Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACA0_LEIMA

TriTrypDb:

LmjF.02.0250 , LMJLV39_020007400 , LMJSD75_020007400

Length:

1107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9ACA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACA0

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.588
CLV_C14_Caspase3-7	1026	1030	PF00656	0.676
CLV_C14_Caspase3-7	1099	1103	PF00656	0.629
CLV_C14_Caspase3-7	384	388	PF00656	0.634
CLV_C14_Caspase3-7	820	824	PF00656	0.618
CLV_NRD_NRD_1	1083	1085	PF00675	0.616
CLV_NRD_NRD_1	218	220	PF00675	0.652
CLV_NRD_NRD_1	248	250	PF00675	0.765
CLV_NRD_NRD_1	345	347	PF00675	0.705
CLV_NRD_NRD_1	377	379	PF00675	0.509

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTU3	Leptomonas seymouri	41%	96%
A0A3S5H4Z1	Leishmania donovani	91%	97%
A4H3C1	Leishmania braziliensis	71%	96%
A4HRM2	Leishmania infantum	90%	97%
E9AJI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%

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