Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC65_LEIMA

TriTrypDb:

LmjF.01.0740 , LMJLV39_010012800 , LMJSD75_010012800

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.528
CLV_C14_Caspase3-7	231	235	PF00656	0.760
CLV_C14_Caspase3-7	394	398	PF00656	0.672
CLV_NRD_NRD_1	14	16	PF00675	0.579
CLV_NRD_NRD_1	173	175	PF00675	0.628
CLV_NRD_NRD_1	284	286	PF00675	0.547
CLV_NRD_NRD_1	408	410	PF00675	0.670
CLV_NRD_NRD_1	516	518	PF00675	0.639
CLV_NRD_NRD_1	521	523	PF00675	0.533
CLV_NRD_NRD_1	707	709	PF00675	0.426
CLV_NRD_NRD_1	732	734	PF00675	0.512
CLV_PCSK_FUR_1	514	518	PF00082	0.560
CLV_PCSK_KEX2_1	14	16	PF00082	0.579
CLV_PCSK_KEX2_1	173	175	PF00082	0.628
CLV_PCSK_KEX2_1	284	286	PF00082	0.547
CLV_PCSK_KEX2_1	308	310	PF00082	0.499
CLV_PCSK_KEX2_1	408	410	PF00082	0.670
CLV_PCSK_KEX2_1	516	518	PF00082	0.634
CLV_PCSK_KEX2_1	521	523	PF00082	0.543
CLV_PCSK_KEX2_1	546	548	PF00082	0.673
CLV_PCSK_KEX2_1	670	672	PF00082	0.543
CLV_PCSK_KEX2_1	675	677	PF00082	0.477
CLV_PCSK_KEX2_1	706	708	PF00082	0.419
CLV_PCSK_KEX2_1	732	734	PF00082	0.512
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.515
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.567
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.543
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.477
CLV_PCSK_PC7_1	169	175	PF00082	0.612
CLV_PCSK_PC7_1	517	523	PF00082	0.616
CLV_PCSK_PC7_1	671	677	PF00082	0.479
CLV_PCSK_SKI1_1	169	173	PF00082	0.604
CLV_PCSK_SKI1_1	275	279	PF00082	0.489
CLV_PCSK_SKI1_1	284	288	PF00082	0.542
CLV_PCSK_SKI1_1	339	343	PF00082	0.550
CLV_PCSK_SKI1_1	4	8	PF00082	0.534
CLV_PCSK_SKI1_1	517	521	PF00082	0.615
CLV_PCSK_SKI1_1	667	671	PF00082	0.538
CLV_PCSK_SKI1_1	708	712	PF00082	0.512
CLV_Separin_Metazoa	618	622	PF03568	0.500
DEG_SCF_FBW7_2	611	618	PF00400	0.489
DEG_SPOP_SBC_1	420	424	PF00917	0.621
DOC_ANK_TNKS_1	112	119	PF00023	0.433
DOC_ANK_TNKS_1	482	489	PF00023	0.643
DOC_CKS1_1	260	265	PF01111	0.636
DOC_CYCLIN_yCln2_LP_2	316	322	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.588
DOC_MAPK_gen_1	14	20	PF00069	0.536
DOC_MAPK_gen_1	521	529	PF00069	0.501
DOC_MAPK_HePTP_8	322	334	PF00069	0.467
DOC_MAPK_MEF2A_6	325	334	PF00069	0.463
DOC_MAPK_MEF2A_6	612	619	PF00069	0.588
DOC_PP1_RVXF_1	661	667	PF00149	0.501
DOC_PP2B_LxvP_1	417	420	PF13499	0.592
DOC_PP2B_LxvP_1	620	623	PF13499	0.419
DOC_PP4_FxxP_1	260	263	PF00568	0.635
DOC_USP7_MATH_1	208	212	PF00917	0.770
DOC_USP7_MATH_1	213	217	PF00917	0.723
DOC_USP7_MATH_1	232	236	PF00917	0.662
DOC_USP7_MATH_1	239	243	PF00917	0.573
DOC_USP7_MATH_1	270	274	PF00917	0.600
DOC_USP7_MATH_1	487	491	PF00917	0.712
DOC_USP7_MATH_1	551	555	PF00917	0.574
DOC_USP7_MATH_1	623	627	PF00917	0.557
DOC_USP7_MATH_1	656	660	PF00917	0.502
DOC_WW_Pin1_4	153	158	PF00397	0.658
DOC_WW_Pin1_4	195	200	PF00397	0.665
DOC_WW_Pin1_4	206	211	PF00397	0.647
DOC_WW_Pin1_4	259	264	PF00397	0.751
DOC_WW_Pin1_4	549	554	PF00397	0.674
DOC_WW_Pin1_4	593	598	PF00397	0.695
DOC_WW_Pin1_4	599	604	PF00397	0.614
DOC_WW_Pin1_4	611	616	PF00397	0.510
DOC_WW_Pin1_4	70	75	PF00397	0.632
DOC_WW_Pin1_4	716	721	PF00397	0.500
LIG_14-3-3_CanoR_1	173	177	PF00244	0.684
LIG_14-3-3_CanoR_1	197	206	PF00244	0.665
LIG_14-3-3_CanoR_1	293	299	PF00244	0.607
LIG_14-3-3_CanoR_1	598	603	PF00244	0.588
LIG_14-3-3_CanoR_1	692	697	PF00244	0.470
LIG_Actin_WH2_2	571	587	PF00022	0.483
LIG_BIR_III_2	537	541	PF00653	0.485
LIG_BIR_III_4	501	505	PF00653	0.569
LIG_deltaCOP1_diTrp_1	565	574	PF00928	0.587
LIG_eIF4E_1	674	680	PF01652	0.548
LIG_FHA_1	103	109	PF00498	0.678
LIG_FHA_1	26	32	PF00498	0.712
LIG_FHA_1	295	301	PF00498	0.585
LIG_FHA_1	573	579	PF00498	0.543
LIG_FHA_1	612	618	PF00498	0.520
LIG_FHA_1	675	681	PF00498	0.500
LIG_FHA_1	717	723	PF00498	0.542
LIG_FHA_2	229	235	PF00498	0.713
LIG_FHA_2	260	266	PF00498	0.590
LIG_FHA_2	324	330	PF00498	0.474
LIG_FHA_2	367	373	PF00498	0.564
LIG_FHA_2	508	514	PF00498	0.587
LIG_FHA_2	98	104	PF00498	0.539
LIG_Integrin_RGD_1	671	673	PF01839	0.607
LIG_LIR_Apic_2	258	263	PF02991	0.651
LIG_LIR_Apic_2	55	60	PF02991	0.550
LIG_LIR_Gen_1	324	334	PF02991	0.466
LIG_LIR_Gen_1	565	574	PF02991	0.541
LIG_LIR_Gen_1	629	635	PF02991	0.534
LIG_LIR_Gen_1	650	657	PF02991	0.510
LIG_LIR_Nem_3	268	274	PF02991	0.523
LIG_LIR_Nem_3	314	320	PF02991	0.506
LIG_LIR_Nem_3	324	330	PF02991	0.614
LIG_LIR_Nem_3	446	450	PF02991	0.607
LIG_LIR_Nem_3	565	571	PF02991	0.592
LIG_LIR_Nem_3	629	634	PF02991	0.459
LIG_LIR_Nem_3	650	654	PF02991	0.513
LIG_MAD2	339	347	PF02301	0.451
LIG_MYND_1	738	742	PF01753	0.468
LIG_NRP_CendR_1	750	751	PF00754	0.601
LIG_Pex14_1	358	362	PF04695	0.433
LIG_PTAP_UEV_1	552	557	PF05743	0.588
LIG_REV1ctd_RIR_1	27	35	PF16727	0.608
LIG_REV1ctd_RIR_1	571	581	PF16727	0.552
LIG_RPA_C_Fungi	466	478	PF08784	0.551
LIG_SH2_CRK	274	278	PF00017	0.497
LIG_SH2_CRK	313	317	PF00017	0.451
LIG_SH2_NCK_1	317	321	PF00017	0.473
LIG_SH2_NCK_1	57	61	PF00017	0.578
LIG_SH2_PTP2	17	20	PF00017	0.533
LIG_SH2_PTP2	631	634	PF00017	0.486
LIG_SH2_SRC	57	60	PF00017	0.570
LIG_SH2_STAP1	313	317	PF00017	0.451
LIG_SH2_STAT5	17	20	PF00017	0.533
LIG_SH2_STAT5	276	279	PF00017	0.614
LIG_SH2_STAT5	313	316	PF00017	0.457
LIG_SH2_STAT5	61	64	PF00017	0.602
LIG_SH2_STAT5	631	634	PF00017	0.459
LIG_SH3_3	118	124	PF00018	0.500
LIG_SH3_3	128	134	PF00018	0.742
LIG_SH3_3	151	157	PF00018	0.585
LIG_SH3_3	20	26	PF00018	0.480
LIG_SH3_3	344	350	PF00018	0.491
LIG_SH3_3	371	377	PF00018	0.749
LIG_SH3_3	550	556	PF00018	0.644
LIG_SH3_3	600	606	PF00018	0.611
LIG_SH3_3	66	72	PF00018	0.608
LIG_SH3_3	736	742	PF00018	0.464
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.539
LIG_SUMO_SIM_anti_2	449	455	PF11976	0.604
LIG_SUMO_SIM_anti_2	562	568	PF11976	0.612
LIG_SUMO_SIM_anti_2	616	621	PF11976	0.399
LIG_SUMO_SIM_anti_2	693	699	PF11976	0.507
LIG_SUMO_SIM_par_1	105	111	PF11976	0.693
LIG_SUMO_SIM_par_1	318	324	PF11976	0.476
LIG_TRAF2_1	286	289	PF00917	0.521
LIG_TRAF2_1	602	605	PF00917	0.585
LIG_TRAF2_1	627	630	PF00917	0.488
LIG_TYR_ITIM	315	320	PF00017	0.595
MOD_CDK_SPK_2	593	598	PF00069	0.566
MOD_CDK_SPxxK_3	716	723	PF00069	0.431
MOD_CK1_1	198	204	PF00069	0.687
MOD_CK1_1	211	217	PF00069	0.589
MOD_CK1_1	235	241	PF00069	0.761
MOD_CK1_1	395	401	PF00069	0.709
MOD_CK1_1	443	449	PF00069	0.509
MOD_CK1_1	554	560	PF00069	0.803
MOD_CK1_1	572	578	PF00069	0.574
MOD_CK1_1	67	73	PF00069	0.651
MOD_CK2_1	221	227	PF00069	0.746
MOD_CK2_1	323	329	PF00069	0.479
MOD_CK2_1	366	372	PF00069	0.552
MOD_CK2_1	424	430	PF00069	0.637
MOD_CK2_1	443	449	PF00069	0.568
MOD_CK2_1	487	493	PF00069	0.697
MOD_CK2_1	507	513	PF00069	0.657
MOD_CK2_1	599	605	PF00069	0.568
MOD_CK2_1	623	629	PF00069	0.531
MOD_Cter_Amidation	282	285	PF01082	0.524
MOD_Cter_Amidation	748	751	PF01082	0.578
MOD_GlcNHglycan	200	203	PF01048	0.666
MOD_GlcNHglycan	210	213	PF01048	0.675
MOD_GlcNHglycan	223	226	PF01048	0.639
MOD_GlcNHglycan	236	240	PF01048	0.581
MOD_GlcNHglycan	241	244	PF01048	0.790
MOD_GlcNHglycan	369	372	PF01048	0.495
MOD_GlcNHglycan	386	389	PF01048	0.630
MOD_GlcNHglycan	394	397	PF01048	0.641
MOD_GlcNHglycan	426	429	PF01048	0.604
MOD_GlcNHglycan	442	445	PF01048	0.603
MOD_GlcNHglycan	482	486	PF01048	0.714
MOD_GlcNHglycan	489	492	PF01048	0.659
MOD_GlcNHglycan	553	556	PF01048	0.666
MOD_GlcNHglycan	559	562	PF01048	0.663
MOD_GlcNHglycan	625	628	PF01048	0.550
MOD_GlcNHglycan	698	701	PF01048	0.509
MOD_GlcNHglycan	714	717	PF01048	0.508
MOD_GlcNHglycan	89	92	PF01048	0.542
MOD_GSK3_1	153	160	PF00069	0.794
MOD_GSK3_1	211	218	PF00069	0.731
MOD_GSK3_1	228	235	PF00069	0.786
MOD_GSK3_1	255	262	PF00069	0.598
MOD_GSK3_1	380	387	PF00069	0.626
MOD_GSK3_1	403	410	PF00069	0.776
MOD_GSK3_1	420	427	PF00069	0.652
MOD_GSK3_1	593	600	PF00069	0.473
MOD_GSK3_1	633	640	PF00069	0.465
MOD_GSK3_1	692	699	PF00069	0.529
MOD_GSK3_1	712	719	PF00069	0.676
MOD_N-GLC_1	557	562	PF02516	0.674
MOD_NEK2_1	102	107	PF00069	0.530
MOD_NEK2_1	172	177	PF00069	0.700
MOD_NEK2_1	221	226	PF00069	0.646
MOD_NEK2_1	287	292	PF00069	0.489
MOD_NEK2_1	633	638	PF00069	0.376
MOD_NEK2_2	727	732	PF00069	0.519
MOD_PIKK_1	177	183	PF00454	0.698
MOD_PIKK_1	67	73	PF00454	0.649
MOD_PIKK_1	79	85	PF00454	0.583
MOD_PK_1	119	125	PF00069	0.601
MOD_PK_1	692	698	PF00069	0.467
MOD_PKA_2	172	178	PF00069	0.664
MOD_PKA_2	292	298	PF00069	0.589
MOD_PKA_2	404	410	PF00069	0.641
MOD_PKA_2	470	476	PF00069	0.576
MOD_PKA_2	584	590	PF00069	0.545
MOD_PKA_2	597	603	PF00069	0.553
MOD_PKB_1	479	487	PF00069	0.547
MOD_Plk_1	102	108	PF00069	0.527
MOD_Plk_1	323	329	PF00069	0.479
MOD_Plk_1	569	575	PF00069	0.578
MOD_Plk_4	102	108	PF00069	0.530
MOD_Plk_4	25	31	PF00069	0.675
MOD_Plk_4	311	317	PF00069	0.516
MOD_Plk_4	569	575	PF00069	0.578
MOD_Plk_4	656	662	PF00069	0.522
MOD_Plk_4	692	698	PF00069	0.570
MOD_ProDKin_1	153	159	PF00069	0.657
MOD_ProDKin_1	195	201	PF00069	0.665
MOD_ProDKin_1	206	212	PF00069	0.648
MOD_ProDKin_1	259	265	PF00069	0.748
MOD_ProDKin_1	549	555	PF00069	0.675
MOD_ProDKin_1	593	599	PF00069	0.702
MOD_ProDKin_1	611	617	PF00069	0.536
MOD_ProDKin_1	70	76	PF00069	0.634
MOD_ProDKin_1	716	722	PF00069	0.496
TRG_DiLeu_BaEn_1	167	172	PF01217	0.530
TRG_DiLeu_BaEn_1	629	634	PF01217	0.487
TRG_DiLeu_BaEn_3	80	86	PF01217	0.550
TRG_DiLeu_BaEn_4	629	635	PF01217	0.486
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.545
TRG_ENDOCYTIC_2	17	20	PF00928	0.533
TRG_ENDOCYTIC_2	257	260	PF00928	0.594
TRG_ENDOCYTIC_2	274	277	PF00928	0.503
TRG_ENDOCYTIC_2	313	316	PF00928	0.457
TRG_ENDOCYTIC_2	317	320	PF00928	0.491
TRG_ENDOCYTIC_2	631	634	PF00928	0.535
TRG_ENDOCYTIC_2	651	654	PF00928	0.515
TRG_ENDOCYTIC_2	683	686	PF00928	0.467
TRG_ER_diArg_1	13	15	PF00400	0.541
TRG_ER_diArg_1	172	174	PF00400	0.619
TRG_ER_diArg_1	31	34	PF00400	0.544
TRG_ER_diArg_1	408	411	PF00400	0.651
TRG_ER_diArg_1	520	522	PF00400	0.565
TRG_ER_diArg_1	590	593	PF00400	0.523
TRG_ER_diArg_1	706	708	PF00400	0.419
TRG_ER_diArg_1	731	733	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II66	Leptomonas seymouri	55%	100%
A0A3S5H4W8	Leishmania donovani	91%	99%
A4H391	Leishmania braziliensis	76%	100%
A4HRJ7	Leishmania infantum	91%	100%
E9AJG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%