LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase
Gene product:
phosphoglycan beta 1,3 galactosyltransferase
Species:
Leishmania major
UniProt:
E9AC95_LEIMA
TriTrypDb:
LmjF.02.0200 * , LMJLV39_000020000 * , LMJSD75_020006900 *
Length:
773

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 14
GO:0016020 membrane 2 54
GO:0031090 organelle membrane 3 14
GO:0098588 bounding membrane of organelle 4 14
GO:0110165 cellular anatomical entity 1 54

Expansion

Sequence features

E9AC95
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC95

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 54
GO:0006807 nitrogen compound metabolic process 2 54
GO:0008152 metabolic process 1 54
GO:0019538 protein metabolic process 3 54
GO:0036211 protein modification process 4 54
GO:0043170 macromolecule metabolic process 3 54
GO:0043412 macromolecule modification 4 54
GO:0043413 macromolecule glycosylation 3 54
GO:0044238 primary metabolic process 2 54
GO:0070085 glycosylation 2 54
GO:0071704 organic substance metabolic process 2 54
GO:1901564 organonitrogen compound metabolic process 3 54
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 54
GO:0008194 UDP-glycosyltransferase activity 4 14
GO:0016740 transferase activity 2 54
GO:0016757 glycosyltransferase activity 3 54
GO:0016758 hexosyltransferase activity 4 54

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.515
CLV_NRD_NRD_1 15 17 PF00675 0.535
CLV_NRD_NRD_1 208 210 PF00675 0.567
CLV_NRD_NRD_1 233 235 PF00675 0.580
CLV_NRD_NRD_1 332 334 PF00675 0.710
CLV_NRD_NRD_1 416 418 PF00675 0.714
CLV_NRD_NRD_1 566 568 PF00675 0.601
CLV_NRD_NRD_1 595 597 PF00675 0.532
CLV_NRD_NRD_1 601 603 PF00675 0.533
CLV_NRD_NRD_1 734 736 PF00675 0.552
CLV_NRD_NRD_1 87 89 PF00675 0.594
CLV_PCSK_KEX2_1 10 12 PF00082 0.520
CLV_PCSK_KEX2_1 17 19 PF00082 0.541
CLV_PCSK_KEX2_1 208 210 PF00082 0.569
CLV_PCSK_KEX2_1 233 235 PF00082 0.583
CLV_PCSK_KEX2_1 293 295 PF00082 0.604
CLV_PCSK_KEX2_1 331 333 PF00082 0.714
CLV_PCSK_KEX2_1 416 418 PF00082 0.643
CLV_PCSK_KEX2_1 44 46 PF00082 0.647
CLV_PCSK_KEX2_1 566 568 PF00082 0.589
CLV_PCSK_KEX2_1 595 597 PF00082 0.536
CLV_PCSK_KEX2_1 601 603 PF00082 0.533
CLV_PCSK_KEX2_1 734 736 PF00082 0.590
CLV_PCSK_KEX2_1 87 89 PF00082 0.594
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.487
CLV_PCSK_PC1ET2_1 293 295 PF00082 0.564
CLV_PCSK_PC1ET2_1 44 46 PF00082 0.623
CLV_PCSK_PC7_1 229 235 PF00082 0.555
CLV_PCSK_PC7_1 7 13 PF00082 0.475
CLV_PCSK_PC7_1 730 736 PF00082 0.562
CLV_PCSK_SKI1_1 225 229 PF00082 0.607
CLV_PCSK_SKI1_1 298 302 PF00082 0.563
CLV_PCSK_SKI1_1 333 337 PF00082 0.629
CLV_PCSK_SKI1_1 41 45 PF00082 0.602
CLV_PCSK_SKI1_1 441 445 PF00082 0.621
CLV_PCSK_SKI1_1 508 512 PF00082 0.643
CLV_PCSK_SKI1_1 602 606 PF00082 0.519
CLV_PCSK_SKI1_1 687 691 PF00082 0.593
CLV_PCSK_SKI1_1 704 708 PF00082 0.537
CLV_Separin_Metazoa 280 284 PF03568 0.476
DEG_APCC_DBOX_1 208 216 PF00400 0.329
DEG_APCC_DBOX_1 578 586 PF00400 0.349
DEG_Nend_UBRbox_1 1 4 PF02207 0.632
DEG_SCF_FBW7_1 377 384 PF00400 0.517
DOC_CKS1_1 268 273 PF01111 0.476
DOC_CKS1_1 378 383 PF01111 0.527
DOC_CYCLIN_yCln2_LP_2 375 381 PF00134 0.555
DOC_CYCLIN_yCln2_LP_2 61 67 PF00134 0.420
DOC_MAPK_gen_1 16 24 PF00069 0.730
DOC_MAPK_gen_1 208 214 PF00069 0.421
DOC_MAPK_gen_1 576 584 PF00069 0.385
DOC_MAPK_gen_1 90 99 PF00069 0.395
DOC_MAPK_JIP1_4 18 24 PF00069 0.627
DOC_MAPK_MEF2A_6 159 167 PF00069 0.384
DOC_MAPK_MEF2A_6 17 26 PF00069 0.742
DOC_MAPK_MEF2A_6 405 412 PF00069 0.470
DOC_MAPK_MEF2A_6 429 438 PF00069 0.364
DOC_MAPK_MEF2A_6 581 589 PF00069 0.345
DOC_MAPK_MEF2A_6 90 99 PF00069 0.414
DOC_PP1_RVXF_1 403 410 PF00149 0.368
DOC_PP1_RVXF_1 439 446 PF00149 0.464
DOC_PP1_RVXF_1 599 606 PF00149 0.296
DOC_PP2B_LxvP_1 375 378 PF13499 0.549
DOC_PP2B_LxvP_1 531 534 PF13499 0.436
DOC_PP4_FxxP_1 383 386 PF00568 0.395
DOC_USP7_MATH_1 151 155 PF00917 0.534
DOC_USP7_MATH_1 166 170 PF00917 0.394
DOC_USP7_MATH_1 264 268 PF00917 0.466
DOC_USP7_MATH_1 316 320 PF00917 0.445
DOC_USP7_MATH_1 335 339 PF00917 0.341
DOC_USP7_MATH_1 575 579 PF00917 0.408
DOC_USP7_MATH_1 665 669 PF00917 0.281
DOC_WW_Pin1_4 106 111 PF00397 0.367
DOC_WW_Pin1_4 267 272 PF00397 0.493
DOC_WW_Pin1_4 345 350 PF00397 0.524
DOC_WW_Pin1_4 362 367 PF00397 0.454
DOC_WW_Pin1_4 377 382 PF00397 0.494
DOC_WW_Pin1_4 525 530 PF00397 0.428
LIG_14-3-3_CanoR_1 131 138 PF00244 0.456
LIG_14-3-3_CanoR_1 233 237 PF00244 0.507
LIG_14-3-3_CanoR_1 337 341 PF00244 0.388
LIG_14-3-3_CanoR_1 487 492 PF00244 0.480
LIG_14-3-3_CanoR_1 595 603 PF00244 0.354
LIG_14-3-3_CanoR_1 60 64 PF00244 0.465
LIG_14-3-3_CanoR_1 704 713 PF00244 0.360
LIG_14-3-3_CanoR_1 735 741 PF00244 0.380
LIG_14-3-3_CanoR_1 77 83 PF00244 0.436
LIG_Actin_WH2_2 173 189 PF00022 0.406
LIG_Actin_WH2_2 29 46 PF00022 0.249
LIG_Actin_WH2_2 322 339 PF00022 0.360
LIG_BIR_III_4 73 77 PF00653 0.373
LIG_CaM_IQ_9 696 712 PF13499 0.312
LIG_deltaCOP1_diTrp_1 637 642 PF00928 0.290
LIG_eIF4E_1 29 35 PF01652 0.275
LIG_eIF4E_1 296 302 PF01652 0.331
LIG_FHA_1 115 121 PF00498 0.536
LIG_FHA_1 169 175 PF00498 0.532
LIG_FHA_1 363 369 PF00498 0.448
LIG_FHA_1 509 515 PF00498 0.491
LIG_FHA_1 526 532 PF00498 0.434
LIG_FHA_1 648 654 PF00498 0.336
LIG_FHA_1 78 84 PF00498 0.407
LIG_FHA_2 236 242 PF00498 0.455
LIG_FHA_2 275 281 PF00498 0.484
