Putative glycerate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerate kinase, putative

Species:

Leishmania major

UniProt:

E9ACC4_LEIMA

TriTrypDb:

LmjF.02.0500 , LMJLV39_020010100 , LMJSD75_020010200

Length:

953

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACC4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0031388	organic acid phosphorylation	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008887	glycerate kinase activity	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.480
CLV_C14_Caspase3-7	461	465	PF00656	0.640
CLV_NRD_NRD_1	236	238	PF00675	0.253
CLV_NRD_NRD_1	279	281	PF00675	0.327
CLV_NRD_NRD_1	395	397	PF00675	0.689
CLV_NRD_NRD_1	626	628	PF00675	0.513
CLV_NRD_NRD_1	679	681	PF00675	0.739
CLV_NRD_NRD_1	868	870	PF00675	0.468
CLV_NRD_NRD_1	932	934	PF00675	0.523
CLV_PCSK_FUR_1	234	238	PF00082	0.270
CLV_PCSK_KEX2_1	236	238	PF00082	0.253
CLV_PCSK_KEX2_1	279	281	PF00082	0.327
CLV_PCSK_KEX2_1	395	397	PF00082	0.689
CLV_PCSK_KEX2_1	626	628	PF00082	0.513
CLV_PCSK_KEX2_1	679	681	PF00082	0.758
CLV_PCSK_KEX2_1	688	690	PF00082	0.683
CLV_PCSK_KEX2_1	868	870	PF00082	0.468
CLV_PCSK_KEX2_1	932	934	PF00082	0.523
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.801
CLV_PCSK_SKI1_1	279	283	PF00082	0.334
CLV_PCSK_SKI1_1	316	320	PF00082	0.480
CLV_PCSK_SKI1_1	352	356	PF00082	0.343
CLV_PCSK_SKI1_1	501	505	PF00082	0.343
CLV_PCSK_SKI1_1	640	644	PF00082	0.401
CLV_PCSK_SKI1_1	790	794	PF00082	0.563
CLV_PCSK_SKI1_1	885	889	PF00082	0.486
CLV_PCSK_SKI1_1	932	936	PF00082	0.622
DEG_APCC_DBOX_1	315	323	PF00400	0.480
DEG_SPOP_SBC_1	836	840	PF00917	0.668
DOC_CKS1_1	194	199	PF01111	0.410
DOC_CKS1_1	661	666	PF01111	0.460
DOC_CKS1_1	825	830	PF01111	0.521
DOC_CKS1_1	900	905	PF01111	0.500
DOC_CYCLIN_RxL_1	882	889	PF00134	0.353
DOC_MAPK_MEF2A_6	279	286	PF00069	0.343
DOC_MAPK_MEF2A_6	68	76	PF00069	0.739
DOC_MAPK_RevD_3	224	237	PF00069	0.270
DOC_PP1_RVXF_1	267	274	PF00149	0.325
DOC_PP2B_LxvP_1	168	171	PF13499	0.729
DOC_PP2B_LxvP_1	702	705	PF13499	0.694
DOC_PP4_FxxP_1	875	878	PF00568	0.431
DOC_PP4_FxxP_1	906	909	PF00568	0.626
DOC_USP7_MATH_1	135	139	PF00917	0.468
DOC_USP7_MATH_1	2	6	PF00917	0.664
DOC_USP7_MATH_1	22	26	PF00917	0.600
DOC_USP7_MATH_1	35	39	PF00917	0.722
DOC_USP7_MATH_1	471	475	PF00917	0.787
DOC_USP7_MATH_1	518	522	PF00917	0.609
DOC_USP7_MATH_1	551	555	PF00917	0.466
DOC_USP7_MATH_1	605	609	PF00917	0.623
DOC_USP7_MATH_1	706	710	PF00917	0.676
DOC_USP7_MATH_1	836	840	PF00917	0.692
DOC_WW_Pin1_4	157	162	PF00397	0.676
