U1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC87_LEIMA

TriTrypDb:

LmjF.02.0130 , LMJLV39_020006300 , LMJSD75_020006300

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	6
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005686	U2 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	6
GO:0071004	U2-type prespliceosome	5	2
GO:0071010	prespliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	6
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	6

Expansion

Sequence features

E9AC87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC87

Function

Biological processes
Term	Name	Level	Count
GO:0000245	spliceosomal complex assembly	7	2
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	4
GO:0006397	mRNA processing	7	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008380	RNA splicing	7	4
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.380
CLV_NRD_NRD_1	62	64	PF00675	0.477
CLV_NRD_NRD_1	87	89	PF00675	0.435
CLV_PCSK_KEX2_1	25	27	PF00082	0.414
CLV_PCSK_KEX2_1	62	64	PF00082	0.468
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.405
CLV_PCSK_SKI1_1	206	210	PF00082	0.443
DOC_CKS1_1	124	129	PF01111	0.380
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.324
DOC_MAPK_gen_1	141	150	PF00069	0.380
DOC_MAPK_gen_1	62	73	PF00069	0.546
DOC_MAPK_gen_1	86	96	PF00069	0.532
DOC_MAPK_HePTP_8	138	150	PF00069	0.380
DOC_MAPK_MEF2A_6	141	150	PF00069	0.380
DOC_PP4_FxxP_1	124	127	PF00568	0.289
DOC_USP7_MATH_1	111	115	PF00917	0.615
DOC_USP7_MATH_1	200	204	PF00917	0.255
DOC_USP7_MATH_1	212	216	PF00917	0.360
DOC_USP7_UBL2_3	195	199	PF12436	0.324
DOC_WW_Pin1_4	123	128	PF00397	0.387
LIG_14-3-3_CanoR_1	162	171	PF00244	0.265
LIG_CaM_IQ_9	55	71	PF13499	0.520
LIG_deltaCOP1_diTrp_1	218	224	PF00928	0.350
LIG_eIF4E_1	178	184	PF01652	0.380
LIG_FHA_1	155	161	PF00498	0.375
LIG_FHA_1	189	195	PF00498	0.308
LIG_FHA_1	31	37	PF00498	0.389
LIG_FHA_1	53	59	PF00498	0.447
LIG_FHA_1	6	12	PF00498	0.462
LIG_FHA_2	131	137	PF00498	0.282
LIG_FHA_2	149	155	PF00498	0.355
LIG_FHA_2	79	85	PF00498	0.498
LIG_IBAR_NPY_1	21	23	PF08397	0.496
LIG_LIR_Gen_1	142	153	PF02991	0.270
LIG_LIR_Gen_1	176	185	PF02991	0.289
LIG_LIR_Gen_1	187	197	PF02991	0.313
LIG_LIR_Nem_3	142	148	PF02991	0.270
LIG_LIR_Nem_3	176	182	PF02991	0.289
LIG_LIR_Nem_3	187	192	PF02991	0.313
LIG_LIR_Nem_3	223	227	PF02991	0.297
LIG_LIR_Nem_3	232	237	PF02991	0.332
LIG_LIR_Nem_3	9	15	PF02991	0.479
LIG_PTB_Apo_2	18	25	PF02174	0.494
LIG_Rb_LxCxE_1	35	55	PF01857	0.475
LIG_SH2_CRK	189	193	PF00017	0.324
LIG_SH2_NCK_1	12	16	PF00017	0.534
LIG_SH2_NCK_1	189	193	PF00017	0.324
LIG_SH2_SRC	12	15	PF00017	0.539
LIG_SH2_STAP1	189	193	PF00017	0.380
LIG_SH2_STAP1	231	235	PF00017	0.283
LIG_SH2_STAT5	178	181	PF00017	0.322
LIG_SH2_STAT5	189	192	PF00017	0.324
LIG_SH2_STAT5	23	26	PF00017	0.513
LIG_SH2_STAT5	231	234	PF00017	0.392
LIG_SH2_STAT5	40	43	PF00017	0.499
LIG_SH3_3	168	174	PF00018	0.324
LIG_SH3_5	174	178	PF00018	0.350
LIG_SUMO_SIM_par_1	90	97	PF11976	0.537
LIG_WRC_WIRS_1	128	133	PF05994	0.324
MOD_CK1_1	130	136	PF00069	0.350
MOD_CK2_1	148	154	PF00069	0.355
MOD_CK2_1	162	168	PF00069	0.270
MOD_CK2_1	212	218	PF00069	0.295
MOD_CK2_1	78	84	PF00069	0.497
MOD_CMANNOS	221	224	PF00535	0.350
MOD_GlcNHglycan	102	105	PF01048	0.573
MOD_GlcNHglycan	113	116	PF01048	0.624
MOD_GlcNHglycan	164	167	PF01048	0.293
MOD_GlcNHglycan	2	5	PF01048	0.577
MOD_GlcNHglycan	96	99	PF01048	0.610
MOD_GSK3_1	123	130	PF00069	0.334
MOD_N-GLC_1	200	205	PF02516	0.350
MOD_N-GLC_1	5	10	PF02516	0.515
MOD_NEK2_1	94	99	PF00069	0.479
MOD_NEK2_2	127	132	PF00069	0.324
MOD_PIKK_1	148	154	PF00454	0.470
MOD_PIKK_1	200	206	PF00454	0.399
MOD_Plk_4	229	235	PF00069	0.362
MOD_ProDKin_1	123	129	PF00069	0.387
TRG_DiLeu_BaEn_2	42	48	PF01217	0.460
TRG_DiLeu_BaEn_4	43	49	PF01217	0.464
TRG_ENDOCYTIC_2	12	15	PF00928	0.539
TRG_ENDOCYTIC_2	181	184	PF00928	0.288
TRG_ENDOCYTIC_2	189	192	PF00928	0.252
TRG_ENDOCYTIC_2	231	234	PF00928	0.315
TRG_Pf-PMV_PEXEL_1	69	74	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I8	Leptomonas seymouri	74%	96%
A0A0S4J697	Bodo saltans	40%	100%
A0A3S5H4Y4	Leishmania donovani	96%	100%
A4H3A7	Leishmania braziliensis	86%	100%
A4HRL6	Leishmania infantum	96%	100%
C9ZJ05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AJI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q54B65	Dictyostelium discoideum	26%	100%
Q9P7L8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
V5AQR9	Trypanosoma cruzi	50%	97%