Metallo-peptidase, Clan MG, Family M24

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Xaa-Pro aminopeptidase, putative

Species:

Leishmania major

UniProt:

E9AC78_LEIMA

TriTrypDb:

LmjF.02.0040 , LMJLV39_020005200 , LMJSD75_020005300

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AC78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC78

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004177	aminopeptidase activity	5	13
GO:0005488	binding	1	13
GO:0008233	peptidase activity	3	13
GO:0008235	metalloexopeptidase activity	5	13
GO:0008237	metallopeptidase activity	4	13
GO:0008238	exopeptidase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0070006	metalloaminopeptidase activity	6	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.217
CLV_NRD_NRD_1	151	153	PF00675	0.279
CLV_NRD_NRD_1	169	171	PF00675	0.349
CLV_NRD_NRD_1	262	264	PF00675	0.438
CLV_NRD_NRD_1	390	392	PF00675	0.418
CLV_PCSK_KEX2_1	169	171	PF00082	0.417
CLV_PCSK_KEX2_1	390	392	PF00082	0.248
CLV_PCSK_SKI1_1	263	267	PF00082	0.417
CLV_PCSK_SKI1_1	278	282	PF00082	0.335
CLV_PCSK_SKI1_1	299	303	PF00082	0.329
CLV_PCSK_SKI1_1	335	339	PF00082	0.440
CLV_PCSK_SKI1_1	456	460	PF00082	0.304
CLV_PCSK_SKI1_1	599	603	PF00082	0.238
CLV_PCSK_SKI1_1	65	69	PF00082	0.497
DEG_APCC_DBOX_1	390	398	PF00400	0.248
DEG_APCC_DBOX_1	455	463	PF00400	0.364
DEG_Nend_Nbox_1	1	3	PF02207	0.454
DOC_CYCLIN_RxL_1	595	606	PF00134	0.238
DOC_CYCLIN_RxL_1	62	71	PF00134	0.259
DOC_MAPK_gen_1	179	187	PF00069	0.264
DOC_MAPK_gen_1	278	288	PF00069	0.248
DOC_MAPK_gen_1	299	307	PF00069	0.285
DOC_MAPK_gen_1	390	396	PF00069	0.417
DOC_MAPK_HePTP_8	215	227	PF00069	0.417
DOC_MAPK_MEF2A_6	218	227	PF00069	0.313
DOC_MAPK_MEF2A_6	281	290	PF00069	0.248
DOC_MAPK_MEF2A_6	551	558	PF00069	0.396
DOC_PP1_RVXF_1	321	328	PF00149	0.285
DOC_PP1_RVXF_1	410	417	PF00149	0.285
DOC_PP1_RVXF_1	63	70	PF00149	0.385
DOC_PP4_FxxP_1	416	419	PF00568	0.285
DOC_PP4_MxPP_1	144	147	PF00568	0.532
DOC_USP7_MATH_1	147	151	PF00917	0.359
DOC_USP7_MATH_1	33	37	PF00917	0.252
DOC_USP7_MATH_1	436	440	PF00917	0.385
DOC_USP7_MATH_2	381	387	PF00917	0.417
DOC_USP7_UBL2_3	149	153	PF12436	0.297
DOC_WW_Pin1_4	113	118	PF00397	0.411
DOC_WW_Pin1_4	377	382	PF00397	0.377
DOC_WW_Pin1_4	609	614	PF00397	0.523
LIG_14-3-3_CanoR_1	270	279	PF00244	0.375
LIG_14-3-3_CanoR_1	530	539	PF00244	0.499
LIG_Actin_WH2_2	186	202	PF00022	0.304
LIG_Actin_WH2_2	283	301	PF00022	0.326
LIG_BRCT_BRCA1_1	438	442	PF00533	0.417
LIG_BRCT_BRCA1_1	44	48	PF00533	0.217
LIG_BRCT_BRCA1_2	438	444	PF00533	0.417
LIG_Clathr_ClatBox_1	60	64	PF01394	0.292
LIG_eIF4E_1	596	602	PF01652	0.238
LIG_eIF4E_1	83	89	PF01652	0.252
LIG_FHA_1	231	237	PF00498	0.390
LIG_FHA_1	283	289	PF00498	0.395
LIG_FHA_1	320	326	PF00498	0.302
LIG_FHA_1	405	411	PF00498	0.319
LIG_FHA_1	426	432	PF00498	0.282
LIG_FHA_1	444	450	PF00498	0.279
LIG_FHA_1	487	493	PF00498	0.248
LIG_FHA_1	56	62	PF00498	0.252
