Putative proteasome regulatory non-ATPase subunit 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATPase subunit 6, putative

Species:

Leishmania major

UniProt:

E9ACB2_LEIMA

TriTrypDb:

LmjF.02.0370 , LMJLV39_020008600 , LMJSD75_020008700

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0008541	proteasome regulatory particle, lid subcomplex	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	11
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0000502	proteasome complex	3	9
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:1905368	peptidase complex	3	9
GO:1905369	endopeptidase complex	4	9

Expansion

Sequence features

E9ACB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACB2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.565
CLV_C14_Caspase3-7	288	292	PF00656	0.477
CLV_C14_Caspase3-7	43	47	PF00656	0.562
CLV_C14_Caspase3-7	501	505	PF00656	0.755
CLV_NRD_NRD_1	122	124	PF00675	0.370
CLV_NRD_NRD_1	126	128	PF00675	0.353
CLV_NRD_NRD_1	146	148	PF00675	0.297
CLV_NRD_NRD_1	163	165	PF00675	0.372
CLV_NRD_NRD_1	254	256	PF00675	0.446
CLV_NRD_NRD_1	339	341	PF00675	0.339
CLV_NRD_NRD_1	390	392	PF00675	0.408
CLV_NRD_NRD_1	525	527	PF00675	0.675
CLV_NRD_NRD_1	94	96	PF00675	0.306
CLV_PCSK_KEX2_1	126	128	PF00082	0.307
CLV_PCSK_KEX2_1	163	165	PF00082	0.473
CLV_PCSK_KEX2_1	254	256	PF00082	0.566
CLV_PCSK_KEX2_1	339	341	PF00082	0.339
CLV_PCSK_KEX2_1	495	497	PF00082	0.814
CLV_PCSK_KEX2_1	520	522	PF00082	0.709
CLV_PCSK_KEX2_1	525	527	PF00082	0.689
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.808
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.703
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.694
CLV_PCSK_PC7_1	521	527	PF00082	0.721
CLV_PCSK_SKI1_1	127	131	PF00082	0.319
CLV_PCSK_SKI1_1	168	172	PF00082	0.413
CLV_PCSK_SKI1_1	192	196	PF00082	0.422
CLV_PCSK_SKI1_1	280	284	PF00082	0.449
CLV_PCSK_SKI1_1	29	33	PF00082	0.306
CLV_PCSK_SKI1_1	352	356	PF00082	0.363
CLV_PCSK_SKI1_1	79	83	PF00082	0.309
CLV_PCSK_SKI1_1	95	99	PF00082	0.306
CLV_Separin_Metazoa	336	340	PF03568	0.601
DEG_APCC_DBOX_1	132	140	PF00400	0.624
DEG_APCC_DBOX_1	167	175	PF00400	0.402
DEG_APCC_DBOX_1	253	261	PF00400	0.412
DEG_APCC_DBOX_1	28	36	PF00400	0.506
DEG_APCC_DBOX_1	351	359	PF00400	0.519
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DOC_CYCLIN_RxL_1	25	34	PF00134	0.552
DOC_CYCLIN_RxL_1	349	359	PF00134	0.494
DOC_CYCLIN_RxL_1	89	99	PF00134	0.519
DOC_MAPK_gen_1	254	262	PF00069	0.441
DOC_MAPK_MEF2A_6	168	176	PF00069	0.380
DOC_USP7_MATH_1	151	155	PF00917	0.487
DOC_USP7_MATH_1	194	198	PF00917	0.527
DOC_USP7_MATH_1	253	257	PF00917	0.461
DOC_USP7_MATH_1	319	323	PF00917	0.552
DOC_USP7_MATH_1	324	328	PF00917	0.519
DOC_USP7_MATH_1	367	371	PF00917	0.605
DOC_USP7_MATH_1	412	416	PF00917	0.797
DOC_USP7_UBL2_3	462	466	PF12436	0.518
DOC_USP7_UBL2_3	92	96	PF12436	0.562
DOC_WW_Pin1_4	266	271	PF00397	0.483
DOC_WW_Pin1_4	356	361	PF00397	0.601
LIG_14-3-3_CanoR_1	126	130	PF00244	0.601
LIG_14-3-3_CanoR_1	147	155	PF00244	0.517
LIG_14-3-3_CanoR_1	199	206	PF00244	0.568
LIG_14-3-3_CanoR_1	25	32	PF00244	0.578
LIG_14-3-3_CanoR_1	254	258	PF00244	0.463
LIG_Actin_WH2_2	342	358	PF00022	0.562
LIG_Actin_WH2_2	380	396	PF00022	0.562
LIG_APCC_ABBA_1	404	409	PF00400	0.586
LIG_BRCT_BRCA1_1	421	425	PF00533	0.644
LIG_Clathr_ClatBox_1	372	376	PF01394	0.506
LIG_Clathr_ClatBox_1	404	408	PF01394	0.562
LIG_eIF4E_1	56	62	PF01652	0.562
LIG_FHA_1	167	173	PF00498	0.525
LIG_FHA_1	328	334	PF00498	0.601
LIG_FHA_1	35	41	PF00498	0.594
LIG_FHA_1	89	95	PF00498	0.506
LIG_FHA_2	10	16	PF00498	0.603
LIG_FHA_2	25	31	PF00498	0.591
LIG_FHA_2	286	292	PF00498	0.454
LIG_FHA_2	346	352	PF00498	0.552
LIG_FHA_2	445	451	PF00498	0.539
LIG_Integrin_RGD_1	22	24	PF01839	0.527
LIG_LIR_Apic_2	204	209	PF02991	0.447
LIG_LIR_Gen_1	231	240	PF02991	0.398
LIG_LIR_Gen_1	241	250	PF02991	0.442
LIG_LIR_Gen_1	256	265	PF02991	0.387
LIG_LIR_Gen_1	305	312	PF02991	0.519
LIG_LIR_Gen_1	344	354	PF02991	0.517
LIG_LIR_Gen_1	359	369	PF02991	0.484
LIG_LIR_Gen_1	450	460	PF02991	0.467
LIG_LIR_Nem_3	179	185	PF02991	0.374
LIG_LIR_Nem_3	231	236	PF02991	0.447
LIG_LIR_Nem_3	238	243	PF02991	0.439
LIG_LIR_Nem_3	256	262	PF02991	0.386
LIG_LIR_Nem_3	305	311	PF02991	0.519
LIG_LIR_Nem_3	344	349	PF02991	0.507
LIG_LIR_Nem_3	359	364	PF02991	0.513
LIG_LIR_Nem_3	450	455	PF02991	0.466
LIG_LIR_Nem_3	457	463	PF02991	0.470
LIG_NRBOX	154	160	PF00104	0.453
LIG_NRBOX	272	278	PF00104	0.464
LIG_NRBOX	57	63	PF00104	0.535
LIG_PCNA_yPIPBox_3	453	466	PF02747	0.622
LIG_Rb_pABgroove_1	454	462	PF01858	0.485
LIG_SH2_CRK	206	210	PF00017	0.450
LIG_SH2_CRK	233	237	PF00017	0.483
LIG_SH2_CRK	259	263	PF00017	0.387
LIG_SH2_CRK	346	350	PF00017	0.506
LIG_SH2_CRK	361	365	PF00017	0.506
LIG_SH2_CRK	452	456	PF00017	0.477
LIG_SH2_GRB2like	426	429	PF00017	0.745
LIG_SH2_NCK_1	361	365	PF00017	0.519
LIG_SH2_NCK_1	426	430	PF00017	0.743
LIG_SH2_PTP2	138	141	PF00017	0.517
LIG_SH2_SRC	138	141	PF00017	0.517
LIG_SH2_SRC	426	429	PF00017	0.745
LIG_SH2_SRC	442	445	PF00017	0.514
LIG_SH2_STAP1	233	237	PF00017	0.483
LIG_SH2_STAP1	426	430	PF00017	0.743
LIG_SH2_STAT3	300	303	PF00017	0.531
LIG_SH2_STAT5	138	141	PF00017	0.553
LIG_SH2_STAT5	175	178	PF00017	0.469
LIG_SH2_STAT5	206	209	PF00017	0.476
LIG_SH2_STAT5	235	238	PF00017	0.454
LIG_SH2_STAT5	368	371	PF00017	0.547
LIG_SH3_3	354	360	PF00018	0.601
LIG_SUMO_SIM_par_1	166	173	PF11976	0.532
LIG_SUMO_SIM_par_1	60	65	PF11976	0.536
LIG_TRAF2_1	12	15	PF00917	0.408
LIG_TRAF2_1	483	486	PF00917	0.606
LIG_TYR_ITIM	136	141	PF00017	0.521
LIG_TYR_ITIM	257	262	PF00017	0.387
LIG_UBA3_1	307	314	PF00899	0.419
MOD_CDK_SPxxK_3	356	363	PF00069	0.473
MOD_CK1_1	197	203	PF00069	0.549
MOD_CK1_1	263	269	PF00069	0.475
MOD_CK1_1	278	284	PF00069	0.516
MOD_CK1_1	3	9	PF00069	0.484
MOD_CK1_1	310	316	PF00069	0.485
MOD_CK1_1	327	333	PF00069	0.250
MOD_CK1_1	34	40	PF00069	0.383
MOD_CK2_1	208	214	PF00069	0.553
MOD_CK2_1	24	30	PF00069	0.506
MOD_CK2_1	266	272	PF00069	0.479
MOD_CK2_1	278	284	PF00069	0.427
MOD_CK2_1	345	351	PF00069	0.383
MOD_CK2_1	444	450	PF00069	0.544
MOD_CK2_1	9	15	PF00069	0.608
MOD_GlcNHglycan	155	158	PF01048	0.545
MOD_GlcNHglycan	196	199	PF01048	0.547
