LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase
Gene product:
phosphoglycan beta 1,3 galactosyltransferase
Species:
Leishmania major
UniProt:
E9AC92_LEIMA
TriTrypDb:
LmjF.02.0170 , LMJLV39_020006800 , LMJSD75_020007000 *
Length:
843

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 15
GO:0016020 membrane 2 53
GO:0031090 organelle membrane 3 15
GO:0098588 bounding membrane of organelle 4 15
GO:0110165 cellular anatomical entity 1 53

Expansion

Sequence features

E9AC92
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC92

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 53
GO:0006807 nitrogen compound metabolic process 2 53
GO:0008152 metabolic process 1 53
GO:0019538 protein metabolic process 3 53
GO:0036211 protein modification process 4 53
GO:0043170 macromolecule metabolic process 3 53
GO:0043412 macromolecule modification 4 53
GO:0043413 macromolecule glycosylation 3 53
GO:0044238 primary metabolic process 2 53
GO:0070085 glycosylation 2 53
GO:0071704 organic substance metabolic process 2 53
GO:1901564 organonitrogen compound metabolic process 3 53
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 53
GO:0008194 UDP-glycosyltransferase activity 4 15
GO:0016740 transferase activity 2 53
GO:0016757 glycosyltransferase activity 3 53
GO:0016758 hexosyltransferase activity 4 53

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 12 14 PF00675 0.466
CLV_NRD_NRD_1 124 126 PF00675 0.509
CLV_NRD_NRD_1 317 319 PF00675 0.580
CLV_NRD_NRD_1 342 344 PF00675 0.575
CLV_NRD_NRD_1 397 399 PF00675 0.666
CLV_NRD_NRD_1 439 441 PF00675 0.710
CLV_NRD_NRD_1 444 446 PF00675 0.695
CLV_NRD_NRD_1 463 465 PF00675 0.581
CLV_NRD_NRD_1 522 524 PF00675 0.719
CLV_NRD_NRD_1 695 697 PF00675 0.571
CLV_NRD_NRD_1 782 784 PF00675 0.560
CLV_PCSK_KEX2_1 11 13 PF00082 0.471
CLV_PCSK_KEX2_1 123 125 PF00082 0.534
CLV_PCSK_KEX2_1 254 256 PF00082 0.637
CLV_PCSK_KEX2_1 317 319 PF00082 0.576
CLV_PCSK_KEX2_1 342 344 PF00082 0.580
CLV_PCSK_KEX2_1 397 399 PF00082 0.682
CLV_PCSK_KEX2_1 439 441 PF00082 0.708
CLV_PCSK_KEX2_1 444 446 PF00082 0.693
CLV_PCSK_KEX2_1 463 465 PF00082 0.581
CLV_PCSK_KEX2_1 522 524 PF00082 0.646
CLV_PCSK_KEX2_1 592 594 PF00082 0.612
CLV_PCSK_KEX2_1 695 697 PF00082 0.625
CLV_PCSK_KEX2_1 781 783 PF00082 0.567
CLV_PCSK_KEX2_1 805 807 PF00082 0.630
CLV_PCSK_KEX2_1 831 833 PF00082 0.569
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.470
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.491
CLV_PCSK_PC1ET2_1 254 256 PF00082 0.624
CLV_PCSK_PC1ET2_1 592 594 PF00082 0.576
