Phosphoglycan beta 1,2 arabinosyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycan beta 1,2 arabinosyltransferase

Species:

Leishmania major

UniProt:

E9AC97_LEIMA

TriTrypDb:

LmjF.02.0220 , LMJLV39_020006900 , LMJLV39_020007000 , LMJSD75_020007100

Length:

942

Annotations

LeishMANIAdb annotations

A signal-anchored enzyme family expanded in Leishmaniids. Any identification as glycosyltransferase is highly tentative.. Localization: Golgi (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005796	Golgi lumen	5	3
GO:0016020	membrane	2	8
GO:0031974	membrane-enclosed lumen	2	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AC97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC97

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	3
GO:0005996	monosaccharide metabolic process	3	3
GO:0006012	galactose metabolic process	5	3
GO:0008152	metabolic process	1	3
GO:0019318	hexose metabolic process	4	3
GO:0044238	primary metabolic process	2	3
GO:0044281	small molecule metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008378	galactosyltransferase activity	5	3
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	3
GO:0016758	hexosyltransferase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	679	683	PF00656	0.446
CLV_NRD_NRD_1	104	106	PF00675	0.391
CLV_NRD_NRD_1	150	152	PF00675	0.488
CLV_NRD_NRD_1	156	158	PF00675	0.392
CLV_NRD_NRD_1	24	26	PF00675	0.403
CLV_NRD_NRD_1	261	263	PF00675	0.649
CLV_NRD_NRD_1	36	38	PF00675	0.373
CLV_NRD_NRD_1	472	474	PF00675	0.568
CLV_NRD_NRD_1	502	504	PF00675	0.654
CLV_NRD_NRD_1	525	527	PF00675	0.564
CLV_NRD_NRD_1	537	539	PF00675	0.609
CLV_NRD_NRD_1	829	831	PF00675	0.648
CLV_NRD_NRD_1	918	920	PF00675	0.534
CLV_PCSK_KEX2_1	104	106	PF00082	0.391
CLV_PCSK_KEX2_1	150	152	PF00082	0.530
CLV_PCSK_KEX2_1	156	158	PF00082	0.399
CLV_PCSK_KEX2_1	24	26	PF00082	0.403
CLV_PCSK_KEX2_1	36	38	PF00082	0.373
CLV_PCSK_KEX2_1	472	474	PF00082	0.568
CLV_PCSK_KEX2_1	502	504	PF00082	0.654
CLV_PCSK_KEX2_1	525	527	PF00082	0.564
CLV_PCSK_KEX2_1	829	831	PF00082	0.624
CLV_PCSK_KEX2_1	918	920	PF00082	0.534
CLV_PCSK_SKI1_1	151	155	PF00082	0.505
CLV_PCSK_SKI1_1	208	212	PF00082	0.642
CLV_PCSK_SKI1_1	334	338	PF00082	0.631
CLV_PCSK_SKI1_1	394	398	PF00082	0.541
CLV_PCSK_SKI1_1	486	490	PF00082	0.545
CLV_PCSK_SKI1_1	873	877	PF00082	0.514
CLV_PCSK_SKI1_1	91	95	PF00082	0.365
CLV_Separin_Metazoa	522	526	PF03568	0.327
DEG_COP1_1	395	403	PF00400	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DOC_CKS1_1	51	56	PF01111	0.575
DOC_CKS1_1	582	587	PF01111	0.423
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.564
DOC_MAPK_gen_1	262	271	PF00069	0.468
DOC_MAPK_gen_1	334	342	PF00069	0.413
DOC_MAPK_gen_1	36	45	PF00069	0.570
DOC_MAPK_gen_1	502	509	PF00069	0.357
DOC_MAPK_gen_1	711	720	PF00069	0.406
DOC_MAPK_gen_1	851	860	PF00069	0.369
DOC_MAPK_MEF2A_6	334	342	PF00069	0.413
DOC_MAPK_MEF2A_6	371	379	PF00069	0.338
DOC_PP2B_LxvP_1	214	217	PF13499	0.539
DOC_PP4_FxxP_1	552	555	PF00568	0.344
DOC_PP4_FxxP_1	582	585	PF00568	0.554
DOC_PP4_FxxP_1	636	639	PF00568	0.336
DOC_PP4_FxxP_1	78	81	PF00568	0.594
DOC_USP7_MATH_1	184	188	PF00917	0.526
DOC_USP7_MATH_1	191	195	PF00917	0.499
DOC_USP7_MATH_1	248	252	PF00917	0.511
DOC_USP7_MATH_1	437	441	PF00917	0.464
DOC_USP7_MATH_1	555	559	PF00917	0.424
DOC_USP7_MATH_1	655	659	PF00917	0.431
DOC_USP7_UBL2_3	840	844	PF12436	0.336
DOC_WW_Pin1_4	201	206	PF00397	0.558
DOC_WW_Pin1_4	447	452	PF00397	0.341
DOC_WW_Pin1_4	50	55	PF00397	0.578
DOC_WW_Pin1_4	512	517	PF00397	0.432
DOC_WW_Pin1_4	550	555	PF00397	0.491
DOC_WW_Pin1_4	581	586	PF00397	0.475
DOC_WW_Pin1_4	861	866	PF00397	0.334
LIG_14-3-3_CanoR_1	144	152	PF00244	0.717
LIG_14-3-3_CanoR_1	459	466	PF00244	0.303
LIG_14-3-3_CanoR_1	731	735	PF00244	0.420
LIG_14-3-3_CanoR_1	774	778	PF00244	0.357
LIG_14-3-3_CanoR_1	830	836	PF00244	0.314
LIG_14-3-3_CanoR_1	838	844	PF00244	0.335
LIG_Actin_WH2_2	637	654	PF00022	0.386
LIG_Actin_WH2_2	760	776	PF00022	0.303
LIG_BIR_III_4	616	620	PF00653	0.468
LIG_BIR_III_4	682	686	PF00653	0.448
LIG_BRCT_BRCA1_1	432	436	PF00533	0.272
LIG_BRCT_BRCA1_1	548	552	PF00533	0.327
LIG_BRCT_BRCA1_1	565	569	PF00533	0.396
LIG_BRCT_BRCA1_1	85	89	PF00533	0.565
LIG_CSL_BTD_1	340	343	PF09270	0.392
LIG_deltaCOP1_diTrp_1	543	552	PF00928	0.312
LIG_FHA_1	209	215	PF00498	0.452
LIG_FHA_1	230	236	PF00498	0.547
LIG_FHA_1	255	261	PF00498	0.460
LIG_FHA_1	359	365	PF00498	0.480
LIG_FHA_1	385	391	PF00498	0.372
LIG_FHA_1	395	401	PF00498	0.406
LIG_FHA_1	441	447	PF00498	0.376
LIG_FHA_1	690	696	PF00498	0.389
LIG_FHA_1	786	792	PF00498	0.344
LIG_FHA_2	238	244	PF00498	0.476
LIG_FHA_2	271	277	PF00498	0.445
LIG_FHA_2	365	371	PF00498	0.427
LIG_FHA_2	397	403	PF00498	0.392
LIG_FHA_2	479	485	PF00498	0.333
LIG_FHA_2	582	588	PF00498	0.433
LIG_FHA_2	896	902	PF00498	0.272
LIG_Integrin_RGD_1	112	114	PF01839	0.454
LIG_LIR_Apic_2	347	351	PF02991	0.425
LIG_LIR_Apic_2	443	447	PF02991	0.371
LIG_LIR_Apic_2	549	555	PF02991	0.339
LIG_LIR_Apic_2	579	585	PF02991	0.537
LIG_LIR_Apic_2	77	81	PF02991	0.593
LIG_LIR_Gen_1	176	186	PF02991	0.684
LIG_LIR_Gen_1	410	417	PF02991	0.384
LIG_LIR_Gen_1	474	485	PF02991	0.342
LIG_LIR_Gen_1	592	601	PF02991	0.385
LIG_LIR_Gen_1	62	72	PF02991	0.583
LIG_LIR_Gen_1	891	902	PF02991	0.302
LIG_LIR_Nem_3	410	416	PF02991	0.380
LIG_LIR_Nem_3	474	480	PF02991	0.309
LIG_LIR_Nem_3	505	509	PF02991	0.373
LIG_LIR_Nem_3	592	597	PF02991	0.421
LIG_LIR_Nem_3	62	68	PF02991	0.589
LIG_LIR_Nem_3	645	651	PF02991	0.392
LIG_LIR_Nem_3	738	744	PF02991	0.400
LIG_LIR_Nem_3	764	769	PF02991	0.350
LIG_LIR_Nem_3	77	83	PF02991	0.575
LIG_LIR_Nem_3	788	793	PF02991	0.344
LIG_LIR_Nem_3	864	870	PF02991	0.366
LIG_LIR_Nem_3	891	897	PF02991	0.346
LIG_LIR_Nem_3	935	941	PF02991	0.406
LIG_MYND_1	512	516	PF01753	0.418
LIG_NRBOX	426	432	PF00104	0.322
LIG_NRBOX	646	652	PF00104	0.383
LIG_PCNA_yPIPBox_3	521	534	PF02747	0.373
LIG_PCNA_yPIPBox_3	872	885	PF02747	0.291
LIG_PTB_Apo_2	874	881	PF02174	0.336
LIG_PTB_Phospho_1	874	880	PF10480	0.332
LIG_SH2_CRK	477	481	PF00017	0.325
LIG_SH2_CRK	506	510	PF00017	0.342
LIG_SH2_CRK	868	872	PF00017	0.350
LIG_SH2_CRK	938	942	PF00017	0.316
LIG_SH2_PTP2	444	447	PF00017	0.324
LIG_SH2_PTP2	894	897	PF00017	0.313
LIG_SH2_SRC	880	883	PF00017	0.337
LIG_SH2_SRC	933	936	PF00017	0.354
LIG_SH2_STAP1	665	669	PF00017	0.414
LIG_SH2_STAP1	769	773	PF00017	0.389
LIG_SH2_STAT3	793	796	PF00017	0.392
LIG_SH2_STAT5	172	175	PF00017	0.339
LIG_SH2_STAT5	237	240	PF00017	0.405
LIG_SH2_STAT5	358	361	PF00017	0.443
LIG_SH2_STAT5	444	447	PF00017	0.389
LIG_SH2_STAT5	457	460	PF00017	0.376
LIG_SH2_STAT5	477	480	PF00017	0.200
LIG_SH2_STAT5	635	638	PF00017	0.349
LIG_SH2_STAT5	732	735	PF00017	0.397
LIG_SH2_STAT5	766	769	PF00017	0.351
LIG_SH2_STAT5	785	788	PF00017	0.399
LIG_SH2_STAT5	790	793	PF00017	0.390
LIG_SH2_STAT5	894	897	PF00017	0.313
LIG_SH2_STAT5	933	936	PF00017	0.377
LIG_SH2_STAT5	938	941	PF00017	0.344
LIG_SH3_2	152	157	PF14604	0.606
LIG_SH3_3	149	155	PF00018	0.625
LIG_SH3_3	178	184	PF00018	0.501
LIG_SH3_3	302	308	PF00018	0.442
LIG_SH3_3	337	343	PF00018	0.474
LIG_SH3_3	370	376	PF00018	0.436
LIG_SH3_3	46	52	PF00018	0.578
LIG_SH3_3	506	512	PF00018	0.401
LIG_SH3_3	526	532	PF00018	0.373
LIG_SH3_4	9	16	PF00018	0.620
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.325
LIG_SUMO_SIM_anti_2	267	274	PF11976	0.459
LIG_SUMO_SIM_par_1	375	380	PF11976	0.347
LIG_TRAF2_1	240	243	PF00917	0.486
LIG_TRAF2_1	265	268	PF00917	0.529
LIG_TRAF2_1	274	277	PF00917	0.355
LIG_TRAF2_1	293	296	PF00917	0.303
LIG_TYR_ITIM	504	509	PF00017	0.440
LIG_TYR_ITIM	892	897	PF00017	0.432
LIG_WRC_WIRS_1	446	451	PF05994	0.466
LIG_WRC_WIRS_1	934	939	PF05994	0.426
MOD_CDK_SPxxK_3	201	208	PF00069	0.615
MOD_CDK_SPxxK_3	550	557	PF00069	0.426
MOD_CK1_1	166	172	PF00069	0.403
MOD_CK1_1	315	321	PF00069	0.696
MOD_CK1_1	383	389	PF00069	0.466
MOD_CK1_1	440	446	PF00069	0.558
MOD_CK1_1	746	752	PF00069	0.451
MOD_CK1_1	753	759	PF00069	0.382
MOD_CK1_1	910	916	PF00069	0.402
MOD_CK1_1	936	942	PF00069	0.395
MOD_CK2_1	127	133	PF00069	0.557
MOD_CK2_1	191	197	PF00069	0.767
MOD_CK2_1	237	243	PF00069	0.585
MOD_CK2_1	248	254	PF00069	0.517
MOD_CK2_1	262	268	PF00069	0.684
MOD_CK2_1	270	276	PF00069	0.471
MOD_CK2_1	396	402	PF00069	0.473
MOD_CK2_1	478	484	PF00069	0.402
MOD_CK2_1	581	587	PF00069	0.494
MOD_CK2_1	746	752	PF00069	0.508
MOD_CK2_1	758	764	PF00069	0.340
MOD_CK2_1	895	901	PF00069	0.307
MOD_Cter_Amidation	34	37	PF01082	0.477
MOD_DYRK1A_RPxSP_1	550	554	PF00069	0.482
MOD_GlcNHglycan	16	20	PF01048	0.524
MOD_GlcNHglycan	193	196	PF01048	0.748
MOD_GlcNHglycan	273	276	PF01048	0.480
MOD_GlcNHglycan	314	317	PF01048	0.659
MOD_GlcNHglycan	460	463	PF01048	0.326
MOD_GlcNHglycan	629	632	PF01048	0.417
MOD_GlcNHglycan	653	656	PF01048	0.428
MOD_GlcNHglycan	657	660	PF01048	0.390
MOD_GlcNHglycan	667	670	PF01048	0.351
MOD_GlcNHglycan	760	763	PF01048	0.418
MOD_GlcNHglycan	794	799	PF01048	0.527
MOD_GSK3_1	1	8	PF00069	0.515
MOD_GSK3_1	115	122	PF00069	0.547
MOD_GSK3_1	191	198	PF00069	0.720
MOD_GSK3_1	375	382	PF00069	0.424
MOD_GSK3_1	407	414	PF00069	0.400
MOD_GSK3_1	546	553	PF00069	0.531
MOD_GSK3_1	55	62	PF00069	0.469
MOD_GSK3_1	651	658	PF00069	0.401
MOD_GSK3_1	673	680	PF00069	0.538
MOD_GSK3_1	730	737	PF00069	0.566
MOD_GSK3_1	743	750	PF00069	0.377
MOD_GSK3_1	773	780	PF00069	0.493
MOD_GSK3_1	906	913	PF00069	0.353
MOD_LATS_1	3	9	PF00433	0.516
MOD_N-GLC_1	135	140	PF02516	0.568
MOD_N-GLC_1	195	200	PF02516	0.626
MOD_N-GLC_1	254	259	PF02516	0.518
MOD_N-GLC_1	298	303	PF02516	0.648
MOD_N-GLC_1	440	445	PF02516	0.393
MOD_N-GLC_1	821	826	PF02516	0.493
MOD_NEK2_1	1	6	PF00069	0.512
MOD_NEK2_1	119	124	PF00069	0.639
MOD_NEK2_1	173	178	PF00069	0.400
MOD_NEK2_1	430	435	PF00069	0.398
MOD_NEK2_1	546	551	PF00069	0.440
MOD_NEK2_1	599	604	PF00069	0.485
MOD_NEK2_1	63	68	PF00069	0.527
MOD_NEK2_1	689	694	PF00069	0.455
MOD_NEK2_1	720	725	PF00069	0.514
MOD_NEK2_1	773	778	PF00069	0.599
MOD_NEK2_1	89	94	PF00069	0.455
MOD_NEK2_2	933	938	PF00069	0.426
MOD_OFUCOSY	160	167	PF10250	0.271
MOD_PIKK_1	137	143	PF00454	0.572
MOD_PIKK_1	235	241	PF00454	0.483
MOD_PK_1	563	569	PF00069	0.461
MOD_PKA_1	262	268	PF00069	0.519
MOD_PKA_2	143	149	PF00069	0.665
MOD_PKA_2	312	318	PF00069	0.634
MOD_PKA_2	364	370	PF00069	0.578
MOD_PKA_2	437	443	PF00069	0.542
MOD_PKA_2	458	464	PF00069	0.332
MOD_PKA_2	569	575	PF00069	0.436
MOD_PKA_2	651	657	PF00069	0.443
MOD_PKA_2	689	695	PF00069	0.617
MOD_PKA_2	730	736	PF00069	0.501
MOD_PKA_2	773	779	PF00069	0.529
MOD_PKA_2	83	89	PF00069	0.446
MOD_PKB_1	707	715	PF00069	0.544
MOD_Plk_1	254	260	PF00069	0.528
MOD_Plk_1	298	304	PF00069	0.498
MOD_Plk_1	440	446	PF00069	0.393
MOD_Plk_1	642	648	PF00069	0.417
MOD_Plk_1	753	759	PF00069	0.409
MOD_Plk_2-3	730	736	PF00069	0.501
MOD_Plk_4	384	390	PF00069	0.481
MOD_Plk_4	541	547	PF00069	0.407
MOD_Plk_4	563	569	PF00069	0.481
MOD_Plk_4	59	65	PF00069	0.472
MOD_Plk_4	743	749	PF00069	0.471
MOD_Plk_4	786	792	PF00069	0.355
MOD_Plk_4	933	939	PF00069	0.431
MOD_ProDKin_1	201	207	PF00069	0.710
MOD_ProDKin_1	447	453	PF00069	0.415
MOD_ProDKin_1	50	56	PF00069	0.458
MOD_ProDKin_1	512	518	PF00069	0.529
MOD_ProDKin_1	550	556	PF00069	0.623
MOD_ProDKin_1	581	587	PF00069	0.589
MOD_ProDKin_1	861	867	PF00069	0.387
TRG_DiLeu_BaEn_4	267	273	PF01217	0.564
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.533
TRG_ENDOCYTIC_2	477	480	PF00928	0.319
TRG_ENDOCYTIC_2	506	509	PF00928	0.464
TRG_ENDOCYTIC_2	867	870	PF00928	0.527
TRG_ENDOCYTIC_2	894	897	PF00928	0.473
TRG_ENDOCYTIC_2	938	941	PF00928	0.436
TRG_ER_diArg_1	150	152	PF00400	0.607
TRG_ER_diArg_1	155	157	PF00400	0.508
TRG_ER_diArg_1	24	27	PF00400	0.492
TRG_ER_diArg_1	471	473	PF00400	0.431
TRG_ER_diArg_1	501	503	PF00400	0.546
TRG_ER_diArg_1	524	526	PF00400	0.461
TRG_ER_diArg_1	828	830	PF00400	0.676
TRG_ER_diArg_1	917	919	PF00400	0.390
TRG_NES_CRM1_1	491	505	PF08389	0.410
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW42	Leptomonas seymouri	31%	100%
A0A0N1P9X3	Leptomonas seymouri	42%	100%
A0A3Q8IMZ0	Leishmania donovani	33%	100%
A4HRS2	Leishmania infantum	88%	100%
A4I9M1	Leishmania infantum	33%	100%
E9AC93	Leishmania major	100%	100%
E9B4M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q3F6	Leishmania major	33%	100%