RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

E9AC88_LEIMA

TriTrypDb:

LmjF.02.0140 , LMJLV39_020006400 , LMJSD75_020006400

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AC88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC88

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.661
CLV_C14_Caspase3-7	368	372	PF00656	0.784
CLV_NRD_NRD_1	18	20	PF00675	0.475
CLV_NRD_NRD_1	195	197	PF00675	0.677
CLV_NRD_NRD_1	303	305	PF00675	0.634
CLV_NRD_NRD_1	445	447	PF00675	0.535
CLV_PCSK_KEX2_1	445	447	PF00082	0.581
CLV_PCSK_KEX2_1	532	534	PF00082	0.623
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.623
CLV_PCSK_SKI1_1	343	347	PF00082	0.506
CLV_PCSK_SKI1_1	527	531	PF00082	0.614
CLV_PCSK_SKI1_1	539	543	PF00082	0.480
CLV_PCSK_SKI1_1	758	762	PF00082	0.614
CLV_PCSK_SKI1_1	850	854	PF00082	0.430
CLV_Separin_Metazoa	103	107	PF03568	0.458
CLV_Separin_Metazoa	731	735	PF03568	0.549
DEG_Kelch_Keap1_1	722	727	PF01344	0.564
DEG_Nend_UBRbox_2	1	3	PF02207	0.533
DEG_ODPH_VHL_1	75	88	PF01847	0.365
DEG_SCF_FBW7_1	297	303	PF00400	0.549
DOC_ANK_TNKS_1	3	10	PF00023	0.527
DOC_CDC14_PxL_1	481	489	PF14671	0.427
DOC_CKS1_1	105	110	PF01111	0.570
DOC_CKS1_1	159	164	PF01111	0.826
DOC_CKS1_1	297	302	PF01111	0.707
DOC_CKS1_1	355	360	PF01111	0.434
DOC_MAPK_DCC_7	479	489	PF00069	0.489
DOC_MAPK_gen_1	19	27	PF00069	0.481
DOC_MAPK_gen_1	428	435	PF00069	0.528
DOC_MAPK_gen_1	561	570	PF00069	0.595
DOC_MAPK_MEF2A_6	428	435	PF00069	0.454
DOC_PP1_SILK_1	95	100	PF00149	0.365
DOC_PP2B_LxvP_1	487	490	PF13499	0.518
DOC_PP2B_LxvP_1	579	582	PF13499	0.689
DOC_PP4_FxxP_1	401	404	PF00568	0.698
DOC_PP4_FxxP_1	809	812	PF00568	0.774
DOC_PP4_FxxP_1	878	881	PF00568	0.430
DOC_USP7_MATH_1	300	304	PF00917	0.579
DOC_USP7_MATH_1	369	373	PF00917	0.716
DOC_USP7_MATH_1	382	386	PF00917	0.810
DOC_USP7_MATH_1	407	411	PF00917	0.736
DOC_USP7_MATH_1	490	494	PF00917	0.499
DOC_USP7_MATH_1	500	504	PF00917	0.678
DOC_USP7_MATH_1	531	535	PF00917	0.698
DOC_USP7_MATH_1	681	685	PF00917	0.609
DOC_USP7_MATH_1	742	746	PF00917	0.574
DOC_WW_Pin1_4	104	109	PF00397	0.489
DOC_WW_Pin1_4	158	163	PF00397	0.763
DOC_WW_Pin1_4	296	301	PF00397	0.709
DOC_WW_Pin1_4	354	359	PF00397	0.438
DOC_WW_Pin1_4	411	416	PF00397	0.787
DOC_WW_Pin1_4	591	596	PF00397	0.766
DOC_WW_Pin1_4	643	648	PF00397	0.607
DOC_WW_Pin1_4	679	684	PF00397	0.663
DOC_WW_Pin1_4	772	777	PF00397	0.810
DOC_WW_Pin1_4	791	796	PF00397	0.575
DOC_WW_Pin1_4	808	813	PF00397	0.739
DOC_WW_Pin1_4	816	821	PF00397	0.628
LIG_14-3-3_CanoR_1	125	135	PF00244	0.538
LIG_14-3-3_CanoR_1	216	224	PF00244	0.668
LIG_14-3-3_CanoR_1	286	294	PF00244	0.670
LIG_14-3-3_CanoR_1	539	544	PF00244	0.478
LIG_14-3-3_CanoR_1	585	595	PF00244	0.725
LIG_14-3-3_CanoR_1	734	740	PF00244	0.576
