LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase
Gene product:
phosphoglycan beta 1,3 galactosyltransferase
Species:
Leishmania major
UniProt:
E9AC91_LEIMA
TriTrypDb:
LmjF.02.0160 , LMJLV39_020006800 * , LMJSD75_020006700 * , LMJSD75_020006800 *
Length:
817

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 15
GO:0016020 membrane 2 53
GO:0031090 organelle membrane 3 15
GO:0098588 bounding membrane of organelle 4 15
GO:0110165 cellular anatomical entity 1 53

Expansion

Sequence features

E9AC91
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC91

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 53
GO:0006807 nitrogen compound metabolic process 2 53
GO:0008152 metabolic process 1 53
GO:0019538 protein metabolic process 3 53
GO:0036211 protein modification process 4 53
GO:0043170 macromolecule metabolic process 3 53
GO:0043412 macromolecule modification 4 53
GO:0043413 macromolecule glycosylation 3 53
GO:0044238 primary metabolic process 2 53
GO:0070085 glycosylation 2 53
GO:0071704 organic substance metabolic process 2 53
GO:1901564 organonitrogen compound metabolic process 3 53
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 53
GO:0008194 UDP-glycosyltransferase activity 4 15
GO:0016740 transferase activity 2 53
GO:0016757 glycosyltransferase activity 3 53
GO:0016758 hexosyltransferase activity 4 53

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 12 14 PF00675 0.440
CLV_NRD_NRD_1 289 291 PF00675 0.577
CLV_NRD_NRD_1 314 316 PF00675 0.569
CLV_NRD_NRD_1 369 371 PF00675 0.656
CLV_NRD_NRD_1 411 413 PF00675 0.701
CLV_NRD_NRD_1 416 418 PF00675 0.693
CLV_NRD_NRD_1 435 437 PF00675 0.580
CLV_NRD_NRD_1 494 496 PF00675 0.714
CLV_NRD_NRD_1 667 669 PF00675 0.560
CLV_NRD_NRD_1 754 756 PF00675 0.588
CLV_NRD_NRD_1 83 85 PF00675 0.448
CLV_NRD_NRD_1 93 95 PF00675 0.486
CLV_PCSK_KEX2_1 11 13 PF00082 0.442
CLV_PCSK_KEX2_1 226 228 PF00082 0.651
CLV_PCSK_KEX2_1 289 291 PF00082 0.570
CLV_PCSK_KEX2_1 314 316 PF00082 0.561
CLV_PCSK_KEX2_1 369 371 PF00082 0.671
CLV_PCSK_KEX2_1 411 413 PF00082 0.699
CLV_PCSK_KEX2_1 416 418 PF00082 0.690
CLV_PCSK_KEX2_1 435 437 PF00082 0.581
CLV_PCSK_KEX2_1 494 496 PF00082 0.643
CLV_PCSK_KEX2_1 564 566 PF00082 0.604
CLV_PCSK_KEX2_1 667 669 PF00082 0.574
CLV_PCSK_KEX2_1 753 755 PF00082 0.572
CLV_PCSK_KEX2_1 777 779 PF00082 0.611
CLV_PCSK_KEX2_1 83 85 PF00082 0.485
CLV_PCSK_KEX2_1 93 95 PF00082 0.495
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.441
CLV_PCSK_PC1ET2_1 226 228 PF00082 0.642
CLV_PCSK_PC1ET2_1 564 566 PF00082 0.569
CLV_PCSK_PC1ET2_1 777 779 PF00082 0.608
CLV_PCSK_PC7_1 310 316 PF00082 0.550
CLV_PCSK_PC7_1 412 418 PF00082 0.575
CLV_PCSK_PC7_1 663 669 PF00082 0.535
CLV_PCSK_SKI1_1 106 110 PF00082 0.289
CLV_PCSK_SKI1_1 306 310 PF00082 0.603
CLV_PCSK_SKI1_1 384 388 PF00082 0.604
CLV_PCSK_SKI1_1 435 439 PF00082 0.580
CLV_PCSK_SKI1_1 519 523 PF00082 0.618
CLV_PCSK_SKI1_1 595 599 PF00082 0.568
CLV_PCSK_SKI1_1 774 778 PF00082 0.567
CLV_PCSK_SKI1_1 94 98 PF00082 0.432
DEG_APCC_DBOX_1 105 113 PF00400 0.463
DEG_APCC_DBOX_1 289 297 PF00400 0.334
DEG_APCC_DBOX_1 369 377 PF00400 0.418
DEG_SCF_FBW7_1 455 462 PF00400 0.508
DEG_SPOP_SBC_1 75 79 PF00917 0.654
DOC_CKS1_1 456 461 PF01111 0.510
DOC_CYCLIN_yCln2_LP_2 183 189 PF00134 0.372
DOC_CYCLIN_yCln2_LP_2 4 10 PF00134 0.636
DOC_CYCLIN_yCln2_LP_2 453 459 PF00134 0.551
DOC_MAPK_gen_1 289 295 PF00069 0.423
DOC_MAPK_gen_1 83 92 PF00069 0.630
DOC_MAPK_JIP1_4 86 92 PF00069 0.619
DOC_MAPK_MEF2A_6 110 119 PF00069 0.401
DOC_MAPK_MEF2A_6 240 248 PF00069 0.382
DOC_MAPK_MEF2A_6 483 490 PF00069 0.467
DOC_MAPK_MEF2A_6 507 516 PF00069 0.364
DOC_MAPK_NFAT4_5 110 118 PF00069 0.250
DOC_PP1_RVXF_1 481 488 PF00149 0.362
DOC_PP1_RVXF_1 517 524 PF00149 0.457
DOC_PP2B_LxvP_1 453 456 PF13499 0.555
DOC_PP4_FxxP_1 461 464 PF00568 0.388
DOC_USP7_MATH_1 232 236 PF00917 0.544
DOC_USP7_MATH_1 247 251 PF00917 0.369
DOC_USP7_MATH_1 349 353 PF00917 0.519
DOC_USP7_MATH_1 441 445 PF00917 0.422
DOC_USP7_MATH_1 63 67 PF00917 0.677
DOC_USP7_MATH_1 803 807 PF00917 0.322
DOC_WW_Pin1_4 182 187 PF00397 0.407
DOC_WW_Pin1_4 3 8 PF00397 0.645
DOC_WW_Pin1_4 424 429 PF00397 0.518
DOC_WW_Pin1_4 455 460 PF00397 0.484
DOC_WW_Pin1_4 59 64 PF00397 0.665
DOC_WW_Pin1_4 707 712 PF00397 0.338
DOC_WW_Pin1_4 76 81 PF00397 0.664
DOC_WW_Pin1_4 776 781 PF00397 0.396
LIG_14-3-3_CanoR_1 12 18 PF00244 0.641
LIG_14-3-3_CanoR_1 216 220 PF00244 0.460
LIG_14-3-3_CanoR_1 314 318 PF00244 0.505
LIG_14-3-3_CanoR_1 370 378 PF00244 0.405
LIG_14-3-3_CanoR_1 435 440 PF00244 0.453
LIG_14-3-3_CanoR_1 753 762 PF00244 0.387
LIG_14-3-3_CanoR_1 86 91 PF00244 0.677
LIG_Actin_WH2_2 175 190 PF00022 0.383
LIG_Actin_WH2_2 254 270 PF00022 0.405
LIG_Actin_WH2_2 653 669 PF00022 0.309
LIG_AP2alpha_2 154 156 PF02296 0.421
LIG_BIR_II_1 1 5 PF00653 0.643
LIG_BRCT_BRCA1_1 38 42 PF00533 0.630
LIG_EH1_1 607 615 PF00400 0.282
LIG_FHA_1 14 20 PF00498 0.684
LIG_FHA_1 196 202 PF00498 0.559
LIG_FHA_1 250 256 PF00498 0.524
LIG_FHA_1 3 9 PF00498 0.669
LIG_FHA_1 385 391 PF00498 0.412
LIG_FHA_1 441 447 PF00498 0.446
LIG_FHA_1 605 611 PF00498 0.317
LIG_FHA_2 317 323 PF00498 0.443
LIG_FHA_2 377 383 PF00498 0.519
LIG_FHA_2 708 714 PF00498 0.323
LIG_FHA_2 764 770 PF00498 0.355
LIG_FHA_2 803 809 PF00498 0.357
LIG_GBD_Chelix_1 113 121 PF00786 0.254
LIG_Integrin_isoDGR_2 733 735 PF01839 0.558
LIG_LIR_Apic_2 458 464 PF02991 0.396
LIG_LIR_Apic_2 505 511 PF02991 0.488
LIG_LIR_Apic_2 798 803 PF02991 0.317
LIG_LIR_Gen_1 154 160 PF02991 0.515
LIG_LIR_Gen_1 319 324 PF02991 0.359
LIG_LIR_Gen_1 525 536 PF02991 0.391
LIG_LIR_Gen_1 542 552 PF02991 0.386
LIG_LIR_Gen_1 683 691 PF02991 0.381
LIG_LIR_Gen_1 698 706 PF02991 0.418
LIG_LIR_Gen_1 808 815 PF02991 0.315
LIG_LIR_Nem_3 154 159 PF02991 0.518
LIG_LIR_Nem_3 273 278 PF02991 0.397
LIG_LIR_Nem_3 316 320 PF02991 0.504
LIG_LIR_Nem_3 525 531 PF02991 0.443
LIG_LIR_Nem_3 542 548 PF02991 0.349
LIG_LIR_Nem_3 683 688 PF02991 0.382
LIG_LIR_Nem_3 698 704 PF02991 0.424
LIG_LIR_Nem_3 713 717 PF02991 0.313
LIG_LIR_Nem_3 808 814 PF02991 0.355
LIG_NRBOX 656 662 PF00104 0.311
LIG_PCNA_yPIPBox_3 176 188 PF02747 0.377
LIG_Pex14_2 193 197 PF04695 0.351
LIG_Pex14_2 96 100 PF04695 0.608
LIG_PTB_Apo_2 530 537 PF02174 0.286
LIG_PTB_Apo_2 573 580 PF02174 0.369
LIG_PTB_Apo_2 596 603 PF02174 0.297
LIG_PTB_Phospho_1 573 579 PF10480 0.370
LIG_REV1ctd_RIR_1 718 727 PF16727 0.313
LIG_SH2_CRK 122 126 PF00017 0.407
LIG_SH2_CRK 811 815 PF00017 0.365
LIG_SH2_GRB2like 793 796 PF00017 0.342
LIG_SH2_NCK_1 122 126 PF00017 0.402
LIG_SH2_NCK_1 782 786 PF00017 0.399
LIG_SH2_PTP2 545 548 PF00017 0.343
LIG_SH2_SRC 320 323 PF00017 0.373
LIG_SH2_SRC 526 529 PF00017 0.397
LIG_SH2_SRC 716 719 PF00017 0.299
LIG_SH2_STAP1 122 126 PF00017 0.407
LIG_SH2_STAP1 50 54 PF00017 0.634
LIG_SH2_STAP1 526 530 PF00017 0.485
LIG_SH2_STAP1 579 583 PF00017 0.350
LIG_SH2_STAP1 797 801 PF00017 0.408
LIG_SH2_STAT3 50 53 PF00017 0.628
LIG_SH2_STAT5 122 125 PF00017 0.434
LIG_SH2_STAT5 144 147 PF00017 0.420
LIG_SH2_STAT5 213 216 PF00017 0.433
LIG_SH2_STAT5 292 295 PF00017 0.417
LIG_SH2_STAT5 338 341 PF00017 0.449
LIG_SH2_STAT5 448 451 PF00017 0.398
LIG_SH2_STAT5 467 470 PF00017 0.450
LIG_SH2_STAT5 545 548 PF00017 0.369
LIG_SH2_STAT5 557 560 PF00017 0.397
LIG_SH2_STAT5 680 683 PF00017 0.383
LIG_SH2_STAT5 716 719 PF00017 0.472
LIG_SH2_STAT5 811 814 PF00017 0.317
LIG_SH3_3 135 141 PF00018 0.427
LIG_SH3_3 285 291 PF00018 0.491
LIG_SH3_3 453 459 PF00018 0.527
LIG_SH3_3 543 549 PF00018 0.348
LIG_SH3_3 563 569 PF00018 0.381
LIG_SUMO_SIM_par_1 117 123 PF11976 0.272
LIG_TRAF2_1 319 322 PF00917 0.387
LIG_TYR_ITIM 318 323 PF00017 0.578
MOD_CDC14_SPxK_1 185 188 PF00782 0.427
MOD_CDK_SPxK_1 182 188 PF00069 0.446
MOD_CDK_SPxxK_3 76 83 PF00069 0.521
MOD_CK1_1 2 8 PF00069 0.539
MOD_CK1_1 352 358 PF00069 0.735
MOD_CK1_1 36 42 PF00069 0.579
MOD_CK1_1 59 65 PF00069 0.594
MOD_CK1_1 79 85 PF00069 0.591
MOD_CK2_1 316 322 PF00069 0.526
MOD_CK2_1 361 367 PF00069 0.593
MOD_CK2_1 376 382 PF00069 0.666
MOD_CK2_1 460 466 PF00069 0.454
MOD_CK2_1 733 739 PF00069 0.509
MOD_CK2_1 763 769 PF00069 0.385
MOD_GlcNHglycan 100 103 PF01048 0.496
MOD_GlcNHglycan 234 237 PF01048 0.696
MOD_GlcNHglycan 355 358 PF01048 0.675
MOD_GlcNHglycan 363 366 PF01048 0.545
MOD_GlcNHglycan 37 41 PF01048 0.612
MOD_GlcNHglycan 373 376 PF01048 0.481
MOD_GlcNHglycan 442 446 PF01048 0.583
MOD_GlcNHglycan 449 452 PF01048 0.553
MOD_GlcNHglycan 472 475 PF01048 0.587
MOD_GlcNHglycan 576 579 PF01048 0.489
MOD_GlcNHglycan 58 61 PF01048 0.588
MOD_GSK3_1 120 127 PF00069 0.453
MOD_GSK3_1 178 185 PF00069 0.490
MOD_GSK3_1 211 218 PF00069 0.551
MOD_GSK3_1 349 356 PF00069 0.736
MOD_GSK3_1 431 438 PF00069 0.568
MOD_GSK3_1 447 454 PF00069 0.537
MOD_GSK3_1 455 462 PF00069 0.460
MOD_GSK3_1 59 66 PF00069 0.591
MOD_GSK3_1 70 77 PF00069 0.628
MOD_N-GLC_1 127 132 PF02516 0.466
MOD_N-GLC_1 360 365 PF02516 0.581
MOD_N-GLC_1 583 588 PF02516 0.343
MOD_N-GLC_1 640 645 PF02516 0.364
MOD_NEK2_1 120 125 PF00069 0.505
MOD_NEK2_1 134 139 PF00069 0.510
MOD_NEK2_1 246 251 PF00069 0.417
MOD_NEK2_1 391 396 PF00069 0.472
MOD_NEK2_1 447 452 PF00069 0.364
MOD_NEK2_1 48 53 PF00069 0.534
MOD_NEK2_1 725 730 PF00069 0.383
MOD_NEK2_2 195 200 PF00069 0.680
MOD_NEK2_2 215 220 PF00069 0.482
MOD_NEK2_2 88 93 PF00069 0.510
MOD_PIKK_1 49 55 PF00454 0.514
MOD_PIKK_1 514 520 PF00454 0.579
MOD_PKA_1 12 18 PF00069 0.505
MOD_PKA_1 435 441 PF00069 0.425
MOD_PKA_1 494 500 PF00069 0.653
MOD_PKA_1 753 759 PF00069 0.435
MOD_PKA_2 12 18 PF00069 0.544
MOD_PKA_2 215 221 PF00069 0.607
MOD_PKA_2 313 319 PF00069 0.617
MOD_PKA_2 371 377 PF00069 0.498
MOD_PKA_2 435 441 PF00069 0.545
MOD_PKA_2 494 500 PF00069 0.602
MOD_PKA_2 662 668 PF00069 0.347
MOD_PKA_2 753 759 PF00069 0.450
MOD_PKB_1 84 92 PF00069 0.511
MOD_Plk_1 441 447 PF00069 0.436
MOD_Plk_1 541 547 PF00069 0.396
MOD_Plk_1 697 703 PF00069 0.447
MOD_Plk_4 120 126 PF00069 0.489
MOD_Plk_4 178 184 PF00069 0.498
MOD_Plk_4 38 44 PF00069 0.536
MOD_Plk_4 541 547 PF00069 0.400
MOD_Plk_4 604 610 PF00069 0.349
MOD_Plk_4 700 706 PF00069 0.542
MOD_ProDKin_1 182 188 PF00069 0.472
MOD_ProDKin_1 3 9 PF00069 0.530
MOD_ProDKin_1 424 430 PF00069 0.627
MOD_ProDKin_1 455 461 PF00069 0.579
MOD_ProDKin_1 59 65 PF00069 0.558
MOD_ProDKin_1 707 713 PF00069 0.377
MOD_ProDKin_1 76 82 PF00069 0.553
MOD_ProDKin_1 776 782 PF00069 0.454
MOD_SUMO_rev_2 620 628 PF00179 0.430
TRG_DiLeu_BaEn_1 442 447 PF01217 0.377
TRG_DiLeu_BaLyEn_6 609 614 PF01217 0.430
TRG_ENDOCYTIC_2 122 125 PF00928 0.408
TRG_ENDOCYTIC_2 292 295 PF00928 0.491
TRG_ENDOCYTIC_2 320 323 PF00928 0.618
TRG_ENDOCYTIC_2 528 531 PF00928 0.603
TRG_ENDOCYTIC_2 545 548 PF00928 0.297
TRG_ENDOCYTIC_2 714 717 PF00928 0.313
TRG_ENDOCYTIC_2 811 814 PF00928 0.382
TRG_ER_diArg_1 288 290 PF00400 0.448
TRG_ER_diArg_1 368 370 PF00400 0.550
TRG_ER_diArg_1 411 413 PF00400 0.599
TRG_ER_diArg_1 415 417 PF00400 0.575
TRG_ER_diArg_1 435 437 PF00400 0.441
TRG_ER_diArg_1 494 496 PF00400 0.500
TRG_ER_diArg_1 666 668 PF00400 0.440
TRG_ER_diArg_1 693 696 PF00400 0.429
TRG_ER_diArg_1 753 755 PF00400 0.391
TRG_ER_diArg_1 83 85 PF00400 0.540
TRG_ER_diArg_1 92 94 PF00400 0.591
TRG_Pf-PMV_PEXEL_1 500 504 PF00026 0.470
TRG_Pf-PMV_PEXEL_1 612 616 PF00026 0.479

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 41% 100%
A0A3S5H4Y6 Leishmania donovani 79% 100%
A0A3S5H4Y9 Leishmania donovani 38% 82%
A0A3S7WT86 Leishmania donovani 41% 79%
A0A3S7WWA6 Leishmania donovani 41% 100%
A0A451EJD9 Leishmania donovani 41% 100%
A0A451EJF4 Leishmania donovani 87% 100%
A0A451EJF6 Leishmania donovani 69% 100%
A0A451EJF8 Leishmania donovani 58% 100%
A0A451EJF9 Leishmania donovani 68% 95%
A4H3A9 Leishmania braziliensis 64% 100%
A4H3B4 Leishmania braziliensis 67% 100%
A4H3B6 Leishmania braziliensis 60% 100%
A4H3B8 Leishmania braziliensis 60% 99%
A4H3B9 Leishmania braziliensis 36% 92%
A4H4W8 Leishmania braziliensis 37% 100%
A4HJ20 Leishmania braziliensis 62% 100%
A4HNK3 Leishmania braziliensis 40% 100%
A4HNK6 Leishmania braziliensis 38% 100%
A4HRL9 Leishmania infantum 88% 100%
A4HRM0 Leishmania infantum 70% 100%
A4HRM1 Leishmania infantum 69% 100%
A4HRS1 Leishmania infantum 68% 95%
A4HRS3 Leishmania infantum 38% 82%
A4HRS5 Leishmania infantum 59% 100%
A4HZM0 Leishmania infantum 41% 100%
A4I7C7 Leishmania infantum 41% 100%
A4IAQ2 Leishmania infantum 40% 100%
E9AC92 Leishmania major 93% 97%
E9AC94 Leishmania major 38% 69%
E9AC95 Leishmania major 60% 100%
E9AC96 Leishmania major 72% 95%
E9AC98 Leishmania major 38% 82%
E9AEH8 Leishmania major 42% 100%
E9AHA6 Leishmania infantum 40% 100%
E9AIP8 Leishmania braziliensis 37% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 83%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
Q4Q5T6 Leishmania major 43% 100%
Q4QCL8 Leishmania major 42% 100%
Q4QFJ3 Leishmania major 41% 79%
Q4QIG9 Leishmania major 43% 100%
Q7YXU9 Leishmania major 42% 100%
Q7YXV1 Leishmania major 43% 97%
Q7YXV2 Leishmania major 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS