Phosphoglycan beta 1,2 arabinosyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycan beta 1,2 arabinosyltransferase

Species:

Leishmania major

UniProt:

E9AC93_LEIMA

TriTrypDb:

LmjF.02.0180 , LMJLV39_020006900 , LMJLV39_020007000 , LMJSD75_020007100

Length:

942

Annotations

LeishMANIAdb annotations

A signal-anchored enzyme family expanded in Leishmaniids. Any identification as glycosyltransferase is highly tentative.. Localization: Golgi (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005796	Golgi lumen	5	3
GO:0016020	membrane	2	8
GO:0031974	membrane-enclosed lumen	2	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AC93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC93

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	3
GO:0005996	monosaccharide metabolic process	3	3
GO:0006012	galactose metabolic process	5	3
GO:0008152	metabolic process	1	3
GO:0019318	hexose metabolic process	4	3
GO:0044238	primary metabolic process	2	3
GO:0044281	small molecule metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008378	galactosyltransferase activity	5	3
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	3
GO:0016758	hexosyltransferase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	679	683	PF00656	0.435
CLV_NRD_NRD_1	104	106	PF00675	0.377
CLV_NRD_NRD_1	150	152	PF00675	0.489
CLV_NRD_NRD_1	156	158	PF00675	0.391
CLV_NRD_NRD_1	24	26	PF00675	0.410
CLV_NRD_NRD_1	261	263	PF00675	0.640
CLV_NRD_NRD_1	36	38	PF00675	0.375
CLV_NRD_NRD_1	472	474	PF00675	0.562
CLV_NRD_NRD_1	502	504	PF00675	0.655
CLV_NRD_NRD_1	525	527	PF00675	0.566
CLV_NRD_NRD_1	537	539	PF00675	0.672
CLV_NRD_NRD_1	829	831	PF00675	0.633
CLV_NRD_NRD_1	918	920	PF00675	0.533
CLV_PCSK_KEX2_1	104	106	PF00082	0.377
CLV_PCSK_KEX2_1	150	152	PF00082	0.532
CLV_PCSK_KEX2_1	156	158	PF00082	0.398
CLV_PCSK_KEX2_1	24	26	PF00082	0.410
CLV_PCSK_KEX2_1	36	38	PF00082	0.375
CLV_PCSK_KEX2_1	472	474	PF00082	0.562
CLV_PCSK_KEX2_1	502	504	PF00082	0.655
CLV_PCSK_KEX2_1	525	527	PF00082	0.566
CLV_PCSK_KEX2_1	829	831	PF00082	0.608
CLV_PCSK_KEX2_1	918	920	PF00082	0.533
CLV_PCSK_SKI1_1	151	155	PF00082	0.521
CLV_PCSK_SKI1_1	208	212	PF00082	0.648
CLV_PCSK_SKI1_1	334	338	PF00082	0.661
CLV_PCSK_SKI1_1	394	398	PF00082	0.527
CLV_PCSK_SKI1_1	486	490	PF00082	0.543
CLV_PCSK_SKI1_1	873	877	PF00082	0.540
CLV_PCSK_SKI1_1	91	95	PF00082	0.372
CLV_Separin_Metazoa	522	526	PF03568	0.332
DEG_COP1_1	395	403	PF00400	0.371
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DOC_CKS1_1	51	56	PF01111	0.585
DOC_CKS1_1	582	587	PF01111	0.410
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.577
DOC_MAPK_gen_1	262	271	PF00069	0.460
DOC_MAPK_gen_1	334	342	PF00069	0.458
DOC_MAPK_gen_1	36	45	PF00069	0.579
DOC_MAPK_gen_1	502	509	PF00069	0.350
DOC_MAPK_gen_1	711	720	PF00069	0.408
DOC_MAPK_gen_1	851	860	PF00069	0.361
DOC_MAPK_MEF2A_6	334	342	PF00069	0.458
DOC_MAPK_MEF2A_6	371	379	PF00069	0.338
DOC_PP2B_LxvP_1	214	217	PF13499	0.527
DOC_PP4_FxxP_1	552	555	PF00568	0.379
DOC_PP4_FxxP_1	582	585	PF00568	0.529
DOC_PP4_FxxP_1	636	639	PF00568	0.324
DOC_PP4_FxxP_1	78	81	PF00568	0.594
DOC_USP7_MATH_1	184	188	PF00917	0.529
DOC_USP7_MATH_1	191	195	PF00917	0.513
DOC_USP7_MATH_1	248	252	PF00917	0.503
DOC_USP7_MATH_1	437	441	PF00917	0.441
DOC_USP7_MATH_1	555	559	PF00917	0.460
DOC_USP7_MATH_1	655	659	PF00917	0.445
DOC_WW_Pin1_4	201	206	PF00397	0.558
DOC_WW_Pin1_4	447	452	PF00397	0.368
DOC_WW_Pin1_4	50	55	PF00397	0.589
DOC_WW_Pin1_4	512	517	PF00397	0.439
DOC_WW_Pin1_4	550	555	PF00397	0.439
DOC_WW_Pin1_4	581	586	PF00397	0.469
DOC_WW_Pin1_4	861	866	PF00397	0.331
LIG_14-3-3_CanoR_1	144	152	PF00244	0.705
LIG_14-3-3_CanoR_1	304	308	PF00244	0.444
LIG_14-3-3_CanoR_1	459	466	PF00244	0.347
LIG_14-3-3_CanoR_1	731	735	PF00244	0.448
LIG_14-3-3_CanoR_1	774	778	PF00244	0.362
LIG_14-3-3_CanoR_1	830	836	PF00244	0.324
LIG_14-3-3_CanoR_1	838	844	PF00244	0.348
LIG_Actin_WH2_2	637	654	PF00022	0.388
LIG_Actin_WH2_2	760	776	PF00022	0.311
LIG_BIR_III_4	616	620	PF00653	0.461
LIG_BIR_III_4	682	686	PF00653	0.438
LIG_BRCT_BRCA1_1	432	436	PF00533	0.267
LIG_BRCT_BRCA1_1	548	552	PF00533	0.376
LIG_BRCT_BRCA1_1	565	569	PF00533	0.403
LIG_BRCT_BRCA1_1	85	89	PF00533	0.576
LIG_CSL_BTD_1	340	343	PF09270	0.457
LIG_deltaCOP1_diTrp_1	543	552	PF00928	0.353
LIG_FHA_1	209	215	PF00498	0.454
LIG_FHA_1	230	236	PF00498	0.534
LIG_FHA_1	255	261	PF00498	0.456
LIG_FHA_1	359	365	PF00498	0.493
LIG_FHA_1	385	391	PF00498	0.345
LIG_FHA_1	395	401	PF00498	0.311
LIG_FHA_1	441	447	PF00498	0.376
LIG_FHA_1	690	696	PF00498	0.392
LIG_FHA_1	786	792	PF00498	0.344
LIG_FHA_2	238	244	PF00498	0.459
LIG_FHA_2	271	277	PF00498	0.435
LIG_FHA_2	365	371	PF00498	0.436
LIG_FHA_2	397	403	PF00498	0.376
LIG_FHA_2	479	485	PF00498	0.336
LIG_FHA_2	582	588	PF00498	0.427
LIG_FHA_2	896	902	PF00498	0.275
LIG_Integrin_RGD_1	112	114	PF01839	0.453
LIG_LIR_Apic_2	347	351	PF02991	0.440
LIG_LIR_Apic_2	443	447	PF02991	0.374
LIG_LIR_Apic_2	549	555	PF02991	0.383
LIG_LIR_Apic_2	579	585	PF02991	0.514
LIG_LIR_Apic_2	77	81	PF02991	0.593
LIG_LIR_Gen_1	176	186	PF02991	0.691
LIG_LIR_Gen_1	410	417	PF02991	0.389
LIG_LIR_Gen_1	474	485	PF02991	0.341
LIG_LIR_Gen_1	592	601	PF02991	0.389
LIG_LIR_Gen_1	62	72	PF02991	0.610
LIG_LIR_Gen_1	891	902	PF02991	0.313
LIG_LIR_Nem_3	410	416	PF02991	0.385
LIG_LIR_Nem_3	474	480	PF02991	0.305
LIG_LIR_Nem_3	505	509	PF02991	0.367
LIG_LIR_Nem_3	592	597	PF02991	0.420
LIG_LIR_Nem_3	62	68	PF02991	0.615
LIG_LIR_Nem_3	645	651	PF02991	0.395
LIG_LIR_Nem_3	738	744	PF02991	0.404
LIG_LIR_Nem_3	764	769	PF02991	0.360
LIG_LIR_Nem_3	77	83	PF02991	0.585
LIG_LIR_Nem_3	788	793	PF02991	0.346
LIG_LIR_Nem_3	864	870	PF02991	0.367
LIG_LIR_Nem_3	891	897	PF02991	0.364
LIG_LIR_Nem_3	935	941	PF02991	0.411
LIG_MYND_1	512	516	PF01753	0.413
LIG_NRBOX	426	432	PF00104	0.321
LIG_NRBOX	646	652	PF00104	0.387
LIG_PCNA_yPIPBox_3	521	534	PF02747	0.377
LIG_PCNA_yPIPBox_3	872	885	PF02747	0.318
LIG_PTB_Apo_2	874	881	PF02174	0.361
LIG_PTB_Phospho_1	874	880	PF10480	0.357
LIG_SH2_CRK	477	481	PF00017	0.323
LIG_SH2_CRK	506	510	PF00017	0.342
LIG_SH2_CRK	868	872	PF00017	0.357
LIG_SH2_CRK	938	942	PF00017	0.319
LIG_SH2_PTP2	444	447	PF00017	0.343
LIG_SH2_PTP2	894	897	PF00017	0.321
LIG_SH2_SRC	880	883	PF00017	0.371
LIG_SH2_SRC	933	936	PF00017	0.348
LIG_SH2_STAP1	665	669	PF00017	0.421
LIG_SH2_STAP1	769	773	PF00017	0.394
LIG_SH2_STAT3	793	796	PF00017	0.392
LIG_SH2_STAT5	172	175	PF00017	0.324
LIG_SH2_STAT5	237	240	PF00017	0.393
LIG_SH2_STAT5	358	361	PF00017	0.450
LIG_SH2_STAT5	444	447	PF00017	0.395
LIG_SH2_STAT5	457	460	PF00017	0.436
LIG_SH2_STAT5	477	480	PF00017	0.203
LIG_SH2_STAT5	635	638	PF00017	0.341
LIG_SH2_STAT5	732	735	PF00017	0.438
LIG_SH2_STAT5	766	769	PF00017	0.359
LIG_SH2_STAT5	785	788	PF00017	0.401
LIG_SH2_STAT5	790	793	PF00017	0.391
LIG_SH2_STAT5	894	897	PF00017	0.321
LIG_SH2_STAT5	933	936	PF00017	0.376
LIG_SH2_STAT5	938	941	PF00017	0.351
LIG_SH3_2	152	157	PF14604	0.605
LIG_SH3_3	149	155	PF00018	0.624
LIG_SH3_3	178	184	PF00018	0.527
LIG_SH3_3	302	308	PF00018	0.443
LIG_SH3_3	337	343	PF00018	0.543
LIG_SH3_3	370	376	PF00018	0.445
LIG_SH3_3	46	52	PF00018	0.586
LIG_SH3_3	506	512	PF00018	0.398
LIG_SH3_3	526	532	PF00018	0.376
LIG_SH3_4	9	16	PF00018	0.616
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.310
LIG_SUMO_SIM_anti_2	267	274	PF11976	0.448
LIG_SUMO_SIM_par_1	375	380	PF11976	0.364
LIG_TRAF2_1	240	243	PF00917	0.471
LIG_TRAF2_1	265	268	PF00917	0.514
LIG_TRAF2_1	274	277	PF00917	0.347
LIG_TRAF2_1	293	296	PF00917	0.310
LIG_TYR_ITIM	504	509	PF00017	0.432
LIG_TYR_ITIM	892	897	PF00017	0.452
LIG_WRC_WIRS_1	446	451	PF05994	0.486
LIG_WRC_WIRS_1	934	939	PF05994	0.421
MOD_CDK_SPxxK_3	201	208	PF00069	0.604
MOD_CDK_SPxxK_3	550	557	PF00069	0.472
MOD_CK1_1	166	172	PF00069	0.379
MOD_CK1_1	315	321	PF00069	0.662
MOD_CK1_1	383	389	PF00069	0.465
MOD_CK1_1	440	446	PF00069	0.529
MOD_CK1_1	746	752	PF00069	0.463
MOD_CK1_1	753	759	PF00069	0.388
MOD_CK1_1	910	916	PF00069	0.406
MOD_CK1_1	936	942	PF00069	0.398
MOD_CK2_1	127	133	PF00069	0.546
MOD_CK2_1	191	197	PF00069	0.776
MOD_CK2_1	237	243	PF00069	0.565
MOD_CK2_1	248	254	PF00069	0.501
MOD_CK2_1	262	268	PF00069	0.682
MOD_CK2_1	270	276	PF00069	0.456
MOD_CK2_1	396	402	PF00069	0.461
MOD_CK2_1	478	484	PF00069	0.404
MOD_CK2_1	581	587	PF00069	0.485
MOD_CK2_1	746	752	PF00069	0.514
MOD_CK2_1	758	764	PF00069	0.353
MOD_CK2_1	895	901	PF00069	0.315
MOD_Cter_Amidation	34	37	PF01082	0.478
MOD_DYRK1A_RPxSP_1	550	554	PF00069	0.536
MOD_GlcNHglycan	16	20	PF01048	0.523
MOD_GlcNHglycan	193	196	PF01048	0.758
MOD_GlcNHglycan	273	276	PF01048	0.463
MOD_GlcNHglycan	314	317	PF01048	0.660
MOD_GlcNHglycan	460	463	PF01048	0.380
MOD_GlcNHglycan	629	632	PF01048	0.416
MOD_GlcNHglycan	653	656	PF01048	0.453
MOD_GlcNHglycan	657	660	PF01048	0.415
MOD_GlcNHglycan	667	670	PF01048	0.389
MOD_GlcNHglycan	760	763	PF01048	0.429
MOD_GlcNHglycan	794	799	PF01048	0.525
MOD_GSK3_1	1	8	PF00069	0.516
MOD_GSK3_1	115	122	PF00069	0.540
MOD_GSK3_1	191	198	PF00069	0.727
MOD_GSK3_1	375	382	PF00069	0.421
MOD_GSK3_1	407	414	PF00069	0.415
MOD_GSK3_1	546	553	PF00069	0.539
MOD_GSK3_1	55	62	PF00069	0.485
MOD_GSK3_1	651	658	PF00069	0.424
MOD_GSK3_1	673	680	PF00069	0.558
MOD_GSK3_1	730	737	PF00069	0.609
MOD_GSK3_1	743	750	PF00069	0.400
MOD_GSK3_1	773	780	PF00069	0.500
MOD_GSK3_1	906	913	PF00069	0.354
MOD_LATS_1	3	9	PF00433	0.516
MOD_N-GLC_1	135	140	PF02516	0.557
MOD_N-GLC_1	195	200	PF02516	0.611
MOD_N-GLC_1	254	259	PF02516	0.502
MOD_N-GLC_1	298	303	PF02516	0.628
MOD_N-GLC_1	440	445	PF02516	0.387
MOD_N-GLC_1	821	826	PF02516	0.475
MOD_NEK2_1	1	6	PF00069	0.513
MOD_NEK2_1	119	124	PF00069	0.616
MOD_NEK2_1	173	178	PF00069	0.391
MOD_NEK2_1	430	435	PF00069	0.395
MOD_NEK2_1	546	551	PF00069	0.510
MOD_NEK2_1	599	604	PF00069	0.447
MOD_NEK2_1	63	68	PF00069	0.522
