582	PF00069	0.576
MOD_Plk_4	656	662	PF00069	0.708
MOD_Plk_4	678	684	PF00069	0.595
MOD_Plk_4	782	788	PF00069	0.625
MOD_Plk_4	810	816	PF00069	0.623
MOD_Plk_4	826	832	PF00069	0.671
MOD_ProDKin_1	110	116	PF00069	0.744
MOD_ProDKin_1	147	153	PF00069	0.709
MOD_ProDKin_1	17	23	PF00069	0.707
MOD_ProDKin_1	173	179	PF00069	0.774
MOD_ProDKin_1	2	8	PF00069	0.784
MOD_ProDKin_1	287	293	PF00069	0.676
MOD_ProDKin_1	359	365	PF00069	0.658
MOD_ProDKin_1	389	395	PF00069	0.779
MOD_ProDKin_1	426	432	PF00069	0.727
MOD_ProDKin_1	498	504	PF00069	0.814
MOD_ProDKin_1	572	578	PF00069	0.719
MOD_ProDKin_1	675	681	PF00069	0.716
TRG_DiLeu_BaEn_1	656	661	PF01217	0.706
TRG_DiLeu_BaEn_1	811	816	PF01217	0.622
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.667
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.715
TRG_ENDOCYTIC_2	410	413	PF00928	0.702
TRG_ENDOCYTIC_2	674	677	PF00928	0.575
TRG_ENDOCYTIC_2	812	815	PF00928	0.620
TRG_ER_diArg_1	127	130	PF00400	0.736
TRG_ER_diArg_1	203	205	PF00400	0.698
TRG_ER_diArg_1	297	299	PF00400	0.834
TRG_ER_diArg_1	621	623	PF00400	0.743
TRG_ER_diArg_1	851	853	PF00400	0.762
TRG_NLS_MonoExtN_4	500	507	PF00514	0.724
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.749
TRG_Pf-PMV_PEXEL_1	853	858	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJI8	Leishmania donovani	91%	100%
A4H3E3	Leishmania braziliensis	60%	100%
A4HRP8	Leishmania infantum	91%	100%
E9AJL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%