Putative voltage-dependent anion-selective channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

voltage-dependent anion-selective channel, putative

Species:

Leishmania major

UniProt:

E9ACB9_LEIMA

TriTrypDb:

LmjF.02.0450 , LMJLV39_020009600 , LMJSD75_020009700

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	17
GO:0016020	membrane	2	17
GO:0019867	outer membrane	3	17
GO:0031090	organelle membrane	3	17
GO:0031966	mitochondrial membrane	4	17
GO:0031968	organelle outer membrane	4	17
GO:0098588	bounding membrane of organelle	4	17
GO:0110165	cellular anatomical entity	1	17
GO:0005739	mitochondrion	5	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0020022	acidocalcisome	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046930	pore complex	3	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9ACB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACB9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006839	mitochondrial transport	4	3
GO:0009987	cellular process	1	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0006811	monoatomic ion transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	17
GO:0005216	monoatomic ion channel activity	4	17
GO:0005244	voltage-gated monoatomic ion channel activity	4	17
GO:0005253	monoatomic anion channel activity	5	17
GO:0008308	voltage-gated monoatomic anion channel activity	5	17
GO:0008509	monoatomic anion transmembrane transporter activity	4	17
GO:0015075	monoatomic ion transmembrane transporter activity	3	17
GO:0015103	inorganic anion transmembrane transporter activity	4	17
GO:0015267	channel activity	4	17
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	17
GO:0022803	passive transmembrane transporter activity	3	17
GO:0022832	voltage-gated channel activity	6	17
GO:0022836	gated channel activity	5	17
GO:0022857	transmembrane transporter activity	2	17
GO:0015288	porin activity	6	1
GO:0022829	wide pore channel activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	266	270	PF00082	0.393
CLV_PCSK_SKI1_1	73	77	PF00082	0.606
DEG_SPOP_SBC_1	40	44	PF00917	0.437
DOC_CYCLIN_RxL_1	180	190	PF00134	0.377
DOC_MAPK_gen_1	266	274	PF00069	0.400
DOC_MAPK_MEF2A_6	132	140	PF00069	0.476
DOC_MAPK_MEF2A_6	255	264	PF00069	0.431
DOC_MAPK_MEF2A_6	73	82	PF00069	0.431
DOC_PP1_RVXF_1	157	164	PF00149	0.352
DOC_PP1_RVXF_1	240	247	PF00149	0.444
DOC_PP1_RVXF_1	65	71	PF00149	0.520
DOC_USP7_UBL2_3	128	132	PF12436	0.424
DOC_USP7_UBL2_3	153	157	PF12436	0.412
DOC_USP7_UBL2_3	27	31	PF12436	0.408
DOC_USP7_UBL2_3	6	10	PF12436	0.455
LIG_14-3-3_CanoR_1	255	261	PF00244	0.599
LIG_Actin_WH2_2	240	257	PF00022	0.502
LIG_EH1_1	89	97	PF00400	0.560
LIG_FHA_1	179	185	PF00498	0.433
LIG_FHA_1	186	192	PF00498	0.424
LIG_FHA_1	233	239	PF00498	0.518
LIG_FHA_1	257	263	PF00498	0.456
LIG_FHA_2	150	156	PF00498	0.400
LIG_GBD_Chelix_1	260	268	PF00786	0.377
LIG_LIR_Nem_3	2	8	PF02991	0.482
LIG_Pex14_1	246	250	PF04695	0.408
LIG_SH2_CRK	65	69	PF00017	0.517
LIG_SH2_STAT5	250	253	PF00017	0.405
LIG_SH2_STAT5	8	11	PF00017	0.456
LIG_SH3_3	193	199	PF00018	0.436
LIG_SUMO_SIM_par_1	183	188	PF11976	0.481
LIG_SUMO_SIM_par_1	258	263	PF11976	0.454
MOD_CK1_1	190	196	PF00069	0.430
MOD_CK2_1	19	25	PF00069	0.411
MOD_GlcNHglycan	60	63	PF01048	0.551
MOD_GSK3_1	14	21	PF00069	0.416
MOD_GSK3_1	157	164	PF00069	0.550
MOD_GSK3_1	214	221	PF00069	0.431
MOD_GSK3_1	256	263	PF00069	0.450
MOD_GSK3_1	40	47	PF00069	0.431
MOD_GSK3_1	69	76	PF00069	0.502
MOD_N-GLC_1	18	23	PF02516	0.437
MOD_NEK2_1	136	141	PF00069	0.523
MOD_NEK2_1	175	180	PF00069	0.383
MOD_NEK2_1	185	190	PF00069	0.326
MOD_NEK2_1	232	237	PF00069	0.526
MOD_NEK2_1	272	277	PF00069	0.579
MOD_NEK2_1	41	46	PF00069	0.615
MOD_NEK2_1	58	63	PF00069	0.550
MOD_PIKK_1	127	133	PF00454	0.553
MOD_Plk_1	104	110	PF00069	0.504
MOD_Plk_1	264	270	PF00069	0.514
MOD_Plk_4	187	193	PF00069	0.484
MOD_Plk_4	246	252	PF00069	0.514
MOD_SUMO_rev_2	21	28	PF00179	0.507
MOD_SUMO_rev_2	72	81	PF00179	0.559
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.383
TRG_ENDOCYTIC_2	65	68	PF00928	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUD3	Leptomonas seymouri	32%	94%
A0A0N1IIR1	Leptomonas seymouri	56%	100%
A0A0S4JQ02	Bodo saltans	29%	100%
A0A1X0NJX9	Trypanosomatidae	31%	100%
A0A3R7M1M0	Trypanosoma rangeli	35%	100%
A0A3S5H502	Leishmania donovani	94%	100%
A0A3S5H503	Leishmania donovani	28%	95%
A0A422NPQ5	Trypanosoma rangeli	33%	100%
A4H3D7	Leishmania braziliensis	30%	95%
A4HRP1	Leishmania infantum	94%	100%
A4HRP2	Leishmania infantum	28%	95%
C9ZJ24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ACC0	Leishmania major	29%	100%
E9AJK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AJK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	95%