C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC71_LEIMA

TriTrypDb:

LmjF.01.0800 , LMJLV39_010013400 , LMJSD75_010013400

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.712
CLV_C14_Caspase3-7	441	445	PF00656	0.595
CLV_NRD_NRD_1	103	105	PF00675	0.526
CLV_NRD_NRD_1	315	317	PF00675	0.547
CLV_NRD_NRD_1	489	491	PF00675	0.702
CLV_NRD_NRD_1	89	91	PF00675	0.786
CLV_PCSK_FUR_1	313	317	PF00082	0.541
CLV_PCSK_KEX2_1	103	105	PF00082	0.526
CLV_PCSK_KEX2_1	163	165	PF00082	0.512
CLV_PCSK_KEX2_1	315	317	PF00082	0.547
CLV_PCSK_KEX2_1	89	91	PF00082	0.786
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.549
CLV_PCSK_SKI1_1	163	167	PF00082	0.516
CLV_PCSK_SKI1_1	285	289	PF00082	0.734
CLV_PCSK_SKI1_1	435	439	PF00082	0.755
DEG_APCC_DBOX_1	70	78	PF00400	0.651
DEG_ODPH_VHL_1	45	57	PF01847	0.522
DEG_ODPH_VHL_1	74	85	PF01847	0.716
DEG_SCF_FBW7_1	140	146	PF00400	0.677
DOC_CDC14_PxL_1	43	51	PF14671	0.550
DOC_CKS1_1	140	145	PF01111	0.676
DOC_MAPK_DCC_7	71	79	PF00069	0.678
DOC_MAPK_gen_1	175	183	PF00069	0.544
DOC_MAPK_gen_1	321	329	PF00069	0.590
DOC_MAPK_gen_1	71	79	PF00069	0.678
DOC_MAPK_JIP1_4	316	322	PF00069	0.535
DOC_PP1_RVXF_1	299	306	PF00149	0.503
DOC_PP1_RVXF_1	328	335	PF00149	0.593
DOC_PP2B_LxvP_1	123	126	PF13499	0.660
DOC_PP2B_LxvP_1	45	48	PF13499	0.627
DOC_PP4_MxPP_1	1	4	PF00568	0.512
DOC_USP7_MATH_1	134	138	PF00917	0.714
DOC_USP7_MATH_1	143	147	PF00917	0.615
DOC_USP7_MATH_1	234	238	PF00917	0.660
DOC_USP7_MATH_1	290	294	PF00917	0.663
DOC_USP7_MATH_1	377	381	PF00917	0.558
DOC_USP7_MATH_1	445	449	PF00917	0.582
DOC_USP7_MATH_1	470	474	PF00917	0.727
DOC_USP7_MATH_1	50	54	PF00917	0.699
DOC_WW_Pin1_4	124	129	PF00397	0.672
DOC_WW_Pin1_4	139	144	PF00397	0.559
DOC_WW_Pin1_4	285	290	PF00397	0.736
DOC_WW_Pin1_4	292	297	PF00397	0.628
DOC_WW_Pin1_4	418	423	PF00397	0.764
DOC_WW_Pin1_4	428	433	PF00397	0.645
DOC_WW_Pin1_4	436	441	PF00397	0.717
DOC_WW_Pin1_4	475	480	PF00397	0.710
LIG_14-3-3_CanoR_1	10	14	PF00244	0.531
LIG_14-3-3_CanoR_1	435	440	PF00244	0.750
LIG_14-3-3_CanoR_1	490	498	PF00244	0.644
LIG_14-3-3_CanoR_1	89	98	PF00244	0.676
LIG_Actin_WH2_2	201	218	PF00022	0.590
LIG_BIR_III_2	476	480	PF00653	0.583
LIG_BIR_III_4	398	402	PF00653	0.633
LIG_BRCT_BRCA1_1	96	100	PF00533	0.669
LIG_Clathr_ClatBox_1	244	248	PF01394	0.653
LIG_eIF4E_1	323	329	PF01652	0.584
LIG_EVH1_2	3	7	PF00568	0.493
LIG_FHA_1	222	228	PF00498	0.643
LIG_FHA_1	239	245	PF00498	0.667
LIG_FHA_1	355	361	PF00498	0.736
LIG_FHA_1	499	505	PF00498	0.719
LIG_FHA_2	439	445	PF00498	0.738
LIG_LIR_Gen_1	380	390	PF02991	0.465
LIG_LIR_Nem_3	380	385	PF02991	0.469
LIG_MYND_1	72	76	PF01753	0.783
LIG_PTAP_UEV_1	144	149	PF05743	0.586
LIG_REV1ctd_RIR_1	5	14	PF16727	0.520
LIG_SH2_CRK	102	106	PF00017	0.693
LIG_SH2_CRK	382	386	PF00017	0.524
LIG_SH2_NCK_1	382	386	PF00017	0.524
LIG_SH2_STAT3	13	16	PF00017	0.525
LIG_SH2_STAT5	13	16	PF00017	0.525
LIG_SH2_STAT5	331	334	PF00017	0.490
LIG_SH3_3	137	143	PF00018	0.648
LIG_SH3_3	272	278	PF00018	0.484
LIG_SH3_3	349	355	PF00018	0.759
LIG_SH3_3	44	50	PF00018	0.504
LIG_SH3_CIN85_PxpxPR_1	296	301	PF14604	0.616
LIG_SUMO_SIM_par_1	224	230	PF11976	0.521
LIG_SUMO_SIM_par_1	277	283	PF11976	0.633
LIG_SUMO_SIM_par_1	75	81	PF11976	0.715
LIG_WW_2	47	50	PF00397	0.490
MOD_CDC14_SPxK_1	421	424	PF00782	0.646
MOD_CDC14_SPxK_1	478	481	PF00782	0.583
MOD_CDK_SPxK_1	418	424	PF00069	0.645
MOD_CDK_SPxK_1	475	481	PF00069	0.590
MOD_CDK_SPxxK_3	428	435	PF00069	0.585
MOD_CDK_SPxxK_3	436	443	PF00069	0.630
MOD_CK1_1	127	133	PF00069	0.615
MOD_CK1_1	139	145	PF00069	0.636
MOD_CK1_1	267	273	PF00069	0.534
MOD_CK1_1	33	39	PF00069	0.683
MOD_CK1_1	386	392	PF00069	0.640
MOD_CK1_1	431	437	PF00069	0.579
MOD_CK1_1	458	464	PF00069	0.807
MOD_CK1_1	485	491	PF00069	0.725
MOD_CK1_1	53	59	PF00069	0.622
MOD_CK2_1	182	188	PF00069	0.540
MOD_Cter_Amidation	161	164	PF01082	0.557
MOD_GlcNHglycan	105	108	PF01048	0.582
MOD_GlcNHglycan	113	116	PF01048	0.682
MOD_GlcNHglycan	129	132	PF01048	0.605
MOD_GlcNHglycan	136	139	PF01048	0.606
MOD_GlcNHglycan	145	148	PF01048	0.592
MOD_GlcNHglycan	184	187	PF01048	0.542
MOD_GlcNHglycan	232	235	PF01048	0.629
MOD_GlcNHglycan	236	239	PF01048	0.645
MOD_GlcNHglycan	257	260	PF01048	0.633
MOD_GlcNHglycan	290	293	PF01048	0.654
MOD_GlcNHglycan	347	350	PF01048	0.763
MOD_GlcNHglycan	35	38	PF01048	0.696
MOD_GlcNHglycan	410	414	PF01048	0.547
MOD_GlcNHglycan	447	450	PF01048	0.663
MOD_GlcNHglycan	457	460	PF01048	0.687
MOD_GlcNHglycan	472	475	PF01048	0.556
MOD_GlcNHglycan	58	61	PF01048	0.711
MOD_GlcNHglycan	80	83	PF01048	0.760
MOD_GlcNHglycan	91	94	PF01048	0.673
MOD_GSK3_1	134	141	PF00069	0.693
MOD_GSK3_1	230	237	PF00069	0.625
MOD_GSK3_1	26	33	PF00069	0.703
MOD_GSK3_1	267	274	PF00069	0.602
MOD_GSK3_1	288	295	PF00069	0.657
MOD_GSK3_1	427	434	PF00069	0.711
MOD_GSK3_1	482	489	PF00069	0.718
MOD_GSK3_1	492	499	PF00069	0.674
MOD_GSK3_1	85	92	PF00069	0.666
MOD_N-GLC_2	116	118	PF02516	0.707
MOD_NEK2_1	26	31	PF00069	0.536
MOD_NEK2_1	322	327	PF00069	0.578
MOD_NEK2_1	427	432	PF00069	0.631
MOD_NEK2_1	498	503	PF00069	0.597
MOD_NEK2_1	85	90	PF00069	0.696
MOD_NEK2_1	9	14	PF00069	0.599
MOD_NEK2_2	117	122	PF00069	0.546
MOD_NEK2_2	271	276	PF00069	0.454
MOD_PK_1	30	36	PF00069	0.688
MOD_PKA_1	103	109	PF00069	0.597
MOD_PKA_1	490	496	PF00069	0.753
MOD_PKA_1	89	95	PF00069	0.706
MOD_PKA_2	103	109	PF00069	0.693
MOD_PKA_2	174	180	PF00069	0.592
MOD_PKA_2	255	261	PF00069	0.719
MOD_PKA_2	482	488	PF00069	0.711
MOD_PKA_2	89	95	PF00069	0.657
MOD_PKA_2	9	15	PF00069	0.530
MOD_Plk_4	482	488	PF00069	0.604
MOD_Plk_4	9	15	PF00069	0.530
MOD_ProDKin_1	124	130	PF00069	0.674
MOD_ProDKin_1	139	145	PF00069	0.558
MOD_ProDKin_1	285	291	PF00069	0.740
MOD_ProDKin_1	292	298	PF00069	0.621
MOD_ProDKin_1	418	424	PF00069	0.768
MOD_ProDKin_1	428	434	PF00069	0.643
MOD_ProDKin_1	436	442	PF00069	0.719
MOD_ProDKin_1	475	481	PF00069	0.714
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.673
TRG_ENDOCYTIC_2	382	385	PF00928	0.469
TRG_ER_diArg_1	102	104	PF00400	0.551
TRG_ER_diArg_1	172	175	PF00400	0.379
TRG_ER_diArg_1	315	317	PF00400	0.547
TRG_ER_diArg_1	71	74	PF00400	0.674
TRG_ER_diArg_1	89	91	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS86	Leptomonas seymouri	51%	100%
A0A3S7WNL4	Leishmania donovani	91%	100%
A4H395	Leishmania braziliensis	69%	100%
A4HRK3	Leishmania infantum	92%	100%
E9AJG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%