Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACC3_LEIMA

TriTrypDb:

LmjF.02.0490 , LMJLV39_020010000 , LMJSD75_020010100

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.620
CLV_C14_Caspase3-7	534	538	PF00656	0.661
CLV_NRD_NRD_1	213	215	PF00675	0.668
CLV_NRD_NRD_1	226	228	PF00675	0.744
CLV_NRD_NRD_1	254	256	PF00675	0.661
CLV_NRD_NRD_1	286	288	PF00675	0.694
CLV_NRD_NRD_1	295	297	PF00675	0.628
CLV_NRD_NRD_1	414	416	PF00675	0.629
CLV_NRD_NRD_1	555	557	PF00675	0.620
CLV_NRD_NRD_1	559	561	PF00675	0.603
CLV_NRD_NRD_1	579	581	PF00675	0.502
CLV_NRD_NRD_1	678	680	PF00675	0.608
CLV_PCSK_FUR_1	224	228	PF00082	0.654
CLV_PCSK_FUR_1	411	415	PF00082	0.627
CLV_PCSK_FUR_1	556	560	PF00082	0.603
CLV_PCSK_KEX2_1	15	17	PF00082	0.666
CLV_PCSK_KEX2_1	188	190	PF00082	0.674
CLV_PCSK_KEX2_1	213	215	PF00082	0.699
CLV_PCSK_KEX2_1	226	228	PF00082	0.759
CLV_PCSK_KEX2_1	254	256	PF00082	0.661
CLV_PCSK_KEX2_1	286	288	PF00082	0.694
CLV_PCSK_KEX2_1	295	297	PF00082	0.628
CLV_PCSK_KEX2_1	413	415	PF00082	0.626
CLV_PCSK_KEX2_1	557	559	PF00082	0.637
CLV_PCSK_KEX2_1	579	581	PF00082	0.642
CLV_PCSK_KEX2_1	676	678	PF00082	0.622
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.666
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.674
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.637
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.590
CLV_PCSK_SKI1_1	570	574	PF00082	0.656
CLV_PCSK_SKI1_1	656	660	PF00082	0.494
CLV_PCSK_SKI1_1	695	699	PF00082	0.612
CLV_PCSK_SKI1_1	73	77	PF00082	0.487
DEG_APCC_DBOX_1	478	486	PF00400	0.496
DEG_COP1_1	541	549	PF00400	0.512
DEG_SPOP_SBC_1	309	313	PF00917	0.659
DOC_CDC14_PxL_1	491	499	PF14671	0.520
DOC_CYCLIN_RxL_1	567	576	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	587	593	PF00134	0.671
DOC_CYCLIN_yCln2_LP_2	681	687	PF00134	0.602
DOC_MAPK_MEF2A_6	679	688	PF00069	0.461
DOC_MAPK_RevD_3	662	678	PF00069	0.626
DOC_PP2B_LxvP_1	392	395	PF13499	0.580
DOC_PP2B_LxvP_1	704	707	PF13499	0.599
DOC_PP4_FxxP_1	150	153	PF00568	0.668
DOC_PP4_FxxP_1	166	169	PF00568	0.668
DOC_PP4_FxxP_1	391	394	PF00568	0.603
DOC_USP7_MATH_1	130	134	PF00917	0.734
DOC_USP7_MATH_1	142	146	PF00917	0.707
DOC_USP7_MATH_1	201	205	PF00917	0.565
DOC_USP7_MATH_1	264	268	PF00917	0.753
DOC_USP7_MATH_1	309	313	PF00917	0.564
DOC_USP7_MATH_1	320	324	PF00917	0.538
DOC_USP7_MATH_1	337	341	PF00917	0.546
DOC_USP7_MATH_1	366	370	PF00917	0.646
DOC_USP7_MATH_1	445	449	PF00917	0.675
DOC_USP7_MATH_1	487	491	PF00917	0.584
DOC_USP7_MATH_1	506	510	PF00917	0.510
DOC_USP7_MATH_1	591	595	PF00917	0.641
DOC_USP7_MATH_1	607	611	PF00917	0.572
DOC_WW_Pin1_4	105	110	PF00397	0.615
DOC_WW_Pin1_4	316	321	PF00397	0.762
DOC_WW_Pin1_4	466	471	PF00397	0.671
DOC_WW_Pin1_4	474	479	PF00397	0.575
DOC_WW_Pin1_4	573	578	PF00397	0.659
DOC_WW_Pin1_4	618	623	PF00397	0.665
DOC_WW_Pin1_4	663	668	PF00397	0.647
DOC_WW_Pin1_4	94	99	PF00397	0.702
LIG_14-3-3_CanoR_1	254	262	PF00244	0.559
LIG_14-3-3_CanoR_1	397	406	PF00244	0.595
LIG_14-3-3_CanoR_1	459	463	PF00244	0.536
LIG_14-3-3_CanoR_1	570	578	PF00244	0.642
LIG_14-3-3_CanoR_1	579	588	PF00244	0.616
LIG_14-3-3_CanoR_1	636	645	PF00244	0.684
LIG_APCC_ABBA_1	483	488	PF00400	0.632
LIG_BIR_III_2	631	635	PF00653	0.561
LIG_BRCT_BRCA1_1	241	245	PF00533	0.609
LIG_BRCT_BRCA1_1	354	358	PF00533	0.552
LIG_BRCT_BRCA1_1	498	502	PF00533	0.508
LIG_deltaCOP1_diTrp_1	350	358	PF00928	0.549
LIG_EH1_1	338	346	PF00400	0.574
LIG_FHA_1	127	133	PF00498	0.644
LIG_FHA_1	218	224	PF00498	0.692
LIG_FHA_1	398	404	PF00498	0.590
LIG_FHA_1	478	484	PF00498	0.638
LIG_FHA_1	521	527	PF00498	0.693
LIG_FHA_1	622	628	PF00498	0.574
LIG_FHA_1	670	676	PF00498	0.622
LIG_FHA_1	84	90	PF00498	0.557
LIG_FHA_2	366	372	PF00498	0.503
LIG_FHA_2	609	615	PF00498	0.581
LIG_LIR_Apic_2	149	153	PF02991	0.671
LIG_LIR_Gen_1	187	197	PF02991	0.574
LIG_LIR_Gen_1	350	358	PF02991	0.549
LIG_LIR_Gen_1	386	395	PF02991	0.585
LIG_LIR_Nem_3	187	193	PF02991	0.573
LIG_LIR_Nem_3	350	356	PF02991	0.544
LIG_LIR_Nem_3	386	392	PF02991	0.583
LIG_LIR_Nem_3	480	484	PF02991	0.637
LIG_LIR_Nem_3	690	696	PF02991	0.606
LIG_LIR_Nem_3	70	74	PF02991	0.612
LIG_Pex14_1	498	502	PF04695	0.648
LIG_Pex14_2	354	358	PF04695	0.552
LIG_SH2_CRK	693	697	PF00017	0.621
LIG_SH2_NCK_1	551	555	PF00017	0.625
LIG_SH2_NCK_1	699	703	PF00017	0.630
LIG_SH2_PTP2	484	487	PF00017	0.633
LIG_SH2_SRC	484	487	PF00017	0.633
LIG_SH2_STAP1	399	403	PF00017	0.588
LIG_SH2_STAP1	551	555	PF00017	0.590
LIG_SH2_STAT5	353	356	PF00017	0.547
LIG_SH2_STAT5	389	392	PF00017	0.570
LIG_SH2_STAT5	399	402	PF00017	0.497
LIG_SH2_STAT5	484	487	PF00017	0.633
LIG_SH2_STAT5	549	552	PF00017	0.504
LIG_SH2_STAT5	71	74	PF00017	0.615
LIG_SH3_2	272	277	PF14604	0.667
LIG_SH3_3	145	151	PF00018	0.677
LIG_SH3_3	268	274	PF00018	0.670
LIG_SH3_3	277	283	PF00018	0.622
LIG_SH3_3	360	366	PF00018	0.596
LIG_SH3_3	464	470	PF00018	0.671
LIG_SH3_CIN85_PxpxPR_1	474	479	PF14604	0.505
LIG_SUMO_SIM_anti_2	457	465	PF11976	0.533
LIG_TRAF2_1	514	517	PF00917	0.670
LIG_TYR_ITIM	691	696	PF00017	0.612
LIG_ULM_U2AF65_1	676	681	PF00076	0.483
LIG_WW_3	576	580	PF00397	0.665
MOD_CDK_SPK_2	474	479	PF00069	0.505
MOD_CDK_SPxK_1	573	579	PF00069	0.628
MOD_CDK_SPxxK_3	573	580	PF00069	0.663
MOD_CDK_SPxxK_3	663	670	PF00069	0.646
MOD_CDK_SPxxK_3	94	101	PF00069	0.704
MOD_CK1_1	108	114	PF00069	0.610
MOD_CK1_1	146	152	PF00069	0.803
MOD_CK1_1	311	317	PF00069	0.650
MOD_CK1_1	369	375	PF00069	0.637
MOD_CK1_1	379	385	PF00069	0.531
MOD_CK1_1	477	483	PF00069	0.635
MOD_CK1_1	490	496	PF00069	0.503
MOD_CK1_1	620	626	PF00069	0.659
MOD_CK2_1	365	371	PF00069	0.509
MOD_CK2_1	697	703	PF00069	0.589
MOD_GlcNHglycan	110	113	PF01048	0.691
MOD_GlcNHglycan	114	117	PF01048	0.706
MOD_GlcNHglycan	126	129	PF01048	0.583
MOD_GlcNHglycan	145	148	PF01048	0.639
MOD_GlcNHglycan	2	5	PF01048	0.645
MOD_GlcNHglycan	330	333	PF01048	0.634
MOD_GlcNHglycan	335	338	PF01048	0.580
MOD_GlcNHglycan	368	371	PF01048	0.647
MOD_GlcNHglycan	434	437	PF01048	0.574
MOD_GlcNHglycan	464	467	PF01048	0.606
MOD_GlcNHglycan	508	511	PF01048	0.686
MOD_GlcNHglycan	583	586	PF01048	0.685
MOD_GlcNHglycan	595	598	PF01048	0.572
MOD_GlcNHglycan	639	642	PF01048	0.693
MOD_GlcNHglycan	77	80	PF01048	0.503
MOD_GSK3_1	108	115	PF00069	0.647
MOD_GSK3_1	120	127	PF00069	0.715
MOD_GSK3_1	142	149	PF00069	0.732
MOD_GSK3_1	180	187	PF00069	0.574
MOD_GSK3_1	235	242	PF00069	0.754
MOD_GSK3_1	253	260	PF00069	0.773
MOD_GSK3_1	296	303	PF00069	0.559
MOD_GSK3_1	316	323	PF00069	0.516
MOD_GSK3_1	333	340	PF00069	0.557
MOD_GSK3_1	365	372	PF00069	0.618
MOD_GSK3_1	379	386	PF00069	0.518
MOD_GSK3_1	454	461	PF00069	0.629
MOD_GSK3_1	462	469	PF00069	0.645
MOD_GSK3_1	608	615	PF00069	0.677
MOD_GSK3_1	616	623	PF00069	0.600
MOD_N-GLC_1	184	189	PF02516	0.642
MOD_N-GLC_1	379	384	PF02516	0.585
MOD_NEK2_1	181	186	PF00069	0.679
MOD_NEK2_1	310	315	PF00069	0.656
MOD_NEK2_1	335	340	PF00069	0.614
MOD_NEK2_1	383	388	PF00069	0.603
MOD_NEK2_1	431	436	PF00069	0.538
MOD_NEK2_1	462	467	PF00069	0.638
MOD_NEK2_1	572	577	PF00069	0.622
MOD_NEK2_1	61	66	PF00069	0.642
MOD_NEK2_1	617	622	PF00069	0.537
MOD_PKA_2	120	126	PF00069	0.584
MOD_PKA_2	22	28	PF00069	0.647
MOD_PKA_2	253	259	PF00069	0.699
MOD_PKA_2	366	372	PF00069	0.643
MOD_PKA_2	451	457	PF00069	0.648
MOD_PKA_2	458	464	PF00069	0.608
MOD_PKA_2	669	675	PF00069	0.622
MOD_Plk_1	379	385	PF00069	0.611
MOD_Plk_1	487	493	PF00069	0.583
MOD_Plk_1	51	57	PF00069	0.613
MOD_Plk_1	591	597	PF00069	0.634
MOD_Plk_4	458	464	PF00069	0.573
MOD_Plk_4	545	551	PF00069	0.603
MOD_ProDKin_1	105	111	PF00069	0.615
MOD_ProDKin_1	316	322	PF00069	0.762
MOD_ProDKin_1	466	472	PF00069	0.671
MOD_ProDKin_1	474	480	PF00069	0.577
MOD_ProDKin_1	573	579	PF00069	0.663
MOD_ProDKin_1	618	624	PF00069	0.665
MOD_ProDKin_1	663	669	PF00069	0.646
MOD_ProDKin_1	94	100	PF00069	0.703
MOD_SUMO_rev_2	242	250	PF00179	0.611
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.594
TRG_ENDOCYTIC_2	353	356	PF00928	0.547
TRG_ENDOCYTIC_2	389	392	PF00928	0.574
TRG_ENDOCYTIC_2	693	696	PF00928	0.627
TRG_ER_diArg_1	212	214	PF00400	0.620
TRG_ER_diArg_1	223	226	PF00400	0.628
TRG_ER_diArg_1	285	287	PF00400	0.681
TRG_ER_diArg_1	413	415	PF00400	0.626
TRG_ER_diArg_1	556	559	PF00400	0.635
TRG_ER_diArg_1	578	580	PF00400	0.639
TRG_ER_diArg_1	602	605	PF00400	0.665
TRG_ER_diArg_1	677	679	PF00400	0.519
TRG_NLS_MonoCore_2	555	560	PF00514	0.631
TRG_NLS_MonoCore_2	675	680	PF00514	0.481
TRG_NLS_MonoExtC_3	555	560	PF00514	0.599
TRG_NLS_MonoExtN_4	556	561	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H504	Leishmania donovani	89%	100%
A4HRP4	Leishmania infantum	88%	100%
E9AJL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%