Soluble_NSF_attachment_protein_-_SNAP_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Soluble NSF attachment protein, SNAP, putative

Species:

Leishmania major

UniProt:

E9ACA6_LEIMA

TriTrypDb:

LmjF.02.0310 , LMJLV39_020008000 , LMJSD75_020008100

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2

Expansion

Sequence features

E9ACA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACA6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006886	intracellular protein transport	4	7
GO:0008104	protein localization	4	7
GO:0009987	cellular process	1	7
GO:0015031	protein transport	4	7
GO:0016043	cellular component organization	3	2
GO:0022411	cellular component disassembly	4	2
GO:0032984	protein-containing complex disassembly	5	2
GO:0033036	macromolecule localization	2	7
GO:0035494	SNARE complex disassembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0045184	establishment of protein localization	3	7
GO:0046907	intracellular transport	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7
GO:0070727	cellular macromolecule localization	3	7
GO:0071702	organic substance transport	4	7
GO:0071705	nitrogen compound transport	4	7
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005483	soluble NSF attachment protein activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019905	syntaxin binding	4	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.658
CLV_C14_Caspase3-7	28	32	PF00656	0.586
CLV_C14_Caspase3-7	304	308	PF00656	0.367
CLV_C14_Caspase3-7	480	484	PF00656	0.580
CLV_C14_Caspase3-7	516	520	PF00656	0.402
CLV_MEL_PAP_1	241	247	PF00089	0.574
CLV_NRD_NRD_1	189	191	PF00675	0.618
CLV_NRD_NRD_1	264	266	PF00675	0.351
CLV_NRD_NRD_1	411	413	PF00675	0.519
CLV_NRD_NRD_1	683	685	PF00675	0.420
CLV_PCSK_KEX2_1	188	190	PF00082	0.582
CLV_PCSK_KEX2_1	264	266	PF00082	0.351
CLV_PCSK_KEX2_1	411	413	PF00082	0.660
CLV_PCSK_KEX2_1	683	685	PF00082	0.423
CLV_PCSK_SKI1_1	289	293	PF00082	0.318
CLV_PCSK_SKI1_1	310	314	PF00082	0.318
CLV_PCSK_SKI1_1	393	397	PF00082	0.403
CLV_PCSK_SKI1_1	557	561	PF00082	0.362
CLV_PCSK_SKI1_1	620	624	PF00082	0.478
CLV_PCSK_SKI1_1	642	646	PF00082	0.389
CLV_PCSK_SKI1_1	684	688	PF00082	0.391
DEG_APCC_DBOX_1	521	529	PF00400	0.357
DEG_APCC_KENBOX_2	635	639	PF00400	0.403
DOC_CKS1_1	595	600	PF01111	0.595
DOC_CYCLIN_RxL_1	307	316	PF00134	0.403
DOC_CYCLIN_RxL_1	551	563	PF00134	0.387
DOC_CYCLIN_RxL_1	681	691	PF00134	0.385
