Soluble_NSF_attachment_protein_-_SNAP_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Soluble NSF attachment protein, SNAP, putative

Species:

Leishmania major

UniProt:

E9ACA6_LEIMA

TriTrypDb:

LmjF.02.0310 , LMJLV39_020008000 , LMJSD75_020008100

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2

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Expansion

Sequence features

E9ACA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACA6

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006886	intracellular protein transport	4	7
GO:0008104	protein localization	4	7
GO:0009987	cellular process	1	7
GO:0015031	protein transport	4	7
GO:0016043	cellular component organization	3	2
GO:0022411	cellular component disassembly	4	2
GO:0032984	protein-containing complex disassembly	5	2
GO:0033036	macromolecule localization	2	7
GO:0035494	SNARE complex disassembly	6	2

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Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005483	soluble NSF attachment protein activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019905	syntaxin binding	4	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.658
CLV_C14_Caspase3-7	28	32	PF00656	0.586
CLV_C14_Caspase3-7	304	308	PF00656	0.367
CLV_C14_Caspase3-7	480	484	PF00656	0.580
CLV_C14_Caspase3-7	516	520	PF00656	0.402
CLV_MEL_PAP_1	241	247	PF00089	0.574
CLV_NRD_NRD_1	189	191	PF00675	0.618
CLV_NRD_NRD_1	264	266	PF00675	0.351
CLV_NRD_NRD_1	411	413	PF00675	0.519
CLV_NRD_NRD_1	683	685	PF00675	0.420

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9E1	Leptomonas seymouri	48%	90%
A0A3S5H4Z6	Leishmania donovani	89%	100%
A4H3C9	Leishmania braziliensis	61%	99%
A4HRM8	Leishmania infantum	89%	100%
E9AJJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%

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