LIG_FHA_2 688 694 PF00498 0.372
LIG_FHA_2 737 743 PF00498 0.390
LIG_Integrin_isoDGR_2 629 631 PF01839 0.514
LIG_LIR_Apic_2 380 386 PF02991 0.407
LIG_LIR_Apic_2 427 433 PF02991 0.481
LIG_LIR_Gen_1 238 243 PF02991 0.370
LIG_LIR_Gen_1 447 458 PF02991 0.388
LIG_LIR_Gen_1 464 474 PF02991 0.395
LIG_LIR_Gen_1 522 531 PF02991 0.440
LIG_LIR_Gen_1 62 69 PF02991 0.504
LIG_LIR_Gen_1 637 647 PF02991 0.387
LIG_LIR_Gen_1 654 660 PF02991 0.405
LIG_LIR_Nem_3 192 197 PF02991 0.399
LIG_LIR_Nem_3 235 239 PF02991 0.508
LIG_LIR_Nem_3 447 453 PF02991 0.436
LIG_LIR_Nem_3 464 470 PF02991 0.357
LIG_LIR_Nem_3 522 527 PF02991 0.444
LIG_LIR_Nem_3 597 603 PF02991 0.434
LIG_LIR_Nem_3 62 68 PF02991 0.507
LIG_LIR_Nem_3 637 642 PF02991 0.378
LIG_LIR_Nem_3 654 658 PF02991 0.407
LIG_LIR_Nem_3 667 673 PF02991 0.323
LIG_LIR_Nem_3 717 723 PF02991 0.364
LIG_LIR_Nem_3 765 770 PF02991 0.341
LIG_NRBOX 29 35 PF00104 0.313
LIG_Pex14_1 638 642 PF04695 0.293
LIG_PTB_Apo_2 452 459 PF02174 0.289
LIG_RPA_C_Fungi 561 573 PF08784 0.331
LIG_RPA_C_Fungi 591 603 PF08784 0.334
LIG_SH2_CRK 494 498 PF00017 0.511
LIG_SH2_CRK 524 528 PF00017 0.541
LIG_SH2_CRK 600 604 PF00017 0.380
LIG_SH2_CRK 617 621 PF00017 0.315
LIG_SH2_CRK 767 771 PF00017 0.405
LIG_SH2_GRB2like 524 527 PF00017 0.518
LIG_SH2_GRB2like 749 752 PF00017 0.389
LIG_SH2_NCK_1 524 528 PF00017 0.509
LIG_SH2_PTP2 467 470 PF00017 0.392
LIG_SH2_SRC 239 242 PF00017 0.454
LIG_SH2_SRC 448 451 PF00017 0.460
LIG_SH2_SRC 524 527 PF00017 0.518
LIG_SH2_STAP1 448 452 PF00017 0.587
LIG_SH2_STAP1 749 753 PF00017 0.503
LIG_SH2_STAT5 211 214 PF00017 0.498
LIG_SH2_STAT5 257 260 PF00017 0.533
LIG_SH2_STAT5 29 32 PF00017 0.299
LIG_SH2_STAT5 370 373 PF00017 0.480
LIG_SH2_STAT5 389 392 PF00017 0.406
LIG_SH2_STAT5 467 470 PF00017 0.430
LIG_SH2_STAT5 479 482 PF00017 0.483
LIG_SH2_STAT5 634 637 PF00017 0.439
LIG_SH2_STAT5 670 673 PF00017 0.589
LIG_SH2_STAT5 674 677 PF00017 0.511
LIG_SH3_3 204 210 PF00018 0.566
LIG_SH3_3 343 349 PF00018 0.410
LIG_SH3_3 375 381 PF00018 0.647
LIG_SH3_3 465 471 PF00018 0.402
LIG_Sin3_3 20 27 PF02671 0.244
LIG_SUMO_SIM_anti_2 31 37 PF11976 0.304
LIG_TRAF2_1 238 241 PF00917 0.461
LIG_TRAF2_1 689 692 PF00917 0.433
LIG_TYR_ITIM 237 242 PF00017 0.594
LIG_UBA3_1 39 44 PF00899 0.449
MOD_CDK_SPxxK_3 345 352 PF00069 0.358
MOD_CDK_SPxxK_3 525 532 PF00069 0.505
MOD_CK1_1 267 273 PF00069 0.731
MOD_CK2_1 235 241 PF00069 0.540
MOD_CK2_1 274 280 PF00069 0.603
MOD_CK2_1 382 388 PF00069 0.467
MOD_CK2_1 532 538 PF00069 0.449
MOD_CK2_1 687 693 PF00069 0.513
MOD_CK2_1 736 742 PF00069 0.422
MOD_GlcNHglycan 135 138 PF01048 0.633
MOD_GlcNHglycan 153 156 PF01048 0.655
