Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC53_LEIMA

TriTrypDb:

LmjF.01.0620 , LMJLV39_010011500 , LMJSD75_010011500

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.387
CLV_NRD_NRD_1	282	284	PF00675	0.707
CLV_NRD_NRD_1	317	319	PF00675	0.608
CLV_NRD_NRD_1	336	338	PF00675	0.650
CLV_NRD_NRD_1	458	460	PF00675	0.693
CLV_NRD_NRD_1	483	485	PF00675	0.582
CLV_NRD_NRD_1	540	542	PF00675	0.572
CLV_PCSK_FUR_1	334	338	PF00082	0.659
CLV_PCSK_FUR_1	456	460	PF00082	0.696
CLV_PCSK_FUR_1	530	534	PF00082	0.493
CLV_PCSK_KEX2_1	281	283	PF00082	0.721
CLV_PCSK_KEX2_1	316	318	PF00082	0.611
CLV_PCSK_KEX2_1	336	338	PF00082	0.512
CLV_PCSK_KEX2_1	443	445	PF00082	0.653
CLV_PCSK_KEX2_1	458	460	PF00082	0.751
CLV_PCSK_KEX2_1	483	485	PF00082	0.630
CLV_PCSK_KEX2_1	532	534	PF00082	0.494
CLV_PCSK_KEX2_1	538	540	PF00082	0.499
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.653
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.494
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.499
CLV_PCSK_PC7_1	454	460	PF00082	0.675
CLV_PCSK_PC7_1	528	534	PF00082	0.493
CLV_PCSK_SKI1_1	81	85	PF00082	0.369
DEG_APCC_DBOX_1	105	113	PF00400	0.371
DEG_APCC_DBOX_1	527	535	PF00400	0.579
DEG_APCC_DBOX_1	80	88	PF00400	0.377
DEG_Kelch_Keap1_1	250	255	PF01344	0.614
DEG_SCF_FBW7_1	301	308	PF00400	0.692
DEG_SCF_FBW7_1	380	386	PF00400	0.590
DEG_SPOP_SBC_1	246	250	PF00917	0.620
DEG_SPOP_SBC_1	586	590	PF00917	0.595
DOC_ANK_TNKS_1	567	574	PF00023	0.640
DOC_CDC14_PxL_1	45	53	PF14671	0.436
DOC_CKS1_1	380	385	PF01111	0.597
DOC_CYCLIN_RxL_1	405	419	PF00134	0.435
DOC_MAPK_gen_1	101	109	PF00069	0.393
DOC_MAPK_MEF2A_6	512	521	PF00069	0.507
DOC_PP1_RVXF_1	409	416	PF00149	0.501
DOC_PP2B_LxvP_1	381	384	PF13499	0.551
DOC_PP4_FxxP_1	502	505	PF00568	0.588
DOC_USP7_MATH_1	144	148	PF00917	0.584
DOC_USP7_MATH_1	376	380	PF00917	0.647
DOC_USP7_MATH_1	416	420	PF00917	0.564
DOC_USP7_MATH_1	448	452	PF00917	0.617
DOC_USP7_MATH_1	505	509	PF00917	0.618
DOC_USP7_MATH_1	586	590	PF00917	0.676
DOC_USP7_UBL2_3	538	542	PF12436	0.547
DOC_WW_Pin1_4	18	23	PF00397	0.625
DOC_WW_Pin1_4	301	306	PF00397	0.768
DOC_WW_Pin1_4	329	334	PF00397	0.638
DOC_WW_Pin1_4	336	341	PF00397	0.640
DOC_WW_Pin1_4	379	384	PF00397	0.612
DOC_WW_Pin1_4	512	517	PF00397	0.587
DOC_WW_Pin1_4	580	585	PF00397	0.683
LIG_14-3-3_CanoR_1	281	290	PF00244	0.715
LIG_14-3-3_CanoR_1	296	301	PF00244	0.524
LIG_14-3-3_CanoR_1	306	310	PF00244	0.602
LIG_14-3-3_CanoR_1	316	325	PF00244	0.529
LIG_14-3-3_CanoR_1	352	361	PF00244	0.684
LIG_14-3-3_CanoR_1	444	448	PF00244	0.571
LIG_14-3-3_CanoR_1	522	527	PF00244	0.509
LIG_14-3-3_CanoR_1	559	563	PF00244	0.620
LIG_14-3-3_CanoR_1	58	67	PF00244	0.394
LIG_APCC_ABBA_1	399	404	PF00400	0.412
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_BIR_III_1	1	5	PF00653	0.537
LIG_BIR_III_3	1	5	PF00653	0.537
LIG_DLG_GKlike_1	296	304	PF00625	0.686
LIG_FHA_1	111	117	PF00498	0.445
LIG_FHA_1	171	177	PF00498	0.512
LIG_FHA_1	214	220	PF00498	0.410
LIG_FHA_1	223	229	PF00498	0.406
LIG_FHA_1	302	308	PF00498	0.621
LIG_FHA_1	551	557	PF00498	0.513
LIG_FHA_2	203	209	PF00498	0.388
LIG_FHA_2	247	253	PF00498	0.671
LIG_FHA_2	387	393	PF00498	0.551
LIG_Integrin_isoDGR_2	350	352	PF01839	0.557
LIG_LIR_Apic_2	398	403	PF02991	0.444
LIG_LIR_Apic_2	501	505	PF02991	0.593
LIG_LIR_Apic_2	508	514	PF02991	0.548
LIG_LIR_Gen_1	113	123	PF02991	0.458
LIG_LIR_Gen_1	235	242	PF02991	0.387
LIG_LIR_Gen_1	375	385	PF02991	0.512
LIG_LIR_Gen_1	61	67	PF02991	0.394
LIG_LIR_Nem_3	113	118	PF02991	0.447
LIG_LIR_Nem_3	156	160	PF02991	0.569
LIG_LIR_Nem_3	235	239	PF02991	0.387
LIG_LIR_Nem_3	355	361	PF02991	0.552
LIG_LIR_Nem_3	375	380	PF02991	0.471
LIG_LIR_Nem_3	61	66	PF02991	0.401
LIG_NRBOX	296	302	PF00104	0.593
LIG_PCNA_yPIPBox_3	224	237	PF02747	0.332
LIG_Pex14_2	239	243	PF04695	0.394
LIG_SH2_CRK	358	362	PF00017	0.553
LIG_SH2_CRK	511	515	PF00017	0.507
LIG_SH2_STAP1	562	566	PF00017	0.631
LIG_SH2_STAT5	115	118	PF00017	0.350
LIG_SH2_STAT5	236	239	PF00017	0.384
LIG_SH2_STAT5	400	403	PF00017	0.443
LIG_SH3_3	507	513	PF00018	0.558
LIG_SUMO_SIM_par_1	108	113	PF11976	0.455
LIG_SUMO_SIM_par_1	215	221	PF11976	0.409
LIG_SUMO_SIM_par_1	389	398	PF11976	0.522
LIG_TRAF2_1	389	392	PF00917	0.556
LIG_UBA3_1	40	47	PF00899	0.495
MOD_CDK_SPK_2	301	306	PF00069	0.693
MOD_CDK_SPK_2	329	334	PF00069	0.702
MOD_CDK_SPxxK_3	329	336	PF00069	0.651
MOD_CDK_SPxxK_3	580	587	PF00069	0.685
MOD_CK1_1	244	250	PF00069	0.608
MOD_CK1_1	285	291	PF00069	0.611
MOD_CK1_1	332	338	PF00069	0.641
MOD_CK1_1	346	352	PF00069	0.739
MOD_CK1_1	379	385	PF00069	0.720
MOD_CK1_1	446	452	PF00069	0.639
MOD_CK1_1	61	67	PF00069	0.485
MOD_CK2_1	246	252	PF00069	0.661
MOD_CK2_1	386	392	PF00069	0.475
MOD_CK2_1	89	95	PF00069	0.388
MOD_Cter_Amidation	481	484	PF01082	0.579
MOD_DYRK1A_RPxSP_1	512	516	PF00069	0.508
MOD_GlcNHglycan	146	149	PF01048	0.655
MOD_GlcNHglycan	150	153	PF01048	0.601
MOD_GlcNHglycan	160	163	PF01048	0.517
MOD_GlcNHglycan	176	179	PF01048	0.562
MOD_GlcNHglycan	194	200	PF01048	0.410
MOD_GlcNHglycan	230	233	PF01048	0.401
MOD_GlcNHglycan	252	255	PF01048	0.769
MOD_GlcNHglycan	287	290	PF01048	0.739
MOD_GlcNHglycan	418	421	PF01048	0.601
MOD_GlcNHglycan	450	453	PF01048	0.636
MOD_GlcNHglycan	467	470	PF01048	0.651
MOD_GlcNHglycan	471	474	PF01048	0.619
MOD_GlcNHglycan	486	489	PF01048	0.496
MOD_GlcNHglycan	63	66	PF01048	0.481
MOD_GSK3_1	144	151	PF00069	0.571
MOD_GSK3_1	158	165	PF00069	0.534
MOD_GSK3_1	170	177	PF00069	0.469
MOD_GSK3_1	18	25	PF00069	0.613
MOD_GSK3_1	218	225	PF00069	0.488
MOD_GSK3_1	241	248	PF00069	0.503
MOD_GSK3_1	281	288	PF00069	0.716
MOD_GSK3_1	301	308	PF00069	0.464
MOD_GSK3_1	316	323	PF00069	0.520
MOD_GSK3_1	328	335	PF00069	0.658
MOD_GSK3_1	336	343	PF00069	0.609
MOD_GSK3_1	368	375	PF00069	0.542
MOD_GSK3_1	379	386	PF00069	0.508
MOD_GSK3_1	416	423	PF00069	0.528
MOD_GSK3_1	446	453	PF00069	0.698
MOD_GSK3_1	465	472	PF00069	0.625
MOD_GSK3_1	517	524	PF00069	0.502
MOD_GSK3_1	54	61	PF00069	0.419
MOD_GSK3_1	558	565	PF00069	0.678
MOD_LATS_1	294	300	PF00433	0.673
MOD_N-GLC_1	465	470	PF02516	0.654
MOD_N-GLC_1	522	527	PF02516	0.509
MOD_NEK2_1	160	165	PF00069	0.572
MOD_NEK2_1	174	179	PF00069	0.574
MOD_NEK2_1	202	207	PF00069	0.462
MOD_NEK2_1	290	295	PF00069	0.697
MOD_NEK2_1	464	469	PF00069	0.658
MOD_NEK2_1	517	522	PF00069	0.527
MOD_PIKK_1	110	116	PF00454	0.423
MOD_PIKK_1	241	247	PF00454	0.525
MOD_PIKK_1	316	322	PF00454	0.710
MOD_PIKK_1	340	346	PF00454	0.643
MOD_PIKK_1	550	556	PF00454	0.591
MOD_PKA_1	281	287	PF00069	0.704
MOD_PKA_1	316	322	PF00069	0.611
MOD_PKA_1	443	449	PF00069	0.648
MOD_PKA_2	268	274	PF00069	0.639
MOD_PKA_2	281	287	PF00069	0.557
MOD_PKA_2	305	311	PF00069	0.600
MOD_PKA_2	316	322	PF00069	0.613
MOD_PKA_2	351	357	PF00069	0.681
MOD_PKA_2	443	449	PF00069	0.648
MOD_PKA_2	521	527	PF00069	0.503
MOD_PKA_2	558	564	PF00069	0.619
MOD_Plk_1	181	187	PF00069	0.424
MOD_Plk_1	522	528	PF00069	0.485
MOD_Plk_1	54	60	PF00069	0.487
MOD_Plk_4	162	168	PF00069	0.496
MOD_Plk_4	218	224	PF00069	0.484
MOD_Plk_4	296	302	PF00069	0.600
MOD_Plk_4	376	382	PF00069	0.639
MOD_Plk_4	420	426	PF00069	0.501
MOD_Plk_4	436	442	PF00069	0.609
MOD_Plk_4	522	528	PF00069	0.436
MOD_ProDKin_1	18	24	PF00069	0.627
MOD_ProDKin_1	301	307	PF00069	0.767
MOD_ProDKin_1	329	335	PF00069	0.638
MOD_ProDKin_1	336	342	PF00069	0.640
MOD_ProDKin_1	379	385	PF00069	0.604
MOD_ProDKin_1	512	518	PF00069	0.585
MOD_ProDKin_1	580	586	PF00069	0.680
MOD_SUMO_rev_2	535	540	PF00179	0.446
TRG_DiLeu_BaEn_1	392	397	PF01217	0.409
TRG_ENDOCYTIC_2	115	118	PF00928	0.350
TRG_ENDOCYTIC_2	157	160	PF00928	0.574
TRG_ENDOCYTIC_2	236	239	PF00928	0.384
TRG_ENDOCYTIC_2	358	361	PF00928	0.553
TRG_ENDOCYTIC_2	406	409	PF00928	0.486
TRG_ER_diArg_1	280	283	PF00400	0.733
TRG_ER_diArg_1	315	318	PF00400	0.658
TRG_ER_diArg_1	333	336	PF00400	0.640
TRG_ER_diArg_1	456	459	PF00400	0.698
TRG_ER_diArg_1	527	530	PF00400	0.489
TRG_NES_CRM1_1	72	86	PF08389	0.376
TRG_NLS_MonoExtC_3	537	542	PF00514	0.436
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P577	Leptomonas seymouri	42%	93%
A0A451EJB6	Leishmania donovani	88%	99%
A4H333	Leishmania braziliensis	61%	96%
A4HRI5	Leishmania infantum	89%	100%
E9AJE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%