Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC70_LEIMA

TriTrypDb:

LmjF.01.0790 , LMJLV39_010013200 , LMJSD75_010013200

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.579
CLV_C14_Caspase3-7	63	67	PF00656	0.669
CLV_C14_Caspase3-7	99	103	PF00656	0.673
CLV_NRD_NRD_1	129	131	PF00675	0.655
CLV_NRD_NRD_1	209	211	PF00675	0.722
CLV_NRD_NRD_1	344	346	PF00675	0.786
CLV_NRD_NRD_1	384	386	PF00675	0.617
CLV_NRD_NRD_1	475	477	PF00675	0.602
CLV_NRD_NRD_1	68	70	PF00675	0.744
CLV_PCSK_KEX2_1	129	131	PF00082	0.655
CLV_PCSK_KEX2_1	209	211	PF00082	0.722
CLV_PCSK_KEX2_1	343	345	PF00082	0.783
CLV_PCSK_KEX2_1	384	386	PF00082	0.617
CLV_PCSK_KEX2_1	475	477	PF00082	0.602
CLV_PCSK_KEX2_1	482	484	PF00082	0.502
CLV_PCSK_KEX2_1	68	70	PF00082	0.744
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.502
CLV_PCSK_SKI1_1	157	161	PF00082	0.476
CLV_PCSK_SKI1_1	510	514	PF00082	0.553
DEG_Nend_Nbox_1	1	3	PF02207	0.709
DEG_SPOP_SBC_1	19	23	PF00917	0.583
DEG_SPOP_SBC_1	421	425	PF00917	0.758
DOC_MAPK_gen_1	275	284	PF00069	0.515
DOC_MAPK_gen_1	384	391	PF00069	0.607
DOC_MAPK_gen_1	482	489	PF00069	0.622
DOC_MAPK_MEF2A_6	261	268	PF00069	0.458
DOC_PP1_RVXF_1	486	492	PF00149	0.622
DOC_USP7_MATH_1	112	116	PF00917	0.698
DOC_USP7_MATH_1	146	150	PF00917	0.709
DOC_USP7_MATH_1	166	170	PF00917	0.469
DOC_USP7_MATH_1	200	204	PF00917	0.654
DOC_USP7_MATH_1	205	209	PF00917	0.634
DOC_USP7_MATH_1	252	256	PF00917	0.697
DOC_USP7_MATH_1	286	290	PF00917	0.613
DOC_USP7_MATH_1	305	309	PF00917	0.573
DOC_USP7_MATH_1	312	316	PF00917	0.640
DOC_USP7_MATH_1	319	323	PF00917	0.596
DOC_USP7_MATH_1	368	372	PF00917	0.607
DOC_USP7_MATH_1	421	425	PF00917	0.719
DOC_USP7_MATH_1	438	442	PF00917	0.663
DOC_USP7_MATH_1	452	456	PF00917	0.507
DOC_USP7_MATH_1	492	496	PF00917	0.652
DOC_USP7_MATH_1	54	58	PF00917	0.737
DOC_USP7_MATH_1	83	87	PF00917	0.684
DOC_WW_Pin1_4	106	111	PF00397	0.684
DOC_WW_Pin1_4	135	140	PF00397	0.699
DOC_WW_Pin1_4	196	201	PF00397	0.732
DOC_WW_Pin1_4	232	237	PF00397	0.626
DOC_WW_Pin1_4	299	304	PF00397	0.700
DOC_WW_Pin1_4	315	320	PF00397	0.535
DOC_WW_Pin1_4	404	409	PF00397	0.629
LIG_14-3-3_CanoR_1	106	110	PF00244	0.709
LIG_14-3-3_CanoR_1	129	139	PF00244	0.647
LIG_14-3-3_CanoR_1	285	291	PF00244	0.659
LIG_14-3-3_CanoR_1	343	352	PF00244	0.685
LIG_14-3-3_CanoR_1	356	364	PF00244	0.557
LIG_14-3-3_CanoR_1	422	432	PF00244	0.762
LIG_14-3-3_CanoR_1	453	460	PF00244	0.728
LIG_14-3-3_CanoR_1	510	515	PF00244	0.553
LIG_14-3-3_CanoR_1	79	83	PF00244	0.681
LIG_BIR_III_4	362	366	PF00653	0.677
LIG_BIR_III_4	392	396	PF00653	0.716
LIG_FHA_1	1	7	PF00498	0.659
LIG_FHA_1	25	31	PF00498	0.622
LIG_FHA_1	409	415	PF00498	0.707
LIG_FHA_1	428	434	PF00498	0.557
LIG_FHA_1	507	513	PF00498	0.556
LIG_FHA_2	214	220	PF00498	0.686
LIG_LIR_Apic_2	162	168	PF02991	0.479
LIG_LIR_Apic_2	465	469	PF02991	0.650
LIG_LIR_Gen_1	174	182	PF02991	0.488
LIG_LIR_Nem_3	169	173	PF02991	0.442
LIG_LIR_Nem_3	174	180	PF02991	0.460
LIG_LIR_Nem_3	396	402	PF02991	0.601
LIG_LIR_Nem_3	444	448	PF02991	0.598
LIG_SH2_CRK	449	453	PF00017	0.666
LIG_SH2_GRB2like	226	229	PF00017	0.656
LIG_SH2_GRB2like	445	448	PF00017	0.701
LIG_SH2_PTP2	271	274	PF00017	0.485
LIG_SH2_SRC	466	469	PF00017	0.562
