Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC84_LEIMA

TriTrypDb:

LmjF.02.0090 , LMJLV39_020005700 , LMJSD75_020005800

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AC84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.443
CLV_C14_Caspase3-7	149	153	PF00656	0.566
CLV_NRD_NRD_1	116	118	PF00675	0.446
CLV_NRD_NRD_1	299	301	PF00675	0.452
CLV_NRD_NRD_1	67	69	PF00675	0.625
CLV_NRD_NRD_1	72	74	PF00675	0.565
CLV_NRD_NRD_1	8	10	PF00675	0.615
CLV_PCSK_KEX2_1	115	117	PF00082	0.458
CLV_PCSK_KEX2_1	348	350	PF00082	0.620
CLV_PCSK_KEX2_1	67	69	PF00082	0.621
CLV_PCSK_KEX2_1	71	73	PF00082	0.574
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.584
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.622
CLV_PCSK_PC7_1	111	117	PF00082	0.395
CLV_PCSK_PC7_1	67	73	PF00082	0.680
CLV_PCSK_SKI1_1	139	143	PF00082	0.399
CLV_PCSK_SKI1_1	15	19	PF00082	0.528
DOC_CKS1_1	331	336	PF01111	0.675
DOC_MAPK_gen_1	71	82	PF00069	0.601
DOC_MAPK_MEF2A_6	76	84	PF00069	0.556
DOC_PP2B_LxvP_1	166	169	PF13499	0.554
DOC_USP7_MATH_1	160	164	PF00917	0.501
DOC_USP7_MATH_1	226	230	PF00917	0.487
DOC_USP7_MATH_1	3	7	PF00917	0.494
DOC_USP7_MATH_1	340	344	PF00917	0.677
DOC_USP7_MATH_1	49	53	PF00917	0.655
DOC_USP7_UBL2_3	29	33	PF12436	0.582
DOC_USP7_UBL2_3	57	61	PF12436	0.643
DOC_WW_Pin1_4	224	229	PF00397	0.595
DOC_WW_Pin1_4	330	335	PF00397	0.740
DOC_WW_Pin1_4	86	91	PF00397	0.659
LIG_14-3-3_CanoR_1	221	228	PF00244	0.550
LIG_14-3-3_CanoR_1	71	80	PF00244	0.557
LIG_BRCT_BRCA1_1	21	25	PF00533	0.603
LIG_FHA_1	262	268	PF00498	0.496
LIG_FHA_1	277	283	PF00498	0.419
LIG_FHA_1	3	9	PF00498	0.491
LIG_FHA_1	97	103	PF00498	0.621
LIG_FHA_2	202	208	PF00498	0.505
LIG_FHA_2	229	235	PF00498	0.584
LIG_FHA_2	60	66	PF00498	0.660
LIG_Integrin_isoDGR_2	37	39	PF01839	0.628
LIG_LIR_Gen_1	206	216	PF02991	0.427
LIG_LIR_Gen_1	22	30	PF02991	0.586
LIG_LIR_Gen_1	79	88	PF02991	0.529
LIG_LIR_Nem_3	206	211	PF02991	0.442
LIG_LIR_Nem_3	22	28	PF02991	0.503
LIG_LIR_Nem_3	293	298	PF02991	0.488
LIG_LIR_Nem_3	79	84	PF02991	0.542
LIG_NRP_CendR_1	349	352	PF00754	0.734
LIG_Pex14_2	291	295	PF04695	0.477
LIG_SH2_NCK_1	159	163	PF00017	0.400
LIG_SH2_SRC	127	130	PF00017	0.455
LIG_SH2_STAT5	127	130	PF00017	0.430
LIG_SH2_STAT5	154	157	PF00017	0.402
LIG_SH2_STAT5	201	204	PF00017	0.592
LIG_SH2_STAT5	235	238	PF00017	0.548
LIG_SH2_STAT5	290	293	PF00017	0.462
LIG_TRAF2_1	147	150	PF00917	0.502
LIG_UBA3_1	17	23	PF00899	0.503
LIG_UBA3_1	24	33	PF00899	0.538
MOD_CDK_SPK_2	86	91	PF00069	0.503
MOD_CK1_1	19	25	PF00069	0.599
MOD_CK1_1	343	349	PF00069	0.645
MOD_CK1_1	52	58	PF00069	0.653
MOD_CK1_1	59	65	PF00069	0.530
MOD_CK1_1	89	95	PF00069	0.671
MOD_CK2_1	201	207	PF00069	0.477
MOD_CK2_1	28	34	PF00069	0.424
MOD_GlcNHglycan	129	132	PF01048	0.454
MOD_GlcNHglycan	18	21	PF01048	0.531
MOD_GlcNHglycan	184	187	PF01048	0.599
MOD_GlcNHglycan	224	227	PF01048	0.527
MOD_GlcNHglycan	228	231	PF01048	0.548
MOD_GlcNHglycan	302	306	PF01048	0.584
MOD_GlcNHglycan	335	338	PF01048	0.654
MOD_GlcNHglycan	5	8	PF01048	0.617
MOD_GlcNHglycan	51	54	PF01048	0.620
MOD_GSK3_1	178	185	PF00069	0.602
MOD_GSK3_1	199	206	PF00069	0.542
MOD_GSK3_1	222	229	PF00069	0.548
MOD_GSK3_1	276	283	PF00069	0.460
MOD_GSK3_1	318	325	PF00069	0.671
MOD_GSK3_1	329	336	PF00069	0.613
MOD_GSK3_1	45	52	PF00069	0.512
MOD_GSK3_1	67	74	PF00069	0.583
MOD_GSK3_1	92	99	PF00069	0.572
MOD_N-GLC_1	340	345	PF02516	0.699
MOD_NEK2_1	178	183	PF00069	0.599
MOD_NEK2_1	303	308	PF00069	0.559
MOD_PIKK_1	270	276	PF00454	0.582
MOD_PIKK_1	71	77	PF00454	0.712
MOD_PK_1	76	82	PF00069	0.662
MOD_PKA_1	67	73	PF00069	0.612
MOD_PKA_2	110	116	PF00069	0.461
MOD_PKA_2	222	228	PF00069	0.480
MOD_PKA_2	270	276	PF00069	0.485
MOD_PKA_2	67	73	PF00069	0.620
MOD_Plk_1	13	19	PF00069	0.571
MOD_Plk_1	199	205	PF00069	0.577
MOD_Plk_4	13	19	PF00069	0.526
MOD_Plk_4	76	82	PF00069	0.538
MOD_ProDKin_1	224	230	PF00069	0.594
MOD_ProDKin_1	330	336	PF00069	0.740
MOD_ProDKin_1	86	92	PF00069	0.657
TRG_DiLeu_BaEn_1	13	18	PF01217	0.571
TRG_DiLeu_BaEn_4	13	19	PF01217	0.588
TRG_ER_diArg_1	109	112	PF00400	0.447
TRG_ER_diArg_1	268	271	PF00400	0.469
TRG_ER_diArg_1	349	352	PF00400	0.662
TRG_ER_diArg_1	66	68	PF00400	0.735
TRG_ER_diArg_1	71	73	PF00400	0.715
TRG_NLS_MonoCore_2	346	351	PF00514	0.734
TRG_NLS_MonoExtC_3	346	351	PF00514	0.660
TRG_NLS_MonoExtC_3	59	65	PF00514	0.681
TRG_NLS_MonoExtN_4	347	352	PF00514	0.681
TRG_NLS_MonoExtN_4	57	64	PF00514	0.698
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM5	Leptomonas seymouri	57%	100%
A0A0S4JHT8	Bodo saltans	29%	98%
A0A1X0NKG5	Trypanosomatidae	37%	90%
A0A3S5H4Y1	Leishmania donovani	89%	99%
A0A422N6Z1	Trypanosoma rangeli	40%	90%
A4H3B2	Leishmania braziliensis	77%	100%
A4HRL2	Leishmania infantum	89%	99%
C9ZJ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9AJH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
V5B685	Trypanosoma cruzi	39%	90%