Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC82_LEIMA

TriTrypDb:

LmjF.02.0080 , LMJLV39_020005600 , LMJSD75_020005700

Length:

996

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.688
CLV_C14_Caspase3-7	942	946	PF00656	0.653
CLV_NRD_NRD_1	145	147	PF00675	0.561
CLV_NRD_NRD_1	228	230	PF00675	0.483
CLV_NRD_NRD_1	454	456	PF00675	0.498
CLV_NRD_NRD_1	744	746	PF00675	0.625
CLV_PCSK_FUR_1	143	147	PF00082	0.548
CLV_PCSK_FUR_1	975	979	PF00082	0.510
CLV_PCSK_KEX2_1	143	145	PF00082	0.545
CLV_PCSK_KEX2_1	228	230	PF00082	0.476
CLV_PCSK_KEX2_1	454	456	PF00082	0.498
CLV_PCSK_KEX2_1	744	746	PF00082	0.749
CLV_PCSK_KEX2_1	977	979	PF00082	0.595
CLV_PCSK_PC1ET2_1	977	979	PF00082	0.595
CLV_PCSK_PC7_1	140	146	PF00082	0.572
CLV_PCSK_SKI1_1	130	134	PF00082	0.515
CLV_PCSK_SKI1_1	220	224	PF00082	0.545
CLV_PCSK_SKI1_1	228	232	PF00082	0.416
CLV_PCSK_SKI1_1	425	429	PF00082	0.463
CLV_PCSK_SKI1_1	486	490	PF00082	0.606
CLV_PCSK_SKI1_1	591	595	PF00082	0.446
CLV_PCSK_SKI1_1	596	600	PF00082	0.453
CLV_PCSK_SKI1_1	615	619	PF00082	0.373
CLV_PCSK_SKI1_1	897	901	PF00082	0.557
CLV_Separin_Metazoa	112	116	PF03568	0.669
DEG_APCC_DBOX_1	424	432	PF00400	0.458
DEG_APCC_DBOX_1	826	834	PF00400	0.711
DEG_Kelch_Keap1_1	957	962	PF01344	0.724
DEG_SCF_FBW7_1	953	959	PF00400	0.720
DEG_SCF_FBW7_2	832	838	PF00400	0.726
DEG_SPOP_SBC_1	639	643	PF00917	0.497
DEG_SPOP_SBC_1	811	815	PF00917	0.699
DOC_ANK_TNKS_1	743	750	PF00023	0.515
DOC_CKS1_1	514	519	PF01111	0.605
DOC_CKS1_1	618	623	PF01111	0.551
DOC_CKS1_1	832	837	PF01111	0.726
DOC_CKS1_1	953	958	PF01111	0.719
DOC_CYCLIN_RxL_1	217	227	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	618	624	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.589
DOC_MAPK_DCC_7	75	83	PF00069	0.392
DOC_MAPK_gen_1	150	158	PF00069	0.539
DOC_MAPK_MEF2A_6	248	255	PF00069	0.493
DOC_MAPK_MEF2A_6	441	448	PF00069	0.387
DOC_MAPK_MEF2A_6	75	83	PF00069	0.392
DOC_PP2B_LxvP_1	114	117	PF13499	0.680
DOC_PP2B_LxvP_1	754	757	PF13499	0.726
DOC_USP7_MATH_1	11	15	PF00917	0.606
DOC_USP7_MATH_1	214	218	PF00917	0.520
DOC_USP7_MATH_1	340	344	PF00917	0.606
DOC_USP7_MATH_1	356	360	PF00917	0.550
DOC_USP7_MATH_1	363	367	PF00917	0.654
DOC_USP7_MATH_1	43	47	PF00917	0.705
DOC_USP7_MATH_1	682	686	PF00917	0.602
DOC_USP7_MATH_1	707	711	PF00917	0.787
DOC_USP7_MATH_1	763	767	PF00917	0.598
DOC_USP7_MATH_1	807	811	PF00917	0.770
DOC_USP7_MATH_1	848	852	PF00917	0.679
DOC_USP7_MATH_1	917	921	PF00917	0.572
DOC_USP7_MATH_1	956	960	PF00917	0.826
DOC_WW_Pin1_4	167	172	PF00397	0.667
DOC_WW_Pin1_4	221	226	PF00397	0.556
DOC_WW_Pin1_4	39	44	PF00397	0.751
DOC_WW_Pin1_4	513	518	PF00397	0.603
DOC_WW_Pin1_4	617	622	PF00397	0.588
DOC_WW_Pin1_4	816	821	PF00397	0.794
DOC_WW_Pin1_4	831	836	PF00397	0.557
DOC_WW_Pin1_4	846	851	PF00397	0.669
DOC_WW_Pin1_4	952	957	PF00397	0.755
DOC_WW_Pin1_4	965	970	PF00397	0.661
LIG_14-3-3_CanoR_1	361	370	PF00244	0.622
LIG_14-3-3_CanoR_1	454	458	PF00244	0.510
LIG_14-3-3_CanoR_1	476	484	PF00244	0.537
LIG_14-3-3_CanoR_1	486	491	PF00244	0.444
LIG_14-3-3_CanoR_1	525	530	PF00244	0.487
LIG_14-3-3_CanoR_1	596	601	PF00244	0.556
LIG_14-3-3_CanoR_1	640	645	PF00244	0.699
LIG_14-3-3_CanoR_1	827	831	PF00244	0.599
LIG_14-3-3_CanoR_1	89	97	PF00244	0.632
LIG_14-3-3_CanoR_1	923	927	PF00244	0.539
LIG_14-3-3_CanoR_1	975	985	PF00244	0.610
LIG_14-3-3_CanoR_1	987	993	PF00244	0.564
LIG_Actin_WH2_2	394	409	PF00022	0.578
LIG_APCC_ABBAyCdc20_2	441	447	PF00400	0.389
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BRCT_BRCA1_1	318	322	PF00533	0.559
LIG_BRCT_BRCA1_1	560	564	PF00533	0.610
LIG_BRCT_BRCA1_1	674	678	PF00533	0.705
LIG_BRCT_BRCA1_1	934	938	PF00533	0.670
LIG_deltaCOP1_diTrp_1	838	843	PF00928	0.563
LIG_FHA_1	158	164	PF00498	0.696
LIG_FHA_1	178	184	PF00498	0.538
LIG_FHA_1	459	465	PF00498	0.550
LIG_FHA_1	551	557	PF00498	0.675
LIG_FHA_1	590	596	PF00498	0.451
LIG_FHA_1	60	66	PF00498	0.486
LIG_FHA_1	763	769	PF00498	0.774
LIG_FHA_1	827	833	PF00498	0.589
LIG_FHA_1	856	862	PF00498	0.678
LIG_FHA_1	894	900	PF00498	0.531
LIG_FHA_1	922	928	PF00498	0.381
LIG_FHA_1	981	987	PF00498	0.570
LIG_FHA_2	180	186	PF00498	0.623
LIG_FHA_2	289	295	PF00498	0.453
LIG_FHA_2	45	51	PF00498	0.698
LIG_FHA_2	713	719	PF00498	0.597
LIG_FHA_2	785	791	PF00498	0.766
LIG_GBD_Chelix_1	400	408	PF00786	0.463
LIG_Integrin_RGD_1	153	155	PF01839	0.549
LIG_LIR_Apic_2	721	726	PF02991	0.740
LIG_LIR_Gen_1	396	406	PF02991	0.429
LIG_LIR_Gen_1	442	452	PF02991	0.597
LIG_LIR_Gen_1	489	497	PF02991	0.511
LIG_LIR_Gen_1	561	572	PF02991	0.501
LIG_LIR_Gen_1	592	602	PF02991	0.554
LIG_LIR_Gen_1	772	781	PF02991	0.617
LIG_LIR_Nem_3	396	401	PF02991	0.444
LIG_LIR_Nem_3	442	448	PF02991	0.608
LIG_LIR_Nem_3	489	494	PF02991	0.501
LIG_LIR_Nem_3	561	567	PF02991	0.488
LIG_LIR_Nem_3	592	597	PF02991	0.400
LIG_LIR_Nem_3	675	681	PF02991	0.682
LIG_LIR_Nem_3	772	776	PF02991	0.605
LIG_NRBOX	596	602	PF00104	0.558
LIG_PCNA_yPIPBox_3	928	938	PF02747	0.446
LIG_Pex14_1	369	373	PF04695	0.551
LIG_PTB_Apo_2	587	594	PF02174	0.389
LIG_REV1ctd_RIR_1	591	600	PF16727	0.410
LIG_SH2_CRK	326	330	PF00017	0.400
LIG_SH2_GRB2like	147	150	PF00017	0.618
LIG_SH2_GRB2like	588	591	PF00017	0.518
LIG_SH2_SRC	328	331	PF00017	0.499
LIG_SH2_STAP1	285	289	PF00017	0.600
LIG_SH2_STAP1	293	297	PF00017	0.440
LIG_SH2_STAP1	326	330	PF00017	0.476
LIG_SH2_STAT3	901	904	PF00017	0.606
LIG_SH2_STAT5	147	150	PF00017	0.618
LIG_SH2_STAT5	315	318	PF00017	0.622
LIG_SH2_STAT5	328	331	PF00017	0.560
LIG_SH2_STAT5	405	408	PF00017	0.456
LIG_SH2_STAT5	416	419	PF00017	0.563
LIG_SH2_STAT5	445	448	PF00017	0.591
LIG_SH2_STAT5	723	726	PF00017	0.746
LIG_SH3_3	350	356	PF00018	0.684
LIG_SH3_3	676	682	PF00018	0.671
LIG_SH3_3	801	807	PF00018	0.635
LIG_SH3_3	829	835	PF00018	0.655
LIG_SH3_3	864	870	PF00018	0.661
LIG_SH3_3	983	989	PF00018	0.549
LIG_SUMO_SIM_anti_2	55	64	PF11976	0.529
LIG_SUMO_SIM_anti_2	80	85	PF11976	0.378
LIG_SUMO_SIM_par_1	124	131	PF11976	0.373
LIG_SUMO_SIM_par_1	460	466	PF11976	0.548
LIG_TRAF2_1	159	162	PF00917	0.672
LIG_TRAF2_1	182	185	PF00917	0.614
LIG_TRAF2_1	503	506	PF00917	0.527
LIG_TRAF2_1	689	692	PF00917	0.612
LIG_TRAF2_1	787	790	PF00917	0.766
LIG_TYR_ITIM	324	329	PF00017	0.573
LIG_UBA3_1	569	573	PF00899	0.637
LIG_WRC_WIRS_1	370	375	PF05994	0.545
LIG_WRPW_2	88	91	PF00400	0.583
MOD_CDK_SPxxK_3	221	228	PF00069	0.551
MOD_CK1_1	164	170	PF00069	0.648
MOD_CK1_1	260	266	PF00069	0.613
MOD_CK1_1	359	365	PF00069	0.650
MOD_CK1_1	368	374	PF00069	0.388
MOD_CK1_1	46	52	PF00069	0.694
MOD_CK1_1	515	521	PF00069	0.574
MOD_CK1_1	558	564	PF00069	0.507
MOD_CK1_1	643	649	PF00069	0.583
MOD_CK1_1	785	791	PF00069	0.642
MOD_CK1_1	810	816	PF00069	0.804
MOD_CK1_1	957	963	PF00069	0.825
MOD_CK2_1	106	112	PF00069	0.693
MOD_CK2_1	125	131	PF00069	0.452
MOD_CK2_1	156	162	PF00069	0.659
MOD_CK2_1	179	185	PF00069	0.530
MOD_CK2_1	204	210	PF00069	0.664
MOD_CK2_1	221	227	PF00069	0.501
MOD_CK2_1	288	294	PF00069	0.500
MOD_CK2_1	630	636	PF00069	0.549
MOD_CK2_1	707	713	PF00069	0.558
MOD_CK2_1	784	790	PF00069	0.765
MOD_CK2_1	857	863	PF00069	0.676
MOD_CK2_1	956	962	PF00069	0.815
MOD_CK2_1	976	982	PF00069	0.426
MOD_GlcNHglycan	106	111	PF01048	0.748
MOD_GlcNHglycan	259	262	PF01048	0.613
MOD_GlcNHglycan	294	297	PF01048	0.578
MOD_GlcNHglycan	318	321	PF01048	0.550
MOD_GlcNHglycan	342	345	PF01048	0.695
MOD_GlcNHglycan	361	364	PF01048	0.711
MOD_GlcNHglycan	478	481	PF01048	0.401
MOD_GlcNHglycan	557	560	PF01048	0.616
MOD_GlcNHglycan	632	635	PF01048	0.524
MOD_GlcNHglycan	645	648	PF01048	0.636
MOD_GlcNHglycan	784	787	PF01048	0.595
MOD_GlcNHglycan	809	812	PF01048	0.786
MOD_GlcNHglycan	846	849	PF01048	0.669
MOD_GlcNHglycan	9	12	PF01048	0.688
MOD_GlcNHglycan	91	94	PF01048	0.584
MOD_GlcNHglycan	934	937	PF01048	0.626
MOD_GlcNHglycan	956	959	PF01048	0.825
MOD_GlcNHglycan	972	975	PF01048	0.524
MOD_GSK3_1	121	128	PF00069	0.530
MOD_GSK3_1	157	164	PF00069	0.676
MOD_GSK3_1	173	180	PF00069	0.647
MOD_GSK3_1	199	206	PF00069	0.646
MOD_GSK3_1	209	216	PF00069	0.598
MOD_GSK3_1	259	266	PF00069	0.590
MOD_GSK3_1	284	291	PF00069	0.474
MOD_GSK3_1	311	318	PF00069	0.694
MOD_GSK3_1	359	366	PF00069	0.641
MOD_GSK3_1	39	46	PF00069	0.689
MOD_GSK3_1	417	424	PF00069	0.553
MOD_GSK3_1	453	460	PF00069	0.563
MOD_GSK3_1	482	489	PF00069	0.414
MOD_GSK3_1	525	532	PF00069	0.603
MOD_GSK3_1	55	62	PF00069	0.496
MOD_GSK3_1	555	562	PF00069	0.556
MOD_GSK3_1	639	646	PF00069	0.609
MOD_GSK3_1	668	675	PF00069	0.721
MOD_GSK3_1	7	14	PF00069	0.637
MOD_GSK3_1	759	766	PF00069	0.628
MOD_GSK3_1	807	814	PF00069	0.764
MOD_GSK3_1	844	851	PF00069	0.679
MOD_GSK3_1	855	862	PF00069	0.647
MOD_GSK3_1	917	924	PF00069	0.447
MOD_GSK3_1	952	959	PF00069	0.757
MOD_GSK3_1	976	983	PF00069	0.689
MOD_N-GLC_1	589	594	PF02516	0.499
MOD_N-GLC_1	797	802	PF02516	0.628
MOD_N-GLC_1	964	969	PF02516	0.733
MOD_NEK2_1	199	204	PF00069	0.629
MOD_NEK2_1	292	297	PF00069	0.568
MOD_NEK2_1	309	314	PF00069	0.484
MOD_NEK2_1	324	329	PF00069	0.573
MOD_NEK2_1	457	462	PF00069	0.522
MOD_NEK2_1	555	560	PF00069	0.577
MOD_NEK2_1	59	64	PF00069	0.625
MOD_NEK2_1	844	849	PF00069	0.758
MOD_NEK2_1	861	866	PF00069	0.449
MOD_NEK2_1	922	927	PF00069	0.607
MOD_NEK2_1	930	935	PF00069	0.524
MOD_NEK2_2	559	564	PF00069	0.510
MOD_NEK2_2	589	594	PF00069	0.460
MOD_NEK2_2	917	922	PF00069	0.557
MOD_PIKK_1	177	183	PF00454	0.542
MOD_PIKK_1	200	206	PF00454	0.534
MOD_PIKK_1	439	445	PF00454	0.555
MOD_PIKK_1	668	674	PF00454	0.740
MOD_PIKK_1	785	791	PF00454	0.766
MOD_PIKK_1	97	103	PF00454	0.586
MOD_PKA_2	363	369	PF00069	0.631
MOD_PKA_2	453	459	PF00069	0.505
MOD_PKA_2	639	645	PF00069	0.614
MOD_PKA_2	826	832	PF00069	0.628
MOD_PKA_2	893	899	PF00069	0.639
MOD_PKA_2	922	928	PF00069	0.535
MOD_Plk_1	421	427	PF00069	0.517
MOD_Plk_1	589	595	PF00069	0.457
MOD_Plk_2-3	273	279	PF00069	0.597
MOD_Plk_2-3	288	294	PF00069	0.350
MOD_Plk_4	204	210	PF00069	0.664
MOD_Plk_4	214	220	PF00069	0.466
MOD_Plk_4	288	294	PF00069	0.494
MOD_Plk_4	311	317	PF00069	0.696
MOD_Plk_4	324	330	PF00069	0.425
MOD_Plk_4	369	375	PF00069	0.447
MOD_Plk_4	486	492	PF00069	0.608
MOD_Plk_4	525	531	PF00069	0.528
MOD_Plk_4	559	565	PF00069	0.549
MOD_Plk_4	596	602	PF00069	0.490
MOD_Plk_4	61	67	PF00069	0.590
MOD_Plk_4	682	688	PF00069	0.635
MOD_Plk_4	718	724	PF00069	0.732
MOD_Plk_4	749	755	PF00069	0.705
MOD_Plk_4	77	83	PF00069	0.364
MOD_Plk_4	917	923	PF00069	0.553
MOD_Plk_4	980	986	PF00069	0.588
MOD_Plk_4	988	994	PF00069	0.570
MOD_ProDKin_1	167	173	PF00069	0.668
MOD_ProDKin_1	221	227	PF00069	0.547
MOD_ProDKin_1	39	45	PF00069	0.752
MOD_ProDKin_1	513	519	PF00069	0.601
MOD_ProDKin_1	617	623	PF00069	0.580
MOD_ProDKin_1	816	822	PF00069	0.790
MOD_ProDKin_1	831	837	PF00069	0.549
MOD_ProDKin_1	846	852	PF00069	0.671
MOD_ProDKin_1	952	958	PF00069	0.755
MOD_ProDKin_1	965	971	PF00069	0.658
MOD_SUMO_rev_2	100	110	PF00179	0.603
MOD_SUMO_rev_2	568	575	PF00179	0.642
MOD_SUMO_rev_2	935	944	PF00179	0.689
TRG_DiLeu_BaEn_3	741	747	PF01217	0.742
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.483
TRG_ENDOCYTIC_2	326	329	PF00928	0.457
TRG_ENDOCYTIC_2	405	408	PF00928	0.414
TRG_ENDOCYTIC_2	445	448	PF00928	0.591
TRG_ER_diArg_1	143	146	PF00400	0.543
TRG_ER_diArg_1	228	230	PF00400	0.476
TRG_ER_diArg_1	744	746	PF00400	0.625
TRG_NES_CRM1_1	524	539	PF08389	0.546
TRG_Pf-PMV_PEXEL_1	928	932	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K8	Leptomonas seymouri	38%	83%
A0A3S5H4X9	Leishmania donovani	91%	100%
A4H3A4	Leishmania braziliensis	73%	100%
A4HRL0	Leishmania infantum	91%	100%
E9AJH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%