LIG_SH2_STAT5	271	274	PF00017	0.550
LIG_SH2_STAT5	466	469	PF00017	0.562
LIG_SH3_1	297	303	PF00018	0.716
LIG_SH3_3	235	241	PF00018	0.714
LIG_SH3_3	297	303	PF00018	0.766
LIG_SH3_3	44	50	PF00018	0.694
LIG_TRAF2_1	216	219	PF00917	0.696
MOD_CK1_1	115	121	PF00069	0.681
MOD_CK1_1	135	141	PF00069	0.697
MOD_CK1_1	18	24	PF00069	0.665
MOD_CK1_1	26	32	PF00069	0.547
MOD_CK1_1	315	321	PF00069	0.576
MOD_CK1_1	424	430	PF00069	0.762
MOD_CK1_1	441	447	PF00069	0.623
MOD_CK1_1	455	461	PF00069	0.571
MOD_CK1_1	495	501	PF00069	0.676
MOD_CK1_1	57	63	PF00069	0.735
MOD_CK1_1	8	14	PF00069	0.635
MOD_CK2_1	213	219	PF00069	0.704
MOD_GlcNHglycan	102	105	PF01048	0.763
MOD_GlcNHglycan	141	144	PF01048	0.784
MOD_GlcNHglycan	17	20	PF01048	0.642
MOD_GlcNHglycan	202	205	PF01048	0.663
MOD_GlcNHglycan	254	258	PF01048	0.678
MOD_GlcNHglycan	288	291	PF01048	0.631
MOD_GlcNHglycan	307	310	PF01048	0.541
MOD_GlcNHglycan	346	349	PF01048	0.791
MOD_GlcNHglycan	370	373	PF01048	0.615
MOD_GlcNHglycan	426	429	PF01048	0.671
MOD_GlcNHglycan	43	46	PF01048	0.660
MOD_GlcNHglycan	521	524	PF01048	0.594
MOD_GlcNHglycan	59	62	PF01048	0.726
MOD_GSK3_1	129	136	PF00069	0.689
MOD_GSK3_1	15	22	PF00069	0.754
MOD_GSK3_1	196	203	PF00069	0.657
MOD_GSK3_1	315	322	PF00069	0.602
MOD_GSK3_1	37	44	PF00069	0.710
MOD_GSK3_1	404	411	PF00069	0.625
MOD_GSK3_1	420	427	PF00069	0.657
MOD_GSK3_1	452	459	PF00069	0.614
MOD_GSK3_1	506	513	PF00069	0.555
MOD_GSK3_1	78	85	PF00069	0.699
MOD_GSK3_1	87	94	PF00069	0.605
MOD_N-GLC_1	55	60	PF02516	0.608
MOD_NEK2_1	2	7	PF00069	0.655
MOD_NEK2_1	36	41	PF00069	0.587
MOD_NEK2_1	72	77	PF00069	0.702
MOD_OFUCOSY	451	457	PF10250	0.727
MOD_PIKK_1	319	325	PF00454	0.706
MOD_PIKK_1	495	501	PF00454	0.549
MOD_PKA_1	129	135	PF00069	0.634
MOD_PKA_1	343	349	PF00069	0.786
MOD_PKA_2	105	111	PF00069	0.698
MOD_PKA_2	129	135	PF00069	0.608
MOD_PKA_2	195	201	PF00069	0.690
MOD_PKA_2	284	290	PF00069	0.614
MOD_PKA_2	343	349	PF00069	0.786
MOD_PKA_2	421	427	PF00069	0.759
MOD_PKA_2	452	458	PF00069	0.627
MOD_PKA_2	78	84	PF00069	0.788
MOD_PKA_2	8	14	PF00069	0.739
MOD_PKB_1	508	516	PF00069	0.557
MOD_Plk_1	213	219	PF00069	0.696
MOD_Plk_4	166	172	PF00069	0.505
MOD_Plk_4	374	380	PF00069	0.645
MOD_Plk_4	410	416	PF00069	0.711
MOD_Plk_4	428	434	PF00069	0.501
MOD_Plk_4	462	468	PF00069	0.574
MOD_Plk_4	492	498	PF00069	0.653
MOD_Plk_4	60	66	PF00069	0.676
MOD_ProDKin_1	106	112	PF00069	0.685
MOD_ProDKin_1	135	141	PF00069	0.698
MOD_ProDKin_1	196	202	PF00069	0.727
MOD_ProDKin_1	232	238	PF00069	0.627
MOD_ProDKin_1	299	305	PF00069	0.702
MOD_ProDKin_1	315	321	PF00069	0.536
MOD_ProDKin_1	404	410	PF00069	0.629
TRG_DiLeu_BaEn_1	254	259	PF01217	0.676
TRG_DiLeu_BaEn_1	485	490	PF01217	0.616
TRG_DiLeu_LyEn_5	485	490	PF01217	0.616
TRG_ENDOCYTIC_2	271	274	PF00928	0.485
TRG_ER_diArg_1	209	211	PF00400	0.722
TRG_ER_diArg_1	343	345	PF00400	0.790
TRG_ER_diArg_1	474	476	PF00400	0.574
TRG_ER_diArg_1	507	510	PF00400	0.601
TRG_NES_CRM1_1	172	186	PF08389	0.442
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB0	Leptomonas seymouri	41%	99%
A0A451EJD3	Leishmania donovani	89%	100%
A4H394	Leishmania braziliensis	57%	100%
A4HRK2	Leishmania infantum	89%	100%
E9AJG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%