LIG_14-3-3_CanoR_1	833	841	PF00244	0.468
LIG_14-3-3_CanoR_1	868	877	PF00244	0.387
LIG_Actin_WH2_2	742	760	PF00022	0.538
LIG_APCC_ABBA_1	568	573	PF00400	0.560
LIG_BRCT_BRCA1_1	177	181	PF00533	0.682
LIG_BRCT_BRCA1_1	492	496	PF00533	0.534
LIG_BRCT_BRCA1_2	177	183	PF00533	0.639
LIG_CtBP_PxDLS_1	223	227	PF00389	0.649
LIG_EH1_1	339	347	PF00400	0.495
LIG_FHA_1	355	361	PF00498	0.431
LIG_FHA_1	468	474	PF00498	0.579
LIG_FHA_1	624	630	PF00498	0.702
LIG_FHA_1	723	729	PF00498	0.566
LIG_FHA_1	802	808	PF00498	0.691
LIG_FHA_1	9	15	PF00498	0.524
LIG_FHA_1	90	96	PF00498	0.423
LIG_FHA_2	105	111	PF00498	0.489
LIG_FHA_2	112	118	PF00498	0.447
LIG_FHA_2	183	189	PF00498	0.668
LIG_FHA_2	659	665	PF00498	0.632
LIG_LIR_Apic_2	353	358	PF02991	0.503
LIG_LIR_Apic_2	448	452	PF02991	0.494
LIG_LIR_Apic_2	491	497	PF02991	0.577
LIG_LIR_Apic_2	806	812	PF02991	0.761
LIG_LIR_Apic_2	875	881	PF02991	0.430
LIG_LIR_Gen_1	178	186	PF02991	0.668
LIG_LIR_Gen_1	241	252	PF02991	0.584
LIG_LIR_Gen_1	292	301	PF02991	0.702
LIG_LIR_Gen_1	35	45	PF02991	0.456
LIG_LIR_Gen_1	463	473	PF02991	0.487
LIG_LIR_Gen_1	727	735	PF02991	0.650
LIG_LIR_Gen_1	745	753	PF02991	0.454
LIG_LIR_Nem_3	178	184	PF02991	0.678
LIG_LIR_Nem_3	241	247	PF02991	0.662
LIG_LIR_Nem_3	292	297	PF02991	0.779
LIG_LIR_Nem_3	329	334	PF02991	0.457
LIG_LIR_Nem_3	35	41	PF02991	0.435
LIG_LIR_Nem_3	353	359	PF02991	0.567
LIG_LIR_Nem_3	423	429	PF02991	0.551
LIG_LIR_Nem_3	463	469	PF02991	0.474
LIG_LIR_Nem_3	727	732	PF02991	0.651
LIG_LIR_Nem_3	745	750	PF02991	0.434
LIG_LIR_Nem_3	835	841	PF02991	0.472
LIG_PDZ_Class_2	890	895	PF00595	0.570
LIG_SH2_CRK	356	360	PF00017	0.434
LIG_SH2_CRK	38	42	PF00017	0.448
LIG_SH2_CRK	466	470	PF00017	0.484
LIG_SH2_CRK	494	498	PF00017	0.588
LIG_SH2_CRK	668	672	PF00017	0.554
LIG_SH2_CRK	747	751	PF00017	0.531
LIG_SH2_NCK_1	38	42	PF00017	0.495
LIG_SH2_NCK_1	668	672	PF00017	0.626
LIG_SH2_PTP2	449	452	PF00017	0.483
LIG_SH2_PTP2	567	570	PF00017	0.521
LIG_SH2_SRC	307	310	PF00017	0.641
LIG_SH2_SRC	449	452	PF00017	0.483
LIG_SH2_SRC	557	560	PF00017	0.592
LIG_SH2_SRC	567	570	PF00017	0.485
LIG_SH2_STAP1	587	591	PF00017	0.740
LIG_SH2_STAP1	747	751	PF00017	0.531
LIG_SH2_STAT3	841	844	PF00017	0.430
LIG_SH2_STAT5	100	103	PF00017	0.416
LIG_SH2_STAT5	333	336	PF00017	0.438
LIG_SH2_STAT5	348	351	PF00017	0.338
LIG_SH2_STAT5	356	359	PF00017	0.470
LIG_SH2_STAT5	38	41	PF00017	0.438
LIG_SH2_STAT5	424	427	PF00017	0.679
LIG_SH2_STAT5	449	452	PF00017	0.483
LIG_SH2_STAT5	472	475	PF00017	0.508
LIG_SH2_STAT5	557	560	PF00017	0.598
LIG_SH2_STAT5	567	570	PF00017	0.468
LIG_SH2_STAT5	675	678	PF00017	0.476
LIG_SH2_STAT5	768	771	PF00017	0.493
LIG_SH2_STAT5	838	841	PF00017	0.438
LIG_SH3_1	494	500	PF00018	0.603