LIG_FHA_1	596	602	PF00498	0.483
LIG_FHA_2	119	125	PF00498	0.295
LIG_FHA_2	163	169	PF00498	0.343
LIG_FHA_2	27	33	PF00498	0.217
LIG_FHA_2	345	351	PF00498	0.446
LIG_FHA_2	558	564	PF00498	0.277
LIG_LIR_Apic_2	413	419	PF02991	0.285
LIG_LIR_Gen_1	124	132	PF02991	0.436
LIG_LIR_Gen_1	217	227	PF02991	0.374
LIG_LIR_Gen_1	357	367	PF02991	0.294
LIG_LIR_Gen_1	425	435	PF02991	0.304
LIG_LIR_Gen_1	476	484	PF02991	0.285
LIG_LIR_Gen_1	606	613	PF02991	0.546
LIG_LIR_Gen_1	85	94	PF02991	0.252
LIG_LIR_Nem_3	124	128	PF02991	0.436
LIG_LIR_Nem_3	203	209	PF02991	0.272
LIG_LIR_Nem_3	217	223	PF02991	0.272
LIG_LIR_Nem_3	245	249	PF02991	0.346
LIG_LIR_Nem_3	274	280	PF02991	0.417
LIG_LIR_Nem_3	357	362	PF02991	0.300
LIG_LIR_Nem_3	363	367	PF02991	0.282
LIG_LIR_Nem_3	425	430	PF02991	0.304
LIG_LIR_Nem_3	476	480	PF02991	0.285
LIG_LIR_Nem_3	592	596	PF02991	0.409
LIG_LIR_Nem_3	606	611	PF02991	0.652
LIG_LIR_Nem_3	80	86	PF02991	0.349
LIG_MYND_3	96	100	PF01753	0.269
LIG_PALB2_WD40_1	191	199	PF16756	0.248
LIG_Pex14_1	566	570	PF04695	0.406
LIG_Pex14_2	48	52	PF04695	0.304
LIG_PTB_Apo_2	204	211	PF02174	0.417
LIG_SH2_CRK	206	210	PF00017	0.291
LIG_SH2_CRK	427	431	PF00017	0.285
LIG_SH2_CRK	608	612	PF00017	0.544
LIG_SH2_GRB2like	220	223	PF00017	0.436
LIG_SH2_GRB2like	226	229	PF00017	0.396
LIG_SH2_NCK_1	206	210	PF00017	0.335
LIG_SH2_NCK_1	213	217	PF00017	0.321
LIG_SH2_NCK_1	343	347	PF00017	0.364
LIG_SH2_NCK_1	379	383	PF00017	0.350
LIG_SH2_PTP2	155	158	PF00017	0.406
LIG_SH2_PTP2	226	229	PF00017	0.417
LIG_SH2_SRC	211	214	PF00017	0.306
LIG_SH2_SRC	220	223	PF00017	0.299
LIG_SH2_SRC	466	469	PF00017	0.285
LIG_SH2_STAP1	211	215	PF00017	0.329
LIG_SH2_STAP1	427	431	PF00017	0.285
LIG_SH2_STAT5	118	121	PF00017	0.417
LIG_SH2_STAT5	155	158	PF00017	0.439
LIG_SH2_STAT5	226	229	PF00017	0.417
LIG_SH2_STAT5	324	327	PF00017	0.319
LIG_SH2_STAT5	38	41	PF00017	0.252
LIG_SH2_STAT5	395	398	PF00017	0.385
LIG_SH2_STAT5	427	430	PF00017	0.285
LIG_SH2_STAT5	539	542	PF00017	0.409
LIG_SH2_STAT5	593	596	PF00017	0.277
LIG_SH2_STAT5	608	611	PF00017	0.520
LIG_SH3_3	288	294	PF00018	0.427
LIG_SH3_3	91	97	PF00018	0.269
LIG_SUMO_SIM_anti_2	555	563	PF11976	0.458
LIG_SUMO_SIM_par_1	183	188	PF11976	0.361
LIG_SUMO_SIM_par_1	552	557	PF11976	0.339
LIG_TRAF2_1	165	168	PF00917	0.396
LIG_TRAF2_1	77	80	PF00917	0.371
LIG_TRAF2_1	98	101	PF00917	0.401
LIG_TYR_ITIM	204	209	PF00017	0.350
LIG_UBA3_1	173	180	PF00899	0.350
LIG_UBA3_1	60	65	PF00899	0.385
LIG_WRC_WIRS_1	474	479	PF05994	0.285
MOD_CDK_SPxxK_3	609	616	PF00069	0.528
MOD_CK1_1	363	369	PF00069	0.285
MOD_CK1_1	502	508	PF00069	0.361
MOD_CK1_1	542	548	PF00069	0.450
MOD_CK1_1	55	61	PF00069	0.252
MOD_CK1_1	557	563	PF00069	0.241
MOD_CK2_1	118	124	PF00069	0.295
MOD_CK2_1	162	168	PF00069	0.343
MOD_CK2_1	344	350	PF00069	0.373
MOD_CK2_1	377	383	PF00069	0.406
MOD_CK2_1	557	563	PF00069	0.277
MOD_CK2_1	95	101	PF00069	0.346
MOD_Cter_Amidation	261	264	PF01082	0.361
MOD_GlcNHglycan	187	190	PF01048	0.285
MOD_GlcNHglycan	385	388	PF01048	0.288
MOD_GlcNHglycan	398	401	PF01048	0.304
MOD_GlcNHglycan	446	449	PF01048	0.331
MOD_GlcNHglycan	5	8	PF01048	0.423
MOD_GlcNHglycan	533	536	PF01048	0.504
MOD_GlcNHglycan	54	57	PF01048	0.252
MOD_GSK3_1	377	384	PF00069	0.359
MOD_GSK3_1	38	45	PF00069	0.384
MOD_GSK3_1	404	411	PF00069	0.284
MOD_GSK3_1	533	540	PF00069	0.429
MOD_GSK3_1	55	62	PF00069	0.203
MOD_NEK2_1	26	31	PF00069	0.364
MOD_NEK2_1	3	8	PF00069	0.411
MOD_NEK2_1	396	401	PF00069	0.285
MOD_NEK2_1	52	57	PF00069	0.252
MOD_NEK2_2	147	152	PF00069	0.287
MOD_NEK2_2	284	289	PF00069	0.417
MOD_PKA_2	126	132	PF00069	0.380
MOD_PKA_2	269	275	PF00069	0.417
MOD_Plk_1	147	153	PF00069	0.379
MOD_Plk_1	19	25	PF00069	0.289
MOD_Plk_1	554	560	PF00069	0.355
MOD_Plk_2-3	95	101	PF00069	0.401
MOD_Plk_4	425	431	PF00069	0.286
MOD_Plk_4	436	442	PF00069	0.282
MOD_Plk_4	473	479	PF00069	0.285
MOD_Plk_4	499	505	PF00069	0.341
MOD_Plk_4	554	560	PF00069	0.385
MOD_Plk_4	574	580	PF00069	0.156
MOD_Plk_4	606	612	PF00069	0.547
MOD_ProDKin_1	113	119	PF00069	0.411
MOD_ProDKin_1	377	383	PF00069	0.377
MOD_ProDKin_1	609	615	PF00069	0.525
MOD_SUMO_for_1	301	304	PF00179	0.331
MOD_SUMO_rev_2	250	259	PF00179	0.361
MOD_SUMO_rev_2	304	310	PF00179	0.248
MOD_SUMO_rev_2	612	618	PF00179	0.556
MOD_SUMO_rev_2	79	84	PF00179	0.289
TRG_DiLeu_BaEn_1	425	430	PF01217	0.329
TRG_DiLeu_BaEn_1	606	611	PF01217	0.553
TRG_ENDOCYTIC_2	206	209	PF00928	0.300
TRG_ENDOCYTIC_2	213	216	PF00928	0.269
TRG_ENDOCYTIC_2	220	223	PF00928	0.248
TRG_ENDOCYTIC_2	226	229	PF00928	0.285
TRG_ENDOCYTIC_2	249	252	PF00928	0.290
TRG_ENDOCYTIC_2	427	430	PF00928	0.285
TRG_ENDOCYTIC_2	608	611	PF00928	0.553
TRG_ENDOCYTIC_2	83	86	PF00928	0.352
TRG_ER_diArg_1	260	263	PF00400	0.248
TRG_ER_diArg_1	389	391	PF00400	0.248
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I539	Leptomonas seymouri	76%	100%
A0A1X0NZN4	Trypanosomatidae	58%	100%
A0A3Q8IFI4	Leishmania donovani	94%	100%
A0A3R7KZD6	Trypanosoma rangeli	57%	100%
A0A451EJE2	Leishmania donovani	95%	100%
A1CAQ1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	42%	94%
A1DF27	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	45%	95%
A2QGR5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	43%	100%
A4HEE5	Leishmania braziliensis	87%	100%
A4HRK6	Leishmania infantum	95%	100%
A4RF35	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	42%	100%
A6R035	Ajellomyces capsulatus (strain NAm1 / WU24)	41%	100%
A6RK67	Botryotinia fuckeliana (strain B05.10)	42%	100%
A7E4T8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	41%	100%
A8P5H7	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	42%	100%
B0DZL3	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	42%	96%
B0Y3V7	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	45%	95%
B1AVD1	Mus musculus	37%	92%
B2AWV6	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	39%	91%
B2VUU7	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	43%	100%
B6HQC9	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	41%	100%
B6QG01	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	43%	94%
B8M9W2	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	43%	94%
B8NEI6	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	42%	95%
C0NDZ7	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	41%	100%
C0SCV1	Paracoccidioides brasiliensis (strain Pb03)	42%	100%
C1GEY4	Paracoccidioides brasiliensis (strain Pb18)	42%	100%
C1H978	Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01)	42%	100%
C5FHR9	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	39%	99%
C5GXZ9	Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)	42%	100%
C5K105	Blastomyces gilchristii (strain SLH14081)	41%	100%
C5P7J2	Coccidioides posadasii (strain C735)	41%	95%
C6HSY3	Ajellomyces capsulatus (strain H143)	39%	97%
C7Z9Z7	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	43%	100%
C9SR45	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	40%	100%
C9ZKA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D1ZKF3	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	42%	100%
D4ARJ9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	39%	89%
D4D891	Trichophyton verrucosum (strain HKI 0517)	38%	89%
D5GAC6	Tuber melanosporum (strain Mel28)	42%	100%
E3QCU0	Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212)	40%	100%
E3S7K9	Pyrenophora teres f. teres (strain 0-1)	43%	94%
E4USI8	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	41%	97%
E5ABQ8	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)	42%	100%
E9AHA3	Leishmania infantum	95%	100%
E9CTR7	Coccidioides posadasii (strain RMSCC 757 / Silveira)	42%	100%
E9E9B2	Metarhizium acridum (strain CQMa 102)	41%	100%
E9EUE6	Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)	41%	100%
F4JQH3	Arabidopsis thaliana	37%	96%
O43895	Homo sapiens	36%	92%
O44750	Caenorhabditis elegans	36%	100%
O54975	Rattus norvegicus	40%	99%
Q07825	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	83%
Q09795	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
Q0CDB3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	42%	95%
Q0UFY4	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	43%	95%
Q1JPJ2	Bos taurus	39%	99%
Q2H8T2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	40%	99%
Q2U7S5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	95%
Q4Q9J5	Leishmania major	99%	100%
Q4WUD3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	45%	95%
Q54G06	Dictyostelium discoideum	38%	99%
Q5AVF0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	95%
Q6P1B1	Mus musculus	40%	99%
Q7RYL6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	43%	90%
Q8RY11	Arabidopsis thaliana	38%	87%
Q95333	Sus scrofa	36%	92%
Q99MA2	Rattus norvegicus	37%	92%
Q9NQW7	Homo sapiens	40%	99%
Q9VJG0	Drosophila melanogaster	40%	100%
V5DIX7	Trypanosoma cruzi	57%	100%