Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC67_LEIMA

TriTrypDb:

LmjF.01.0760 , LMJLV39_010013000 , LMJSD75_010013000

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.621
CLV_PCSK_KEX2_1	18	20	PF00082	0.624
CLV_PCSK_PC7_1	15	21	PF00082	0.614
CLV_PCSK_SKI1_1	174	178	PF00082	0.477
CLV_PCSK_SKI1_1	310	314	PF00082	0.532
DOC_MAPK_MEF2A_6	259	268	PF00069	0.622
DOC_PP2B_LxvP_1	251	254	PF13499	0.441
DOC_SPAK_OSR1_1	38	42	PF12202	0.332
DOC_USP7_MATH_1	14	18	PF00917	0.664
DOC_USP7_MATH_1	150	154	PF00917	0.444
DOC_USP7_MATH_1	206	210	PF00917	0.696
DOC_USP7_MATH_1	219	223	PF00917	0.505
DOC_USP7_MATH_1	240	244	PF00917	0.643
DOC_USP7_MATH_1	6	10	PF00917	0.657
DOC_WW_Pin1_4	161	166	PF00397	0.617
DOC_WW_Pin1_4	210	215	PF00397	0.654
DOC_WW_Pin1_4	90	95	PF00397	0.618
LIG_14-3-3_CanoR_1	294	303	PF00244	0.575
LIG_14-3-3_CanoR_1	5	14	PF00244	0.557
LIG_AP2alpha_2	62	64	PF02296	0.333
LIG_APCC_ABBA_1	64	69	PF00400	0.385
LIG_BRCT_BRCA1_1	221	225	PF00533	0.590
LIG_FHA_1	120	126	PF00498	0.476
LIG_FHA_1	136	142	PF00498	0.476
LIG_FHA_1	246	252	PF00498	0.512
LIG_FHA_1	307	313	PF00498	0.467
LIG_FHA_1	95	101	PF00498	0.447
LIG_FHA_2	311	317	PF00498	0.464
LIG_LIR_Gen_1	112	121	PF02991	0.434
LIG_LIR_Gen_1	179	186	PF02991	0.466
LIG_LIR_Gen_1	222	231	PF02991	0.531
LIG_LIR_Gen_1	62	71	PF02991	0.506
LIG_LIR_Nem_3	112	116	PF02991	0.421
LIG_LIR_Nem_3	179	183	PF02991	0.444
LIG_LIR_Nem_3	184	189	PF02991	0.451
LIG_LIR_Nem_3	222	228	PF02991	0.549
LIG_LIR_Nem_3	62	67	PF02991	0.518
LIG_LIR_Nem_3	68	73	PF02991	0.427
LIG_PDZ_Class_2	334	339	PF00595	0.477
LIG_SH2_CRK	113	117	PF00017	0.427
LIG_SH2_CRK	180	184	PF00017	0.444
LIG_SH2_CRK	186	190	PF00017	0.428
LIG_SH2_CRK	26	30	PF00017	0.599
LIG_SH2_NCK_1	180	184	PF00017	0.444
LIG_SH2_NCK_1	186	190	PF00017	0.428
LIG_SH2_STAT3	24	27	PF00017	0.438
LIG_SH2_STAT3	322	325	PF00017	0.467
LIG_SH2_STAT5	295	298	PF00017	0.743
LIG_SH2_STAT5	322	325	PF00017	0.467
LIG_SH3_3	162	168	PF00018	0.589
LIG_SH3_3	208	214	PF00018	0.657
LIG_SH3_3	332	338	PF00018	0.517
LIG_SH3_3	41	47	PF00018	0.398
LIG_SH3_3	88	94	PF00018	0.786
LIG_TRAF2_1	305	308	PF00917	0.530
LIG_TYR_ITSM	182	189	PF00017	0.476
MOD_CDK_SPK_2	161	166	PF00069	0.556
MOD_CK1_1	127	133	PF00069	0.559
MOD_CK1_1	187	193	PF00069	0.454
MOD_CK1_1	209	215	PF00069	0.654
MOD_CK2_1	257	263	PF00069	0.616
MOD_CK2_1	302	308	PF00069	0.544
MOD_CK2_1	310	316	PF00069	0.403
MOD_GlcNHglycan	130	133	PF01048	0.606
MOD_GlcNHglycan	143	146	PF01048	0.421
MOD_GlcNHglycan	195	198	PF01048	0.690
MOD_GlcNHglycan	2	5	PF01048	0.658
MOD_GlcNHglycan	221	224	PF01048	0.546
MOD_GlcNHglycan	231	234	PF01048	0.622
MOD_GlcNHglycan	29	32	PF01048	0.445
MOD_GlcNHglycan	8	11	PF01048	0.621
MOD_GSK3_1	124	131	PF00069	0.524
MOD_GSK3_1	156	163	PF00069	0.520
MOD_GSK3_1	181	188	PF00069	0.425
MOD_GSK3_1	205	212	PF00069	0.647
MOD_GSK3_1	302	309	PF00069	0.601
MOD_GSK3_1	90	97	PF00069	0.583
MOD_NEK2_1	128	133	PF00069	0.523
MOD_NEK2_1	141	146	PF00069	0.401
MOD_NEK2_1	156	161	PF00069	0.415
MOD_NEK2_1	285	290	PF00069	0.567
MOD_PIKK_1	156	162	PF00454	0.499
MOD_PKA_2	14	20	PF00069	0.580
MOD_PKA_2	245	251	PF00069	0.649
MOD_PKA_2	269	275	PF00069	0.599
MOD_PKA_2	4	10	PF00069	0.591
MOD_Plk_1	240	246	PF00069	0.647
MOD_Plk_1	306	312	PF00069	0.481
MOD_ProDKin_1	161	167	PF00069	0.614
MOD_ProDKin_1	210	216	PF00069	0.653
MOD_ProDKin_1	90	96	PF00069	0.612
MOD_SUMO_rev_2	273	277	PF00179	0.559
TRG_ENDOCYTIC_2	113	116	PF00928	0.422
TRG_ENDOCYTIC_2	180	183	PF00928	0.439
TRG_ENDOCYTIC_2	186	189	PF00928	0.422
TRG_ENDOCYTIC_2	26	29	PF00928	0.455
TRG_ER_diArg_1	171	174	PF00400	0.572
TRG_ER_diArg_1	18	20	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJC9	Leishmania donovani	88%	69%
E9AJG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%