MOD_GlcNHglycan	2	5	PF01048	0.694
MOD_GlcNHglycan	218	221	PF01048	0.396
MOD_GlcNHglycan	320	324	PF01048	0.404
MOD_GlcNHglycan	500	503	PF01048	0.636
MOD_GlcNHglycan	514	517	PF01048	0.773
MOD_GSK3_1	194	201	PF00069	0.468
MOD_GSK3_1	260	267	PF00069	0.611
MOD_GSK3_1	272	279	PF00069	0.502
MOD_GSK3_1	31	38	PF00069	0.484
MOD_N-GLC_1	228	233	PF02516	0.459
MOD_N-GLC_1	327	332	PF02516	0.361
MOD_N-GLC_1	490	495	PF02516	0.657
MOD_NEK2_1	176	181	PF00069	0.362
MOD_NEK2_1	260	265	PF00069	0.454
MOD_NEK2_1	276	281	PF00069	0.466
MOD_NEK2_1	307	312	PF00069	0.361
MOD_NEK2_1	31	36	PF00069	0.488
MOD_NEK2_1	345	350	PF00069	0.359
MOD_NEK2_2	115	120	PF00069	0.361
MOD_NEK2_2	253	258	PF00069	0.460
MOD_PIKK_1	208	214	PF00454	0.553
MOD_PIKK_1	382	388	PF00454	0.352
MOD_PKA_2	125	131	PF00069	0.473
MOD_PKA_2	146	152	PF00069	0.468
MOD_PKA_2	198	204	PF00069	0.557
MOD_PKA_2	24	30	PF00069	0.421
MOD_PKA_2	253	259	PF00069	0.458
MOD_Plk_1	166	172	PF00069	0.558
MOD_Plk_1	228	234	PF00069	0.462
MOD_Plk_4	201	207	PF00069	0.440
MOD_Plk_4	231	237	PF00069	0.481
MOD_Plk_4	272	278	PF00069	0.579
MOD_Plk_4	307	313	PF00069	0.361
MOD_Plk_4	31	37	PF00069	0.429
MOD_Plk_4	345	351	PF00069	0.364
MOD_Plk_4	437	443	PF00069	0.535
MOD_Plk_4	451	457	PF00069	0.459
MOD_ProDKin_1	266	272	PF00069	0.486
MOD_ProDKin_1	356	362	PF00069	0.473
MOD_SUMO_for_1	483	486	PF00179	0.750
MOD_SUMO_rev_2	173	181	PF00179	0.499
MOD_SUMO_rev_2	225	232	PF00179	0.429
MOD_SUMO_rev_2	278	288	PF00179	0.528
MOD_SUMO_rev_2	376	385	PF00179	0.403
TRG_DiLeu_BaEn_1	272	277	PF01217	0.460
TRG_DiLeu_BaEn_2	124	130	PF01217	0.359
TRG_ENDOCYTIC_2	138	141	PF00928	0.552
TRG_ENDOCYTIC_2	182	185	PF00928	0.383
TRG_ENDOCYTIC_2	233	236	PF00928	0.452
TRG_ENDOCYTIC_2	237	240	PF00928	0.442
TRG_ENDOCYTIC_2	259	262	PF00928	0.435
TRG_ENDOCYTIC_2	346	349	PF00928	0.363
TRG_ENDOCYTIC_2	361	364	PF00928	0.423
TRG_ENDOCYTIC_2	452	455	PF00928	0.479
TRG_ER_diArg_1	130	133	PF00400	0.362
TRG_ER_diArg_1	162	164	PF00400	0.449
TRG_ER_diArg_1	338	340	PF00400	0.389
TRG_NES_CRM1_1	30	46	PF08389	0.405
TRG_NES_CRM1_1	365	376	PF08389	0.359
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L4	Leptomonas seymouri	79%	100%
A0A0S4JHD2	Bodo saltans	55%	100%
A0A1X0NKK6	Trypanosomatidae	59%	93%
A0A3R7KIY0	Trypanosoma rangeli	58%	100%
A0A3S5H4Z8	Leishmania donovani	97%	100%
A4H3D3	Leishmania braziliensis	91%	99%
A4HRN4	Leishmania infantum	97%	100%
A8X379	Caenorhabditis briggsae	30%	100%
C9ZJ16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AJK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F1LMZ8	Rattus norvegicus	42%	100%
F1QGH9	Danio rerio	43%	100%
F6P3G4	Danio rerio	43%	100%
F6XBL2	Xenopus tropicalis	42%	100%
O00231	Homo sapiens	42%	100%
P34481	Caenorhabditis elegans	31%	100%
Q12377	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q20938	Caenorhabditis elegans	38%	100%
Q2KI42	Bos taurus	42%	100%
Q54UB5	Dictyostelium discoideum	37%	100%
Q7KLV9	Drosophila melanogaster	40%	100%
Q8BG32	Mus musculus	42%	100%
Q9LP45	Arabidopsis thaliana	46%	100%
Q9P7S2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%