Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AC59_LEIMA

TriTrypDb:

LmjF.01.0680 , LMJLV39_010012100 , LMJSD75_010012100

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.667
CLV_C14_Caspase3-7	191	195	PF00656	0.644
CLV_C14_Caspase3-7	317	321	PF00656	0.669
CLV_C14_Caspase3-7	643	647	PF00656	0.635
CLV_C14_Caspase3-7	83	87	PF00656	0.588
CLV_NRD_NRD_1	108	110	PF00675	0.579
CLV_NRD_NRD_1	164	166	PF00675	0.567
CLV_NRD_NRD_1	222	224	PF00675	0.673
CLV_NRD_NRD_1	257	259	PF00675	0.667
CLV_NRD_NRD_1	269	271	PF00675	0.610
CLV_NRD_NRD_1	43	45	PF00675	0.603
CLV_NRD_NRD_1	608	610	PF00675	0.712
CLV_NRD_NRD_1	70	72	PF00675	0.642
CLV_NRD_NRD_1	702	704	PF00675	0.610
CLV_NRD_NRD_1	725	727	PF00675	0.664
CLV_NRD_NRD_1	95	97	PF00675	0.738
CLV_PCSK_FUR_1	106	110	PF00082	0.685
CLV_PCSK_FUR_1	220	224	PF00082	0.676
CLV_PCSK_KEX2_1	108	110	PF00082	0.579
CLV_PCSK_KEX2_1	164	166	PF00082	0.567
CLV_PCSK_KEX2_1	222	224	PF00082	0.673
CLV_PCSK_KEX2_1	256	258	PF00082	0.651
CLV_PCSK_KEX2_1	269	271	PF00082	0.602
CLV_PCSK_KEX2_1	42	44	PF00082	0.600
CLV_PCSK_KEX2_1	608	610	PF00082	0.712
CLV_PCSK_KEX2_1	710	712	PF00082	0.665
CLV_PCSK_KEX2_1	725	727	PF00082	0.532
CLV_PCSK_KEX2_1	95	97	PF00082	0.738
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.603
CLV_PCSK_PC1ET2_1	710	712	PF00082	0.665
CLV_PCSK_PC7_1	252	258	PF00082	0.553
CLV_PCSK_SKI1_1	29	33	PF00082	0.603
CLV_PCSK_SKI1_1	36	40	PF00082	0.551
CLV_PCSK_SKI1_1	675	679	PF00082	0.692
CLV_PCSK_SKI1_1	773	777	PF00082	0.558
DEG_APCC_DBOX_1	28	36	PF00400	0.533
DEG_COP1_1	455	463	PF00400	0.556
DEG_SCF_FBW7_1	292	299	PF00400	0.631
DEG_SCF_FBW7_1	539	546	PF00400	0.678
DEG_SPOP_SBC_1	361	365	PF00917	0.653
DEG_SPOP_SBC_1	379	383	PF00917	0.488
DEG_SPOP_SBC_1	538	542	PF00917	0.681
DEG_SPOP_SBC_1	575	579	PF00917	0.636
DEG_SPOP_SBC_1	633	637	PF00917	0.603
DEG_SPOP_SBC_1	754	758	PF00917	0.689
DOC_ANK_TNKS_1	94	101	PF00023	0.656
DOC_CKS1_1	293	298	PF01111	0.696
DOC_CYCLIN_RxL_1	770	779	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.671
DOC_MAPK_gen_1	709	717	PF00069	0.688
DOC_PP2B_LxvP_1	196	199	PF13499	0.664
DOC_USP7_MATH_1	188	192	PF00917	0.644
DOC_USP7_MATH_1	226	230	PF00917	0.647
DOC_USP7_MATH_1	243	247	PF00917	0.445
DOC_USP7_MATH_1	296	300	PF00917	0.605
DOC_USP7_MATH_1	361	365	PF00917	0.684
DOC_USP7_MATH_1	366	370	PF00917	0.613
DOC_USP7_MATH_1	379	383	PF00917	0.491
DOC_USP7_MATH_1	415	419	PF00917	0.551
DOC_USP7_MATH_1	515	519	PF00917	0.705
DOC_USP7_MATH_1	58	62	PF00917	0.692
DOC_USP7_MATH_1	631	635	PF00917	0.611
DOC_USP7_MATH_1	720	724	PF00917	0.683
DOC_USP7_MATH_1	753	757	PF00917	0.688
DOC_WW_Pin1_4	107	112	PF00397	0.662
DOC_WW_Pin1_4	127	132	PF00397	0.510
DOC_WW_Pin1_4	140	145	PF00397	0.574
DOC_WW_Pin1_4	157	162	PF00397	0.533
DOC_WW_Pin1_4	292	297	PF00397	0.664
DOC_WW_Pin1_4	329	334	PF00397	0.666
DOC_WW_Pin1_4	375	380	PF00397	0.646
DOC_WW_Pin1_4	399	404	PF00397	0.673
DOC_WW_Pin1_4	539	544	PF00397	0.677
DOC_WW_Pin1_4	599	604	PF00397	0.747
DOC_WW_Pin1_4	6	11	PF00397	0.677
DOC_WW_Pin1_4	60	65	PF00397	0.642
DOC_WW_Pin1_4	660	665	PF00397	0.792
LIG_14-3-3_CanoR_1	138	146	PF00244	0.636
LIG_14-3-3_CanoR_1	164	169	PF00244	0.686
LIG_14-3-3_CanoR_1	29	39	PF00244	0.470
LIG_14-3-3_CanoR_1	326	333	PF00244	0.607
LIG_14-3-3_CanoR_1	396	403	PF00244	0.623
LIG_14-3-3_CanoR_1	406	414	PF00244	0.606
LIG_14-3-3_CanoR_1	443	449	PF00244	0.675
LIG_14-3-3_CanoR_1	551	557	PF00244	0.593
LIG_14-3-3_CanoR_1	596	604	PF00244	0.725
LIG_14-3-3_CanoR_1	632	641	PF00244	0.703
LIG_14-3-3_CanoR_1	669	675	PF00244	0.710
LIG_14-3-3_CanoR_1	71	80	PF00244	0.624
LIG_14-3-3_CanoR_1	711	717	PF00244	0.729
LIG_14-3-3_CanoR_1	725	733	PF00244	0.658
LIG_APCC_ABBA_1	780	785	PF00400	0.580
LIG_BIR_III_2	194	198	PF00653	0.657
LIG_BIR_III_2	736	740	PF00653	0.657
LIG_BRCT_BRCA1_1	280	284	PF00533	0.631
LIG_BRCT_BRCA1_1	320	324	PF00533	0.562
LIG_FHA_1	191	197	PF00498	0.605
LIG_FHA_1	292	298	PF00498	0.618
LIG_FHA_1	307	313	PF00498	0.563
LIG_FHA_1	453	459	PF00498	0.678
LIG_FHA_1	575	581	PF00498	0.662
LIG_FHA_1	634	640	PF00498	0.596
LIG_FHA_1	767	773	PF00498	0.635
LIG_FHA_2	203	209	PF00498	0.701
LIG_FHA_2	237	243	PF00498	0.542
LIG_FHA_2	306	312	PF00498	0.633
LIG_FHA_2	72	78	PF00498	0.659
LIG_FHA_2	740	746	PF00498	0.594
LIG_FHA_2	765	771	PF00498	0.588
LIG_LIR_Apic_2	621	625	PF02991	0.574
LIG_LIR_Gen_1	473	482	PF02991	0.566
LIG_LIR_Gen_1	493	500	PF02991	0.479
LIG_LIR_Gen_1	9	17	PF02991	0.640
LIG_LIR_Nem_3	167	172	PF02991	0.687
LIG_LIR_Nem_3	473	477	PF02991	0.601
LIG_LIR_Nem_3	479	485	PF02991	0.612
LIG_LIR_Nem_3	493	498	PF02991	0.502
LIG_LIR_Nem_3	9	14	PF02991	0.667
LIG_PTAP_UEV_1	110	115	PF05743	0.700
LIG_Rb_LxCxE_1	115	134	PF01857	0.601
LIG_RPA_C_Fungi	39	51	PF08784	0.476
LIG_SH2_CRK	474	478	PF00017	0.557
LIG_SH2_SRC	783	786	PF00017	0.593
LIG_SH2_STAP1	192	196	PF00017	0.646
LIG_SH2_STAT5	192	195	PF00017	0.623
LIG_SH2_STAT5	495	498	PF00017	0.573
LIG_SH3_1	108	114	PF00018	0.674
LIG_SH3_2	264	269	PF14604	0.726
LIG_SH3_2	664	669	PF14604	0.712
LIG_SH3_3	108	114	PF00018	0.674
LIG_SH3_3	155	161	PF00018	0.658
LIG_SH3_3	261	267	PF00018	0.713
LIG_SH3_3	287	293	PF00018	0.693
LIG_SH3_3	411	417	PF00018	0.595
LIG_SH3_3	455	461	PF00018	0.628
LIG_SH3_3	50	56	PF00018	0.535
LIG_SH3_3	661	667	PF00018	0.718
LIG_SH3_CIN85_PxpxPR_1	159	164	PF14604	0.626
LIG_SUMO_SIM_par_1	125	130	PF11976	0.635
LIG_SUMO_SIM_par_1	634	644	PF11976	0.642
LIG_TYR_ITIM	472	477	PF00017	0.562
MOD_CDC14_SPxK_1	162	165	PF00782	0.559
MOD_CDC14_SPxK_1	666	669	PF00782	0.715
MOD_CDK_SPK_2	159	164	PF00069	0.626
MOD_CDK_SPxK_1	159	165	PF00069	0.556
MOD_CDK_SPxK_1	539	545	PF00069	0.581
MOD_CDK_SPxK_1	663	669	PF00069	0.758
MOD_CDK_SPxxK_3	131	138	PF00069	0.627
MOD_CDK_SPxxK_3	157	164	PF00069	0.630
MOD_CDK_SPxxK_3	399	406	PF00069	0.585
MOD_CK1_1	147	153	PF00069	0.541
MOD_CK1_1	190	196	PF00069	0.670
MOD_CK1_1	218	224	PF00069	0.611
MOD_CK1_1	229	235	PF00069	0.556
MOD_CK1_1	272	278	PF00069	0.709
MOD_CK1_1	364	370	PF00069	0.601
MOD_CK1_1	4	10	PF00069	0.657
MOD_CK1_1	407	413	PF00069	0.718
MOD_CK1_1	441	447	PF00069	0.709
MOD_CK1_1	452	458	PF00069	0.581
MOD_CK1_1	519	525	PF00069	0.714
MOD_CK1_1	533	539	PF00069	0.582
MOD_CK1_1	562	568	PF00069	0.696
MOD_CK1_1	573	579	PF00069	0.644
MOD_CK1_1	597	603	PF00069	0.775
MOD_CK1_1	634	640	PF00069	0.719
MOD_CK1_1	648	654	PF00069	0.665
MOD_CK1_1	662	668	PF00069	0.671
MOD_CK1_1	728	734	PF00069	0.772
MOD_CK1_1	757	763	PF00069	0.682
MOD_CK2_1	116	122	PF00069	0.628
MOD_CK2_1	202	208	PF00069	0.699
MOD_CK2_1	218	224	PF00069	0.577
MOD_CK2_1	236	242	PF00069	0.566
MOD_CK2_1	624	630	PF00069	0.655
MOD_CK2_1	71	77	PF00069	0.663
MOD_CK2_1	82	88	PF00069	0.576
MOD_GlcNHglycan	11	14	PF01048	0.652
MOD_GlcNHglycan	111	114	PF01048	0.697
MOD_GlcNHglycan	140	143	PF01048	0.651
MOD_GlcNHglycan	149	152	PF01048	0.587
MOD_GlcNHglycan	200	203	PF01048	0.698
MOD_GlcNHglycan	217	220	PF01048	0.572
MOD_GlcNHglycan	228	231	PF01048	0.520
MOD_GlcNHglycan	259	262	PF01048	0.692
MOD_GlcNHglycan	3	6	PF01048	0.684
MOD_GlcNHglycan	351	354	PF01048	0.586
MOD_GlcNHglycan	364	367	PF01048	0.606
MOD_GlcNHglycan	375	378	PF01048	0.561
MOD_GlcNHglycan	382	385	PF01048	0.506
MOD_GlcNHglycan	397	400	PF01048	0.560
MOD_GlcNHglycan	440	443	PF01048	0.702
MOD_GlcNHglycan	452	455	PF01048	0.564
MOD_GlcNHglycan	46	49	PF01048	0.591
MOD_GlcNHglycan	518	521	PF01048	0.717
MOD_GlcNHglycan	535	538	PF01048	0.667
MOD_GlcNHglycan	561	564	PF01048	0.717
MOD_GlcNHglycan	60	63	PF01048	0.604
MOD_GlcNHglycan	604	607	PF01048	0.711
MOD_GlcNHglycan	651	654	PF01048	0.743
MOD_GlcNHglycan	727	730	PF01048	0.706
MOD_GlcNHglycan	751	754	PF01048	0.718
MOD_GlcNHglycan	757	760	PF01048	0.666
MOD_GlcNHglycan	88	92	PF01048	0.596
MOD_GSK3_1	127	134	PF00069	0.656
MOD_GSK3_1	140	147	PF00069	0.533
MOD_GSK3_1	198	205	PF00069	0.719
MOD_GSK3_1	207	214	PF00069	0.629
MOD_GSK3_1	271	278	PF00069	0.682
MOD_GSK3_1	279	286	PF00069	0.632
MOD_GSK3_1	291	298	PF00069	0.668
MOD_GSK3_1	325	332	PF00069	0.695
MOD_GSK3_1	356	363	PF00069	0.675
MOD_GSK3_1	375	382	PF00069	0.504
MOD_GSK3_1	395	402	PF00069	0.523
MOD_GSK3_1	404	411	PF00069	0.660
MOD_GSK3_1	434	441	PF00069	0.725
MOD_GSK3_1	443	450	PF00069	0.629
MOD_GSK3_1	515	522	PF00069	0.759
MOD_GSK3_1	533	540	PF00069	0.595
MOD_GSK3_1	569	576	PF00069	0.766
MOD_GSK3_1	633	640	PF00069	0.630
MOD_GSK3_1	641	648	PF00069	0.673
MOD_GSK3_1	659	666	PF00069	0.777
MOD_GSK3_1	675	682	PF00069	0.648
MOD_GSK3_1	705	712	PF00069	0.736
MOD_GSK3_1	72	79	PF00069	0.696
MOD_GSK3_1	720	727	PF00069	0.625
MOD_GSK3_1	745	752	PF00069	0.595
MOD_GSK3_1	753	760	PF00069	0.667
MOD_GSK3_1	762	769	PF00069	0.526
MOD_N-GLC_1	206	211	PF02516	0.673
MOD_N-GLC_1	275	280	PF02516	0.659
MOD_N-GLC_1	318	323	PF02516	0.628
MOD_NEK2_1	1	6	PF00069	0.582
MOD_NEK2_1	236	241	PF00069	0.521
MOD_NEK2_1	244	249	PF00069	0.453
MOD_NEK2_1	284	289	PF00069	0.662
MOD_NEK2_1	305	310	PF00069	0.660
MOD_NEK2_1	373	378	PF00069	0.647
MOD_NEK2_1	386	391	PF00069	0.568
MOD_NEK2_1	436	441	PF00069	0.725
MOD_NEK2_1	449	454	PF00069	0.579
MOD_NEK2_1	481	486	PF00069	0.619
MOD_NEK2_1	607	612	PF00069	0.618
MOD_NEK2_1	668	673	PF00069	0.720
MOD_NEK2_1	776	781	PF00069	0.610
MOD_PIKK_1	30	36	PF00454	0.546
MOD_PIKK_1	366	372	PF00454	0.692
MOD_PIKK_1	570	576	PF00454	0.668
MOD_PIKK_1	624	630	PF00454	0.788
MOD_PIKK_1	720	726	PF00454	0.741
MOD_PK_1	125	131	PF00069	0.621
MOD_PK_1	778	784	PF00069	0.551
MOD_PKA_1	164	170	PF00069	0.567
MOD_PKA_1	257	263	PF00069	0.660
MOD_PKA_1	269	275	PF00069	0.630
MOD_PKA_1	608	614	PF00069	0.683
MOD_PKA_1	703	709	PF00069	0.671
MOD_PKA_1	71	77	PF00069	0.638
MOD_PKA_1	710	716	PF00069	0.655
MOD_PKA_1	725	731	PF00069	0.605
MOD_PKA_2	164	170	PF00069	0.567
MOD_PKA_2	17	23	PF00069	0.562
MOD_PKA_2	257	263	PF00069	0.660
MOD_PKA_2	269	275	PF00069	0.630
MOD_PKA_2	325	331	PF00069	0.611
MOD_PKA_2	386	392	PF00069	0.692
MOD_PKA_2	395	401	PF00069	0.610
MOD_PKA_2	407	413	PF00069	0.603
MOD_PKA_2	533	539	PF00069	0.767
MOD_PKA_2	607	613	PF00069	0.682
MOD_PKA_2	631	637	PF00069	0.656
MOD_PKA_2	668	674	PF00069	0.660
MOD_PKA_2	702	708	PF00069	0.691
MOD_PKA_2	710	716	PF00069	0.728
MOD_PKA_2	724	730	PF00069	0.644
MOD_PKA_2	739	745	PF00069	0.615
MOD_PKB_1	406	414	PF00069	0.643
MOD_PKB_1	42	50	PF00069	0.560
MOD_Plk_1	206	212	PF00069	0.673
MOD_Plk_1	236	242	PF00069	0.519
MOD_Plk_1	275	281	PF00069	0.654
MOD_Plk_1	318	324	PF00069	0.631
MOD_Plk_4	207	213	PF00069	0.578
MOD_Plk_4	244	250	PF00069	0.423
MOD_Plk_4	279	285	PF00069	0.559
MOD_Plk_4	415	421	PF00069	0.651
MOD_Plk_4	444	450	PF00069	0.672
MOD_Plk_4	634	640	PF00069	0.780
MOD_Plk_4	778	784	PF00069	0.606
MOD_ProDKin_1	107	113	PF00069	0.659
MOD_ProDKin_1	127	133	PF00069	0.508
MOD_ProDKin_1	140	146	PF00069	0.573
MOD_ProDKin_1	157	163	PF00069	0.533
MOD_ProDKin_1	292	298	PF00069	0.665
MOD_ProDKin_1	329	335	PF00069	0.668
MOD_ProDKin_1	375	381	PF00069	0.645
MOD_ProDKin_1	399	405	PF00069	0.672
MOD_ProDKin_1	539	545	PF00069	0.678
MOD_ProDKin_1	599	605	PF00069	0.749
MOD_ProDKin_1	6	12	PF00069	0.679
MOD_ProDKin_1	60	66	PF00069	0.646
MOD_ProDKin_1	660	666	PF00069	0.792
MOD_SUMO_rev_2	119	127	PF00179	0.622
TRG_DiLeu_BaEn_1	122	127	PF01217	0.617
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.534
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.699
TRG_ENDOCYTIC_2	169	172	PF00928	0.690
TRG_ENDOCYTIC_2	474	477	PF00928	0.563
TRG_ENDOCYTIC_2	495	498	PF00928	0.578
TRG_ER_diArg_1	163	165	PF00400	0.565
TRG_ER_diArg_1	220	223	PF00400	0.680
TRG_ER_diArg_1	249	252	PF00400	0.453
TRG_ER_diArg_1	268	270	PF00400	0.677
TRG_ER_diArg_1	42	44	PF00400	0.552
TRG_ER_diArg_1	532	535	PF00400	0.683
TRG_ER_diArg_1	607	609	PF00400	0.716
TRG_NES_CRM1_1	770	785	PF08389	0.547
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJC2	Leishmania donovani	86%	100%
A4H386	Leishmania braziliensis	47%	95%
A4HRJ1	Leishmania infantum	85%	100%
E9AJF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%