Tagatose-6-phosphate kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tagatose-6-phosphate kinase-like protein

Species:

Leishmania major

UniProt:

E9AC77_LEIMA

TriTrypDb:

LmjF.02.0030 , LMJLV39_020005100 , LMJSD75_020005100

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC77

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0044237	cellular metabolic process	2	6
GO:0005975	carbohydrate metabolic process	3	4
GO:0044238	primary metabolic process	2	4
GO:0071704	organic substance metabolic process	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0009024	tagatose-6-phosphate kinase activity	5	5
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.456
CLV_C14_Caspase3-7	315	319	PF00656	0.456
CLV_NRD_NRD_1	360	362	PF00675	0.463
CLV_NRD_NRD_1	7	9	PF00675	0.466
CLV_PCSK_KEX2_1	360	362	PF00082	0.478
CLV_PCSK_KEX2_1	7	9	PF00082	0.466
CLV_PCSK_SKI1_1	184	188	PF00082	0.256
CLV_PCSK_SKI1_1	223	227	PF00082	0.260
CLV_PCSK_SKI1_1	336	340	PF00082	0.256
CLV_PCSK_SKI1_1	85	89	PF00082	0.257
DEG_APCC_DBOX_1	183	191	PF00400	0.520
DEG_Nend_UBRbox_1	1	4	PF02207	0.438
DEG_SPOP_SBC_1	373	377	PF00917	0.587
DOC_ANK_TNKS_1	359	366	PF00023	0.477
DOC_CKS1_1	259	264	PF01111	0.456
DOC_CYCLIN_RxL_1	68	77	PF00134	0.379
DOC_MAPK_gen_1	360	368	PF00069	0.492
DOC_MAPK_gen_1	7	15	PF00069	0.471
DOC_MAPK_MEF2A_6	53	62	PF00069	0.312
DOC_MAPK_MEF2A_6	7	16	PF00069	0.420
DOC_PP1_SILK_1	243	248	PF00149	0.520
DOC_PP2B_LxvP_1	237	240	PF13499	0.456
DOC_PP2B_PxIxI_1	57	63	PF00149	0.458
DOC_USP7_MATH_1	203	207	PF00917	0.520
DOC_USP7_MATH_1	340	344	PF00917	0.456
DOC_USP7_MATH_1	373	377	PF00917	0.587
DOC_WW_Pin1_4	107	112	PF00397	0.429
DOC_WW_Pin1_4	17	22	PF00397	0.418
DOC_WW_Pin1_4	204	209	PF00397	0.456
DOC_WW_Pin1_4	258	263	PF00397	0.456
DOC_WW_Pin1_4	306	311	PF00397	0.456
DOC_WW_Pin1_4	327	332	PF00397	0.520
DOC_WW_Pin1_4	44	49	PF00397	0.471
DOC_WW_Pin1_4	54	59	PF00397	0.332
LIG_14-3-3_CanoR_1	115	119	PF00244	0.491
LIG_14-3-3_CanoR_1	40	49	PF00244	0.476
LIG_14-3-3_CanoR_1	85	90	PF00244	0.560
LIG_BRCT_BRCA1_1	109	113	PF00533	0.448
LIG_DLG_GKlike_1	8	15	PF00625	0.420
LIG_FHA_1	163	169	PF00498	0.456
LIG_FHA_1	272	278	PF00498	0.456
LIG_FHA_1	327	333	PF00498	0.520
LIG_FHA_1	70	76	PF00498	0.359
LIG_FHA_2	153	159	PF00498	0.456
LIG_FHA_2	161	167	PF00498	0.456
LIG_FHA_2	27	33	PF00498	0.461
LIG_FHA_2	328	334	PF00498	0.520
LIG_LIR_Gen_1	212	221	PF02991	0.520
LIG_MAD2	276	284	PF02301	0.520
LIG_NRBOX	11	17	PF00104	0.422
LIG_PDZ_Class_1	376	381	PF00595	0.645
LIG_PTB_Apo_2	63	70	PF02174	0.430
LIG_SH2_SRC	325	328	PF00017	0.456
LIG_SH2_STAP1	268	272	PF00017	0.548
LIG_SH2_STAT3	268	271	PF00017	0.520
LIG_SH2_STAT5	211	214	PF00017	0.520
LIG_SH2_STAT5	288	291	PF00017	0.456
LIG_SH2_STAT5	325	328	PF00017	0.472
LIG_SH2_STAT5	92	95	PF00017	0.456
LIG_SH3_2	48	53	PF14604	0.443
LIG_SH3_3	141	147	PF00018	0.520
LIG_SH3_3	296	302	PF00018	0.457
LIG_SH3_3	304	310	PF00018	0.420
LIG_SH3_3	45	51	PF00018	0.596
LIG_SH3_3	59	65	PF00018	0.340
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.419
LIG_SUMO_SIM_par_1	223	228	PF11976	0.456
LIG_SUMO_SIM_par_1	276	282	PF11976	0.456
LIG_SUMO_SIM_par_1	71	77	PF11976	0.297
LIG_TRFH_1	17	21	PF08558	0.418
LIG_WRC_WIRS_1	118	123	PF05994	0.456
MOD_CK1_1	162	168	PF00069	0.520
MOD_CK1_1	27	33	PF00069	0.461
MOD_CK2_1	160	166	PF00069	0.547
MOD_CK2_1	257	263	PF00069	0.456
MOD_CK2_1	327	333	PF00069	0.520
MOD_GlcNHglycan	103	106	PF01048	0.256
MOD_GlcNHglycan	169	173	PF01048	0.287
MOD_GlcNHglycan	26	29	PF01048	0.455
MOD_GlcNHglycan	263	266	PF01048	0.269
MOD_GlcNHglycan	285	288	PF01048	0.256
MOD_GlcNHglycan	342	345	PF01048	0.264
MOD_GSK3_1	113	120	PF00069	0.456
MOD_GSK3_1	152	159	PF00069	0.520
MOD_GSK3_1	20	27	PF00069	0.430
MOD_GSK3_1	254	261	PF00069	0.474
MOD_GSK3_1	36	43	PF00069	0.473
MOD_GSK3_1	364	371	PF00069	0.448
MOD_GSK3_1	372	379	PF00069	0.584
MOD_N-GLC_1	160	165	PF02516	0.320
MOD_N-GLC_2	99	101	PF02516	0.256
MOD_NEK2_1	113	118	PF00069	0.520
MOD_NEK2_1	24	29	PF00069	0.449
MOD_NEK2_1	69	74	PF00069	0.374
MOD_NEK2_2	114	119	PF00069	0.429
MOD_PIKK_1	156	162	PF00454	0.520
MOD_PKA_2	101	107	PF00069	0.433
MOD_PKA_2	114	120	PF00069	0.456
MOD_PKA_2	212	218	PF00069	0.456
MOD_Plk_1	160	166	PF00069	0.520
MOD_Plk_1	233	239	PF00069	0.461
MOD_Plk_1	8	14	PF00069	0.420
MOD_Plk_4	117	123	PF00069	0.466
MOD_Plk_4	241	247	PF00069	0.468
MOD_Plk_4	8	14	PF00069	0.472
MOD_ProDKin_1	107	113	PF00069	0.429
MOD_ProDKin_1	17	23	PF00069	0.420
MOD_ProDKin_1	204	210	PF00069	0.456
MOD_ProDKin_1	258	264	PF00069	0.456
MOD_ProDKin_1	306	312	PF00069	0.456
MOD_ProDKin_1	327	333	PF00069	0.520
MOD_ProDKin_1	44	50	PF00069	0.466
MOD_ProDKin_1	54	60	PF00069	0.315
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.606
TRG_ER_diArg_1	359	361	PF00400	0.553
TRG_ER_diArg_1	6	8	PF00400	0.421
TRG_NES_CRM1_1	271	282	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6N7	Leptomonas seymouri	69%	100%
A0A3S5H4X6	Leishmania donovani	94%	100%
A2RGF2	Streptococcus pyogenes serotype M5 (strain Manfredo)	27%	100%
A3CPH5	Streptococcus sanguinis (strain SK36)	27%	100%
A5IUY2	Staphylococcus aureus (strain JH9)	28%	100%
A6QJ37	Staphylococcus aureus (strain Newman)	28%	100%
A6U3S3	Staphylococcus aureus (strain JH1)	28%	100%
A7X575	Staphylococcus aureus (strain Mu3 / ATCC 700698)	28%	100%
A8YYG0	Staphylococcus aureus (strain USA300 / TCH1516)	28%	100%
B1IBZ5	Streptococcus pneumoniae (strain Hungary19A-6)	30%	100%
B2IPT7	Streptococcus pneumoniae (strain CGSP14)	30%	100%
B5E4T0	Streptococcus pneumoniae serotype 19F (strain G54)	29%	100%
B5XII4	Streptococcus pyogenes serotype M49 (strain NZ131)	27%	100%
B8ZQ64	Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)	30%	100%
B9DU93	Streptococcus uberis (strain ATCC BAA-854 / 0140J)	28%	100%
C1C7G0	Streptococcus pneumoniae (strain 70585)	30%	100%
C1CEF2	Streptococcus pneumoniae (strain JJA)	30%	100%
C1CKT7	Streptococcus pneumoniae (strain P1031)	29%	100%
C1CRA6	Streptococcus pneumoniae (strain Taiwan19F-14)	29%	100%
D4GYE6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	27%	100%
E9AHA4	Leishmania infantum	94%	100%
O31714	Bacillus subtilis (strain 168)	27%	100%
P06999	Escherichia coli (strain K12)	25%	100%
P0A0B8	Staphylococcus aureus (strain MW2)	28%	100%
P0A0B9	Staphylococcus aureus (strain NCTC 8325 / PS 47)	28%	100%
P0AEW9	Escherichia coli (strain K12)	25%	100%
P0AEX0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	25%	100%
P0AEX1	Escherichia coli O157:H7	25%	100%
P0AEX2	Shigella flexneri	25%	100%
P0DC12	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	28%	100%
P0DC13	Streptococcus pyogenes serotype M3 (strain SSI-1)	28%	100%
P23391	Lactococcus lactis subsp. lactis	27%	100%
P26421	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	28%	100%
P44330	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
P65698	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
P65699	Staphylococcus aureus (strain N315)	28%	100%
P75038	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	26%	100%
P9WID2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WID3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q04KC3	Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)	30%	100%
Q1J4Q3	Streptococcus pyogenes serotype M4 (strain MGAS10750)	27%	100%
Q1J9U8	Streptococcus pyogenes serotype M12 (strain MGAS2096)	28%	100%
Q1JEY9	Streptococcus pyogenes serotype M2 (strain MGAS10270)	27%	100%
Q1JJZ7	Streptococcus pyogenes serotype M12 (strain MGAS9429)	28%	100%
Q2FET9	Staphylococcus aureus (strain USA300)	28%	100%
Q2YYJ5	Staphylococcus aureus (strain bovine RF122 / ET3-1)	28%	100%
Q3JZ20	Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)	27%	100%
Q48RC4	Streptococcus pyogenes serotype M28 (strain MGAS6180)	27%	100%
Q4L872	Staphylococcus haemolyticus (strain JCSC1435)	25%	100%
Q4Q9J4	Leishmania major	100%	100%
Q5HE12	Staphylococcus aureus (strain COL)	28%	100%
Q5HM37	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	100%
Q5X9Y3	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	27%	100%
Q6G7C1	Staphylococcus aureus (strain MSSA476)	28%	100%
Q6GEN6	Staphylococcus aureus (strain MRSA252)	28%	100%
Q833W9	Enterococcus faecalis (strain ATCC 700802 / V583)	25%	100%
Q8CRJ4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q8DPP1	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	30%	100%
Q8DXC2	Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)	27%	100%
Q8E346	Streptococcus agalactiae serotype III (strain NEM316)	27%	100%
Q8E4R7	Streptococcus agalactiae serotype III (strain NEM316)	26%	100%
Q8NZD9	Streptococcus pyogenes serotype M18 (strain MGAS8232)	27%	100%
Q8XNK5	Clostridium perfringens (strain 13 / Type A)	24%	100%
Q97QL2	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	29%	100%
Q99Y14	Streptococcus pyogenes serotype M1	28%	100%
Q9KM71	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	22%	100%