MOD_NEK2_1	689	694	PF00069	0.478
MOD_NEK2_1	720	725	PF00069	0.514
MOD_NEK2_1	773	778	PF00069	0.611
MOD_NEK2_1	89	94	PF00069	0.464
MOD_NEK2_2	933	938	PF00069	0.425
MOD_OFUCOSY	160	167	PF10250	0.261
MOD_PIKK_1	137	143	PF00454	0.562
MOD_PIKK_1	235	241	PF00454	0.483
MOD_PK_1	563	569	PF00069	0.466
MOD_PKA_1	262	268	PF00069	0.514
MOD_PKA_2	143	149	PF00069	0.652
MOD_PKA_2	303	309	PF00069	0.502
MOD_PKA_2	312	318	PF00069	0.606
MOD_PKA_2	364	370	PF00069	0.598
MOD_PKA_2	437	443	PF00069	0.513
MOD_PKA_2	458	464	PF00069	0.393
MOD_PKA_2	569	575	PF00069	0.451
MOD_PKA_2	651	657	PF00069	0.464
MOD_PKA_2	689	695	PF00069	0.476
MOD_PKA_2	730	736	PF00069	0.541
MOD_PKA_2	773	779	PF00069	0.535
MOD_PKA_2	83	89	PF00069	0.459
MOD_PKB_1	707	715	PF00069	0.551
MOD_Plk_1	254	260	PF00069	0.520
MOD_Plk_1	298	304	PF00069	0.494
MOD_Plk_1	440	446	PF00069	0.389
MOD_Plk_1	642	648	PF00069	0.411
MOD_Plk_1	753	759	PF00069	0.412
MOD_Plk_2-3	730	736	PF00069	0.541
MOD_Plk_4	384	390	PF00069	0.472
MOD_Plk_4	541	547	PF00069	0.459
MOD_Plk_4	563	569	PF00069	0.470
MOD_Plk_4	59	65	PF00069	0.479
MOD_Plk_4	743	749	PF00069	0.482
MOD_Plk_4	786	792	PF00069	0.356
MOD_Plk_4	933	939	PF00069	0.433
MOD_ProDKin_1	201	207	PF00069	0.709
MOD_ProDKin_1	447	453	PF00069	0.449
MOD_ProDKin_1	50	56	PF00069	0.471
MOD_ProDKin_1	512	518	PF00069	0.539
MOD_ProDKin_1	550	556	PF00069	0.539
MOD_ProDKin_1	581	587	PF00069	0.580
MOD_ProDKin_1	861	867	PF00069	0.383
TRG_DiLeu_BaEn_4	267	273	PF01217	0.552
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.541
TRG_ENDOCYTIC_2	477	480	PF00928	0.316
TRG_ENDOCYTIC_2	506	509	PF00928	0.456
TRG_ENDOCYTIC_2	867	870	PF00928	0.545
TRG_ENDOCYTIC_2	894	897	PF00928	0.494
TRG_ENDOCYTIC_2	938	941	PF00928	0.446
TRG_ER_diArg_1	150	152	PF00400	0.609
TRG_ER_diArg_1	155	157	PF00400	0.510
TRG_ER_diArg_1	24	27	PF00400	0.501
TRG_ER_diArg_1	471	473	PF00400	0.426
TRG_ER_diArg_1	501	503	PF00400	0.544
TRG_ER_diArg_1	524	526	PF00400	0.460
TRG_ER_diArg_1	828	830	PF00400	0.667
TRG_ER_diArg_1	917	919	PF00400	0.390
TRG_NES_CRM1_1	491	505	PF08389	0.395
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW42	Leptomonas seymouri	31%	100%
A0A0N1P9X3	Leptomonas seymouri	42%	100%
A0A3Q8IMZ0	Leishmania donovani	33%	100%
A4HRS2	Leishmania infantum	88%	100%
A4I9M1	Leishmania infantum	33%	100%
E9AC97	Leishmania major	100%	100%
E9B4M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q3F6	Leishmania major	33%	100%