DNA-damage inducible protein DDI1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-damage inducible protein DDI1-like protein

Species:

Leishmania major

UniProt:

E9AC52_LEIMA

TriTrypDb:

LmjF.01.0610 , LMJLV39_010011400 , LMJSD75_010011400

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC52

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0019538	protein metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004175	endopeptidase activity	4	5
GO:0004190	aspartic-type endopeptidase activity	5	5
GO:0008233	peptidase activity	3	5
GO:0016787	hydrolase activity	2	5
GO:0070001	aspartic-type peptidase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.518
CLV_PCSK_KEX2_1	10	12	PF00082	0.518
CLV_PCSK_KEX2_1	134	136	PF00082	0.329
CLV_PCSK_KEX2_1	68	70	PF00082	0.342
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.196
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.329
DEG_APCC_DBOX_1	72	80	PF00400	0.529
DEG_Nend_UBRbox_2	1	3	PF02207	0.681
DEG_SCF_TRCP1_1	58	64	PF00400	0.529
DOC_MAPK_gen_1	134	142	PF00069	0.592
DOC_MAPK_gen_1	203	213	PF00069	0.396
DOC_MAPK_gen_1	83	91	PF00069	0.529
DOC_MAPK_MEF2A_6	134	142	PF00069	0.529
DOC_MAPK_MEF2A_6	83	91	PF00069	0.529
DOC_PP2B_LxvP_1	42	45	PF13499	0.529
DOC_USP7_MATH_1	61	65	PF00917	0.529
DOC_WW_Pin1_4	100	105	PF00397	0.529
DOC_WW_Pin1_4	29	34	PF00397	0.596
LIG_CtBP_PxDLS_1	104	108	PF00389	0.529
LIG_LIR_Gen_1	208	216	PF02991	0.396
LIG_LIR_Gen_1	34	44	PF02991	0.529
LIG_LIR_Nem_3	208	213	PF02991	0.396
LIG_LIR_Nem_3	34	39	PF02991	0.529
LIG_PCNA_yPIPBox_3	203	211	PF02747	0.396
LIG_SH2_CRK	13	17	PF00017	0.504
LIG_SH2_NCK_1	13	17	PF00017	0.504
LIG_SH2_STAT5	111	114	PF00017	0.596
LIG_SH2_STAT5	117	120	PF00017	0.526
LIG_SH2_STAT5	31	34	PF00017	0.559
LIG_SH2_STAT5	43	46	PF00017	0.586
LIG_SH3_3	152	158	PF00018	0.470
LIG_SH3_3	190	196	PF00018	0.760
LIG_UBA3_1	126	134	PF00899	0.396
LIG_UBA3_1	138	143	PF00899	0.496
MOD_CK1_1	214	220	PF00069	0.396
MOD_CK2_1	196	202	PF00069	0.596
MOD_GlcNHglycan	213	216	PF01048	0.407
MOD_GlcNHglycan	58	61	PF01048	0.329
MOD_GSK3_1	182	189	PF00069	0.609
MOD_NEK2_1	211	216	PF00069	0.396
MOD_NEK2_1	56	61	PF00069	0.529
MOD_PIKK_1	217	223	PF00454	0.349
MOD_Plk_4	37	43	PF00069	0.396
MOD_Plk_4	61	67	PF00069	0.529
MOD_ProDKin_1	100	106	PF00069	0.529
MOD_ProDKin_1	29	35	PF00069	0.596
TRG_DiLeu_BaEn_1	72	77	PF01217	0.529
TRG_ENDOCYTIC_2	111	114	PF00928	0.529
TRG_ENDOCYTIC_2	13	16	PF00928	0.506
TRG_ER_diArg_1	10	12	PF00400	0.518
TRG_ER_diArg_1	82	85	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNK4	Leishmania donovani	95%	100%
A4HRI4	Leishmania infantum	95%	100%
E9AJE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q10256	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	73%