DOC_MAPK_gen_1	522	531	PF00069	0.363
DOC_MAPK_JIP1_4	493	499	PF00069	0.545
DOC_MAPK_MEF2A_6	340	348	PF00069	0.318
DOC_MAPK_MEF2A_6	522	531	PF00069	0.363
DOC_MAPK_NFAT4_5	524	532	PF00069	0.294
DOC_PP1_RVXF_1	287	294	PF00149	0.318
DOC_PP2B_PxIxI_1	343	349	PF00149	0.318
DOC_PP4_FxxP_1	468	471	PF00568	0.628
DOC_USP7_MATH_1	105	109	PF00917	0.648
DOC_USP7_MATH_1	165	169	PF00917	0.733
DOC_USP7_MATH_1	194	198	PF00917	0.591
DOC_USP7_MATH_1	217	221	PF00917	0.670
DOC_USP7_MATH_1	243	247	PF00917	0.576
DOC_USP7_MATH_1	294	298	PF00917	0.439
DOC_USP7_MATH_1	347	351	PF00917	0.297
DOC_USP7_MATH_1	439	443	PF00917	0.698
DOC_USP7_MATH_1	476	480	PF00917	0.634
DOC_USP7_MATH_1	48	52	PF00917	0.755
DOC_USP7_MATH_1	77	81	PF00917	0.725
DOC_USP7_MATH_1	82	86	PF00917	0.652
DOC_WW_Pin1_4	232	237	PF00397	0.531
DOC_WW_Pin1_4	247	252	PF00397	0.589
DOC_WW_Pin1_4	429	434	PF00397	0.634
DOC_WW_Pin1_4	447	452	PF00397	0.639
DOC_WW_Pin1_4	467	472	PF00397	0.648
DOC_WW_Pin1_4	594	599	PF00397	0.627
LIG_14-3-3_CanoR_1	158	164	PF00244	0.540
LIG_14-3-3_CanoR_1	244	252	PF00244	0.568
LIG_14-3-3_CanoR_1	264	274	PF00244	0.401
LIG_14-3-3_CanoR_1	508	514	PF00244	0.531
LIG_14-3-3_CanoR_1	569	574	PF00244	0.536
LIG_14-3-3_CanoR_1	649	654	PF00244	0.391
LIG_14-3-3_CanoR_1	683	687	PF00244	0.444
LIG_14-3-3_CanoR_1	81	91	PF00244	0.555
LIG_Actin_WH2_2	325	342	PF00022	0.403
LIG_APCC_ABBA_1	396	401	PF00400	0.318
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BIR_III_2	47	51	PF00653	0.607
LIG_BIR_III_4	226	230	PF00653	0.625
LIG_BRCT_BRCA1_1	191	195	PF00533	0.608
LIG_BRCT_BRCA1_1	495	499	PF00533	0.699
LIG_BRCT_BRCA1_1	79	83	PF00533	0.650
LIG_deltaCOP1_diTrp_1	283	292	PF00928	0.318
LIG_FHA_1	144	150	PF00498	0.601
LIG_FHA_1	173	179	PF00498	0.543
LIG_FHA_1	199	205	PF00498	0.646
LIG_FHA_1	286	292	PF00498	0.318
LIG_FHA_1	420	426	PF00498	0.529
LIG_FHA_1	430	436	PF00498	0.618
LIG_FHA_1	472	478	PF00498	0.783
LIG_FHA_1	484	490	PF00498	0.655
LIG_FHA_1	554	560	PF00498	0.392
LIG_FHA_1	561	567	PF00498	0.354
LIG_FHA_2	198	204	PF00498	0.618
LIG_FHA_2	266	272	PF00498	0.377
LIG_FHA_2	442	448	PF00498	0.692
LIG_FHA_2	652	658	PF00498	0.458
LIG_LIR_Apic_2	465	471	PF02991	0.622
LIG_LIR_Gen_1	108	116	PF02991	0.569
LIG_LIR_Gen_1	235	245	PF02991	0.572
LIG_LIR_Gen_1	297	306	PF02991	0.297
LIG_LIR_Gen_1	609	616	PF02991	0.397
LIG_LIR_Gen_1	685	694	PF02991	0.473
LIG_LIR_Gen_1	89	97	PF02991	0.643
LIG_LIR_Nem_3	192	198	PF02991	0.591
LIG_LIR_Nem_3	235	241	PF02991	0.570
LIG_LIR_Nem_3	297	302	PF02991	0.297
LIG_LIR_Nem_3	556	561	PF02991	0.446
LIG_LIR_Nem_3	609	615	PF02991	0.395
LIG_LIR_Nem_3	619	625	PF02991	0.427
LIG_LIR_Nem_3	89	95	PF02991	0.644
LIG_LYPXL_SIV_4	266	274	PF13949	0.377
LIG_MYND_1	433	437	PF01753	0.601
LIG_NRBOX	524	530	PF00104	0.354
LIG_PCNA_yPIPBox_3	634	645	PF02747	0.372
LIG_PTAP_UEV_1	450	455	PF05743	0.650
LIG_PTB_Apo_2	316	323	PF02174	0.351
LIG_SH2_CRK	238	242	PF00017	0.569
LIG_SH2_CRK	561	565	PF00017	0.426
LIG_SH2_NCK_1	238	242	PF00017	0.569
LIG_SH2_NCK_1	267	271	PF00017	0.308
LIG_SH2_SRC	535	538	PF00017	0.472
LIG_SH2_STAT3	358	361	PF00017	0.351
LIG_SH2_STAT5	267	270	PF00017	0.428
LIG_SH2_STAT5	558	561	PF00017	0.439
LIG_SH2_STAT5	611	614	PF00017	0.418
LIG_SH3_3	230	236	PF00018	0.574
LIG_SH3_3	430	436	PF00018	0.588
LIG_SH3_3	448	454	PF00018	0.649
LIG_SH3_3	579	585	PF00018	0.584
LIG_SH3_3	592	598	PF00018	0.494
LIG_SUMO_SIM_par_1	525	530	PF11976	0.461
LIG_TRAF2_1	269	272	PF00917	0.351
LIG_TRAF2_1	384	387	PF00917	0.351
LIG_TYR_ITIM	559	564	PF00017	0.428
LIG_UBA3_1	377	385	PF00899	0.450
LIG_WW_1	504	507	PF00397	0.553
LIG_WW_2	433	436	PF00397	0.596
MOD_CDK_SPK_2	467	472	PF00069	0.625
MOD_CK1_1	108	114	PF00069	0.621
MOD_CK1_1	115	121	PF00069	0.621
MOD_CK1_1	197	203	PF00069	0.591
MOD_CK1_1	220	226	PF00069	0.646
MOD_CK1_1	25	31	PF00069	0.517
MOD_CK1_1	40	46	PF00069	0.607
MOD_CK1_1	461	467	PF00069	0.599
MOD_CK1_1	470	476	PF00069	0.616
MOD_CK1_1	484	490	PF00069	0.738
MOD_CK1_1	51	57	PF00069	0.605
MOD_CK1_1	572	578	PF00069	0.542
MOD_CK1_1	76	82	PF00069	0.725
MOD_CK2_1	197	203	PF00069	0.644
MOD_CK2_1	213	219	PF00069	0.636
MOD_CK2_1	265	271	PF00069	0.386
MOD_CK2_1	664	670	PF00069	0.436
MOD_CK2_1	682	688	PF00069	0.476
MOD_GlcNHglycan	114	117	PF01048	0.713
MOD_GlcNHglycan	164	168	PF01048	0.743
MOD_GlcNHglycan	191	194	PF01048	0.683
MOD_GlcNHglycan	215	218	PF01048	0.630
MOD_GlcNHglycan	219	222	PF01048	0.643
MOD_GlcNHglycan	226	230	PF01048	0.690
MOD_GlcNHglycan	3	6	PF01048	0.629
MOD_GlcNHglycan	39	42	PF01048	0.630
MOD_GlcNHglycan	437	440	PF01048	0.641
MOD_GlcNHglycan	441	444	PF01048	0.622
MOD_GlcNHglycan	479	482	PF01048	0.706
MOD_GlcNHglycan	61	64	PF01048	0.687
MOD_GlcNHglycan	75	78	PF01048	0.653
MOD_GSK3_1	1	8	PF00069	0.759
MOD_GSK3_1	108	115	PF00069	0.673
MOD_GSK3_1	139	146	PF00069	0.566