CLV_PCSK_PC1ET2_1 805 807 PF00082 0.612
CLV_PCSK_PC1ET2_1 831 833 PF00082 0.531
CLV_PCSK_PC7_1 338 344 PF00082 0.551
CLV_PCSK_PC7_1 440 446 PF00082 0.578
CLV_PCSK_PC7_1 691 697 PF00082 0.537
CLV_PCSK_SKI1_1 159 163 PF00082 0.666
CLV_PCSK_SKI1_1 334 338 PF00082 0.603
CLV_PCSK_SKI1_1 412 416 PF00082 0.618
CLV_PCSK_SKI1_1 463 467 PF00082 0.576
CLV_PCSK_SKI1_1 547 551 PF00082 0.621
CLV_PCSK_SKI1_1 623 627 PF00082 0.571
CLV_PCSK_SKI1_1 802 806 PF00082 0.562
CLV_PCSK_SKI1_1 824 828 PF00082 0.538
DEG_APCC_DBOX_1 123 131 PF00400 0.611
DEG_APCC_DBOX_1 317 325 PF00400 0.328
DEG_APCC_DBOX_1 397 405 PF00400 0.441
DEG_Nend_UBRbox_2 1 3 PF02207 0.670
DEG_SCF_FBW7_1 483 490 PF00400 0.515
DOC_CKS1_1 484 489 PF01111 0.518
DOC_CYCLIN_yCln2_LP_2 481 487 PF00134 0.558
DOC_CYCLIN_yCln2_LP_2 67 73 PF00134 0.616
DOC_MAPK_gen_1 113 121 PF00069 0.733
DOC_MAPK_gen_1 123 135 PF00069 0.571
DOC_MAPK_gen_1 157 164 PF00069 0.443
DOC_MAPK_gen_1 317 323 PF00069 0.422
DOC_MAPK_JIP1_4 125 131 PF00069 0.627
DOC_MAPK_MEF2A_6 123 131 PF00069 0.752
DOC_MAPK_MEF2A_6 268 276 PF00069 0.389
DOC_MAPK_MEF2A_6 511 518 PF00069 0.474
DOC_MAPK_MEF2A_6 535 544 PF00069 0.367
DOC_PP1_RVXF_1 509 516 PF00149 0.365
DOC_PP1_RVXF_1 545 552 PF00149 0.465
DOC_PP1_RVXF_1 624 631 PF00149 0.336
DOC_PP2B_LxvP_1 33 36 PF13499 0.642
DOC_PP2B_LxvP_1 481 484 PF13499 0.560
DOC_PP4_FxxP_1 489 492 PF00568 0.407
DOC_USP7_MATH_1 103 107 PF00917 0.698
DOC_USP7_MATH_1 260 264 PF00917 0.531
DOC_USP7_MATH_1 275 279 PF00917 0.400
DOC_USP7_MATH_1 377 381 PF00917 0.517
DOC_USP7_MATH_1 469 473 PF00917 0.419
DOC_USP7_MATH_1 62 66 PF00917 0.716
DOC_USP7_MATH_1 87 91 PF00917 0.687
DOC_USP7_UBL2_3 827 831 PF12436 0.318
DOC_WW_Pin1_4 452 457 PF00397 0.536
DOC_WW_Pin1_4 483 488 PF00397 0.487
DOC_WW_Pin1_4 735 740 PF00397 0.338
DOC_WW_Pin1_4 804 809 PF00397 0.388
DOC_WW_Pin1_4 89 94 PF00397 0.686
LIG_14-3-3_CanoR_1 113 119 PF00244 0.651
LIG_14-3-3_CanoR_1 244 248 PF00244 0.457
LIG_14-3-3_CanoR_1 342 346 PF00244 0.507
LIG_14-3-3_CanoR_1 398 406 PF00244 0.431
LIG_14-3-3_CanoR_1 463 468 PF00244 0.459
LIG_14-3-3_CanoR_1 623 629 PF00244 0.313
LIG_14-3-3_CanoR_1 781 790 PF00244 0.380
LIG_14-3-3_CanoR_1 86 95 PF00244 0.681
LIG_Actin_WH2_2 114 130 PF00022 0.615
LIG_Actin_WH2_2 282 298 PF00022 0.406
LIG_Actin_WH2_2 681 697 PF00022 0.324
LIG_BRCT_BRCA1_1 626 630 PF00533 0.289
LIG_EH1_1 60 68 PF00400 0.624
LIG_EH1_1 635 643 PF00400 0.281
LIG_eIF4E_1 209 215 PF01652 0.400
LIG_FHA_1 178 184 PF00498 0.488
LIG_FHA_1 224 230 PF00498 0.589
LIG_FHA_1 278 284 PF00498 0.529
LIG_FHA_1 413 419 PF00498 0.415
LIG_FHA_1 469 475 PF00498 0.443
LIG_FHA_1 620 626 PF00498 0.317
LIG_FHA_1 633 639 PF00498 0.318
LIG_FHA_1 66 72 PF00498 0.641
LIG_FHA_2 345 351 PF00498 0.449
LIG_FHA_2 405 411 PF00498 0.537
LIG_FHA_2 736 742 PF00498 0.322
LIG_FHA_2 792 798 PF00498 0.323
LIG_Integrin_isoDGR_2 761 763 PF01839 0.559
LIG_LIR_Apic_2 486 492 PF02991 0.409
LIG_LIR_Apic_2 533 539 PF02991 0.493
LIG_LIR_Gen_1 117 126 PF02991 0.624
LIG_LIR_Gen_1 347 352 PF02991 0.360
LIG_LIR_Gen_1 553 564 PF02991 0.390
LIG_LIR_Gen_1 570 580 PF02991 0.388
LIG_LIR_Gen_1 711 719 PF02991 0.384
LIG_LIR_Gen_1 726 734 PF02991 0.414
LIG_LIR_Nem_3 117 121 PF02991 0.633
LIG_LIR_Nem_3 29 33 PF02991 0.635
LIG_LIR_Nem_3 301 306 PF02991 0.399
LIG_LIR_Nem_3 344 348 PF02991 0.508
LIG_LIR_Nem_3 553 559 PF02991 0.437
LIG_LIR_Nem_3 570 576 PF02991 0.350
LIG_LIR_Nem_3 68 72 PF02991 0.642
LIG_LIR_Nem_3 711 716 PF02991 0.385
LIG_LIR_Nem_3 726 732 PF02991 0.419
LIG_LIR_Nem_3 741 745 PF02991 0.309
LIG_NRBOX 143 149 PF00104 0.295
LIG_NRBOX 684 690 PF00104 0.312
LIG_Pex14_1 69 73 PF04695 0.615
LIG_PTB_Apo_2 24 31 PF02174 0.630
LIG_PTB_Apo_2 558 565 PF02174 0.288
LIG_PTB_Apo_2 601 608 PF02174 0.371
LIG_PTB_Phospho_1 601 607 PF10480 0.373
LIG_REV1ctd_RIR_1 746 755 PF16727 0.313
LIG_SH2_CRK 22 26 PF00017 0.642
LIG_SH2_GRB2like 821 824 PF00017 0.335
LIG_SH2_NCK_1 810 814 PF00017 0.387
LIG_SH2_PTP2 573 576 PF00017 0.345
LIG_SH2_SRC 348 351 PF00017 0.374
LIG_SH2_SRC 554 557 PF00017 0.390
LIG_SH2_SRC 744 747 PF00017 0.301
LIG_SH2_STAP1 554 558 PF00017 0.481
LIG_SH2_STAP1 607 611 PF00017 0.350
LIG_SH2_STAT5 241 244 PF00017 0.404
LIG_SH2_STAT5 320 323 PF00017 0.420
LIG_SH2_STAT5 366 369 PF00017 0.453
LIG_SH2_STAT5 476 479 PF00017 0.402
LIG_SH2_STAT5 495 498 PF00017 0.374
LIG_SH2_STAT5 573 576 PF00017 0.371
LIG_SH2_STAT5 585 588 PF00017 0.405
LIG_SH2_STAT5 708 711 PF00017 0.388
LIG_SH2_STAT5 744 747 PF00017 0.478
LIG_SH2_STAT5 825 828 PF00017 0.345
LIG_SH3_3 152 158 PF00018 0.453
LIG_SH3_3 313 319 PF00018 0.491
LIG_SH3_3 481 487 PF00018 0.530
LIG_SH3_3 571 577 PF00018 0.350
LIG_SH3_3 591 597 PF00018 0.384
LIG_SH3_3 837 843 PF00018 0.306
LIG_SH3_3 92 98 PF00018 0.667
LIG_SUMO_SIM_anti_2 143 149 PF11976 0.298
LIG_TRAF2_1 347 350 PF00917 0.384
LIG_TYR_ITIM 346 351 PF00017 0.582
MOD_CK1_1 106 112 PF00069 0.541
MOD_CK1_1 380 386 PF00069 0.723
MOD_CK1_1 621 627 PF00069 0.357
MOD_CK1_1 65 71 PF00069 0.573
MOD_CK2_1 215 221 PF00069 0.460
MOD_CK2_1 344 350 PF00069 0.530
MOD_CK2_1 389 395 PF00069 0.622
MOD_CK2_1 404 410 PF00069 0.688
MOD_CK2_1 488 494 PF00069 0.477
MOD_CK2_1 609 615 PF00069 0.397
MOD_CK2_1 761 767 PF00069 0.509
MOD_CK2_1 791 797 PF00069 0.369
MOD_Cter_Amidation 121 124 PF01082 0.506
MOD_GlcNHglycan 151 154 PF01048 0.501
MOD_GlcNHglycan 217 220 PF01048 0.511
MOD_GlcNHglycan 262 265 PF01048 0.640
MOD_GlcNHglycan 383 386 PF01048 0.652
MOD_GlcNHglycan 391 394 PF01048 0.587
MOD_GlcNHglycan 401 404 PF01048 0.511
MOD_GlcNHglycan 470 474 PF01048 0.582
MOD_GlcNHglycan 477 480 PF01048 0.554
MOD_GlcNHglycan 500 503 PF01048 0.588
MOD_GlcNHglycan 604 607 PF01048 0.425
MOD_GlcNHglycan 610 614 PF01048 0.368
MOD_GlcNHglycan 7 10 PF01048 0.564
MOD_GlcNHglycan 89 92 PF01048 0.605
MOD_GSK3_1 102 109 PF00069 0.565
MOD_GSK3_1 239 246 PF00069 0.567
MOD_GSK3_1 377 384 PF00069 0.734
MOD_GSK3_1 459 466 PF00069 0.581
MOD_GSK3_1 475 482 PF00069 0.542
MOD_GSK3_1 483 490 PF00069 0.478
MOD_GSK3_1 61 68 PF00069 0.610
MOD_N-GLC_1 162 167 PF02516 0.550
MOD_N-GLC_1 193 198 PF02516 0.464
MOD_N-GLC_1 26 31 PF02516 0.511
MOD_N-GLC_1 388 393 PF02516 0.628
MOD_N-GLC_1 668 673 PF02516 0.374
MOD_NEK2_1 140 145 PF00069 0.388
MOD_NEK2_1 149 154 PF00069 0.528
MOD_NEK2_1 162 167 PF00069 0.530
MOD_NEK2_1 193 198 PF00069 0.563
MOD_NEK2_1 274 279 PF00069 0.454
MOD_NEK2_1 419 424 PF00069 0.473
MOD_NEK2_1 475 480 PF00069 0.365
MOD_NEK2_1 5 10 PF00069 0.563
MOD_NEK2_1 61 66 PF00069 0.552
MOD_NEK2_1 74 79 PF00069 0.544
MOD_NEK2_1 753 758 PF00069 0.381
MOD_NEK2_2 223 228 PF00069 0.735
MOD_NEK2_2 243 248 PF00069 0.432
MOD_PIKK_1 542 548 PF00454 0.580
MOD_PKA_1 463 469 PF00069 0.427
MOD_PKA_1 522 528 PF00069 0.659
MOD_PKA_1 781 787 PF00069 0.408
MOD_PKA_2 114 120 PF00069 0.545
MOD_PKA_2 149 155 PF00069 0.503
MOD_PKA_2 243 249 PF00069 0.599
MOD_PKA_2 341 347 PF00069 0.619
MOD_PKA_2 399 405 PF00069 0.532
MOD_PKA_2 463 469 PF00069 0.556
MOD_PKA_2 522 528 PF00069 0.607
MOD_PKA_2 690 696 PF00069 0.363
MOD_PKA_2 781 787 PF00069 0.423
MOD_Plk_1 162 168 PF00069 0.550
MOD_Plk_1 26 32 PF00069 0.510
MOD_Plk_1 469 475 PF00069 0.436
MOD_Plk_1 569 575 PF00069 0.398
MOD_Plk_1 725 731 PF00069 0.438
MOD_Plk_4 114 120 PF00069 0.537
MOD_Plk_4 140 146 PF00069 0.361
MOD_Plk_4 569 575 PF00069 0.398
MOD_Plk_4 62 68 PF00069 0.531
MOD_Plk_4 632 638 PF00069 0.352
MOD_Plk_4 728 734 PF00069 0.543
MOD_ProDKin_1 452 458 PF00069 0.658
MOD_ProDKin_1 483 489 PF00069 0.585
MOD_ProDKin_1 735 741 PF00069 0.377
MOD_ProDKin_1 804 810 PF00069 0.444
MOD_ProDKin_1 89 95 PF00069 0.581
MOD_SUMO_rev_2 648 656 PF00179 0.424
TRG_DiLeu_BaEn_1 470 475 PF01217 0.376
TRG_DiLeu_BaLyEn_6 637 642 PF01217 0.431
TRG_DiLeu_BaLyEn_6 67 72 PF01217 0.493
TRG_ENDOCYTIC_2 22 25 PF00928 0.537
TRG_ENDOCYTIC_2 320 323 PF00928 0.494
TRG_ENDOCYTIC_2 348 351 PF00928 0.623
TRG_ENDOCYTIC_2 556 559 PF00928 0.596
TRG_ENDOCYTIC_2 573 576 PF00928 0.298
TRG_ENDOCYTIC_2 742 745 PF00928 0.314
TRG_ER_diArg_1 124 126 PF00400 0.614
TRG_ER_diArg_1 173 176 PF00400 0.556
TRG_ER_diArg_1 316 318 PF00400 0.453
TRG_ER_diArg_1 396 398 PF00400 0.568
TRG_ER_diArg_1 439 441 PF00400 0.611
TRG_ER_diArg_1 443 445 PF00400 0.581
TRG_ER_diArg_1 463 465 PF00400 0.440
TRG_ER_diArg_1 522 524 PF00400 0.504
TRG_ER_diArg_1 694 696 PF00400 0.454
TRG_ER_diArg_1 721 724 PF00400 0.429
TRG_ER_diArg_1 781 783 PF00400 0.375
TRG_Pf-PMV_PEXEL_1 528 532 PF00026 0.470
TRG_Pf-PMV_PEXEL_1 640 644 PF00026 0.481

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 42% 100%
A0A3S5H4Y6 Leishmania donovani 77% 100%
A0A3S5H4Y9 Leishmania donovani 38% 85%
A0A3S7WT86 Leishmania donovani 41% 82%
A0A3S7WWA6 Leishmania donovani 42% 100%
A0A451EJD9 Leishmania donovani 41% 100%
A0A451EJF4 Leishmania donovani 80% 100%
A0A451EJF6 Leishmania donovani 67% 100%
A0A451EJF8 Leishmania donovani 55% 100%
A0A451EJF9 Leishmania donovani 72% 98%
A4H3A9 Leishmania braziliensis 63% 100%
A4H3B4 Leishmania braziliensis 70% 100%
A4H3B6 Leishmania braziliensis 59% 100%
A4H3B8 Leishmania braziliensis 60% 100%
A4H3B9 Leishmania braziliensis 40% 95%
A4H4W8 Leishmania braziliensis 39% 100%
A4HJ20 Leishmania braziliensis 58% 100%
A4HNK3 Leishmania braziliensis 40% 100%
A4HNK6 Leishmania braziliensis 38% 100%
A4HRL9 Leishmania infantum 80% 100%
A4HRM0 Leishmania infantum 69% 100%
A4HRM1 Leishmania infantum 68% 100%
A4HRS1 Leishmania infantum 71% 98%
A4HRS3 Leishmania infantum 38% 85%
A4HRS5 Leishmania infantum 55% 100%
A4HZM0 Leishmania infantum 41% 100%
A4I7C7 Leishmania infantum 41% 100%
A4IAQ2 Leishmania infantum 41% 100%
E9AC91 Leishmania major 93% 100%
E9AC94 Leishmania major 38% 71%
E9AC95 Leishmania major 56% 100%
E9AC96 Leishmania major 81% 98%
E9AC98 Leishmania major 38% 85%
E9AEH8 Leishmania major 42% 100%
E9AHA6 Leishmania infantum 41% 100%
E9AIP8 Leishmania braziliensis 39% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 85%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
Q4Q5T6 Leishmania major 43% 100%
Q4QCL8 Leishmania major 43% 100%
Q4QFJ3 Leishmania major 41% 82%
Q4QIG9 Leishmania major 43% 100%
Q7YXU9 Leishmania major 43% 100%
Q7YXV1 Leishmania major 43% 100%
Q7YXV2 Leishmania major 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS