Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC84_LEIMA

TriTrypDb:

LmjF.02.0090 , LMJLV39_020005700 , LMJSD75_020005800

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AC84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC84

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.443
CLV_C14_Caspase3-7	149	153	PF00656	0.566
CLV_NRD_NRD_1	116	118	PF00675	0.446
CLV_NRD_NRD_1	299	301	PF00675	0.452
CLV_NRD_NRD_1	67	69	PF00675	0.625
CLV_NRD_NRD_1	72	74	PF00675	0.565
CLV_NRD_NRD_1	8	10	PF00675	0.615
CLV_PCSK_KEX2_1	115	117	PF00082	0.458
CLV_PCSK_KEX2_1	348	350	PF00082	0.620
CLV_PCSK_KEX2_1	67	69	PF00082	0.621

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM5	Leptomonas seymouri	57%	100%
A0A0S4JHT8	Bodo saltans	29%	98%
A0A1X0NKG5	Trypanosomatidae	37%	90%
A0A3S5H4Y1	Leishmania donovani	89%	99%
A0A422N6Z1	Trypanosoma rangeli	40%	90%
A4H3B2	Leishmania braziliensis	77%	100%
A4HRL2	Leishmania infantum	89%	99%
C9ZJ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9AJH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
V5B685	Trypanosoma cruzi	39%	90%

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