Small GTP binding protein rab6-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small GTP binding protein rab6-like protein

Species:

Leishmania major

UniProt:

E9ACA1_LEIMA

TriTrypDb:

LmjF.02.0260 , LMJLV39_020007500 , LMJSD75_020007500

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACA1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	2
GO:0006891	intra-Golgi vesicle-mediated transport	6	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0016482	cytosolic transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0042147	retrograde transport, endosome to Golgi	5	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.371
CLV_PCSK_KEX2_1	146	148	PF00082	0.283
CLV_PCSK_SKI1_1	177	181	PF00082	0.296
CLV_PCSK_SKI1_1	26	30	PF00082	0.262
DEG_Nend_UBRbox_3	1	3	PF02207	0.632
DEG_SPOP_SBC_1	202	206	PF00917	0.500
DOC_CKS1_1	239	244	PF01111	0.573
DOC_PP2B_LxvP_1	187	190	PF13499	0.507
DOC_PP2B_LxvP_1	20	23	PF13499	0.409
DOC_PP2B_PxIxI_1	54	60	PF00149	0.399
DOC_USP7_MATH_1	13	17	PF00917	0.569
DOC_USP7_MATH_1	202	206	PF00917	0.688
DOC_USP7_MATH_1	213	217	PF00917	0.695
DOC_WW_Pin1_4	233	238	PF00397	0.564
LIG_14-3-3_CanoR_1	86	91	PF00244	0.285
LIG_14-3-3_CanoR_1	96	104	PF00244	0.304
LIG_BRCT_BRCA1_1	161	165	PF00533	0.276
LIG_FHA_1	36	42	PF00498	0.297
LIG_FHA_1	54	60	PF00498	0.281
LIG_FHA_1	63	69	PF00498	0.294
LIG_FHA_1	99	105	PF00498	0.278
LIG_LIR_Gen_1	112	120	PF02991	0.401
LIG_LIR_Gen_1	162	170	PF02991	0.264
LIG_LIR_Gen_1	85	95	PF02991	0.399
LIG_LIR_Nem_3	112	117	PF02991	0.275
LIG_LIR_Nem_3	162	168	PF02991	0.275
LIG_LIR_Nem_3	85	90	PF02991	0.262
LIG_Pex14_2	113	117	PF04695	0.277
LIG_REV1ctd_RIR_1	59	68	PF16727	0.278
LIG_SH2_STAT5	94	97	PF00017	0.262
LIG_SH3_3	231	237	PF00018	0.664
LIG_SUMO_SIM_anti_2	130	135	PF11976	0.356
LIG_SUMO_SIM_par_1	100	106	PF11976	0.282
LIG_SUMO_SIM_par_1	26	32	PF11976	0.278
LIG_SxIP_EBH_1	86	97	PF03271	0.278
LIG_TRAF2_1	150	153	PF00917	0.278
LIG_TRAF2_1	82	85	PF00917	0.262
LIG_WRC_WIRS_1	46	51	PF05994	0.262
MOD_CK1_1	109	115	PF00069	0.263
MOD_CK1_1	159	165	PF00069	0.379
MOD_CK1_1	16	22	PF00069	0.374
MOD_CK1_1	218	224	PF00069	0.628
MOD_CK1_1	249	255	PF00069	0.668
MOD_CK1_1	3	9	PF00069	0.615
MOD_CK1_1	39	45	PF00069	0.278
MOD_CK1_1	98	104	PF00069	0.293
MOD_CK2_1	147	153	PF00069	0.262
MOD_GlcNHglycan	114	117	PF01048	0.359
MOD_GlcNHglycan	126	129	PF01048	0.347
MOD_GlcNHglycan	148	152	PF01048	0.399
MOD_GlcNHglycan	15	18	PF01048	0.397
MOD_GlcNHglycan	167	171	PF01048	0.262
MOD_GlcNHglycan	2	5	PF01048	0.641
MOD_GlcNHglycan	205	208	PF01048	0.653
MOD_GlcNHglycan	215	218	PF01048	0.679
MOD_GlcNHglycan	220	223	PF01048	0.726
MOD_GlcNHglycan	225	228	PF01048	0.727
MOD_GlcNHglycan	242	245	PF01048	0.614
MOD_GlcNHglycan	97	100	PF01048	0.273
MOD_GSK3_1	105	112	PF00069	0.113
MOD_GSK3_1	197	204	PF00069	0.524
MOD_GSK3_1	31	38	PF00069	0.195
MOD_GSK3_1	86	93	PF00069	0.278
MOD_N-GLC_1	249	254	PF02516	0.708
MOD_NEK2_1	166	171	PF00069	0.284
MOD_NEK2_1	62	67	PF00069	0.262
MOD_NEK2_1	78	83	PF00069	0.354
MOD_PKA_1	156	162	PF00069	0.353
MOD_PKA_2	109	115	PF00069	0.288
MOD_PKA_2	95	101	PF00069	0.283
MOD_Plk_1	159	165	PF00069	0.216
MOD_Plk_1	31	37	PF00069	0.278
MOD_Plk_4	109	115	PF00069	0.278
MOD_Plk_4	159	165	PF00069	0.419
MOD_Plk_4	36	42	PF00069	0.285
MOD_Plk_4	86	92	PF00069	0.278
MOD_Plk_4	98	104	PF00069	0.233
MOD_ProDKin_1	233	239	PF00069	0.565
TRG_ENDOCYTIC_2	46	49	PF00928	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A0	Leptomonas seymouri	71%	100%
A0A0N0P6P8	Leptomonas seymouri	36%	100%
A0A0N0P971	Leptomonas seymouri	28%	100%
A0A0N1HU31	Leptomonas seymouri	32%	100%
A0A0N1I5E3	Leptomonas seymouri	31%	100%
A0A0N1IJ36	Leptomonas seymouri	35%	100%
A0A0S4IJB7	Bodo saltans	34%	100%
A0A0S4IRD6	Bodo saltans	30%	100%
A0A0S4IWD9	Bodo saltans	30%	81%
A0A0S4IWG2	Bodo saltans	25%	79%
A0A0S4IY79	Bodo saltans	33%	100%
A0A0S4J1G8	Bodo saltans	38%	100%
A0A0S4J9T5	Bodo saltans	32%	100%
A0A0S4JBJ9	Bodo saltans	39%	100%
A0A0S4JDW3	Bodo saltans	59%	100%
A0A0S4JHS1	Bodo saltans	33%	100%
A0A0S4JKI9	Bodo saltans	29%	100%
A0A0S4JQT6	Bodo saltans	25%	100%
A0A0S4JR87	Bodo saltans	34%	100%
A0A0S4JVK4	Bodo saltans	35%	100%
A0A0S4KHE5	Bodo saltans	38%	100%
A0A1X0NLK7	Trypanosomatidae	33%	100%
A0A1X0NLM1	Trypanosomatidae	57%	100%
A0A1X0NN55	Trypanosomatidae	23%	100%
A0A1X0NQ87	Trypanosomatidae	32%	74%
A0A1X0NQG4	Trypanosomatidae	32%	100%
A0A1X0NVM5	Trypanosomatidae	35%	100%
A0A1X0NXM2	Trypanosomatidae	36%	81%
A0A1X0P1V3	Trypanosomatidae	36%	100%
A0A1X0P706	Trypanosomatidae	32%	100%
A0A3Q8I8T8	Leishmania donovani	35%	100%
A0A3Q8ICX9	Leishmania donovani	38%	100%
A0A3Q8ID64	Leishmania donovani	36%	100%
A0A3Q8IE68	Leishmania donovani	37%	100%
A0A3Q8IK84	Leishmania donovani	37%	100%
A0A3R7KA22	Trypanosoma rangeli	31%	100%
A0A3R7LXW6	Trypanosoma rangeli	32%	100%
A0A3R7LYA6	Trypanosoma rangeli	30%	100%
A0A3R7N3U0	Trypanosoma rangeli	27%	100%
A0A3R7N6U0	Trypanosoma rangeli	52%	100%
A0A3R7RHV7	Trypanosoma rangeli	31%	100%
A0A3R7RKC1	Trypanosoma rangeli	32%	100%
A0A3S5H4Z2	Leishmania donovani	95%	100%
A0A3S5H5Y5	Leishmania donovani	40%	100%
A0A3S5H6H3	Leishmania donovani	31%	100%
A0A3S5H7K4	Leishmania donovani	31%	100%
A0A3S7WRA9	Leishmania donovani	38%	100%
A0A3S7WV84	Leishmania donovani	38%	100%
A0A3S7X3D1	Leishmania donovani	35%	100%
A0A3S7X5J2	Leishmania donovani	28%	100%
A0A422MUR1	Trypanosoma rangeli	37%	100%
A0A422NH56	Trypanosoma rangeli	30%	100%
A0A422P0L6	Trypanosoma rangeli	40%	100%
A1KXP5	Leishmania donovani	45%	100%
A4D1S5	Homo sapiens	38%	100%
A4H506	Leishmania braziliensis	35%	100%
A4H679	Leishmania braziliensis	37%	100%
A4H6A4	Leishmania braziliensis	38%	100%
A4H6A5	Leishmania braziliensis	31%	100%
A4H9M3	Leishmania braziliensis	37%	100%
A4HEE8	Leishmania braziliensis	31%	100%
A4HFK0	Leishmania braziliensis	37%	100%
A4HH17	Leishmania braziliensis	31%	100%
A4HHR8	Leishmania braziliensis	43%	100%
A4HIB4	Leishmania braziliensis	36%	100%
A4HK33	Leishmania braziliensis	39%	100%
A4HKH2	Leishmania braziliensis	28%	100%
A4HKJ3	Leishmania braziliensis	38%	100%
A4HLP5	Leishmania braziliensis	37%	100%
A4HRM3	Leishmania infantum	95%	100%
A4HT72	Leishmania infantum	40%	100%
A4HUK3	Leishmania infantum	38%	100%
A4HUM8	Leishmania infantum	35%	100%
A4HUM9	Leishmania infantum	31%	100%
A4HVF7	Leishmania infantum	45%	100%
A4HXY7	Leishmania infantum	38%	100%
A4I1I6	Leishmania infantum	31%	100%
A4I446	Leishmania infantum	31%	100%
A4I5J8	Leishmania infantum	35%	100%
A4I7N3	Leishmania infantum	38%	100%
A4I7Z9	Leishmania infantum	28%	100%
A4I825	Leishmania infantum	37%	100%
A4I946	Leishmania infantum	37%	100%
B1A5Z4	Leishmania donovani	31%	100%
B6DT76	Bodo saltans	36%	100%
C9ZIZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
C9ZQX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZVR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZVR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZZR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	81%
D0A3U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A9H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E2RQ15	Canis lupus familiaris	34%	100%
E9AD53	Leishmania major	37%	100%
E9ADL1	Leishmania major	30%	100%
E9AHE8	Leishmania infantum	37%	100%
E9AJI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AL68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AM70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ANA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9ANC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AP56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AXM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AYX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B0U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B2W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B420	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
G4N1S3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	32%	100%
O01803	Caenorhabditis elegans	33%	100%
O04486	Arabidopsis thaliana	31%	100%
O23561	Arabidopsis thaliana	35%	100%
O42819	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
P01123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P11620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P22124	Diplobatis ommata	34%	100%
P22127	Diplobatis ommata	38%	100%
P24409	Canis lupus familiaris	39%	100%
P28186	Arabidopsis thaliana	34%	100%
P31582	Arabidopsis thaliana	45%	100%
P33723	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	34%	100%
P35278	Mus musculus	43%	100%
P35281	Rattus norvegicus	37%	100%
P35283	Mus musculus	36%	100%
P35288	Mus musculus	31%	100%
P35293	Mus musculus	39%	100%
P36018	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P36586	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
P36863	Volvox carteri	35%	100%
P38555	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P41924	Yarrowia lipolytica (strain CLIB 122 / E 150)	35%	100%
P46629	Oryctolagus cuniculus	35%	100%
P51147	Canis lupus familiaris	44%	100%
P51148	Homo sapiens	43%	100%
P59279	Mus musculus	36%	100%
P61026	Homo sapiens	39%	100%
P61027	Mus musculus	39%	100%
P61028	Mus musculus	38%	100%
P70550	Rattus norvegicus	38%	100%
P91580	Ciona intestinalis	36%	100%
P97950	Mus musculus	37%	100%
Q01387	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q01890	Phytophthora infestans	37%	100%
Q14088	Homo sapiens	36%	100%
Q14964	Homo sapiens	33%	100%
Q1ZXE7	Dictyostelium discoideum	31%	100%
Q2HJI8	Bos taurus	38%	100%
Q2TA29	Bos taurus	29%	100%
Q40191	Lotus japonicus	34%	100%
Q40193	Lotus japonicus	34%	100%
Q4Q404	Leishmania major	35%	100%
Q4Q573	Leishmania major	37%	100%
Q4Q595	Leishmania major	28%	100%
Q4Q5N4	Leishmania major	38%	100%
Q4Q7C3	Leishmania major	36%	100%
Q4Q9V1	Leishmania major	31%	100%
Q4QDS9	Leishmania major	38%	100%
Q4QGD2	Leishmania major	43%	100%
Q4QH97	Leishmania major	31%	100%
Q4QH98	Leishmania major	35%	100%
Q4QHC3	Leishmania major	38%	100%
Q4QIN6	Leishmania major	40%	100%
Q4UB16	Theileria annulata	31%	100%
Q54DA7	Dictyostelium discoideum	38%	100%
Q54P07	Dictyostelium discoideum	31%	100%
Q55E31	Dictyostelium discoideum	31%	100%
Q58DS9	Bos taurus	43%	100%
Q5EB77	Rattus norvegicus	39%	100%
Q5M7D1	Xenopus laevis	26%	99%
Q5R4W9	Pongo abelii	35%	100%
Q5R5U1	Pongo abelii	39%	100%
Q5R7L7	Pongo abelii	43%	100%
Q5RDE5	Pongo abelii	27%	100%
Q5ZHW4	Gallus gallus	44%	100%
Q5ZIT5	Gallus gallus	38%	100%
Q6GQP4	Rattus norvegicus	40%	100%
Q86JP3	Dictyostelium discoideum	41%	100%
Q8BHD0	Mus musculus	33%	100%
Q98932	Gallus gallus	43%	100%
Q9CB01	Arabidopsis thaliana	42%	100%
Q9DD03	Mus musculus	39%	100%
Q9LNK1	Arabidopsis thaliana	36%	100%
Q9NP90	Homo sapiens	35%	100%
Q9NZQ0	Homo sapiens	27%	100%
Q9UL25	Homo sapiens	34%	100%
Q9ULC3	Homo sapiens	32%	100%
Q9WTL2	Mus musculus	36%	100%
V5BJM4	Trypanosoma cruzi	34%	100%
V5C1F1	Trypanosoma cruzi	29%	100%
V5C2R1	Trypanosoma cruzi	34%	75%
V5D1K6	Trypanosoma cruzi	34%	100%
V5D6P4	Trypanosoma cruzi	62%	100%