LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AC58_LEIMA
TriTrypDb:
LmjF.01.0670 , LMJLV39_010012000 * , LMJSD75_010012000 *
Length:
305

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC58
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC58

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 5 9 PF00656 0.475
CLV_PCSK_SKI1_1 16 20 PF00082 0.572
DEG_SCF_FBW7_1 165 172 PF00400 0.693
DOC_CKS1_1 142 147 PF01111 0.662
DOC_CKS1_1 166 171 PF01111 0.694
DOC_MAPK_gen_1 126 136 PF00069 0.629
DOC_PP1_RVXF_1 14 20 PF00149 0.553
DOC_PP1_RVXF_1 275 281 PF00149 0.548
DOC_PP4_FxxP_1 19 22 PF00568 0.530
DOC_USP7_MATH_1 125 129 PF00917 0.602
DOC_USP7_MATH_1 198 202 PF00917 0.624
DOC_USP7_MATH_1 282 286 PF00917 0.550
DOC_USP7_MATH_1 40 44 PF00917 0.746
DOC_USP7_MATH_1 79 83 PF00917 0.606
DOC_WW_Pin1_4 141 146 PF00397 0.696
DOC_WW_Pin1_4 161 166 PF00397 0.626
DOC_WW_Pin1_4 169 174 PF00397 0.684
DOC_WW_Pin1_4 211 216 PF00397 0.648
DOC_WW_Pin1_4 223 228 PF00397 0.651
DOC_WW_Pin1_4 235 240 PF00397 0.527
DOC_WW_Pin1_4 278 283 PF00397 0.630
DOC_WW_Pin1_4 63 68 PF00397 0.618
LIG_14-3-3_CanoR_1 129 134 PF00244 0.721
LIG_14-3-3_CanoR_1 16 22 PF00244 0.566
LIG_14-3-3_CanoR_1 296 305 PF00244 0.615
LIG_14-3-3_CanoR_1 50 55 PF00244 0.587
LIG_14-3-3_CanoR_1 85 93 PF00244 0.623
LIG_14-3-3_CanoR_1 95 104 PF00244 0.478
LIG_BRCT_BRCA1_1 298 302 PF00533 0.601
LIG_FHA_1 166 172 PF00498 0.574
LIG_FHA_2 188 194 PF00498 0.585
LIG_FHA_2 22 28 PF00498 0.662
LIG_LIR_Gen_1 183 194 PF02991 0.596
LIG_LIR_Gen_1 299 305 PF02991 0.603
LIG_LIR_Gen_1 45 54 PF02991 0.605
LIG_LIR_Gen_1 8 18 PF02991 0.456
LIG_LIR_LC3C_4 12 15 PF02991 0.446
LIG_LIR_Nem_3 183 189 PF02991 0.603
LIG_LIR_Nem_3 299 305 PF02991 0.603
LIG_LIR_Nem_3 45 51 PF02991 0.602
LIG_LIR_Nem_3 8 13 PF02991 0.451
LIG_MYND_1 169 173 PF01753 0.574
LIG_PDZ_Class_3 300 305 PF00595 0.673
LIG_SH2_CRK 206 210 PF00017 0.646
LIG_SH3_3 163 169 PF00018 0.686
LIG_SH3_3 255 261 PF00018 0.573
LIG_SUMO_SIM_par_1 131 138 PF11976 0.642
MOD_CDC14_SPxK_1 281 284 PF00782 0.548
MOD_CDK_SPK_2 141 146 PF00069 0.665
MOD_CDK_SPxK_1 235 241 PF00069 0.656
MOD_CDK_SPxK_1 278 284 PF00069 0.551
MOD_CK1_1 128 134 PF00069 0.598
MOD_CK1_1 135 141 PF00069 0.608
MOD_CK1_1 159 165 PF00069 0.753
MOD_CK1_1 234 240 PF00069 0.693
MOD_CK1_1 248 254 PF00069 0.728
MOD_CK1_1 291 297 PF00069 0.644
MOD_CK1_1 42 48 PF00069 0.594
MOD_CK1_1 94 100 PF00069 0.575
MOD_CK2_1 187 193 PF00069 0.660
MOD_CK2_1 21 27 PF00069 0.608
MOD_CK2_1 28 34 PF00069 0.662
MOD_CK2_1 295 301 PF00069 0.703
MOD_GlcNHglycan 146 149 PF01048 0.686
MOD_GlcNHglycan 158 161 PF01048 0.762
MOD_GlcNHglycan 200 203 PF01048 0.628
MOD_GlcNHglycan 284 287 PF01048 0.621
MOD_GlcNHglycan 42 45 PF01048 0.590
MOD_GlcNHglycan 81 84 PF01048 0.602
MOD_GlcNHglycan 97 100 PF01048 0.611
MOD_GSK3_1 124 131 PF00069 0.763
MOD_GSK3_1 140 147 PF00069 0.599
MOD_GSK3_1 161 168 PF00069 0.705
MOD_GSK3_1 17 24 PF00069 0.639
MOD_GSK3_1 174 181 PF00069 0.638
MOD_GSK3_1 231 238 PF00069 0.684
MOD_GSK3_1 245 252 PF00069 0.702
MOD_GSK3_1 278 285 PF00069 0.621
MOD_GSK3_1 291 298 PF00069 0.620
MOD_GSK3_1 42 49 PF00069 0.581
MOD_GSK3_1 79 86 PF00069 0.790
MOD_GSK3_1 87 94 PF00069 0.522
MOD_N-GLC_1 140 145 PF02516 0.669
MOD_N-GLC_1 234 239 PF02516 0.612
MOD_N-GLC_1 288 293 PF02516 0.640
MOD_N-GLC_1 40 45 PF02516 0.656
MOD_NEK2_1 156 161 PF00069 0.627
MOD_NEK2_1 179 184 PF00069 0.658
MOD_NEK2_1 246 251 PF00069 0.625
MOD_NEK2_1 270 275 PF00069 0.684
MOD_PIKK_1 159 165 PF00454 0.694
MOD_PIKK_1 291 297 PF00454 0.622
MOD_PIKK_1 42 48 PF00454 0.572
MOD_PK_1 129 135 PF00069 0.628
MOD_PKA_2 125 131 PF00069 0.677
MOD_PKA_2 291 297 PF00069 0.621
MOD_PKA_2 84 90 PF00069 0.656
MOD_PKA_2 94 100 PF00069 0.495
MOD_Plk_4 129 135 PF00069 0.601
MOD_Plk_4 182 188 PF00069 0.612
MOD_ProDKin_1 141 147 PF00069 0.693
MOD_ProDKin_1 161 167 PF00069 0.628
MOD_ProDKin_1 169 175 PF00069 0.681
MOD_ProDKin_1 211 217 PF00069 0.649
MOD_ProDKin_1 223 229 PF00069 0.650
MOD_ProDKin_1 235 241 PF00069 0.528
MOD_ProDKin_1 278 284 PF00069 0.633
MOD_ProDKin_1 63 69 PF00069 0.619
TRG_DiLeu_BaLyEn_6 151 156 PF01217 0.544
TRG_ENDOCYTIC_2 206 209 PF00928 0.647

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I318 Leptomonas seymouri 46% 94%
A0A3S5H4W5 Leishmania donovani 90% 100%
A4H385 Leishmania braziliensis 67% 100%
A4HRJ0 Leishmania infantum 91% 100%
E9AJF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS