Ribosome biogenesis protein SLX9

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACC2_LEIMA

TriTrypDb:

LmjF.02.0480 , LMJLV39_020009900 , LMJSD75_020010000

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.680
CLV_NRD_NRD_1	162	164	PF00675	0.518
CLV_NRD_NRD_1	170	172	PF00675	0.537
CLV_NRD_NRD_1	240	242	PF00675	0.621
CLV_NRD_NRD_1	58	60	PF00675	0.587
CLV_PCSK_KEX2_1	141	143	PF00082	0.603
CLV_PCSK_KEX2_1	162	164	PF00082	0.518
CLV_PCSK_KEX2_1	169	171	PF00082	0.531
CLV_PCSK_KEX2_1	239	241	PF00082	0.653
CLV_PCSK_KEX2_1	24	26	PF00082	0.528
CLV_PCSK_KEX2_1	49	51	PF00082	0.597
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.603
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.528
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.559
CLV_PCSK_SKI1_1	107	111	PF00082	0.509
CLV_PCSK_SKI1_1	162	166	PF00082	0.551
CLV_PCSK_SKI1_1	170	174	PF00082	0.495
CLV_PCSK_SKI1_1	49	53	PF00082	0.546
DEG_APCC_DBOX_1	170	178	PF00400	0.602
DEG_SPOP_SBC_1	71	75	PF00917	0.629
DOC_CKS1_1	224	229	PF01111	0.542
DOC_MAPK_gen_1	116	125	PF00069	0.626
DOC_MAPK_MEF2A_6	116	125	PF00069	0.532
DOC_MAPK_RevD_3	227	240	PF00069	0.566
DOC_PP2B_LxvP_1	172	175	PF13499	0.534
DOC_USP7_MATH_1	175	179	PF00917	0.535
DOC_USP7_MATH_1	71	75	PF00917	0.615
DOC_USP7_UBL2_3	52	56	PF12436	0.573
DOC_WW_Pin1_4	17	22	PF00397	0.516
DOC_WW_Pin1_4	223	228	PF00397	0.532
DOC_WW_Pin1_4	24	29	PF00397	0.510
DOC_WW_Pin1_4	77	82	PF00397	0.668
LIG_14-3-3_CanoR_1	132	137	PF00244	0.631
LIG_14-3-3_CanoR_1	162	167	PF00244	0.608
LIG_14-3-3_CanoR_1	169	175	PF00244	0.623
LIG_14-3-3_CanoR_1	176	184	PF00244	0.451
LIG_14-3-3_CanoR_1	6	15	PF00244	0.530
LIG_AP2alpha_2	206	208	PF02296	0.454
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_FHA_1	156	162	PF00498	0.624
LIG_FHA_1	216	222	PF00498	0.505
LIG_FHA_1	224	230	PF00498	0.543
LIG_FHA_1	89	95	PF00498	0.537
LIG_FHA_2	94	100	PF00498	0.564
LIG_LIR_Gen_1	206	215	PF02991	0.446
LIG_LIR_Nem_3	206	211	PF02991	0.437
LIG_RPA_C_Fungi	158	170	PF08784	0.535
LIG_SH3_3	218	224	PF00018	0.513
LIG_SH3_4	152	159	PF00018	0.570
MOD_CDC14_SPxK_1	3	6	PF00782	0.560
MOD_CDK_SPxxK_3	17	24	PF00069	0.518
MOD_CK1_1	155	161	PF00069	0.640
MOD_CK1_1	2	8	PF00069	0.522
MOD_CK1_1	75	81	PF00069	0.642
MOD_CK1_1	9	15	PF00069	0.511
MOD_CK2_1	175	181	PF00069	0.474
MOD_Cter_Amidation	167	170	PF01082	0.449
MOD_GlcNHglycan	134	137	PF01048	0.635
MOD_GlcNHglycan	177	180	PF01048	0.515
MOD_GlcNHglycan	215	218	PF01048	0.492
MOD_GlcNHglycan	74	77	PF01048	0.650
MOD_GlcNHglycan	8	11	PF01048	0.572
MOD_GlcNHglycan	84	87	PF01048	0.690
MOD_GSK3_1	151	158	PF00069	0.674
MOD_GSK3_1	175	182	PF00069	0.495
MOD_GSK3_1	2	9	PF00069	0.501
MOD_GSK3_1	60	67	PF00069	0.643
MOD_GSK3_1	71	78	PF00069	0.620
MOD_NEK2_1	72	77	PF00069	0.565
MOD_PIKK_1	152	158	PF00454	0.690
MOD_PIKK_1	29	35	PF00454	0.635
MOD_PIKK_1	60	66	PF00454	0.649
MOD_PKA_1	162	168	PF00069	0.583
MOD_PKA_1	170	176	PF00069	0.527
MOD_PKA_2	131	137	PF00069	0.747
MOD_PKA_2	162	168	PF00069	0.682
MOD_PKA_2	170	176	PF00069	0.580
MOD_PKA_2	5	11	PF00069	0.507
MOD_Plk_4	162	168	PF00069	0.664
MOD_ProDKin_1	17	23	PF00069	0.517
MOD_ProDKin_1	223	229	PF00069	0.537
MOD_ProDKin_1	24	30	PF00069	0.510
MOD_ProDKin_1	77	83	PF00069	0.662
TRG_ER_diArg_1	110	113	PF00400	0.570
TRG_ER_diArg_1	161	163	PF00400	0.522
TRG_ER_diArg_1	169	171	PF00400	0.531
TRG_ER_diArg_1	239	241	PF00400	0.628
TRG_NLS_MonoExtN_4	46	53	PF00514	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P478	Leptomonas seymouri	51%	100%
A0A451EJI4	Leishmania donovani	91%	100%
A4H3D9	Leishmania braziliensis	69%	100%
A4HRP3	Leishmania infantum	91%	100%
E9AJL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%