Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC83_LEIMA

TriTrypDb:

LmjF.02.0085

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.543
CLV_NRD_NRD_1	240	242	PF00675	0.627
CLV_NRD_NRD_1	3	5	PF00675	0.539
CLV_NRD_NRD_1	31	33	PF00675	0.741
CLV_NRD_NRD_1	312	314	PF00675	0.606
CLV_NRD_NRD_1	42	44	PF00675	0.696
CLV_PCSK_KEX2_1	145	147	PF00082	0.543
CLV_PCSK_KEX2_1	242	244	PF00082	0.656
CLV_PCSK_KEX2_1	3	5	PF00082	0.539
CLV_PCSK_KEX2_1	31	33	PF00082	0.742
CLV_PCSK_KEX2_1	312	314	PF00082	0.606
CLV_PCSK_KEX2_1	42	44	PF00082	0.695
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.564
CLV_PCSK_PC7_1	27	33	PF00082	0.632
DEG_APCC_DBOX_1	41	49	PF00400	0.500
DEG_SCF_FBW7_1	212	218	PF00400	0.546
DOC_CKS1_1	176	181	PF01111	0.558
DOC_CKS1_1	212	217	PF01111	0.604
DOC_MAPK_gen_1	241	249	PF00069	0.587
DOC_MAPK_gen_1	3	12	PF00069	0.538
DOC_MAPK_MEF2A_6	266	275	PF00069	0.570
DOC_MAPK_MEF2A_6	3	12	PF00069	0.544
DOC_PP1_RVXF_1	160	166	PF00149	0.414
DOC_PP2B_LxvP_1	122	125	PF13499	0.474
DOC_PP4_FxxP_1	173	176	PF00568	0.410
DOC_USP7_MATH_1	102	106	PF00917	0.670
DOC_USP7_MATH_1	158	162	PF00917	0.484
DOC_USP7_MATH_1	17	21	PF00917	0.669
DOC_USP7_MATH_1	274	278	PF00917	0.454
DOC_WW_Pin1_4	107	112	PF00397	0.516
DOC_WW_Pin1_4	133	138	PF00397	0.544
DOC_WW_Pin1_4	175	180	PF00397	0.562
DOC_WW_Pin1_4	196	201	PF00397	0.645
DOC_WW_Pin1_4	211	216	PF00397	0.600
DOC_WW_Pin1_4	278	283	PF00397	0.506
DOC_WW_Pin1_4	71	76	PF00397	0.688
DOC_WW_Pin1_4	98	103	PF00397	0.805
LIG_14-3-3_CanoR_1	119	123	PF00244	0.513
LIG_14-3-3_CanoR_1	183	188	PF00244	0.598
LIG_14-3-3_CanoR_1	42	46	PF00244	0.772
LIG_14-3-3_CanoR_1	57	67	PF00244	0.573
LIG_14-3-3_CanoR_1	77	81	PF00244	0.686
LIG_BRCT_BRCA1_1	153	157	PF00533	0.404
LIG_EVH1_2	116	120	PF00568	0.607
LIG_FHA_1	158	164	PF00498	0.562
LIG_FHA_1	216	222	PF00498	0.633
LIG_FHA_1	244	250	PF00498	0.576
LIG_FHA_1	292	298	PF00498	0.511
LIG_FHA_1	48	54	PF00498	0.531
LIG_FHA_1	76	82	PF00498	0.589
LIG_FHA_2	197	203	PF00498	0.620
LIG_FHA_2	252	258	PF00498	0.539
LIG_LIR_Apic_2	172	176	PF02991	0.465
LIG_LIR_Gen_1	123	130	PF02991	0.640
LIG_LIR_Nem_3	123	129	PF02991	0.485
LIG_LIR_Nem_3	168	173	PF02991	0.402
LIG_MYND_1	34	38	PF01753	0.542
LIG_SH2_STAT5	142	145	PF00017	0.389
LIG_SH2_STAT5	296	299	PF00017	0.366
LIG_SH3_3	111	117	PF00018	0.535
LIG_SH3_3	173	179	PF00018	0.548
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.505
LIG_SUMO_SIM_par_1	245	252	PF11976	0.572
LIG_SUMO_SIM_par_1	271	277	PF11976	0.453
LIG_SUMO_SIM_par_1	49	56	PF11976	0.498
LIG_TRAF2_1	130	133	PF00917	0.510
LIG_TRAF2_1	248	251	PF00917	0.564
LIG_TRFH_1	120	124	PF08558	0.601
MOD_CDC14_SPxK_1	101	104	PF00782	0.705
MOD_CDC14_SPxK_1	74	77	PF00782	0.686
MOD_CDK_SPK_2	196	201	PF00069	0.675
MOD_CDK_SPxK_1	211	217	PF00069	0.606
MOD_CDK_SPxK_1	71	77	PF00069	0.690
MOD_CDK_SPxK_1	98	104	PF00069	0.701
MOD_CK1_1	105	111	PF00069	0.586
MOD_CK1_1	177	183	PF00069	0.478
MOD_CK1_1	206	212	PF00069	0.772
MOD_CK1_1	245	251	PF00069	0.457
MOD_CK1_1	44	50	PF00069	0.639
MOD_CK1_1	56	62	PF00069	0.622
MOD_CK1_1	83	89	PF00069	0.661
MOD_CK2_1	245	251	PF00069	0.596
MOD_CK2_1	308	314	PF00069	0.612
MOD_GlcNHglycan	167	170	PF01048	0.460
MOD_GlcNHglycan	179	182	PF01048	0.422
MOD_GlcNHglycan	19	22	PF01048	0.638
MOD_GlcNHglycan	208	211	PF01048	0.768
MOD_GlcNHglycan	276	279	PF01048	0.500
MOD_GlcNHglycan	288	291	PF01048	0.614
MOD_GlcNHglycan	61	64	PF01048	0.739
MOD_GlcNHglycan	86	89	PF01048	0.662
MOD_GSK3_1	165	172	PF00069	0.447
MOD_GSK3_1	206	213	PF00069	0.737
MOD_GSK3_1	245	252	PF00069	0.580
MOD_GSK3_1	274	281	PF00069	0.516
MOD_GSK3_1	291	298	PF00069	0.571
MOD_GSK3_1	32	39	PF00069	0.618
MOD_GSK3_1	52	59	PF00069	0.607
MOD_GSK3_1	71	78	PF00069	0.757
MOD_GSK3_1	80	87	PF00069	0.611
MOD_GSK3_1	98	105	PF00069	0.689
MOD_N-GLC_1	206	211	PF02516	0.618
MOD_N-GLC_1	53	58	PF02516	0.540
MOD_NEK2_1	12	17	PF00069	0.661
MOD_NEK2_1	157	162	PF00069	0.522
MOD_NEK2_1	182	187	PF00069	0.476
MOD_NEK2_1	188	193	PF00069	0.527
MOD_NEK2_1	22	27	PF00069	0.667
MOD_NEK2_1	249	254	PF00069	0.621
MOD_NEK2_1	295	300	PF00069	0.274
MOD_NEK2_1	52	57	PF00069	0.724
MOD_NEK2_1	66	71	PF00069	0.582
MOD_NEK2_2	291	296	PF00069	0.333
MOD_PIKK_1	284	290	PF00454	0.549
MOD_PKA_1	242	248	PF00069	0.469
MOD_PKA_2	118	124	PF00069	0.682
MOD_PKA_2	182	188	PF00069	0.520
MOD_PKA_2	194	200	PF00069	0.535
MOD_PKA_2	23	29	PF00069	0.669
MOD_PKA_2	242	248	PF00069	0.475
MOD_PKA_2	255	261	PF00069	0.616
MOD_PKA_2	41	47	PF00069	0.709
MOD_PKA_2	56	62	PF00069	0.632
MOD_PKA_2	76	82	PF00069	0.751
MOD_PKB_1	241	249	PF00069	0.615
MOD_Plk_1	158	164	PF00069	0.486
MOD_Plk_2-3	251	257	PF00069	0.655
MOD_Plk_4	169	175	PF00069	0.502
MOD_Plk_4	183	189	PF00069	0.462
MOD_Plk_4	291	297	PF00069	0.324
MOD_Plk_4	47	53	PF00069	0.564
MOD_Plk_4	76	82	PF00069	0.713
MOD_ProDKin_1	107	113	PF00069	0.514
MOD_ProDKin_1	133	139	PF00069	0.560
MOD_ProDKin_1	175	181	PF00069	0.557
MOD_ProDKin_1	196	202	PF00069	0.645
MOD_ProDKin_1	211	217	PF00069	0.601
MOD_ProDKin_1	278	284	PF00069	0.502
MOD_ProDKin_1	71	77	PF00069	0.690
MOD_ProDKin_1	98	104	PF00069	0.807
TRG_ENDOCYTIC_2	5	8	PF00928	0.641
TRG_ER_diArg_1	145	148	PF00400	0.483
TRG_ER_diArg_1	2	4	PF00400	0.532
TRG_ER_diArg_1	240	243	PF00400	0.643
TRG_ER_diArg_1	30	32	PF00400	0.740
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7LQ19	Trypanosoma rangeli	33%	100%
A0A3S5H4Y0	Leishmania donovani	88%	100%
A4H3B3	Leishmania braziliensis	64%	100%
A4HRL1	Leishmania infantum	88%	100%
C9ZIZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AJH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	95%