SRP9-21 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACA3_LEIMA

TriTrypDb:

LmjF.02.0280 , LMJLV39_020007700 , LMJSD75_020007700

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	5
GO:0048500	signal recognition particle	3	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

E9ACA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACA3

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	5
GO:0006612	protein targeting to membrane	5	5
GO:0006613	cotranslational protein targeting to membrane	6	5
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	5
GO:0006810	transport	3	5
GO:0006886	intracellular protein transport	4	5
GO:0008104	protein localization	4	5
GO:0009987	cellular process	1	5
GO:0015031	protein transport	4	5
GO:0033036	macromolecule localization	2	5
GO:0033365	protein localization to organelle	5	5
GO:0045047	protein targeting to ER	6	5
GO:0045184	establishment of protein localization	3	5
GO:0046907	intracellular transport	3	5
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0051641	cellular localization	2	5
GO:0051649	establishment of localization in cell	3	5
GO:0051668	localization within membrane	3	5
GO:0070727	cellular macromolecule localization	3	5
GO:0070972	protein localization to endoplasmic reticulum	6	5
GO:0071702	organic substance transport	4	5
GO:0071705	nitrogen compound transport	4	5
GO:0072594	establishment of protein localization to organelle	4	5
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	5
GO:0072657	protein localization to membrane	4	5
GO:0090150	establishment of protein localization to membrane	4	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0008312	7S RNA binding	5	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.684
CLV_NRD_NRD_1	23	25	PF00675	0.508
CLV_NRD_NRD_1	36	38	PF00675	0.464
CLV_PCSK_KEX2_1	167	169	PF00082	0.621
CLV_PCSK_KEX2_1	23	25	PF00082	0.471
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.600
CLV_PCSK_SKI1_1	26	30	PF00082	0.456
DEG_Nend_UBRbox_1	1	4	PF02207	0.434
DOC_MAPK_gen_1	23	31	PF00069	0.458
DOC_MAPK_MEF2A_6	23	31	PF00069	0.458
DOC_MAPK_NFAT4_5	24	32	PF00069	0.451
DOC_USP7_MATH_1	101	105	PF00917	0.518
DOC_USP7_MATH_1	11	15	PF00917	0.428
DOC_USP7_MATH_1	130	134	PF00917	0.632
DOC_USP7_MATH_1	147	151	PF00917	0.606
DOC_USP7_MATH_1	33	37	PF00917	0.571
DOC_USP7_MATH_1	83	87	PF00917	0.659
DOC_USP7_MATH_1	88	92	PF00917	0.653
DOC_WW_Pin1_4	113	118	PF00397	0.628
DOC_WW_Pin1_4	79	84	PF00397	0.653
LIG_14-3-3_CanoR_1	37	41	PF00244	0.424
LIG_14-3-3_CanoR_1	48	52	PF00244	0.473
LIG_14-3-3_CanoR_1	77	81	PF00244	0.635
LIG_FHA_1	37	43	PF00498	0.479
LIG_FHA_1	50	56	PF00498	0.470
LIG_FHA_2	51	57	PF00498	0.434
LIG_SH3_3	77	83	PF00018	0.623
MOD_CK1_1	104	110	PF00069	0.528
MOD_CK1_1	150	156	PF00069	0.663
MOD_CK1_1	36	42	PF00069	0.468
MOD_CK1_1	79	85	PF00069	0.586
MOD_CK1_1	86	92	PF00069	0.656
MOD_CK2_1	50	56	PF00069	0.429
MOD_CK2_1	88	94	PF00069	0.675
MOD_Cter_Amidation	162	165	PF01082	0.638
MOD_GlcNHglycan	106	109	PF01048	0.518
MOD_GlcNHglycan	132	135	PF01048	0.625
MOD_GlcNHglycan	145	148	PF01048	0.620
MOD_GlcNHglycan	153	156	PF01048	0.760
MOD_GlcNHglycan	90	93	PF01048	0.782
MOD_GlcNHglycan	98	101	PF01048	0.615
MOD_GSK3_1	130	137	PF00069	0.619
MOD_GSK3_1	139	146	PF00069	0.640
MOD_GSK3_1	147	154	PF00069	0.607
MOD_GSK3_1	79	86	PF00069	0.666
MOD_NEK2_1	63	68	PF00069	0.535
MOD_NEK2_2	11	16	PF00069	0.426
MOD_PIKK_1	139	145	PF00454	0.642
MOD_PKA_2	22	28	PF00069	0.491
MOD_PKA_2	36	42	PF00069	0.403
MOD_PKA_2	47	53	PF00069	0.472
MOD_PKA_2	76	82	PF00069	0.634
MOD_Plk_4	36	42	PF00069	0.425
MOD_Plk_4	63	69	PF00069	0.538
MOD_ProDKin_1	113	119	PF00069	0.628
MOD_ProDKin_1	79	85	PF00069	0.656
TRG_DiLeu_BaEn_2	3	9	PF01217	0.498
TRG_ER_diArg_1	22	24	PF00400	0.485
TRG_ER_diArg_1	29	32	PF00400	0.447
TRG_ER_diLys_1	165	169	PF00400	0.600
TRG_NLS_MonoExtC_3	163	168	PF00514	0.608
TRG_NLS_MonoExtN_4	162	168	PF00514	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT10	Leptomonas seymouri	50%	100%
A0A451EJG5	Leishmania donovani	93%	100%
A4H3C6	Leishmania braziliensis	70%	100%
A4HRM5	Leishmania infantum	93%	100%
E9AJJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%