MOD_GlcNHglycan 290 293 PF01048 0.461
MOD_GlcNHglycan 298 301 PF01048 0.451
MOD_GlcNHglycan 318 321 PF01048 0.504
MOD_GlcNHglycan 371 374 PF01048 0.554
MOD_GlcNHglycan 394 397 PF01048 0.588
MOD_GlcNHglycan 497 500 PF01048 0.530
MOD_GlcNHglycan 720 723 PF01048 0.410
MOD_GSK3_1 102 109 PF00069 0.492
MOD_GSK3_1 126 133 PF00069 0.577
MOD_GSK3_1 269 276 PF00069 0.745
MOD_GSK3_1 369 376 PF00069 0.537
MOD_GSK3_1 377 384 PF00069 0.484
MOD_GSK3_1 43 50 PF00069 0.544
MOD_GSK3_1 483 490 PF00069 0.446
MOD_GSK3_1 647 654 PF00069 0.449
MOD_GSK3_1 714 721 PF00069 0.411
MOD_GSK3_1 754 761 PF00069 0.364
MOD_N-GLC_1 102 107 PF02516 0.440
MOD_N-GLC_1 296 301 PF02516 0.398
MOD_N-GLC_1 303 308 PF02516 0.377
MOD_N-GLC_1 525 530 PF02516 0.507
MOD_N-GLC_1 651 656 PF02516 0.378
MOD_N-GLC_1 718 723 PF02516 0.438
MOD_N-GLC_1 730 735 PF02516 0.431
MOD_NEK2_1 165 170 PF00069 0.445
MOD_NEK2_1 249 254 PF00069 0.303
MOD_NEK2_1 28 33 PF00069 0.391
MOD_NEK2_1 3 8 PF00069 0.575
MOD_NEK2_1 336 341 PF00069 0.379
MOD_NEK2_1 369 374 PF00069 0.367
MOD_NEK2_1 43 48 PF00069 0.504
MOD_NEK2_1 481 486 PF00069 0.471
MOD_NEK2_1 714 719 PF00069 0.439
MOD_NEK2_2 114 119 PF00069 0.668
MOD_NEK2_2 544 549 PF00069 0.340
MOD_PIKK_1 309 315 PF00454 0.427
MOD_PIKK_1 436 442 PF00454 0.577
MOD_PIKK_1 481 487 PF00454 0.404
MOD_PIKK_1 551 557 PF00454 0.343
MOD_PKA_1 416 422 PF00069 0.647
MOD_PKA_2 130 136 PF00069 0.579
MOD_PKA_2 232 238 PF00069 0.620
MOD_PKA_2 336 342 PF00069 0.433
MOD_PKA_2 416 422 PF00069 0.596
MOD_PKA_2 59 65 PF00069 0.548
MOD_PKA_2 594 600 PF00069 0.373
MOD_PKA_2 663 669 PF00069 0.316
MOD_PKA_2 76 82 PF00069 0.517
MOD_Plk_1 102 108 PF00069 0.430
MOD_Plk_1 249 255 PF00069 0.283
MOD_Plk_1 296 302 PF00069 0.391
MOD_Plk_1 3 9 PF00069 0.506
MOD_Plk_1 463 469 PF00069 0.403
MOD_Plk_1 651 657 PF00069 0.444
MOD_Plk_4 102 108 PF00069 0.485
MOD_Plk_4 249 255 PF00069 0.319
MOD_Plk_4 463 469 PF00069 0.403
MOD_Plk_4 532 538 PF00069 0.406
MOD_Plk_4 558 564 PF00069 0.373
MOD_Plk_4 654 660 PF00069 0.554
MOD_Plk_4 665 671 PF00069 0.382
MOD_ProDKin_1 106 112 PF00069 0.419
MOD_ProDKin_1 267 273 PF00069 0.602
MOD_ProDKin_1 345 351 PF00069 0.641
MOD_ProDKin_1 362 368 PF00069 0.536
MOD_ProDKin_1 377 383 PF00069 0.596
MOD_ProDKin_1 525 531 PF00069 0.506
TRG_ENDOCYTIC_2 211 214 PF00928 0.498
TRG_ENDOCYTIC_2 239 242 PF00928 0.640
TRG_ENDOCYTIC_2 450 453 PF00928 0.602
TRG_ENDOCYTIC_2 467 470 PF00928 0.299
TRG_ENDOCYTIC_2 494 497 PF00928 0.515
TRG_ENDOCYTIC_2 524 527 PF00928 0.547
TRG_ENDOCYTIC_2 600 603 PF00928 0.523
TRG_ENDOCYTIC_2 617 620 PF00928 0.333
TRG_ENDOCYTIC_2 639 642 PF00928 0.349
TRG_ENDOCYTIC_2 767 770 PF00928 0.378
TRG_ER_diArg_1 15 18 PF00400 0.640
TRG_ER_diArg_1 207 209 PF00400 0.439
TRG_ER_diArg_1 331 333 PF00400 0.626
TRG_ER_diArg_1 416 418 PF00400 0.503
TRG_ER_diArg_1 566 568 PF00400 0.442
TRG_ER_diArg_1 579 582 PF00400 0.486
TRG_ER_diArg_1 600 602 PF00400 0.372
TRG_ER_diArg_1 662 665 PF00400 0.360
TRG_ER_diArg_1 734 736 PF00400 0.399
TRG_ER_diArg_1 87 90 PF00400 0.476
TRG_ER_diArg_1 9 12 PF00400 0.621
TRG_NLS_MonoExtN_4 15 20 PF00514 0.507
TRG_Pf-PMV_PEXEL_1 422 426 PF00026 0.458
TRG_Pf-PMV_PEXEL_1 768 772 PF00026 0.383
TRG_Pf-PMV_PEXEL_1 81 85 PF00026 0.451

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 37% 95%
A0A3S5H4Y6 Leishmania donovani 64% 96%
A0A3S5H4Y9 Leishmania donovani 34% 78%
A0A3S7WT86 Leishmania donovani 40% 75%
A0A3S7WWA6 Leishmania donovani 37% 95%
A0A451EJD9 Leishmania donovani 38% 95%
A0A451EJF4 Leishmania donovani 60% 95%
A0A451EJF6 Leishmania donovani 60% 100%
A0A451EJF8 Leishmania donovani 90% 100%
A0A451EJF9 Leishmania donovani 54% 90%
A4H3A9 Leishmania braziliensis 54% 100%
A4H3B4 Leishmania braziliensis 54% 95%
A4H3B5 Leishmania braziliensis 51% 100%
A4H3B6 Leishmania braziliensis 56% 100%
A4H3B7 Leishmania braziliensis 46% 72%
A4H3B8 Leishmania braziliensis 66% 93%
A4H3B9 Leishmania braziliensis 38% 87%
A4H4W8 Leishmania braziliensis 35% 95%
A4HJ20 Leishmania braziliensis 55% 95%
A4HNK3 Leishmania braziliensis 38% 100%
A4HNK6 Leishmania braziliensis 37% 98%
A4HRL9 Leishmania infantum 60% 95%
A4HRM0 Leishmania infantum 71% 100%
A4HRM1 Leishmania infantum 61% 100%
A4HRS1 Leishmania infantum 54% 90%
A4HRS3 Leishmania infantum 33% 78%
A4HRS5 Leishmania infantum 91% 100%
A4HZM0 Leishmania infantum 37% 95%
A4I7C7 Leishmania infantum 38% 95%
A4IAQ2 Leishmania infantum 37% 95%
E9AC91 Leishmania major 60% 100%
E9AC92 Leishmania major 56% 100%
E9AC96 Leishmania major 57% 90%
E9AC98 Leishmania major 34% 78%
E9AEH8 Leishmania major 39% 95%
E9AHA6 Leishmania infantum 37% 95%
E9AIP8 Leishmania braziliensis 36% 98%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 94%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 97%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 78%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 95%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 95%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 95%
Q4Q5T6 Leishmania major 39% 95%
Q4QCL8 Leishmania major 39% 95%
Q4QFJ3 Leishmania major 40% 75%
Q4QIG9 Leishmania major 38% 95%
Q7YXU9 Leishmania major 37% 95%
Q7YXV1 Leishmania major 38% 91%
Q7YXV2 Leishmania major 39% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS