Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AC54_LEIMA

TriTrypDb:

LmjF.01.0630 , LMJLV39_010011600 , LMJSD75_010011600

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.766
CLV_C14_Caspase3-7	567	571	PF00656	0.585
CLV_NRD_NRD_1	103	105	PF00675	0.597
CLV_NRD_NRD_1	207	209	PF00675	0.641
CLV_NRD_NRD_1	223	225	PF00675	0.735
CLV_NRD_NRD_1	382	384	PF00675	0.817
CLV_NRD_NRD_1	432	434	PF00675	0.835
CLV_NRD_NRD_1	522	524	PF00675	0.685
CLV_NRD_NRD_1	621	623	PF00675	0.783
CLV_NRD_NRD_1	89	91	PF00675	0.598
CLV_PCSK_FUR_1	221	225	PF00082	0.782
CLV_PCSK_FUR_1	382	386	PF00082	0.819
CLV_PCSK_KEX2_1	103	105	PF00082	0.597
CLV_PCSK_KEX2_1	207	209	PF00082	0.641
CLV_PCSK_KEX2_1	223	225	PF00082	0.735
CLV_PCSK_KEX2_1	382	384	PF00082	0.817
CLV_PCSK_KEX2_1	432	434	PF00082	0.835
CLV_PCSK_KEX2_1	521	523	PF00082	0.565
CLV_PCSK_KEX2_1	621	623	PF00082	0.783
CLV_PCSK_KEX2_1	89	91	PF00082	0.598
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.823
CLV_PCSK_PC7_1	85	91	PF00082	0.461
CLV_PCSK_SKI1_1	21	25	PF00082	0.771
CLV_Separin_Metazoa	204	208	PF03568	0.814
DEG_Nend_Nbox_1	1	3	PF02207	0.608
DEG_SPOP_SBC_1	606	610	PF00917	0.650
DOC_CKS1_1	328	333	PF01111	0.715
DOC_CKS1_1	458	463	PF01111	0.761
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.524
DOC_MAPK_DCC_7	556	566	PF00069	0.807
DOC_MAPK_gen_1	521	532	PF00069	0.427
DOC_MAPK_MEF2A_6	525	534	PF00069	0.420
DOC_PP1_RVXF_1	159	165	PF00149	0.738
DOC_USP7_MATH_1	107	111	PF00917	0.711
DOC_USP7_MATH_1	155	159	PF00917	0.762
DOC_USP7_MATH_1	249	253	PF00917	0.705
DOC_USP7_MATH_1	259	263	PF00917	0.618
DOC_USP7_MATH_1	287	291	PF00917	0.843
DOC_USP7_MATH_1	345	349	PF00917	0.795
DOC_USP7_MATH_1	446	450	PF00917	0.752
DOC_USP7_MATH_1	468	472	PF00917	0.755
DOC_USP7_MATH_1	599	603	PF00917	0.827
DOC_USP7_MATH_1	606	610	PF00917	0.729
DOC_USP7_MATH_1	617	621	PF00917	0.563
DOC_WW_Pin1_4	103	108	PF00397	0.761
DOC_WW_Pin1_4	134	139	PF00397	0.533
DOC_WW_Pin1_4	162	167	PF00397	0.761
DOC_WW_Pin1_4	289	294	PF00397	0.574
DOC_WW_Pin1_4	297	302	PF00397	0.614
DOC_WW_Pin1_4	321	326	PF00397	0.668
DOC_WW_Pin1_4	327	332	PF00397	0.702
DOC_WW_Pin1_4	360	365	PF00397	0.596
DOC_WW_Pin1_4	457	462	PF00397	0.795
DOC_WW_Pin1_4	488	493	PF00397	0.648
DOC_WW_Pin1_4	559	564	PF00397	0.810
DOC_WW_Pin1_4	607	612	PF00397	0.652
LIG_14-3-3_CanoR_1	21	29	PF00244	0.513
LIG_14-3-3_CanoR_1	223	232	PF00244	0.819
LIG_14-3-3_CanoR_1	261	265	PF00244	0.808
LIG_14-3-3_CanoR_1	273	281	PF00244	0.613
LIG_14-3-3_CanoR_1	303	309	PF00244	0.669
LIG_14-3-3_CanoR_1	452	458	PF00244	0.758
LIG_14-3-3_CanoR_1	462	472	PF00244	0.628
LIG_14-3-3_CanoR_1	556	561	PF00244	0.765
LIG_14-3-3_CanoR_1	607	611	PF00244	0.648
LIG_BRCT_BRCA1_1	306	310	PF00533	0.801
LIG_BRCT_BRCA1_1	323	327	PF00533	0.560
LIG_CSL_BTD_1	163	166	PF09270	0.720
LIG_FHA_1	146	152	PF00498	0.561
LIG_FHA_1	18	24	PF00498	0.498
LIG_FHA_1	183	189	PF00498	0.748
LIG_FHA_1	273	279	PF00498	0.801
LIG_FHA_1	331	337	PF00498	0.644
LIG_FHA_1	373	379	PF00498	0.573
LIG_FHA_2	582	588	PF00498	0.801
LIG_LIR_Gen_1	240	249	PF02991	0.680
LIG_LIR_Gen_1	307	318	PF02991	0.663
LIG_LIR_Nem_3	240	246	PF02991	0.683
LIG_LIR_Nem_3	296	302	PF02991	0.816
LIG_LIR_Nem_3	307	313	PF02991	0.630
LIG_LIR_Nem_3	473	479	PF02991	0.805
LIG_NRP_CendR_1	622	625	PF00754	0.593
LIG_PCNA_yPIPBox_3	50	62	PF02747	0.642
LIG_Pex14_2	472	476	PF04695	0.561
LIG_SH2_NCK_1	243	247	PF00017	0.813
LIG_SH2_SRC	187	190	PF00017	0.821
LIG_SH2_SRC	238	241	PF00017	0.624
LIG_SH2_STAT5	128	131	PF00017	0.540
LIG_SH2_STAT5	187	190	PF00017	0.821
LIG_SH2_STAT5	238	241	PF00017	0.622
LIG_SH3_3	121	127	PF00018	0.545
LIG_SH3_3	135	141	PF00018	0.543
LIG_SH3_3	243	249	PF00018	0.813
LIG_SH3_3	252	258	PF00018	0.686
LIG_SH3_3	322	328	PF00018	0.675
LIG_SH3_CIN85_PxpxPR_1	45	50	PF14604	0.473
LIG_SUMO_SIM_par_1	143	148	PF11976	0.541
LIG_TRAF2_1	517	520	PF00917	0.682
MOD_CDC14_SPxK_1	292	295	PF00782	0.573
MOD_CDC14_SPxK_1	612	615	PF00782	0.584
MOD_CDK_SPK_2	360	365	PF00069	0.580
MOD_CDK_SPK_2	457	462	PF00069	0.575
MOD_CDK_SPxK_1	289	295	PF00069	0.580
MOD_CDK_SPxK_1	297	303	PF00069	0.533
MOD_CDK_SPxK_1	609	615	PF00069	0.584
MOD_CK1_1	108	114	PF00069	0.758
MOD_CK1_1	131	137	PF00069	0.606
MOD_CK1_1	230	236	PF00069	0.815
MOD_CK1_1	260	266	PF00069	0.809
MOD_CK1_1	27	33	PF00069	0.523
MOD_CK1_1	272	278	PF00069	0.610
MOD_CK1_1	282	288	PF00069	0.733
MOD_CK1_1	350	356	PF00069	0.628
MOD_CK1_1	363	369	PF00069	0.690
MOD_CK1_1	399	405	PF00069	0.667
MOD_CK1_1	453	459	PF00069	0.679
MOD_CK1_1	463	469	PF00069	0.709
MOD_CK1_1	470	476	PF00069	0.545
MOD_CK1_1	484	490	PF00069	0.636
MOD_CK1_1	5	11	PF00069	0.676
MOD_CK1_1	554	560	PF00069	0.802
MOD_CK1_1	609	615	PF00069	0.713
MOD_CK2_1	332	338	PF00069	0.775
MOD_CK2_1	413	419	PF00069	0.824
MOD_CK2_1	444	450	PF00069	0.811
MOD_CK2_1	581	587	PF00069	0.798
MOD_Cter_Amidation	101	104	PF01082	0.738
MOD_Cter_Amidation	221	224	PF01082	0.817
MOD_Cter_Amidation	87	90	PF01082	0.588
MOD_DYRK1A_RPxSP_1	607	611	PF00069	0.590
MOD_GlcNHglycan	107	110	PF01048	0.638
MOD_GlcNHglycan	157	160	PF01048	0.703
MOD_GlcNHglycan	251	254	PF01048	0.655
MOD_GlcNHglycan	281	284	PF01048	0.707
MOD_GlcNHglycan	35	38	PF01048	0.614
MOD_GlcNHglycan	352	355	PF01048	0.666
MOD_GlcNHglycan	365	368	PF01048	0.745
MOD_GlcNHglycan	392	395	PF01048	0.651
MOD_GlcNHglycan	42	45	PF01048	0.611
MOD_GlcNHglycan	435	438	PF01048	0.798
MOD_GlcNHglycan	473	476	PF01048	0.667
MOD_GlcNHglycan	545	548	PF01048	0.623
MOD_GlcNHglycan	592	595	PF01048	0.837
MOD_GlcNHglycan	601	604	PF01048	0.688
MOD_GSK3_1	1	8	PF00069	0.643
MOD_GSK3_1	103	110	PF00069	0.665
MOD_GSK3_1	145	152	PF00069	0.581
MOD_GSK3_1	17	24	PF00069	0.561
MOD_GSK3_1	178	185	PF00069	0.749
MOD_GSK3_1	223	230	PF00069	0.819
MOD_GSK3_1	269	276	PF00069	0.740
MOD_GSK3_1	27	34	PF00069	0.606
MOD_GSK3_1	285	292	PF00069	0.569
MOD_GSK3_1	323	330	PF00069	0.780
MOD_GSK3_1	332	339	PF00069	0.807
MOD_GSK3_1	363	370	PF00069	0.769
MOD_GSK3_1	399	406	PF00069	0.701
MOD_GSK3_1	409	416	PF00069	0.784
MOD_GSK3_1	446	453	PF00069	0.650
MOD_GSK3_1	463	470	PF00069	0.608
MOD_GSK3_1	484	491	PF00069	0.743
MOD_GSK3_1	492	499	PF00069	0.665
MOD_GSK3_1	551	558	PF00069	0.800
MOD_GSK3_1	581	588	PF00069	0.790
MOD_GSK3_1	605	612	PF00069	0.604
MOD_GSK3_1	616	623	PF00069	0.819
MOD_N-GLC_1	228	233	PF02516	0.625
MOD_N-GLC_1	27	32	PF02516	0.520
MOD_N-GLC_1	285	290	PF02516	0.840
MOD_N-GLC_1	585	590	PF02516	0.602
MOD_NEK2_1	1	6	PF00069	0.515
MOD_NEK2_1	118	123	PF00069	0.756
MOD_NEK2_1	145	150	PF00069	0.543
MOD_NEK2_1	390	395	PF00069	0.632
MOD_NEK2_1	403	408	PF00069	0.712
MOD_NEK2_1	555	560	PF00069	0.746
MOD_OFUCOSY	407	413	PF10250	0.619
MOD_PIKK_1	285	291	PF00454	0.840
MOD_PIKK_1	411	417	PF00454	0.561
MOD_PIKK_1	581	587	PF00454	0.734
MOD_PK_1	273	279	PF00069	0.801
MOD_PKA_1	223	229	PF00069	0.821
MOD_PKA_2	155	161	PF00069	0.544
MOD_PKA_2	206	212	PF00069	0.811
MOD_PKA_2	223	229	PF00069	0.550
MOD_PKA_2	260	266	PF00069	0.809
MOD_PKA_2	272	278	PF00069	0.623
MOD_PKA_2	302	308	PF00069	0.771
MOD_PKA_2	31	37	PF00069	0.525
MOD_PKA_2	336	342	PF00069	0.574
MOD_PKA_2	555	561	PF00069	0.805
MOD_PKA_2	606	612	PF00069	0.628
MOD_PKA_2	93	99	PF00069	0.693
MOD_PKB_1	221	229	PF00069	0.818
MOD_PKB_1	433	441	PF00069	0.696
MOD_Plk_1	227	233	PF00069	0.804
MOD_Plk_1	295	301	PF00069	0.822
MOD_Plk_1	450	456	PF00069	0.811
MOD_Plk_1	586	592	PF00069	0.565
MOD_Plk_2-3	228	234	PF00069	0.562
MOD_Plk_4	273	279	PF00069	0.759
MOD_Plk_4	309	315	PF00069	0.616
MOD_Plk_4	453	459	PF00069	0.826
MOD_Plk_4	528	534	PF00069	0.412
MOD_ProDKin_1	103	109	PF00069	0.760
MOD_ProDKin_1	134	140	PF00069	0.533
MOD_ProDKin_1	162	168	PF00069	0.760
MOD_ProDKin_1	289	295	PF00069	0.575
MOD_ProDKin_1	297	303	PF00069	0.613
MOD_ProDKin_1	321	327	PF00069	0.669
MOD_ProDKin_1	360	366	PF00069	0.596
MOD_ProDKin_1	457	463	PF00069	0.792
MOD_ProDKin_1	488	494	PF00069	0.646
MOD_ProDKin_1	559	565	PF00069	0.809
MOD_ProDKin_1	607	613	PF00069	0.649
TRG_DiLeu_BaEn_4	519	525	PF01217	0.687
TRG_ENDOCYTIC_2	243	246	PF00928	0.676
TRG_ER_diArg_1	119	122	PF00400	0.546
TRG_ER_diArg_1	206	208	PF00400	0.654
TRG_ER_diArg_1	221	224	PF00400	0.737
TRG_ER_diArg_1	382	385	PF00400	0.818
TRG_ER_diArg_1	431	433	PF00400	0.843
TRG_ER_diArg_1	521	523	PF00400	0.599
TRG_NLS_MonoExtN_4	382	387	PF00514	0.817
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4W2	Leishmania donovani	75%	89%
A4HRI6	Leishmania infantum	75%	69%
E9AJF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%