Integral membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACB7_LEIMA

TriTrypDb:

LmjF.02.0420 , LMJLV39_020009000 , LMJSD75_020009100

Length:

1000

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 0
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ACB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.674
CLV_C14_Caspase3-7	65	69	PF00656	0.547
CLV_NRD_NRD_1	13	15	PF00675	0.736
CLV_NRD_NRD_1	18	20	PF00675	0.664
CLV_NRD_NRD_1	24	26	PF00675	0.591
CLV_NRD_NRD_1	386	388	PF00675	0.499
CLV_NRD_NRD_1	412	414	PF00675	0.567
CLV_NRD_NRD_1	458	460	PF00675	0.454
CLV_NRD_NRD_1	677	679	PF00675	0.457
CLV_NRD_NRD_1	8	10	PF00675	0.801
CLV_NRD_NRD_1	826	828	PF00675	0.543
CLV_PCSK_FUR_1	410	414	PF00082	0.564
CLV_PCSK_FUR_1	658	662	PF00082	0.500
CLV_PCSK_KEX2_1	13	15	PF00082	0.726
CLV_PCSK_KEX2_1	18	20	PF00082	0.654
CLV_PCSK_KEX2_1	24	26	PF00082	0.582
CLV_PCSK_KEX2_1	386	388	PF00082	0.495
CLV_PCSK_KEX2_1	412	414	PF00082	0.567
CLV_PCSK_KEX2_1	458	460	PF00082	0.454
CLV_PCSK_KEX2_1	660	662	PF00082	0.490
CLV_PCSK_KEX2_1	7	9	PF00082	0.804
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.490
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.787
CLV_PCSK_PC7_1	9	15	PF00082	0.742
CLV_PCSK_SKI1_1	329	333	PF00082	0.412
CLV_PCSK_SKI1_1	447	451	PF00082	0.451
CLV_PCSK_SKI1_1	468	472	PF00082	0.543
CLV_PCSK_SKI1_1	476	480	PF00082	0.459
CLV_PCSK_SKI1_1	678	682	PF00082	0.457
CLV_PCSK_SKI1_1	700	704	PF00082	0.506
CLV_PCSK_SKI1_1	707	711	PF00082	0.363
CLV_PCSK_SKI1_1	777	781	PF00082	0.436
DEG_APCC_DBOX_1	386	394	PF00400	0.603
DEG_APCC_DBOX_1	475	483	PF00400	0.741
DEG_SCF_FBW7_1	589	594	PF00400	0.774
DEG_SPOP_SBC_1	268	272	PF00917	0.674
DOC_ANK_TNKS_1	944	951	PF00023	0.681
DOC_CDC14_PxL_1	479	487	PF14671	0.747
DOC_CKS1_1	512	517	PF01111	0.749
DOC_CKS1_1	552	557	PF01111	0.658
DOC_CKS1_1	855	860	PF01111	0.570
DOC_CYCLIN_RxL_1	472	480	PF00134	0.738
DOC_CYCLIN_yCln2_LP_2	70	73	PF00134	0.555
DOC_MAPK_DCC_7	222	232	PF00069	0.655
DOC_MAPK_gen_1	24	32	PF00069	0.598
DOC_MAPK_gen_1	309	316	PF00069	0.708
DOC_MAPK_gen_1	869	879	PF00069	0.689
DOC_MAPK_HePTP_8	22	34	PF00069	0.606
DOC_MAPK_MEF2A_6	25	34	PF00069	0.596
DOC_MAPK_MEF2A_6	329	337	PF00069	0.612
DOC_MAPK_MEF2A_6	872	881	PF00069	0.679
DOC_PP2B_LxvP_1	576	579	PF13499	0.781
DOC_PP2B_LxvP_1	70	73	PF13499	0.555
DOC_PP2B_PxIxI_1	889	895	PF00149	0.497
DOC_PP4_FxxP_1	672	675	PF00568	0.630
DOC_PP4_MxPP_1	71	74	PF00568	0.555
DOC_USP7_MATH_1	443	447	PF00917	0.746
DOC_USP7_MATH_1	541	545	PF00917	0.731
DOC_USP7_MATH_1	568	572	PF00917	0.739
DOC_USP7_MATH_1	591	595	PF00917	0.784
DOC_USP7_MATH_1	600	604	PF00917	0.701
DOC_USP7_MATH_1	628	632	PF00917	0.790
DOC_USP7_MATH_1	831	835	PF00917	0.745
DOC_WW_Pin1_4	111	116	PF00397	0.430
DOC_WW_Pin1_4	241	246	PF00397	0.768
DOC_WW_Pin1_4	41	46	PF00397	0.672
DOC_WW_Pin1_4	439	444	PF00397	0.764
DOC_WW_Pin1_4	511	516	PF00397	0.746
DOC_WW_Pin1_4	551	556	PF00397	0.686
DOC_WW_Pin1_4	564	569	PF00397	0.630
DOC_WW_Pin1_4	587	592	PF00397	0.782
DOC_WW_Pin1_4	619	624	PF00397	0.808
DOC_WW_Pin1_4	641	646	PF00397	0.760
DOC_WW_Pin1_4	671	676	PF00397	0.634
DOC_WW_Pin1_4	854	859	PF00397	0.557
DOC_WW_Pin1_4	991	996	PF00397	0.692
LIG_14-3-3_CanoR_1	238	247	PF00244	0.666
LIG_14-3-3_CanoR_1	25	31	PF00244	0.665
LIG_14-3-3_CanoR_1	459	469	PF00244	0.706
LIG_14-3-3_CanoR_1	474	479	PF00244	0.669
LIG_14-3-3_CanoR_1	58	64	PF00244	0.400
LIG_14-3-3_CanoR_1	698	703	PF00244	0.617
LIG_14-3-3_CanoR_1	777	782	PF00244	0.639
LIG_14-3-3_CanoR_1	98	102	PF00244	0.459
LIG_APCC_ABBAyCdc20_2	682	688	PF00400	0.686
LIG_BRCT_BRCA1_1	796	800	PF00533	0.678
LIG_BRCT_BRCA1_1	833	837	PF00533	0.709
LIG_Clathr_ClatBox_1	390	394	PF01394	0.697
LIG_CtBP_PxDLS_1	334	338	PF00389	0.497
LIG_EH1_1	907	915	PF00400	0.497
LIG_eIF4E_1	362	368	PF01652	0.497
LIG_eIF4E_1	908	914	PF01652	0.497
LIG_FHA_1	147	153	PF00498	0.542
LIG_FHA_1	212	218	PF00498	0.766
LIG_FHA_1	222	228	PF00498	0.670
LIG_FHA_1	27	33	PF00498	0.592
LIG_FHA_1	41	47	PF00498	0.477
LIG_FHA_1	413	419	PF00498	0.763
LIG_FHA_1	462	468	PF00498	0.771
LIG_FHA_1	530	536	PF00498	0.676
LIG_FHA_1	541	547	PF00498	0.776
LIG_FHA_1	604	610	PF00498	0.763
LIG_FHA_1	65	71	PF00498	0.549
LIG_FHA_1	662	668	PF00498	0.642
LIG_FHA_1	731	737	PF00498	0.520
LIG_FHA_1	988	994	PF00498	0.661
LIG_FHA_2	112	118	PF00498	0.555
LIG_FHA_2	393	399	PF00498	0.708
LIG_FHA_2	555	561	PF00498	0.795
LIG_FHA_2	649	655	PF00498	0.742
LIG_FHA_2	778	784	PF00498	0.647
LIG_FHA_2	789	795	PF00498	0.549
LIG_FHA_2	83	89	PF00498	0.496
LIG_FHA_2	866	872	PF00498	0.711
LIG_GBD_Chelix_1	750	758	PF00786	0.497
LIG_LIR_Apic_2	670	675	PF02991	0.628
LIG_LIR_Apic_2	692	697	PF02991	0.527
LIG_LIR_Apic_2	817	823	PF02991	0.670
LIG_LIR_Gen_1	131	142	PF02991	0.537
LIG_LIR_Gen_1	360	371	PF02991	0.412
LIG_LIR_Gen_1	463	473	PF02991	0.764
LIG_LIR_Gen_1	705	715	PF02991	0.612
LIG_LIR_Gen_1	731	739	PF02991	0.502
LIG_LIR_Gen_1	780	790	PF02991	0.670
LIG_LIR_Gen_1	797	806	PF02991	0.478
LIG_LIR_LC3C_4	365	369	PF02991	0.287
LIG_LIR_Nem_3	131	137	PF02991	0.542
LIG_LIR_Nem_3	302	307	PF02991	0.653
LIG_LIR_Nem_3	360	366	PF02991	0.412
LIG_LIR_Nem_3	373	377	PF02991	0.303
LIG_LIR_Nem_3	463	469	PF02991	0.766
LIG_LIR_Nem_3	705	711	PF02991	0.612
LIG_LIR_Nem_3	731	737	PF02991	0.498
LIG_LIR_Nem_3	780	785	PF02991	0.661
LIG_LIR_Nem_3	797	803	PF02991	0.482
LIG_LIR_Nem_3	834	840	PF02991	0.680
LIG_LIR_Nem_3	845	849	PF02991	0.535
LIG_LYPXL_SIV_4	905	913	PF13949	0.497
LIG_NRBOX	171	177	PF00104	0.392
LIG_NRBOX	193	199	PF00104	0.715
LIG_NRBOX	709	715	PF00104	0.526
LIG_PCNA_yPIPBox_3	87	97	PF02747	0.506
LIG_Pex14_2	121	125	PF04695	0.541
LIG_Pex14_2	846	850	PF04695	0.645
LIG_PTB_Apo_2	666	673	PF02174	0.533
LIG_SH2_CRK	304	308	PF00017	0.645
LIG_SH2_SRC	906	909	PF00017	0.497
LIG_SH2_STAP1	782	786	PF00017	0.633
LIG_SH2_STAT3	488	491	PF00017	0.767
LIG_SH2_STAT5	153	156	PF00017	0.510
LIG_SH2_STAT5	177	180	PF00017	0.497
LIG_SH2_STAT5	304	307	PF00017	0.650
LIG_SH2_STAT5	362	365	PF00017	0.497
LIG_SH2_STAT5	371	374	PF00017	0.363
LIG_SH2_STAT5	380	383	PF00017	0.310
LIG_SH2_STAT5	392	395	PF00017	0.644
LIG_SH2_STAT5	466	469	PF00017	0.773
LIG_SH2_STAT5	771	774	PF00017	0.627
LIG_SH2_STAT5	849	852	PF00017	0.655
LIG_SH2_STAT5	906	909	PF00017	0.497
LIG_SH3_1	201	207	PF00018	0.760
LIG_SH3_3	201	207	PF00018	0.755
LIG_SH3_3	312	318	PF00018	0.671
LIG_SH3_3	549	555	PF00018	0.662
LIG_SH3_3	583	589	PF00018	0.826
LIG_SH3_3	852	858	PF00018	0.688
LIG_SH3_3	884	890	PF00018	0.497
LIG_SH3_3	950	956	PF00018	0.822
LIG_SUMO_SIM_anti_2	29	34	PF11976	0.592
LIG_SUMO_SIM_anti_2	336	343	PF11976	0.497
LIG_SUMO_SIM_anti_2	365	370	PF11976	0.392
LIG_SUMO_SIM_par_1	336	343	PF11976	0.444
LIG_SUMO_SIM_par_1	344	349	PF11976	0.430
LIG_SUMO_SIM_par_1	722	728	PF11976	0.530
LIG_SUMO_SIM_par_1	760	766	PF11976	0.473
LIG_SUMO_SIM_par_1	774	784	PF11976	0.518
LIG_SUMO_SIM_par_1	911	918	PF11976	0.497
LIG_TRAF2_1	395	398	PF00917	0.708
LIG_TRAF2_1	401	404	PF00917	0.673
LIG_TYR_ITSM	300	307	PF00017	0.566
LIG_TYR_ITSM	778	785	PF00017	0.555
LIG_UBA3_1	478	487	PF00899	0.615
LIG_WRC_WIRS_1	347	352	PF05994	0.497
LIG_WRC_WIRS_1	371	376	PF05994	0.427
MOD_CDK_SPxxK_3	551	558	PF00069	0.602
MOD_CDK_SPxxK_3	671	678	PF00069	0.513
MOD_CK1_1	146	152	PF00069	0.683
MOD_CK1_1	241	247	PF00069	0.715
MOD_CK1_1	269	275	PF00069	0.709
MOD_CK1_1	294	300	PF00069	0.560
MOD_CK1_1	41	47	PF00069	0.615
MOD_CK1_1	439	445	PF00069	0.741
MOD_CK1_1	57	63	PF00069	0.466
MOD_CK1_1	571	577	PF00069	0.793
MOD_CK1_1	603	609	PF00069	0.764
MOD_CK1_1	613	619	PF00069	0.631
MOD_CK1_1	727	733	PF00069	0.605
MOD_CK1_1	740	746	PF00069	0.303
MOD_CK1_1	82	88	PF00069	0.622
MOD_CK1_1	838	844	PF00069	0.511
MOD_CK1_1	865	871	PF00069	0.649
MOD_CK1_1	960	966	PF00069	0.750
MOD_CK1_1	994	1000	PF00069	0.586
MOD_CK2_1	111	117	PF00069	0.708
MOD_CK2_1	392	398	PF00069	0.639
MOD_CK2_1	428	434	PF00069	0.770
MOD_CK2_1	777	783	PF00069	0.541
MOD_CK2_1	82	88	PF00069	0.622
MOD_GlcNHglycan	233	236	PF01048	0.734
MOD_GlcNHglycan	240	243	PF01048	0.716
MOD_GlcNHglycan	40	43	PF01048	0.499
MOD_GlcNHglycan	419	422	PF01048	0.708
MOD_GlcNHglycan	430	433	PF01048	0.632
MOD_GlcNHglycan	509	512	PF01048	0.580
MOD_GlcNHglycan	522	525	PF01048	0.643
MOD_GlcNHglycan	543	546	PF01048	0.585
MOD_GlcNHglycan	593	596	PF01048	0.751
MOD_GlcNHglycan	612	615	PF01048	0.551
MOD_GlcNHglycan	630	633	PF01048	0.633
MOD_GlcNHglycan	638	641	PF01048	0.662
MOD_GlcNHglycan	739	742	PF01048	0.620
MOD_GlcNHglycan	837	840	PF01048	0.495
MOD_GlcNHglycan	969	972	PF01048	0.702
MOD_GSK3_1	175	182	PF00069	0.427
MOD_GSK3_1	266	273	PF00069	0.722
MOD_GSK3_1	291	298	PF00069	0.630
MOD_GSK3_1	346	353	PF00069	0.497
MOD_GSK3_1	413	420	PF00069	0.733
MOD_GSK3_1	424	431	PF00069	0.609
MOD_GSK3_1	439	446	PF00069	0.545
MOD_GSK3_1	507	514	PF00069	0.636
MOD_GSK3_1	529	536	PF00069	0.629
MOD_GSK3_1	564	571	PF00069	0.737
MOD_GSK3_1	587	594	PF00069	0.733
MOD_GSK3_1	626	633	PF00069	0.677
MOD_GSK3_1	667	674	PF00069	0.519
MOD_GSK3_1	777	784	PF00069	0.546
MOD_GSK3_1	790	797	PF00069	0.382
MOD_GSK3_1	831	838	PF00069	0.575
MOD_GSK3_1	88	95	PF00069	0.645
MOD_GSK3_1	96	103	PF00069	0.577
MOD_GSK3_1	967	974	PF00069	0.714
MOD_GSK3_1	987	994	PF00069	0.510
MOD_LATS_1	411	417	PF00433	0.710
MOD_N-GLC_1	89	94	PF02516	0.642
MOD_N-GLC_2	320	322	PF02516	0.358
MOD_N-GLC_2	51	53	PF02516	0.632
MOD_NEK2_1	170	175	PF00069	0.497
MOD_NEK2_1	20	25	PF00069	0.698
MOD_NEK2_1	339	344	PF00069	0.497
MOD_NEK2_1	350	355	PF00069	0.460
MOD_NEK2_1	40	45	PF00069	0.404
MOD_NEK2_1	461	466	PF00069	0.719
MOD_NEK2_1	520	525	PF00069	0.707
MOD_NEK2_1	580	585	PF00069	0.707
MOD_NEK2_1	610	615	PF00069	0.583
MOD_NEK2_1	648	653	PF00069	0.628
MOD_NEK2_1	681	686	PF00069	0.574
MOD_NEK2_1	724	729	PF00069	0.565
MOD_NEK2_1	739	744	PF00069	0.398
MOD_NEK2_1	914	919	PF00069	0.497
MOD_NEK2_2	179	184	PF00069	0.609
MOD_NEK2_2	2	7	PF00069	0.589
MOD_NEK2_2	890	895	PF00069	0.497
MOD_OFUCOSY	80	86	PF10250	0.613
MOD_PIKK_1	80	86	PF00454	0.508
MOD_PIKK_1	982	988	PF00454	0.571
MOD_PK_1	156	162	PF00069	0.497
MOD_PK_1	291	297	PF00069	0.541
MOD_PK_1	698	704	PF00069	0.507
MOD_PKA_1	412	418	PF00069	0.712
MOD_PKA_2	20	26	PF00069	0.696
MOD_PKA_2	221	227	PF00069	0.623
MOD_PKA_2	258	264	PF00069	0.658
MOD_PKA_2	412	418	PF00069	0.710
MOD_PKA_2	436	442	PF00069	0.721
MOD_PKA_2	57	63	PF00069	0.620
MOD_PKA_2	737	743	PF00069	0.569
MOD_PKA_2	97	103	PF00069	0.564
MOD_PKB_1	410	418	PF00069	0.710
MOD_PKB_1	472	480	PF00069	0.708
MOD_Plk_1	730	736	PF00069	0.624
MOD_Plk_1	793	799	PF00069	0.577
MOD_Plk_1	816	822	PF00069	0.505
MOD_Plk_1	89	95	PF00069	0.646
MOD_Plk_2-3	250	256	PF00069	0.708
MOD_Plk_2-3	258	264	PF00069	0.650
MOD_Plk_4	170	176	PF00069	0.497
MOD_Plk_4	291	297	PF00069	0.599
MOD_Plk_4	333	339	PF00069	0.423
MOD_Plk_4	340	346	PF00069	0.466
MOD_Plk_4	462	468	PF00069	0.720
MOD_Plk_4	530	536	PF00069	0.587
MOD_Plk_4	681	687	PF00069	0.586
MOD_Plk_4	781	787	PF00069	0.518
MOD_Plk_4	89	95	PF00069	0.646
MOD_Plk_4	915	921	PF00069	0.497
MOD_Plk_4	957	963	PF00069	0.729
MOD_ProDKin_1	111	117	PF00069	0.519
MOD_ProDKin_1	241	247	PF00069	0.717
MOD_ProDKin_1	41	47	PF00069	0.671
MOD_ProDKin_1	439	445	PF00069	0.707
MOD_ProDKin_1	511	517	PF00069	0.687
MOD_ProDKin_1	551	557	PF00069	0.602
MOD_ProDKin_1	564	570	PF00069	0.521
MOD_ProDKin_1	587	593	PF00069	0.727
MOD_ProDKin_1	619	625	PF00069	0.774
MOD_ProDKin_1	641	647	PF00069	0.704
MOD_ProDKin_1	671	677	PF00069	0.518
MOD_ProDKin_1	854	860	PF00069	0.425
MOD_ProDKin_1	991	997	PF00069	0.609
MOD_SUMO_rev_2	701	709	PF00179	0.478
MOD_SUMO_rev_2	821	830	PF00179	0.674
TRG_DiLeu_BaEn_1	663	668	PF01217	0.589
TRG_DiLeu_BaEn_1	705	710	PF01217	0.572
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.501
TRG_DiLeu_BaLyEn_6	774	779	PF01217	0.544
TRG_ENDOCYTIC_2	177	180	PF00928	0.497
TRG_ENDOCYTIC_2	190	193	PF00928	0.503
TRG_ENDOCYTIC_2	304	307	PF00928	0.551
TRG_ENDOCYTIC_2	371	374	PF00928	0.427
TRG_ENDOCYTIC_2	466	469	PF00928	0.722
TRG_ENDOCYTIC_2	782	785	PF00928	0.585
TRG_ENDOCYTIC_2	806	809	PF00928	0.593
TRG_ENDOCYTIC_2	849	852	PF00928	0.558
TRG_ENDOCYTIC_2	906	909	PF00928	0.497
TRG_ER_diArg_1	12	14	PF00400	0.667
TRG_ER_diArg_1	18	21	PF00400	0.578
TRG_ER_diArg_1	201	204	PF00400	0.759
TRG_ER_diArg_1	410	413	PF00400	0.713
TRG_ER_diArg_1	471	474	PF00400	0.710
TRG_ER_diArg_1	582	585	PF00400	0.645
TRG_ER_diArg_1	697	700	PF00400	0.542
TRG_NES_CRM1_1	842	856	PF08389	0.572
TRG_NLS_MonoExtN_4	483	490	PF00514	0.651
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	921	926	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H500	Leishmania donovani	90%	98%
A4H3C5	Leishmania braziliensis	65%	98%
A4HRN9	Leishmania infantum	90%	98%
E9AJK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%