SRP9-21 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACA3_LEIMA

TriTrypDb:

LmjF.02.0280 , LMJLV39_020007700 , LMJSD75_020007700

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	5
GO:0048500	signal recognition particle	3	5
GO:1990904	ribonucleoprotein complex	2	5

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Expansion

Sequence features

E9ACA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACA3

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	5
GO:0006612	protein targeting to membrane	5	5
GO:0006613	cotranslational protein targeting to membrane	6	5
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	5
GO:0006810	transport	3	5
GO:0006886	intracellular protein transport	4	5
GO:0008104	protein localization	4	5
GO:0009987	cellular process	1	5
GO:0015031	protein transport	4	5
GO:0033036	macromolecule localization	2	5

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0008312	7S RNA binding	5	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.684
CLV_NRD_NRD_1	23	25	PF00675	0.508
CLV_NRD_NRD_1	36	38	PF00675	0.464
CLV_PCSK_KEX2_1	167	169	PF00082	0.621
CLV_PCSK_KEX2_1	23	25	PF00082	0.471
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.600
CLV_PCSK_SKI1_1	26	30	PF00082	0.456
DEG_Nend_UBRbox_1	1	4	PF02207	0.434
DOC_MAPK_gen_1	23	31	PF00069	0.458
DOC_MAPK_MEF2A_6	23	31	PF00069	0.458

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT10	Leptomonas seymouri	50%	100%
A0A451EJG5	Leishmania donovani	93%	100%
A4H3C6	Leishmania braziliensis	70%	100%
A4HRM5	Leishmania infantum	93%	100%
E9AJJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%

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