Voltage-dependent anion-selective channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial outer membrane protein porin, putative

Species:

Leishmania major

UniProt:

E9ACC0_LEIMA

TriTrypDb:

LmjF.02.0460 , LMJLV39_020009700 , LMJSD75_020009800

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005741	mitochondrial outer membrane	5	17
GO:0016020	membrane	2	17
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0019867	outer membrane	3	17
GO:0020022	acidocalcisome	5	2
GO:0031090	organelle membrane	3	17
GO:0031966	mitochondrial membrane	4	17
GO:0031968	organelle outer membrane	4	17
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0046930	pore complex	3	2
GO:0098588	bounding membrane of organelle	4	17
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

E9ACC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACC0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	2
GO:0006839	mitochondrial transport	4	3
GO:0009987	cellular process	1	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	17
GO:0005216	monoatomic ion channel activity	4	17
GO:0005244	voltage-gated monoatomic ion channel activity	4	17
GO:0005253	monoatomic anion channel activity	5	17
GO:0008308	voltage-gated monoatomic anion channel activity	5	17
GO:0008509	monoatomic anion transmembrane transporter activity	4	17
GO:0015075	monoatomic ion transmembrane transporter activity	3	17
GO:0015103	inorganic anion transmembrane transporter activity	4	17
GO:0015267	channel activity	4	17
GO:0015288	porin activity	6	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	17
GO:0022803	passive transmembrane transporter activity	3	17
GO:0022829	wide pore channel activity	5	2
GO:0022832	voltage-gated channel activity	6	17
GO:0022836	gated channel activity	5	17
GO:0022857	transmembrane transporter activity	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	131	133	PF00082	0.547
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.547
CLV_PCSK_SKI1_1	29	33	PF00082	0.361
CLV_PCSK_SKI1_1	41	45	PF00082	0.330
CLV_PCSK_SKI1_1	91	95	PF00082	0.543
CLV_Separin_Metazoa	88	92	PF03568	0.424
DOC_CKS1_1	15	20	PF01111	0.537
DOC_MAPK_gen_1	225	234	PF00069	0.545
DOC_PP4_FxxP_1	56	59	PF00568	0.428
DOC_USP7_MATH_1	59	63	PF00917	0.486
DOC_USP7_MATH_1	7	11	PF00917	0.655
DOC_USP7_UBL2_3	22	26	PF12436	0.400
DOC_WW_Pin1_4	137	142	PF00397	0.537
DOC_WW_Pin1_4	14	19	PF00397	0.526
DOC_WW_Pin1_4	83	88	PF00397	0.485
LIG_14-3-3_CanoR_1	192	197	PF00244	0.444
LIG_14-3-3_CanoR_1	212	216	PF00244	0.221
LIG_Actin_WH2_2	67	84	PF00022	0.492
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BRCT_BRCA1_1	204	208	PF00533	0.541
LIG_eIF4E_1	15	21	PF01652	0.528
LIG_FHA_1	123	129	PF00498	0.410
LIG_FHA_1	15	21	PF00498	0.457
LIG_FHA_1	161	167	PF00498	0.438
LIG_FHA_1	188	194	PF00498	0.429
LIG_FHA_1	239	245	PF00498	0.457
LIG_FHA_1	26	32	PF00498	0.476
LIG_FHA_1	271	277	PF00498	0.429
LIG_FHA_1	52	58	PF00498	0.538
LIG_FHA_1	84	90	PF00498	0.499
LIG_FHA_2	140	146	PF00498	0.397
LIG_Integrin_RGD_1	227	229	PF01839	0.549
LIG_LIR_Apic_2	45	51	PF02991	0.377
LIG_LIR_Apic_2	53	59	PF02991	0.431
LIG_LIR_Gen_1	23	32	PF02991	0.356
LIG_LIR_Nem_3	19	24	PF02991	0.419
LIG_Pex14_1	260	264	PF04695	0.393
LIG_RPA_C_Fungi	207	219	PF08784	0.359
LIG_SH2_CRK	15	19	PF00017	0.549
LIG_SH2_CRK	24	28	PF00017	0.494
LIG_SH2_CRK	48	52	PF00017	0.487
LIG_SH2_NCK_1	15	19	PF00017	0.549
LIG_SH2_SRC	164	167	PF00017	0.546
LIG_SH2_STAT3	99	102	PF00017	0.407
LIG_SH2_STAT5	15	18	PF00017	0.505
LIG_SH2_STAT5	264	267	PF00017	0.394
LIG_SH2_STAT5	73	76	PF00017	0.385
LIG_SH2_STAT5	99	102	PF00017	0.548
LIG_SH3_3	240	246	PF00018	0.541
LIG_UBA3_1	89	94	PF00899	0.455
MOD_CK1_1	122	128	PF00069	0.478
MOD_CK2_1	131	137	PF00069	0.482
MOD_CK2_1	139	145	PF00069	0.499
MOD_CK2_1	274	280	PF00069	0.397
MOD_GlcNHglycan	198	201	PF01048	0.488
MOD_GlcNHglycan	5	8	PF01048	0.565
MOD_GlcNHglycan	67	70	PF01048	0.447
MOD_GlcNHglycan	9	12	PF01048	0.520
MOD_GSK3_1	127	134	PF00069	0.508
MOD_GSK3_1	192	199	PF00069	0.421
MOD_GSK3_1	270	277	PF00069	0.422
MOD_GSK3_1	3	10	PF00069	0.646
MOD_GSK3_1	93	100	PF00069	0.515
MOD_N-GLC_1	270	275	PF02516	0.375
MOD_N-GLC_2	169	171	PF02516	0.520
MOD_N-GLC_2	211	213	PF02516	0.422
MOD_NEK2_1	1	6	PF00069	0.675
MOD_NEK2_1	238	243	PF00069	0.511
MOD_NEK2_1	81	86	PF00069	0.552
MOD_NEK2_2	246	251	PF00069	0.492
MOD_NEK2_2	51	56	PF00069	0.489
MOD_PIKK_1	1	7	PF00454	0.492
MOD_PK_1	131	137	PF00069	0.519
MOD_PKA_1	131	137	PF00069	0.378
MOD_PKA_2	131	137	PF00069	0.525
MOD_PKA_2	211	217	PF00069	0.348
MOD_Plk_4	16	22	PF00069	0.401
MOD_Plk_4	202	208	PF00069	0.538
MOD_Plk_4	51	57	PF00069	0.493
MOD_ProDKin_1	137	143	PF00069	0.536
MOD_ProDKin_1	14	20	PF00069	0.513
MOD_ProDKin_1	83	89	PF00069	0.495
MOD_SUMO_rev_2	62	68	PF00179	0.450
MOD_SUMO_rev_2	88	96	PF00179	0.550
TRG_ENDOCYTIC_2	24	27	PF00928	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUD3	Leptomonas seymouri	68%	98%
A0A0N1IIR1	Leptomonas seymouri	31%	100%
A0A0S4JQ02	Bodo saltans	35%	100%
A0A1X0NJX9	Trypanosomatidae	44%	100%
A0A3R7M1M0	Trypanosoma rangeli	43%	100%
A0A3S5H502	Leishmania donovani	31%	100%
A0A3S5H503	Leishmania donovani	97%	100%
A0A422NPQ5	Trypanosoma rangeli	45%	100%
A4H3D7	Leishmania braziliensis	75%	100%
A4HRP1	Leishmania infantum	31%	100%
A4HRP2	Leishmania infantum	97%	100%
C9ZJ24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACB9	Leishmania major	29%	100%
E9AJK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AJK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%