DOC_WW_Pin1_4	193	198	PF00397	0.410
DOC_WW_Pin1_4	20	25	PF00397	0.684
DOC_WW_Pin1_4	224	229	PF00397	0.503
DOC_WW_Pin1_4	335	340	PF00397	0.473
DOC_WW_Pin1_4	38	43	PF00397	0.759
DOC_WW_Pin1_4	451	456	PF00397	0.623
DOC_WW_Pin1_4	472	477	PF00397	0.693
DOC_WW_Pin1_4	48	53	PF00397	0.693
DOC_WW_Pin1_4	519	524	PF00397	0.656
DOC_WW_Pin1_4	526	531	PF00397	0.663
DOC_WW_Pin1_4	660	665	PF00397	0.453
DOC_WW_Pin1_4	80	85	PF00397	0.665
DOC_WW_Pin1_4	824	829	PF00397	0.531
DOC_WW_Pin1_4	837	842	PF00397	0.580
DOC_WW_Pin1_4	899	904	PF00397	0.489
DOC_WW_Pin1_4	97	102	PF00397	0.543
LIG_14-3-3_CanoR_1	269	274	PF00244	0.325
LIG_14-3-3_CanoR_1	305	310	PF00244	0.463
LIG_14-3-3_CanoR_1	501	506	PF00244	0.343
LIG_14-3-3_CanoR_1	569	576	PF00244	0.534
LIG_14-3-3_CanoR_1	7	16	PF00244	0.686
LIG_14-3-3_CanoR_1	790	798	PF00244	0.543
LIG_14-3-3_CanoR_1	895	899	PF00244	0.398
LIG_14-3-3_CanoR_1	932	942	PF00244	0.675
LIG_Actin_WH2_2	663	681	PF00022	0.600
LIG_APCC_ABBA_1	375	380	PF00400	0.480
LIG_BIR_III_2	700	704	PF00653	0.730
LIG_BRCT_BRCA1_1	635	639	PF00533	0.370
LIG_BRCT_BRCA1_1	863	867	PF00533	0.437
LIG_EH1_1	308	316	PF00400	0.343
LIG_eIF4E_1	309	315	PF01652	0.343
LIG_FHA_1	245	251	PF00498	0.320
LIG_FHA_1	39	45	PF00498	0.742
LIG_FHA_1	571	577	PF00498	0.409
LIG_FHA_1	661	667	PF00498	0.477
LIG_FHA_1	673	679	PF00498	0.629
LIG_FHA_1	791	797	PF00498	0.541
LIG_FHA_1	81	87	PF00498	0.587
LIG_FHA_1	818	824	PF00498	0.511
LIG_FHA_1	900	906	PF00498	0.508
LIG_FHA_2	220	226	PF00498	0.280
LIG_FHA_2	409	415	PF00498	0.682
LIG_FHA_2	459	465	PF00498	0.742
LIG_FHA_2	53	59	PF00498	0.608
LIG_FHA_2	838	844	PF00498	0.693
LIG_Integrin_RGD_1	462	464	PF01839	0.608
LIG_Integrin_RGD_1	697	699	PF01839	0.694
LIG_IRF3_LxIS_1	70	77	PF10401	0.738
LIG_LIR_Apic_2	873	878	PF02991	0.452
LIG_LIR_Apic_2	889	894	PF02991	0.543
LIG_LIR_Apic_2	904	909	PF02991	0.441
LIG_LIR_Gen_1	805	815	PF02991	0.556
LIG_LIR_Nem_3	578	583	PF02991	0.479
LIG_LIR_Nem_3	636	642	PF02991	0.391
LIG_LIR_Nem_3	805	810	PF02991	0.455
LIG_MAD2	574	582	PF02301	0.510
LIG_MLH1_MIPbox_1	635	639	PF16413	0.370
LIG_MYND_1	224	228	PF01753	0.375
LIG_MYND_1	903	907	PF01753	0.669
LIG_NRBOX	619	625	PF00104	0.433
LIG_REV1ctd_RIR_1	636	644	PF16727	0.387
LIG_SH2_CRK	891	895	PF00017	0.538
LIG_SH2_CRK	916	920	PF00017	0.438
LIG_SH2_NCK_1	317	321	PF00017	0.445
LIG_SH2_NCK_1	661	665	PF00017	0.503
LIG_SH2_SRC	239	242	PF00017	0.343
LIG_SH2_SRC	647	650	PF00017	0.411
LIG_SH2_STAP1	317	321	PF00017	0.411
LIG_SH2_STAP1	916	920	PF00017	0.411
LIG_SH2_STAT3	641	644	PF00017	0.429
LIG_SH2_STAT5	239	242	PF00017	0.343
LIG_SH2_STAT5	448	451	PF00017	0.642
LIG_SH2_STAT5	483	486	PF00017	0.551
LIG_SH2_STAT5	641	644	PF00017	0.436
LIG_SH2_STAT5	647	650	PF00017	0.388
LIG_SH2_STAT5	772	775	PF00017	0.473
LIG_SH2_STAT5	857	860	PF00017	0.408
LIG_SH2_STAT5	886	889	PF00017	0.403
LIG_SH2_STAT5	891	894	PF00017	0.398
LIG_SH3_1	444	450	PF00018	0.383
LIG_SH3_3	146	152	PF00018	0.656
LIG_SH3_3	153	159	PF00018	0.672
LIG_SH3_3	166	172	PF00018	0.455
LIG_SH3_3	235	241	PF00018	0.343
LIG_SH3_3	444	450	PF00018	0.593
LIG_SH3_3	46	52	PF00018	0.811
LIG_SH3_3	517	523	PF00018	0.664
LIG_SH3_3	576	582	PF00018	0.517
LIG_SH3_3	66	72	PF00018	0.548
LIG_SH3_3	897	903	PF00018	0.448
LIG_SUMO_SIM_anti_2	793	799	PF11976	0.401
LIG_SUMO_SIM_par_1	14	19	PF11976	0.680
LIG_SUMO_SIM_par_1	280	285	PF11976	0.343
LIG_TRAF2_1	152	155	PF00917	0.779
LIG_TRAF2_1	936	939	PF00917	0.614
MOD_CDC14_SPxK_1	100	103	PF00782	0.472
MOD_CDK_SPK_2	837	842	PF00069	0.542
MOD_CDK_SPxK_1	824	830	PF00069	0.477
MOD_CDK_SPxK_1	97	103	PF00069	0.523
MOD_CK1_1	160	166	PF00069	0.684
MOD_CK1_1	340	346	PF00069	0.411
MOD_CK1_1	38	44	PF00069	0.732
MOD_CK1_1	522	528	PF00069	0.653
MOD_CK1_1	749	755	PF00069	0.424
MOD_CK2_1	52	58	PF00069	0.607
MOD_CK2_1	738	744	PF00069	0.487
MOD_CK2_1	837	843	PF00069	0.667
MOD_CK2_1	873	879	PF00069	0.558
MOD_CK2_1	933	939	PF00069	0.598
MOD_CMANNOS	129	132	PF00535	0.617
MOD_Cter_Amidation	686	689	PF01082	0.585
MOD_GlcNHglycan	137	140	PF01048	0.619
MOD_GlcNHglycan	228	231	PF01048	0.375
MOD_GlcNHglycan	262	265	PF01048	0.343
MOD_GlcNHglycan	29	32	PF01048	0.682
MOD_GlcNHglycan	342	345	PF01048	0.399
MOD_GlcNHglycan	37	40	PF01048	0.703
MOD_GlcNHglycan	4	7	PF01048	0.672
MOD_GlcNHglycan	532	535	PF01048	0.747
MOD_GlcNHglycan	537	540	PF01048	0.792
MOD_GlcNHglycan	553	556	PF01048	0.389
MOD_GlcNHglycan	589	592	PF01048	0.664
MOD_GlcNHglycan	635	638	PF01048	0.370
MOD_GlcNHglycan	707	711	PF01048	0.721
MOD_GlcNHglycan	712	715	PF01048	0.640
MOD_GlcNHglycan	736	739	PF01048	0.394
MOD_GlcNHglycan	76	79	PF01048	0.743
MOD_GlcNHglycan	811	814	PF01048	0.468
MOD_GlcNHglycan	864	867	PF01048	0.408
MOD_GlcNHglycan	875	878	PF01048	0.577
MOD_GlcNHglycan	888	891	PF01048	0.386
MOD_GlcNHglycan	9	12	PF01048	0.685
MOD_GlcNHglycan	920	923	PF01048	0.425
MOD_GlcNHglycan	935	938	PF01048	0.528
MOD_GSK3_1	107	114	PF00069	0.631
MOD_GSK3_1	157	164	PF00069	0.683
MOD_GSK3_1	16	23	PF00069	0.685
MOD_GSK3_1	2	9	PF00069	0.599
MOD_GSK3_1	207	214	PF00069	0.350
MOD_GSK3_1	240	247	PF00069	0.334
MOD_GSK3_1	265	272	PF00069	0.390
MOD_GSK3_1	329	336	PF00069	0.346
MOD_GSK3_1	397	404	PF00069	0.740
MOD_GSK3_1	454	461	PF00069	0.676
MOD_GSK3_1	48	55	PF00069	0.630
MOD_GSK3_1	518	525	PF00069	0.656
MOD_GSK3_1	526	533	PF00069	0.665
MOD_GSK3_1	706	713	PF00069	0.673
MOD_GSK3_1	734	741	PF00069	0.399
MOD_GSK3_1	831	838	PF00069	0.733
MOD_NEK2_1	111	116	PF00069	0.498
MOD_NEK2_1	173	178	PF00069	0.558
MOD_NEK2_1	205	210	PF00069	0.343
MOD_NEK2_1	74	79	PF00069	0.751
MOD_NEK2_1	861	866	PF00069	0.404
MOD_NEK2_1	927	932	PF00069	0.477
MOD_NEK2_2	107	112	PF00069	0.582
MOD_PIKK_1	211	217	PF00454	0.270
MOD_PKA_1	932	938	PF00069	0.592
MOD_PKA_2	304	310	PF00069	0.463
MOD_PKA_2	384	390	PF00069	0.457
MOD_PKA_2	6	12	PF00069	0.757
MOD_PKA_2	74	80	PF00069	0.816
MOD_PKA_2	894	900	PF00069	0.406
MOD_PKA_2	932	938	PF00069	0.592
MOD_Plk_1	493	499	PF00069	0.450
MOD_Plk_1	743	749	PF00069	0.461
MOD_Plk_1	927	933	PF00069	0.624
MOD_Plk_4	173	179	PF00069	0.565
MOD_Plk_4	181	187	PF00069	0.617
MOD_Plk_4	493	499	PF00069	0.365
MOD_Plk_4	575	581	PF00069	0.570
MOD_Plk_4	743	749	PF00069	0.537
MOD_Plk_4	818	824	PF00069	0.417
MOD_Plk_4	894	900	PF00069	0.415
MOD_Plk_4	901	907	PF00069	0.520
MOD_ProDKin_1	157	163	PF00069	0.675
MOD_ProDKin_1	193	199	PF00069	0.410
MOD_ProDKin_1	20	26	PF00069	0.687
MOD_ProDKin_1	224	230	PF00069	0.503
MOD_ProDKin_1	335	341	PF00069	0.473
MOD_ProDKin_1	38	44	PF00069	0.762
MOD_ProDKin_1	451	457	PF00069	0.629
MOD_ProDKin_1	472	478	PF00069	0.685
MOD_ProDKin_1	48	54	PF00069	0.691
MOD_ProDKin_1	519	525	PF00069	0.658
MOD_ProDKin_1	526	532	PF00069	0.664
MOD_ProDKin_1	660	666	PF00069	0.453
MOD_ProDKin_1	80	86	PF00069	0.666
MOD_ProDKin_1	824	830	PF00069	0.538
MOD_ProDKin_1	837	843	PF00069	0.582
MOD_ProDKin_1	899	905	PF00069	0.494
MOD_ProDKin_1	97	103	PF00069	0.531
TRG_DiLeu_BaEn_1	278	283	PF01217	0.480
TRG_DiLeu_BaLyEn_6	752	757	PF01217	0.392
TRG_ENDOCYTIC_2	807	810	PF00928	0.587
TRG_ENDOCYTIC_2	916	919	PF00928	0.442
TRG_ER_diArg_1	233	236	PF00400	0.259
TRG_ER_diArg_1	279	281	PF00400	0.327
TRG_ER_diArg_1	625	627	PF00400	0.531
TRG_ER_diArg_1	678	680	PF00400	0.678
TRG_ER_diArg_1	867	869	PF00400	0.440
TRG_ER_diArg_1	931	933	PF00400	0.517
TRG_NES_CRM1_1	428	441	PF08389	0.424
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	790	794	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L9	Leptomonas seymouri	46%	100%
A0A3S5H505	Leishmania donovani	90%	100%
A4H3E1	Leishmania braziliensis	69%	100%
A4HRP5	Leishmania infantum	90%	100%
E9AJL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%