MOD_GSK3_1	159	166	PF00069	0.518
MOD_GSK3_1	194	201	PF00069	0.613
MOD_GSK3_1	213	220	PF00069	0.612
MOD_GSK3_1	243	250	PF00069	0.584
MOD_GSK3_1	328	335	PF00069	0.327
MOD_GSK3_1	435	442	PF00069	0.672
MOD_GSK3_1	457	464	PF00069	0.649
MOD_GSK3_1	467	474	PF00069	0.615
MOD_GSK3_1	477	484	PF00069	0.713
MOD_GSK3_1	48	55	PF00069	0.728
MOD_GSK3_1	509	516	PF00069	0.469
MOD_GSK3_1	549	556	PF00069	0.419
MOD_GSK3_1	574	581	PF00069	0.601
MOD_GSK3_1	596	603	PF00069	0.705
MOD_GSK3_1	611	618	PF00069	0.295
MOD_GSK3_1	73	80	PF00069	0.675
MOD_GSK3_1	95	102	PF00069	0.611
MOD_N-GLC_1	323	328	PF02516	0.403
MOD_NEK2_1	1	6	PF00069	0.647
MOD_NEK2_1	143	148	PF00069	0.598
MOD_NEK2_1	313	318	PF00069	0.329
MOD_NEK2_1	339	344	PF00069	0.438
MOD_NEK2_1	485	490	PF00069	0.651
MOD_NEK2_1	517	522	PF00069	0.413
MOD_NEK2_1	560	565	PF00069	0.343
MOD_NEK2_2	139	144	PF00069	0.544
MOD_NEK2_2	294	299	PF00069	0.351
MOD_NEK2_2	606	611	PF00069	0.441
MOD_NEK2_2	682	687	PF00069	0.437
MOD_PIKK_1	115	121	PF00454	0.812
MOD_PIKK_1	23	29	PF00454	0.474
MOD_PIKK_1	6	12	PF00454	0.710
MOD_PK_1	569	575	PF00069	0.499
MOD_PKA_1	189	195	PF00069	0.568
MOD_PKA_2	143	149	PF00069	0.594
MOD_PKA_2	189	195	PF00069	0.614
MOD_PKA_2	213	219	PF00069	0.544
MOD_PKA_2	243	249	PF00069	0.555
MOD_PKA_2	507	513	PF00069	0.590
MOD_PKA_2	682	688	PF00069	0.442
MOD_Plk_1	457	463	PF00069	0.685
MOD_Plk_1	628	634	PF00069	0.529
MOD_Plk_4	25	31	PF00069	0.646
MOD_Plk_4	294	300	PF00069	0.461
MOD_Plk_4	313	319	PF00069	0.318
MOD_Plk_4	347	353	PF00069	0.297
MOD_Plk_4	527	533	PF00069	0.443
MOD_Plk_4	606	612	PF00069	0.471
MOD_ProDKin_1	232	238	PF00069	0.530
MOD_ProDKin_1	247	253	PF00069	0.581
MOD_ProDKin_1	429	435	PF00069	0.637
MOD_ProDKin_1	447	453	PF00069	0.638
MOD_ProDKin_1	467	473	PF00069	0.649
MOD_ProDKin_1	594	600	PF00069	0.622
MOD_SUMO_for_1	384	387	PF00179	0.351
MOD_SUMO_rev_2	397	405	PF00179	0.331
TRG_DiLeu_BaEn_1	255	260	PF01217	0.318
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.284
TRG_ENDOCYTIC_2	109	112	PF00928	0.627
TRG_ENDOCYTIC_2	238	241	PF00928	0.570
TRG_ENDOCYTIC_2	561	564	PF00928	0.426
TRG_ER_diArg_1	188	190	PF00400	0.620
TRG_ER_diArg_1	411	413	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9E1	Leptomonas seymouri	48%	90%
A0A3S5H4Z6	Leishmania donovani	89%	100%
A4H3C9	Leishmania braziliensis	61%	99%
A4HRM8	Leishmania infantum	89%	100%
E9AJJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%