LIG_SH3_1	796	802	PF00018	0.661
LIG_SH3_2	261	266	PF14604	0.585
LIG_SH3_2	845	850	PF14604	0.385
LIG_SH3_3	160	166	PF00018	0.637
LIG_SH3_3	22	28	PF00018	0.504
LIG_SH3_3	258	264	PF00018	0.595
LIG_SH3_3	277	283	PF00018	0.780
LIG_SH3_3	360	366	PF00018	0.602
LIG_SH3_3	494	500	PF00018	0.573
LIG_SH3_3	71	77	PF00018	0.326
LIG_SH3_3	796	802	PF00018	0.759
LIG_SH3_3	842	848	PF00018	0.429
LIG_SUMO_SIM_anti_2	803	811	PF11976	0.542
LIG_SUMO_SIM_par_1	357	362	PF11976	0.425
LIG_SUMO_SIM_par_1	485	493	PF11976	0.532
LIG_TRAF2_1	778	781	PF00917	0.781
LIG_TYR_ITIM	354	359	PF00017	0.438
LIG_TYR_ITIM	36	41	PF00017	0.485
LIG_TYR_ITIM	565	570	PF00017	0.517
LIG_WRC_WIRS_1	761	766	PF05994	0.555
LIG_WW_3	670	674	PF00397	0.485
MOD_CDC14_SPxK_1	646	649	PF00782	0.659
MOD_CDK_SPK_2	791	796	PF00069	0.564
MOD_CDK_SPxK_1	296	302	PF00069	0.709
MOD_CDK_SPxK_1	643	649	PF00069	0.622
MOD_CDK_SPxxK_3	772	779	PF00069	0.737
MOD_CK1_1	144	150	PF00069	0.571
MOD_CK1_1	225	231	PF00069	0.701
MOD_CK1_1	289	295	PF00069	0.759
MOD_CK1_1	29	35	PF00069	0.485
MOD_CK1_1	414	420	PF00069	0.768
MOD_CK1_1	44	50	PF00069	0.477
MOD_CK1_1	507	513	PF00069	0.742
MOD_CK1_1	611	617	PF00069	0.712
MOD_CK1_1	682	688	PF00069	0.625
MOD_CK1_1	706	712	PF00069	0.674
MOD_CK1_1	736	742	PF00069	0.556
MOD_CK1_1	784	790	PF00069	0.618
MOD_CK1_1	810	816	PF00069	0.750
MOD_CK1_1	821	827	PF00069	0.663
MOD_CK2_1	111	117	PF00069	0.412
MOD_CK2_1	300	306	PF00069	0.511
MOD_CK2_1	658	664	PF00069	0.656
MOD_GlcNHglycan	143	146	PF01048	0.591
MOD_GlcNHglycan	177	180	PF01048	0.755
MOD_GlcNHglycan	252	255	PF01048	0.624
MOD_GlcNHglycan	270	274	PF01048	0.753
MOD_GlcNHglycan	290	294	PF01048	0.803
MOD_GlcNHglycan	367	370	PF01048	0.759
MOD_GlcNHglycan	384	387	PF01048	0.585
MOD_GlcNHglycan	453	456	PF01048	0.505
MOD_GlcNHglycan	507	510	PF01048	0.690
MOD_GlcNHglycan	527	530	PF01048	0.395
MOD_GlcNHglycan	533	536	PF01048	0.576
MOD_GlcNHglycan	610	613	PF01048	0.749
MOD_GlcNHglycan	705	708	PF01048	0.553
MOD_GlcNHglycan	740	743	PF01048	0.655
MOD_GlcNHglycan	784	787	PF01048	0.830
MOD_GlcNHglycan	820	823	PF01048	0.728
MOD_GlcNHglycan	826	830	PF01048	0.717
MOD_GlcNHglycan	834	837	PF01048	0.648
MOD_GSK3_1	182	189	PF00069	0.650
MOD_GSK3_1	234	241	PF00069	0.789
MOD_GSK3_1	285	292	PF00069	0.691
MOD_GSK3_1	296	303	PF00069	0.754
MOD_GSK3_1	32	39	PF00069	0.455
MOD_GSK3_1	346	353	PF00069	0.531
MOD_GSK3_1	365	372	PF00069	0.440
MOD_GSK3_1	407	414	PF00069	0.727
MOD_GSK3_1	416	423	PF00069	0.629
MOD_GSK3_1	44	51	PF00069	0.543
MOD_GSK3_1	500	507	PF00069	0.681
MOD_GSK3_1	54	61	PF00069	0.416
MOD_GSK3_1	587	594	PF00069	0.694
MOD_GSK3_1	702	709	PF00069	0.759
MOD_GSK3_1	736	743	PF00069	0.605
MOD_GSK3_1	760	767	PF00069	0.544
MOD_GSK3_1	807	814	PF00069	0.650
MOD_GSK3_1	821	828	PF00069	0.806
MOD_GSK3_1	89	96	PF00069	0.338
MOD_LATS_1	537	543	PF00433	0.492
MOD_N-GLC_1	32	37	PF02516	0.519
MOD_N-GLC_1	417	422	PF02516	0.559
MOD_N-GLC_1	500	505	PF02516	0.592
MOD_NEK2_1	36	41	PF00069	0.428
MOD_NEK2_1	441	446	PF00069	0.482
MOD_NEK2_1	505	510	PF00069	0.745
MOD_NEK2_1	525	530	PF00069	0.390
MOD_NEK2_1	703	708	PF00069	0.755
MOD_NEK2_1	764	769	PF00069	0.526
MOD_NEK2_1	88	93	PF00069	0.416
MOD_NEK2_2	350	355	PF00069	0.594
MOD_NEK2_2	59	64	PF00069	0.419
MOD_NEK2_2	742	747	PF00069	0.571
MOD_PIKK_1	205	211	PF00454	0.760
MOD_PIKK_1	225	231	PF00454	0.756
MOD_PIKK_1	500	506	PF00454	0.721
MOD_PIKK_1	623	629	PF00454	0.682
MOD_PIKK_1	733	739	PF00454	0.581
MOD_PIKK_1	811	817	PF00454	0.708
MOD_PKA_1	196	202	PF00069	0.604
MOD_PKA_2	195	201	PF00069	0.657
MOD_PKA_2	215	221	PF00069	0.745
MOD_PKA_2	285	291	PF00069	0.552
MOD_PKA_2	350	356	PF00069	0.559
MOD_PKA_2	407	413	PF00069	0.728
MOD_PKA_2	722	728	PF00069	0.636
MOD_PKA_2	733	739	PF00069	0.475
MOD_PKA_2	832	838	PF00069	0.640
MOD_Plk_1	289	295	PF00069	0.767
MOD_Plk_1	32	38	PF00069	0.515
MOD_Plk_1	500	506	PF00069	0.650
MOD_Plk_1	545	551	PF00069	0.584
MOD_Plk_2-3	658	664	PF00069	0.535
MOD_Plk_2-3	8	14	PF00069	0.553
MOD_Plk_4	32	38	PF00069	0.465
MOD_Plk_4	350	356	PF00069	0.597
MOD_Plk_4	420	426	PF00069	0.713
MOD_Plk_4	468	474	PF00069	0.494
MOD_Plk_4	539	545	PF00069	0.471
MOD_Plk_4	682	688	PF00069	0.619
MOD_Plk_4	742	748	PF00069	0.517
MOD_Plk_4	93	99	PF00069	0.401
MOD_ProDKin_1	104	110	PF00069	0.493
MOD_ProDKin_1	158	164	PF00069	0.764
MOD_ProDKin_1	296	302	PF00069	0.709
MOD_ProDKin_1	354	360	PF00069	0.439
MOD_ProDKin_1	411	417	PF00069	0.783
MOD_ProDKin_1	591	597	PF00069	0.764
MOD_ProDKin_1	643	649	PF00069	0.622
MOD_ProDKin_1	679	685	PF00069	0.669
MOD_ProDKin_1	772	778	PF00069	0.812
MOD_ProDKin_1	791	797	PF00069	0.572
MOD_ProDKin_1	808	814	PF00069	0.741
MOD_ProDKin_1	816	822	PF00069	0.629
MOD_SUMO_rev_2	2	11	PF00179	0.474
MOD_SUMO_rev_2	572	577	PF00179	0.662
MOD_SUMO_rev_2	68	72	PF00179	0.365
TRG_DiLeu_BaLyEn_6	483	488	PF01217	0.503
TRG_ENDOCYTIC_2	356	359	PF00928	0.432
TRG_ENDOCYTIC_2	38	41	PF00928	0.438
TRG_ENDOCYTIC_2	466	469	PF00928	0.488
TRG_ENDOCYTIC_2	567	570	PF00928	0.521
TRG_ENDOCYTIC_2	747	750	PF00928	0.527
TRG_ER_diArg_1	301	304	PF00400	0.635
TRG_NES_CRM1_1	467	482	PF08389	0.513
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	850	854	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB49	Leptomonas seymouri	59%	100%
A0A3R7M1K8	Trypanosoma rangeli	26%	100%
A0A3S7WNL7	Leishmania donovani	90%	100%
A4H3A8	Leishmania braziliensis	66%	100%
A4HRL7	Leishmania infantum	91%	100%
E9AJI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%