Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC80_LEIMA

TriTrypDb:

LmjF.02.0060 , LMJLV39_020005400 , LMJSD75_020005500

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	133	135	PF00082	0.347
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.309
CLV_PCSK_PC7_1	129	135	PF00082	0.405
DOC_USP7_MATH_1	2	6	PF00917	0.522
DOC_WW_Pin1_4	59	64	PF00397	0.541
LIG_14-3-3_CanoR_1	30	34	PF00244	0.703
LIG_14-3-3_CanoR_1	88	97	PF00244	0.521
LIG_Clathr_ClatBox_1	96	100	PF01394	0.545
LIG_FHA_1	138	144	PF00498	0.391
LIG_FHA_1	4	10	PF00498	0.442
LIG_GBD_Chelix_1	127	135	PF00786	0.375
LIG_LIR_Gen_1	41	50	PF02991	0.434
LIG_LIR_Nem_3	167	173	PF02991	0.469
LIG_LIR_Nem_3	176	182	PF02991	0.442
LIG_LIR_Nem_3	41	47	PF02991	0.436
LIG_LIR_Nem_3	52	57	PF02991	0.427
LIG_Pex14_2	164	168	PF04695	0.449
LIG_Pex14_2	50	54	PF04695	0.496
LIG_SH2_CRK	179	183	PF00017	0.334
LIG_SH2_GRB2like	142	145	PF00017	0.440
LIG_SH2_SRC	175	178	PF00017	0.319
LIG_SH2_STAP1	175	179	PF00017	0.340
LIG_SH2_STAT5	142	145	PF00017	0.308
LIG_SH2_STAT5	15	18	PF00017	0.457
LIG_SH3_3	6	12	PF00018	0.482
MOD_CK1_1	114	120	PF00069	0.447
MOD_CK1_1	90	96	PF00069	0.528
MOD_CK2_1	29	35	PF00069	0.543
MOD_GlcNHglycan	161	164	PF01048	0.553
MOD_GlcNHglycan	17	20	PF01048	0.447
MOD_GlcNHglycan	31	34	PF01048	0.640
MOD_GlcNHglycan	82	85	PF01048	0.537
MOD_GSK3_1	106	113	PF00069	0.615
MOD_GSK3_1	114	121	PF00069	0.475
MOD_GSK3_1	155	162	PF00069	0.424
MOD_GSK3_1	57	64	PF00069	0.403
MOD_GSK3_1	87	94	PF00069	0.524
MOD_N-GLC_1	111	116	PF02516	0.546
MOD_N-GLC_1	64	69	PF02516	0.516
MOD_NEK2_1	119	124	PF00069	0.375
MOD_NEK2_1	13	18	PF00069	0.411
MOD_NEK2_1	164	169	PF00069	0.387
MOD_NEK2_1	89	94	PF00069	0.560
MOD_NEK2_2	137	142	PF00069	0.323
MOD_PIKK_1	91	97	PF00454	0.491
MOD_PKA_2	29	35	PF00069	0.694
MOD_PKA_2	87	93	PF00069	0.522
MOD_Plk_1	111	117	PF00069	0.507
MOD_Plk_1	164	170	PF00069	0.386
MOD_Plk_1	175	181	PF00069	0.343
MOD_Plk_1	64	70	PF00069	0.510
MOD_Plk_4	137	143	PF00069	0.407
MOD_ProDKin_1	59	65	PF00069	0.556
TRG_DiLeu_BaEn_1	177	182	PF01217	0.381
TRG_DiLeu_BaEn_2	34	40	PF01217	0.417
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.383
TRG_DiLeu_LyEn_5	177	182	PF01217	0.320
TRG_ENDOCYTIC_2	179	182	PF00928	0.331
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ46	Leptomonas seymouri	51%	97%
A0A1X0NKM1	Trypanosomatidae	35%	91%
A0A422N6X4	Trypanosoma rangeli	30%	100%
A0A451EJE3	Leishmania donovani	93%	99%
A4H3A2	Leishmania braziliensis	78%	98%
A4HRK8	Leishmania infantum	93%	99%
C9ZIZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AJH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	89%
V5BFA7	Trypanosoma cruzi	33%	98%