PLAC8 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PLAC8 family, putative

Species:

Leishmania major

UniProt:

E9AC60_LEIMA

TriTrypDb:

LmjF.01.0690 , LMJLV39_010012200 , LMJSD75_010012200

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.270
CLV_PCSK_KEX2_1	152	154	PF00082	0.266
CLV_PCSK_PC7_1	148	154	PF00082	0.270
DOC_CKS1_1	221	226	PF01111	0.468
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.547
DOC_PP2B_LxvP_1	114	117	PF13499	0.270
DOC_PP4_FxxP_1	191	194	PF00568	0.410
DOC_USP7_MATH_1	131	135	PF00917	0.480
DOC_USP7_MATH_1	163	167	PF00917	0.342
DOC_USP7_MATH_1	60	64	PF00917	0.559
DOC_WW_Pin1_4	220	225	PF00397	0.454
LIG_14-3-3_CanoR_1	15	19	PF00244	0.622
LIG_14-3-3_CanoR_1	218	222	PF00244	0.514
LIG_APCC_ABBA_1	48	53	PF00400	0.548
LIG_APCC_ABBAyCdc20_2	3	9	PF00400	0.529
LIG_APCC_ABBAyCdc20_2	47	53	PF00400	0.549
LIG_BIR_II_1	1	5	PF00653	0.732
LIG_BRCT_BRCA1_1	138	142	PF00533	0.503
LIG_BRCT_BRCA1_1	3	7	PF00533	0.527
LIG_Clathr_ClatBox_1	122	126	PF01394	0.343
LIG_deltaCOP1_diTrp_1	209	215	PF00928	0.567
LIG_FHA_1	109	115	PF00498	0.389
LIG_FHA_1	74	80	PF00498	0.410
LIG_FHA_2	34	40	PF00498	0.544
LIG_LIR_Apic_2	188	194	PF02991	0.375
LIG_LIR_Nem_3	112	118	PF02991	0.410
LIG_LIR_Nem_3	139	145	PF02991	0.382
LIG_Pex14_2	142	146	PF04695	0.439
LIG_Rb_LxCxE_1	76	91	PF01857	0.410
LIG_SH2_SRC	115	118	PF00017	0.410
LIG_SH2_SRC	135	138	PF00017	0.410
LIG_SH2_STAT3	219	222	PF00017	0.571
LIG_SH2_STAT5	115	118	PF00017	0.343
LIG_SH2_STAT5	135	138	PF00017	0.476
LIG_SH2_STAT5	145	148	PF00017	0.354
LIG_SH2_STAT5	97	100	PF00017	0.343
LIG_SUMO_SIM_anti_2	179	188	PF11976	0.428
LIG_SUMO_SIM_par_1	179	188	PF11976	0.406
MOD_CK1_1	130	136	PF00069	0.480
MOD_CK1_1	171	177	PF00069	0.441
MOD_CK1_1	220	226	PF00069	0.520
MOD_CK2_1	26	32	PF00069	0.735
MOD_CK2_1	56	62	PF00069	0.663
MOD_GlcNHglycan	100	103	PF01048	0.515
MOD_GlcNHglycan	129	132	PF01048	0.484
MOD_GlcNHglycan	148	151	PF01048	0.489
MOD_GlcNHglycan	158	161	PF01048	0.358
MOD_GlcNHglycan	173	176	PF01048	0.240
MOD_GlcNHglycan	55	59	PF01048	0.691
MOD_GlcNHglycan	76	79	PF01048	0.352
MOD_GSK3_1	127	134	PF00069	0.348
MOD_GSK3_1	165	172	PF00069	0.369
MOD_GSK3_1	213	220	PF00069	0.635
MOD_GSK3_1	56	63	PF00069	0.592
MOD_N-GLC_1	108	113	PF02516	0.352
MOD_NEK2_1	14	19	PF00069	0.628
MOD_NEK2_1	146	151	PF00069	0.486
MOD_NEK2_1	96	101	PF00069	0.405
MOD_PKA_2	14	20	PF00069	0.631
MOD_PKA_2	217	223	PF00069	0.643
MOD_Plk_2-3	26	32	PF00069	0.665
MOD_Plk_4	131	137	PF00069	0.445
MOD_Plk_4	14	20	PF00069	0.631
MOD_Plk_4	141	147	PF00069	0.292
MOD_Plk_4	179	185	PF00069	0.440
MOD_ProDKin_1	220	226	PF00069	0.462
MOD_SUMO_for_1	46	49	PF00179	0.545
MOD_SUMO_rev_2	39	48	PF00179	0.535
TRG_ENDOCYTIC_2	115	118	PF00928	0.413
TRG_ER_diArg_1	151	154	PF00400	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I201	Leptomonas seymouri	40%	100%
A0A451EJC3	Leishmania donovani	88%	99%
A4H387	Leishmania braziliensis	67%	98%
A4HRJ2	Leishmania infantum	88%	99%
E9AJF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%