Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UAA transporter family, putative

Species:

Leishmania major

UniProt:

E9ACA9_LEIMA

TriTrypDb:

LmjF.02.0340 , LMJLV39_020008300 , LMJSD75_020008400

Length:

973

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9ACA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACA9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0009987	cellular process	1	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055085	transmembrane transport	2	4

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0022857	transmembrane transporter activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.760
CLV_C14_Caspase3-7	308	312	PF00656	0.794
CLV_NRD_NRD_1	105	107	PF00675	0.524
CLV_NRD_NRD_1	358	360	PF00675	0.599
CLV_NRD_NRD_1	398	400	PF00675	0.620
CLV_NRD_NRD_1	405	407	PF00675	0.556
CLV_NRD_NRD_1	418	420	PF00675	0.475
CLV_NRD_NRD_1	511	513	PF00675	0.457
CLV_NRD_NRD_1	683	685	PF00675	0.636
CLV_NRD_NRD_1	839	841	PF00675	0.761
CLV_NRD_NRD_1	856	858	PF00675	0.597
CLV_NRD_NRD_1	928	930	PF00675	0.530
CLV_NRD_NRD_1	943	945	PF00675	0.458
CLV_NRD_NRD_1	969	971	PF00675	0.529
CLV_PCSK_FUR_1	509	513	PF00082	0.378
CLV_PCSK_FUR_1	967	971	PF00082	0.521
CLV_PCSK_KEX2_1	105	107	PF00082	0.524
CLV_PCSK_KEX2_1	358	360	PF00082	0.599
CLV_PCSK_KEX2_1	398	400	PF00082	0.620
CLV_PCSK_KEX2_1	405	407	PF00082	0.559
CLV_PCSK_KEX2_1	417	419	PF00082	0.483
CLV_PCSK_KEX2_1	511	513	PF00082	0.457
CLV_PCSK_KEX2_1	683	685	PF00082	0.636
CLV_PCSK_KEX2_1	839	841	PF00082	0.761
CLV_PCSK_KEX2_1	856	858	PF00082	0.597
CLV_PCSK_KEX2_1	943	945	PF00082	0.636
CLV_PCSK_KEX2_1	967	969	PF00082	0.515
CLV_PCSK_SKI1_1	457	461	PF00082	0.551
CLV_PCSK_SKI1_1	5	9	PF00082	0.459
CLV_PCSK_SKI1_1	511	515	PF00082	0.444
CLV_PCSK_SKI1_1	792	796	PF00082	0.698
CLV_PCSK_SKI1_1	929	933	PF00082	0.530
CLV_Separin_Metazoa	497	501	PF03568	0.694
DEG_APCC_DBOX_1	856	864	PF00400	0.526
DEG_APCC_DBOX_1	928	936	PF00400	0.530
DEG_Nend_UBRbox_2	1	3	PF02207	0.760
DEG_SCF_SKP2-CKS1_1	127	134	PF00560	0.693
DEG_SPOP_SBC_1	29	33	PF00917	0.823
DEG_SPOP_SBC_1	880	884	PF00917	0.446
DOC_AGCK_PIF_1	795	800	PF00069	0.392
DOC_ANK_TNKS_1	179	186	PF00023	0.801
DOC_CYCLIN_RxL_1	2	10	PF00134	0.654
DOC_CYCLIN_RxL_1	382	390	PF00134	0.685
DOC_CYCLIN_RxL_1	505	518	PF00134	0.613
DOC_CYCLIN_RxL_1	789	799	PF00134	0.618
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	620	626	PF00134	0.461
DOC_MAPK_gen_1	274	284	PF00069	0.530
DOC_MAPK_gen_1	929	936	PF00069	0.530
DOC_MAPK_MEF2A_6	5	13	PF00069	0.659
DOC_MAPK_MEF2A_6	929	938	PF00069	0.530
DOC_PP1_RVXF_1	383	390	PF00149	0.686
DOC_PP1_RVXF_1	503	509	PF00149	0.633
DOC_PP1_RVXF_1	790	797	PF00149	0.460
DOC_PP2B_LxvP_1	616	619	PF13499	0.594
DOC_PP4_FxxP_1	389	392	PF00568	0.682
DOC_PP4_FxxP_1	624	627	PF00568	0.459
DOC_PP4_FxxP_1	68	71	PF00568	0.520
DOC_PP4_FxxP_1	800	803	PF00568	0.403
DOC_USP7_MATH_1	215	219	PF00917	0.768
DOC_USP7_MATH_1	29	33	PF00917	0.711
DOC_USP7_MATH_1	297	301	PF00917	0.715
DOC_USP7_MATH_1	404	408	PF00917	0.705
DOC_USP7_MATH_1	449	453	PF00917	0.746
DOC_USP7_MATH_1	459	463	PF00917	0.674
DOC_USP7_MATH_1	544	548	PF00917	0.543
DOC_USP7_MATH_1	612	616	PF00917	0.521
DOC_USP7_MATH_1	631	635	PF00917	0.416
DOC_USP7_MATH_1	637	641	PF00917	0.414
DOC_USP7_MATH_1	679	683	PF00917	0.810
DOC_USP7_MATH_1	750	754	PF00917	0.720
DOC_USP7_MATH_1	830	834	PF00917	0.435
DOC_USP7_MATH_1	897	901	PF00917	0.402
DOC_WW_Pin1_4	128	133	PF00397	0.859
DOC_WW_Pin1_4	208	213	PF00397	0.796
DOC_WW_Pin1_4	364	369	PF00397	0.828
DOC_WW_Pin1_4	377	382	PF00397	0.660
DOC_WW_Pin1_4	619	624	PF00397	0.603
DOC_WW_Pin1_4	627	632	PF00397	0.534
DOC_WW_Pin1_4	761	766	PF00397	0.696
LIG_14-3-3_CanoR_1	105	114	PF00244	0.795
LIG_14-3-3_CanoR_1	316	323	PF00244	0.742
LIG_14-3-3_CanoR_1	398	402	PF00244	0.766
LIG_14-3-3_CanoR_1	417	422	PF00244	0.729
LIG_14-3-3_CanoR_1	437	444	PF00244	0.704
LIG_14-3-3_CanoR_1	574	583	PF00244	0.510
LIG_14-3-3_CanoR_1	641	648	PF00244	0.408
LIG_14-3-3_CanoR_1	720	725	PF00244	0.708
LIG_14-3-3_CanoR_1	734	740	PF00244	0.756
LIG_14-3-3_CanoR_1	943	948	PF00244	0.397
LIG_Actin_WH2_2	897	914	PF00022	0.413
LIG_BIR_III_2	194	198	PF00653	0.700
LIG_BRCT_BRCA1_1	620	624	PF00533	0.605
LIG_CSL_BTD_1	421	424	PF09270	0.758
LIG_DLG_GKlike_1	943	951	PF00625	0.269
LIG_EVH1_2	368	372	PF00568	0.657
LIG_FHA_1	188	194	PF00498	0.760
LIG_FHA_1	372	378	PF00498	0.791
LIG_FHA_1	41	47	PF00498	0.760
LIG_FHA_1	462	468	PF00498	0.768
LIG_FHA_1	58	64	PF00498	0.249
LIG_FHA_1	72	78	PF00498	0.366
LIG_FHA_1	85	91	PF00498	0.315
LIG_FHA_1	905	911	PF00498	0.394
LIG_FHA_1	931	937	PF00498	0.530
LIG_FHA_2	302	308	PF00498	0.768
LIG_FHA_2	806	812	PF00498	0.557
LIG_GBD_Chelix_1	247	255	PF00786	0.452
LIG_GBD_Chelix_1	506	514	PF00786	0.545
LIG_LIR_Apic_2	386	392	PF02991	0.693
LIG_LIR_Apic_2	420	424	PF02991	0.733
LIG_LIR_Apic_2	621	627	PF02991	0.457
LIG_LIR_Apic_2	65	71	PF02991	0.510
LIG_LIR_Apic_2	799	803	PF02991	0.399
LIG_LIR_Gen_1	241	251	PF02991	0.591
LIG_LIR_Gen_1	370	379	PF02991	0.782
LIG_LIR_Gen_1	494	504	PF02991	0.700
LIG_LIR_Nem_3	241	247	PF02991	0.569
LIG_LIR_Nem_3	261	267	PF02991	0.303
LIG_LIR_Nem_3	370	375	PF02991	0.781
LIG_LIR_Nem_3	420	426	PF02991	0.730
LIG_LIR_Nem_3	494	499	PF02991	0.715
LIG_LIR_Nem_3	916	920	PF02991	0.606
LIG_LIR_Nem_3	937	941	PF02991	0.530
LIG_MYND_1	627	631	PF01753	0.440
LIG_NRBOX	509	515	PF00104	0.746
LIG_NRBOX	888	894	PF00104	0.401
LIG_NRBOX	89	95	PF00104	0.530
LIG_NRBOX	931	937	PF00104	0.530
LIG_PAM2_1	234	246	PF00658	0.705
LIG_Pex14_1	422	426	PF04695	0.756
LIG_Pex14_2	532	536	PF04695	0.452
LIG_Pex14_2	796	800	PF04695	0.449
LIG_PTAP_UEV_1	874	879	PF05743	0.558
LIG_Rb_LxCxE_1	74	88	PF01857	0.435
LIG_RPA_C_Fungi	598	610	PF08784	0.670
LIG_RPA_C_Fungi	636	648	PF08784	0.481
LIG_SH2_CRK	100	104	PF00017	0.698
LIG_SH2_PTP2	244	247	PF00017	0.530
LIG_SH2_STAP1	587	591	PF00017	0.625
LIG_SH2_STAT3	267	270	PF00017	0.530
LIG_SH2_STAT3	534	537	PF00017	0.549
LIG_SH2_STAT3	963	966	PF00017	0.606
LIG_SH2_STAT5	244	247	PF00017	0.530
LIG_SH2_STAT5	256	259	PF00017	0.481
LIG_SH2_STAT5	667	670	PF00017	0.650
LIG_SH3_3	129	135	PF00018	0.839
LIG_SH3_3	18	24	PF00018	0.754
LIG_SH3_3	230	236	PF00018	0.720
LIG_SH3_3	317	323	PF00018	0.697
LIG_SH3_3	32	38	PF00018	0.688
LIG_SH3_3	625	631	PF00018	0.688
LIG_SH3_3	708	714	PF00018	0.765
LIG_SH3_3	722	728	PF00018	0.617
LIG_SH3_3	759	765	PF00018	0.594
LIG_SH3_3	872	878	PF00018	0.787
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.530
LIG_SUMO_SIM_anti_2	888	893	PF11976	0.296
LIG_SUMO_SIM_par_1	373	380	PF11976	0.747
LIG_SUMO_SIM_par_1	74	80	PF11976	0.530
LIG_SUMO_SIM_par_1	894	900	PF11976	0.530
LIG_SUMO_SIM_par_1	932	937	PF11976	0.530
LIG_TRAF2_1	62	65	PF00917	0.618
LIG_TRAF2_1	690	693	PF00917	0.622
LIG_TRAF2_1	764	767	PF00917	0.773
LIG_TRFH_1	624	628	PF08558	0.560
LIG_WRC_WIRS_1	529	534	PF05994	0.491
LIG_WRC_WIRS_1	775	780	PF05994	0.452
LIG_WRC_WIRS_1	797	802	PF05994	0.592
LIG_WRC_WIRS_1	935	940	PF05994	0.530
LIG_WW_3	36	40	PF00397	0.828
MOD_CDK_SPxK_1	128	134	PF00069	0.610
MOD_CK1_1	118	124	PF00069	0.852
MOD_CK1_1	15	21	PF00069	0.743
MOD_CK1_1	208	214	PF00069	0.827
MOD_CK1_1	222	228	PF00069	0.499
MOD_CK1_1	30	36	PF00069	0.638
MOD_CK1_1	364	370	PF00069	0.799
MOD_CK1_1	400	406	PF00069	0.707
MOD_CK1_1	407	413	PF00069	0.637
MOD_CK1_1	462	468	PF00069	0.749
MOD_CK1_1	640	646	PF00069	0.553
MOD_CK1_1	682	688	PF00069	0.633
MOD_CK1_1	732	738	PF00069	0.738
MOD_CK1_1	838	844	PF00069	0.666
MOD_CK1_1	900	906	PF00069	0.475
MOD_CK2_1	297	303	PF00069	0.806
MOD_CK2_1	491	497	PF00069	0.610
MOD_CK2_1	750	756	PF00069	0.863
MOD_CK2_1	761	767	PF00069	0.607
MOD_CK2_1	77	83	PF00069	0.460
MOD_CK2_1	805	811	PF00069	0.697
MOD_CK2_1	879	885	PF00069	0.540
MOD_Cter_Amidation	941	944	PF01082	0.452
MOD_GlcNHglycan	117	120	PF01048	0.811
MOD_GlcNHglycan	207	210	PF01048	0.824
MOD_GlcNHglycan	219	222	PF01048	0.587
MOD_GlcNHglycan	311	314	PF01048	0.785
MOD_GlcNHglycan	317	320	PF01048	0.759
MOD_GlcNHglycan	402	405	PF01048	0.789
MOD_GlcNHglycan	413	416	PF01048	0.630
MOD_GlcNHglycan	440	443	PF01048	0.552
MOD_GlcNHglycan	461	464	PF01048	0.667
MOD_GlcNHglycan	493	496	PF01048	0.609
MOD_GlcNHglycan	545	549	PF01048	0.580
MOD_GlcNHglycan	60	63	PF01048	0.452
MOD_GlcNHglycan	642	645	PF01048	0.594
MOD_GlcNHglycan	752	755	PF01048	0.669
MOD_GlcNHglycan	784	787	PF01048	0.452
MOD_GlcNHglycan	875	878	PF01048	0.787
MOD_GSK3_1	124	131	PF00069	0.849
MOD_GSK3_1	215	222	PF00069	0.795
MOD_GSK3_1	234	241	PF00069	0.415
MOD_GSK3_1	251	258	PF00069	0.315
MOD_GSK3_1	259	266	PF00069	0.540
MOD_GSK3_1	297	304	PF00069	0.699
MOD_GSK3_1	363	370	PF00069	0.792
MOD_GSK3_1	383	390	PF00069	0.737
MOD_GSK3_1	400	407	PF00069	0.588
MOD_GSK3_1	409	416	PF00069	0.587
MOD_GSK3_1	433	440	PF00069	0.717
MOD_GSK3_1	627	634	PF00069	0.658
MOD_GSK3_1	675	682	PF00069	0.652
MOD_GSK3_1	735	742	PF00069	0.757
MOD_GSK3_1	744	751	PF00069	0.705
MOD_GSK3_1	752	759	PF00069	0.590
MOD_GSK3_1	77	84	PF00069	0.530
MOD_GSK3_1	830	837	PF00069	0.544
MOD_GSK3_1	881	888	PF00069	0.630
MOD_GSK3_1	900	907	PF00069	0.364
MOD_GSK3_1	930	937	PF00069	0.530
MOD_LATS_1	351	357	PF00433	0.756
MOD_N-GLC_1	258	263	PF02516	0.667
MOD_N-GLC_1	301	306	PF02516	0.712
MOD_NEK2_1	143	148	PF00069	0.629
MOD_NEK2_1	251	256	PF00069	0.530
MOD_NEK2_1	263	268	PF00069	0.485
MOD_NEK2_1	273	278	PF00069	0.394
MOD_NEK2_1	387	392	PF00069	0.723
MOD_NEK2_1	599	604	PF00069	0.682
MOD_NEK2_1	675	680	PF00069	0.759
MOD_NEK2_1	77	82	PF00069	0.378
MOD_NEK2_1	796	801	PF00069	0.597
MOD_NEK2_1	834	839	PF00069	0.679
MOD_NEK2_1	85	90	PF00069	0.398
MOD_NEK2_1	887	892	PF00069	0.460
MOD_NEK2_1	904	909	PF00069	0.302
MOD_NEK2_2	729	734	PF00069	0.579
MOD_OFUCOSY	727	733	PF10250	0.573
MOD_PIKK_1	353	359	PF00454	0.756
MOD_PIKK_1	40	46	PF00454	0.721
MOD_PIKK_1	732	738	PF00454	0.729
MOD_PKA_1	405	411	PF00069	0.627
MOD_PKA_1	417	423	PF00069	0.565
MOD_PKA_1	943	949	PF00069	0.530
MOD_PKA_2	226	232	PF00069	0.589
MOD_PKA_2	289	295	PF00069	0.546
MOD_PKA_2	315	321	PF00069	0.757
MOD_PKA_2	397	403	PF00069	0.736
MOD_PKA_2	404	410	PF00069	0.654
MOD_PKA_2	417	423	PF00069	0.581
MOD_PKA_2	514	520	PF00069	0.636
MOD_PKA_2	599	605	PF00069	0.707
MOD_PKA_2	640	646	PF00069	0.716
MOD_PKA_2	682	688	PF00069	0.816
MOD_PKA_2	744	750	PF00069	0.699
MOD_PKA_2	838	844	PF00069	0.705
MOD_PKA_2	943	949	PF00069	0.530
MOD_Plk_1	258	264	PF00069	0.672
MOD_Plk_1	370	376	PF00069	0.742
MOD_Plk_1	433	439	PF00069	0.548
MOD_Plk_1	637	643	PF00069	0.603
MOD_Plk_2-3	301	307	PF00069	0.819
MOD_Plk_4	15	21	PF00069	0.720
MOD_Plk_4	188	194	PF00069	0.782
MOD_Plk_4	251	257	PF00069	0.499
MOD_Plk_4	259	265	PF00069	0.570
MOD_Plk_4	371	377	PF00069	0.785
MOD_Plk_4	579	585	PF00069	0.589
MOD_Plk_4	646	652	PF00069	0.390
MOD_Plk_4	774	780	PF00069	0.530
MOD_Plk_4	830	836	PF00069	0.524
MOD_Plk_4	85	91	PF00069	0.530
MOD_Plk_4	887	893	PF00069	0.433
MOD_Plk_4	900	906	PF00069	0.316
MOD_Plk_4	930	936	PF00069	0.530
MOD_ProDKin_1	128	134	PF00069	0.844
MOD_ProDKin_1	208	214	PF00069	0.755
MOD_ProDKin_1	364	370	PF00069	0.797
MOD_ProDKin_1	377	383	PF00069	0.565
MOD_ProDKin_1	619	625	PF00069	0.764
MOD_ProDKin_1	627	633	PF00069	0.665
MOD_ProDKin_1	761	767	PF00069	0.611
TRG_DiLeu_BaEn_1	849	854	PF01217	0.757
TRG_DiLeu_BaLyEn_6	509	514	PF01217	0.644
TRG_ENDOCYTIC_2	100	103	PF00928	0.649
TRG_ENDOCYTIC_2	244	247	PF00928	0.464
TRG_ER_diArg_1	104	106	PF00400	0.643
TRG_ER_diArg_1	178	181	PF00400	0.821
TRG_ER_diArg_1	417	419	PF00400	0.616
TRG_ER_diArg_1	508	511	PF00400	0.558
TRG_ER_diArg_1	856	858	PF00400	0.690
TRG_ER_diArg_1	943	945	PF00400	0.530
TRG_ER_diArg_1	967	970	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.763
TRG_Pf-PMV_PEXEL_1	511	516	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	701	705	PF00026	0.762

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJH0	Leishmania donovani	85%	100%
A4H3D0	Leishmania braziliensis	59%	100%
A4HRN1	Leishmania infantum	85%	100%
E9AJJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%