LeishMANIAdb
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Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secreted protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania major
UniProt:
E9ACB5_LEIMA
TriTrypDb:
Length:
55

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9ACB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACB5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 4 8 PF00082 0.549
DEG_APCC_DBOX_1 3 11 PF00400 0.650
DEG_Nend_UBRbox_4 1 3 PF02207 0.665
DOC_CYCLIN_yCln2_LP_2 15 21 PF00134 0.549
DOC_WW_Pin1_4 14 19 PF00397 0.549
LIG_EH1_1 7 15 PF00400 0.521
LIG_eIF4E_1 8 14 PF01652 0.410
LIG_IRF3_LxIS_1 18 24 PF10401 0.552
LIG_NRBOX 10 16 PF00104 0.508
LIG_NRBOX 43 49 PF00104 0.549
LIG_Pex14_2 22 26 PF04695 0.449
LIG_SUMO_SIM_par_1 11 17 PF11976 0.549
LIG_TYR_ITIM 6 11 PF00017 0.410
LIG_WRC_WIRS_1 27 32 PF05994 0.446
MOD_CK1_1 29 35 PF00069 0.451
MOD_GlcNHglycan 36 39 PF01048 0.405
MOD_NEK2_1 21 26 PF00069 0.470
MOD_NEK2_1 34 39 PF00069 0.381
MOD_NEK2_1 49 54 PF00069 0.655
MOD_ProDKin_1 14 20 PF00069 0.549
TRG_ENDOCYTIC_2 8 11 PF00928 0.410

Homologs

Protein Taxonomy Sequence identity Coverage
E9AJK3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS