WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC49_LEIMA

TriTrypDb:

LmjF.01.0580 , LMJLV39_010011100 , LMJSD75_010011100

Length:

969

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.582
CLV_C14_Caspase3-7	417	421	PF00656	0.433
CLV_C14_Caspase3-7	895	899	PF00656	0.709
CLV_C14_Caspase3-7	98	102	PF00656	0.529
CLV_NRD_NRD_1	403	405	PF00675	0.408
CLV_NRD_NRD_1	436	438	PF00675	0.517
CLV_NRD_NRD_1	470	472	PF00675	0.550
CLV_NRD_NRD_1	54	56	PF00675	0.704
CLV_PCSK_KEX2_1	436	438	PF00082	0.559
CLV_PCSK_KEX2_1	470	472	PF00082	0.508
CLV_PCSK_KEX2_1	54	56	PF00082	0.637
CLV_PCSK_KEX2_1	564	566	PF00082	0.446
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.483
CLV_PCSK_SKI1_1	225	229	PF00082	0.488
CLV_PCSK_SKI1_1	287	291	PF00082	0.538
CLV_PCSK_SKI1_1	404	408	PF00082	0.367
CLV_PCSK_SKI1_1	439	443	PF00082	0.450
CLV_PCSK_SKI1_1	68	72	PF00082	0.467
CLV_PCSK_SKI1_1	740	744	PF00082	0.498
CLV_PCSK_SKI1_1	745	749	PF00082	0.454
CLV_PCSK_SKI1_1	919	923	PF00082	0.535
DEG_APCC_DBOX_1	811	819	PF00400	0.423
DEG_MDM2_SWIB_1	805	813	PF02201	0.368
DEG_SCF_FBW7_1	352	359	PF00400	0.501
DEG_SCF_FBW7_1	426	432	PF00400	0.610
DEG_SPOP_SBC_1	149	153	PF00917	0.543
DEG_SPOP_SBC_1	330	334	PF00917	0.781
DOC_CKS1_1	353	358	PF01111	0.500
DOC_CKS1_1	426	431	PF01111	0.614
DOC_CYCLIN_RxL_1	281	294	PF00134	0.487
DOC_MAPK_DCC_7	812	820	PF00069	0.426
DOC_MAPK_gen_1	436	442	PF00069	0.480
DOC_MAPK_gen_1	6	14	PF00069	0.506
DOC_MAPK_gen_1	959	967	PF00069	0.468
DOC_MAPK_MEF2A_6	128	136	PF00069	0.556
DOC_MAPK_MEF2A_6	480	489	PF00069	0.416
DOC_MAPK_MEF2A_6	634	643	PF00069	0.406
DOC_MAPK_MEF2A_6	812	820	PF00069	0.426
DOC_MAPK_MEF2A_6	961	969	PF00069	0.515
DOC_PP1_RVXF_1	437	443	PF00149	0.536
DOC_PP1_RVXF_1	957	963	PF00149	0.356
DOC_PP2B_LxvP_1	183	186	PF13499	0.399
DOC_PP2B_PxIxI_1	131	137	PF00149	0.480
DOC_PP4_FxxP_1	16	19	PF00568	0.694
DOC_SPAK_OSR1_1	480	484	PF12202	0.469
DOC_SPAK_OSR1_1	66	70	PF12202	0.552
DOC_USP7_MATH_1	105	109	PF00917	0.627
DOC_USP7_MATH_1	138	142	PF00917	0.454
DOC_USP7_MATH_1	145	149	PF00917	0.509
DOC_USP7_MATH_1	19	23	PF00917	0.725
DOC_USP7_MATH_1	257	261	PF00917	0.567
DOC_USP7_MATH_1	279	283	PF00917	0.614
DOC_USP7_MATH_1	315	319	PF00917	0.793
DOC_USP7_MATH_1	329	333	PF00917	0.753
DOC_USP7_MATH_1	393	397	PF00917	0.408
DOC_USP7_MATH_1	517	521	PF00917	0.620
DOC_USP7_MATH_1	524	528	PF00917	0.728
DOC_USP7_MATH_1	587	591	PF00917	0.588
DOC_USP7_MATH_1	635	639	PF00917	0.404
DOC_USP7_MATH_1	74	78	PF00917	0.695
DOC_USP7_MATH_1	830	834	PF00917	0.627
DOC_USP7_MATH_1	85	89	PF00917	0.665
DOC_USP7_MATH_1	880	884	PF00917	0.719
DOC_USP7_MATH_1	945	949	PF00917	0.405
DOC_USP7_UBL2_3	828	832	PF12436	0.464
DOC_WW_Pin1_4	15	20	PF00397	0.696
DOC_WW_Pin1_4	243	248	PF00397	0.591
DOC_WW_Pin1_4	280	285	PF00397	0.484
DOC_WW_Pin1_4	299	304	PF00397	0.471
DOC_WW_Pin1_4	31	36	PF00397	0.753
DOC_WW_Pin1_4	352	357	PF00397	0.574
DOC_WW_Pin1_4	425	430	PF00397	0.649
DOC_WW_Pin1_4	534	539	PF00397	0.468
DOC_WW_Pin1_4	57	62	PF00397	0.633
DOC_WW_Pin1_4	735	740	PF00397	0.490
LIG_14-3-3_CanoR_1	225	234	PF00244	0.498
LIG_14-3-3_CanoR_1	342	350	PF00244	0.510
LIG_14-3-3_CanoR_1	404	413	PF00244	0.356
LIG_14-3-3_CanoR_1	470	475	PF00244	0.466
LIG_14-3-3_CanoR_1	480	484	PF00244	0.448
LIG_14-3-3_CanoR_1	568	572	PF00244	0.493
LIG_14-3-3_CanoR_1	649	655	PF00244	0.485
LIG_14-3-3_CanoR_1	663	673	PF00244	0.625
LIG_14-3-3_CanoR_1	68	74	PF00244	0.445
LIG_14-3-3_CanoR_1	804	810	PF00244	0.585
LIG_14-3-3_CanoR_1	854	858	PF00244	0.365
LIG_14-3-3_CanoR_1	912	917	PF00244	0.484
LIG_Actin_WH2_2	897	914	PF00022	0.490
LIG_AP2alpha_2	425	427	PF02296	0.616
LIG_APCC_ABBA_1	685	690	PF00400	0.537
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BRCT_BRCA1_1	12	16	PF00533	0.626
LIG_BRCT_BRCA1_1	376	380	PF00533	0.343
LIG_CtBP_PxDLS_1	94	98	PF00389	0.565
LIG_eIF4E_1	841	847	PF01652	0.482
LIG_EVH1_1	353	357	PF00568	0.584
LIG_EVH1_2	656	660	PF00568	0.436
LIG_FHA_1	257	263	PF00498	0.571
LIG_FHA_1	335	341	PF00498	0.539
LIG_FHA_1	389	395	PF00498	0.419
LIG_FHA_1	401	407	PF00498	0.461
LIG_FHA_1	552	558	PF00498	0.473
LIG_FHA_1	650	656	PF00498	0.487
LIG_FHA_1	674	680	PF00498	0.405
LIG_FHA_1	742	748	PF00498	0.455
LIG_FHA_1	762	768	PF00498	0.338
LIG_FHA_1	786	792	PF00498	0.727
LIG_FHA_1	911	917	PF00498	0.668
LIG_FHA_2	115	121	PF00498	0.636
LIG_FHA_2	208	214	PF00498	0.530
LIG_FHA_2	32	38	PF00498	0.756
LIG_FHA_2	58	64	PF00498	0.450
LIG_FHA_2	657	663	PF00498	0.587
LIG_Integrin_RGD_1	222	224	PF01839	0.529
LIG_LIR_Apic_2	13	19	PF02991	0.619
LIG_LIR_Apic_2	652	657	PF02991	0.467
LIG_LIR_Gen_1	171	180	PF02991	0.501
LIG_LIR_Gen_1	371	381	PF02991	0.337
LIG_LIR_Gen_1	578	588	PF02991	0.512
LIG_LIR_Gen_1	645	655	PF02991	0.357
LIG_LIR_Gen_1	721	731	PF02991	0.399
LIG_LIR_Gen_1	758	768	PF02991	0.549
LIG_LIR_Gen_1	918	926	PF02991	0.560
LIG_LIR_LC3C_4	935	938	PF02991	0.421
LIG_LIR_Nem_3	152	158	PF02991	0.525
LIG_LIR_Nem_3	171	175	PF02991	0.529
LIG_LIR_Nem_3	371	376	PF02991	0.352
LIG_LIR_Nem_3	424	430	PF02991	0.713
LIG_LIR_Nem_3	578	583	PF02991	0.529
LIG_LIR_Nem_3	590	596	PF02991	0.353
LIG_LIR_Nem_3	645	650	PF02991	0.439
LIG_LIR_Nem_3	721	726	PF02991	0.420
LIG_LIR_Nem_3	758	763	PF02991	0.469
LIG_LIR_Nem_3	855	860	PF02991	0.371
LIG_LIR_Nem_3	918	923	PF02991	0.538
LIG_LYPXL_SIV_4	722	730	PF13949	0.376
LIG_LYPXL_yS_3	155	158	PF13949	0.564
LIG_MLH1_MIPbox_1	376	380	PF16413	0.343
LIG_NRBOX	285	291	PF00104	0.489
LIG_NRBOX	497	503	PF00104	0.335
LIG_NRBOX	762	768	PF00104	0.488
LIG_PCNA_PIPBox_1	503	512	PF02747	0.356
LIG_PDZ_Class_2	964	969	PF00595	0.503
LIG_Pex14_1	858	862	PF04695	0.459
LIG_Pex14_2	805	809	PF04695	0.387
LIG_PTAP_UEV_1	302	307	PF05743	0.632
LIG_PTB_Apo_2	625	632	PF02174	0.461
LIG_REV1ctd_RIR_1	453	463	PF16727	0.556
LIG_SH2_CRK	390	394	PF00017	0.431
LIG_SH2_CRK	536	540	PF00017	0.285
LIG_SH2_CRK	594	598	PF00017	0.477
LIG_SH2_CRK	723	727	PF00017	0.496
LIG_SH2_NCK_1	536	540	PF00017	0.285
LIG_SH2_NCK_1	594	598	PF00017	0.477
LIG_SH2_NCK_1	723	727	PF00017	0.496
LIG_SH2_PTP2	920	923	PF00017	0.583
LIG_SH2_SRC	654	657	PF00017	0.498
LIG_SH2_SRC	790	793	PF00017	0.447
LIG_SH2_STAP1	258	262	PF00017	0.470
LIG_SH2_STAP1	647	651	PF00017	0.445
LIG_SH2_STAT5	150	153	PF00017	0.593
LIG_SH2_STAT5	197	200	PF00017	0.603
LIG_SH2_STAT5	258	261	PF00017	0.591
LIG_SH2_STAT5	379	382	PF00017	0.444
LIG_SH2_STAT5	390	393	PF00017	0.481
LIG_SH2_STAT5	647	650	PF00017	0.410
LIG_SH2_STAT5	654	657	PF00017	0.487
LIG_SH2_STAT5	741	744	PF00017	0.399
LIG_SH2_STAT5	790	793	PF00017	0.447
LIG_SH2_STAT5	841	844	PF00017	0.497
LIG_SH2_STAT5	920	923	PF00017	0.583
LIG_SH3_2	431	436	PF14604	0.674
LIG_SH3_3	126	132	PF00018	0.561
LIG_SH3_3	25	31	PF00018	0.800
LIG_SH3_3	300	306	PF00018	0.634
LIG_SH3_3	32	38	PF00018	0.577
LIG_SH3_3	348	354	PF00018	0.554
LIG_SH3_3	420	426	PF00018	0.669
LIG_SH3_3	428	434	PF00018	0.723
LIG_SH3_3	511	517	PF00018	0.482
LIG_SH3_3	532	538	PF00018	0.425
LIG_SH3_3	638	644	PF00018	0.402
LIG_SH3_3	704	710	PF00018	0.484
LIG_SH3_3	815	821	PF00018	0.435
LIG_SH3_3	920	926	PF00018	0.490
LIG_SH3_3	928	934	PF00018	0.444
LIG_SUMO_SIM_anti_2	703	708	PF11976	0.413
LIG_SUMO_SIM_par_1	912	918	PF11976	0.552
LIG_TRAF2_1	448	451	PF00917	0.449
LIG_TRFH_1	930	934	PF08558	0.398
LIG_TYR_ITIM	534	539	PF00017	0.287
LIG_TYR_ITSM	151	158	PF00017	0.613
LIG_TYR_ITSM	719	726	PF00017	0.503
LIG_WRC_WIRS_1	169	174	PF05994	0.607
LIG_WRC_WIRS_1	643	648	PF05994	0.346
LIG_WRC_WIRS_1	86	91	PF05994	0.580
LIG_WW_2	351	354	PF00397	0.609
LIG_WW_3	433	437	PF00397	0.516
MOD_CDK_SPK_2	735	740	PF00069	0.390
MOD_CDK_SPxxK_3	280	287	PF00069	0.477
MOD_CK1_1	148	154	PF00069	0.581
MOD_CK1_1	15	21	PF00069	0.774
MOD_CK1_1	176	182	PF00069	0.450
MOD_CK1_1	2	8	PF00069	0.721
MOD_CK1_1	246	252	PF00069	0.575
MOD_CK1_1	260	266	PF00069	0.515
MOD_CK1_1	301	307	PF00069	0.744
MOD_CK1_1	332	338	PF00069	0.769
MOD_CK1_1	369	375	PF00069	0.417
MOD_CK1_1	400	406	PF00069	0.505
MOD_CK1_1	458	464	PF00069	0.570
MOD_CK1_1	537	543	PF00069	0.375
MOD_CK1_1	570	576	PF00069	0.569
MOD_CK1_1	645	651	PF00069	0.440
MOD_CK1_1	783	789	PF00069	0.611
MOD_CK1_1	808	814	PF00069	0.462
MOD_CK1_1	87	93	PF00069	0.683
MOD_CK1_1	883	889	PF00069	0.645
MOD_CK1_1	899	905	PF00069	0.541
MOD_CK2_1	106	112	PF00069	0.618
MOD_CK2_1	178	184	PF00069	0.510
MOD_CK2_1	31	37	PF00069	0.659
MOD_CK2_1	341	347	PF00069	0.631
MOD_CK2_1	57	63	PF00069	0.539
MOD_CK2_1	783	789	PF00069	0.788
MOD_CK2_1	883	889	PF00069	0.743
MOD_GlcNHglycan	147	150	PF01048	0.487
MOD_GlcNHglycan	162	165	PF01048	0.431
MOD_GlcNHglycan	2	5	PF01048	0.706
MOD_GlcNHglycan	21	24	PF01048	0.777
MOD_GlcNHglycan	259	262	PF01048	0.571
MOD_GlcNHglycan	303	306	PF01048	0.642
MOD_GlcNHglycan	315	318	PF01048	0.687
MOD_GlcNHglycan	322	325	PF01048	0.527
MOD_GlcNHglycan	368	371	PF01048	0.472
MOD_GlcNHglycan	397	400	PF01048	0.511
MOD_GlcNHglycan	517	520	PF01048	0.557
MOD_GlcNHglycan	558	561	PF01048	0.388
MOD_GlcNHglycan	666	669	PF01048	0.468
MOD_GlcNHglycan	682	685	PF01048	0.416
MOD_GlcNHglycan	750	753	PF01048	0.429
MOD_GlcNHglycan	793	796	PF01048	0.517
MOD_GlcNHglycan	834	837	PF01048	0.630
MOD_GlcNHglycan	862	865	PF01048	0.607
MOD_GlcNHglycan	876	879	PF01048	0.682
MOD_GlcNHglycan	882	885	PF01048	0.726
MOD_GlcNHglycan	901	904	PF01048	0.456
MOD_GlcNHglycan	95	100	PF01048	0.589
MOD_GSK3_1	10	17	PF00069	0.769
MOD_GSK3_1	145	152	PF00069	0.480
MOD_GSK3_1	19	26	PF00069	0.663
MOD_GSK3_1	207	214	PF00069	0.516
MOD_GSK3_1	242	249	PF00069	0.642
MOD_GSK3_1	256	263	PF00069	0.469
MOD_GSK3_1	291	298	PF00069	0.519
MOD_GSK3_1	329	336	PF00069	0.669
MOD_GSK3_1	352	359	PF00069	0.649
MOD_GSK3_1	393	400	PF00069	0.364
MOD_GSK3_1	425	432	PF00069	0.651
MOD_GSK3_1	455	462	PF00069	0.588
MOD_GSK3_1	515	522	PF00069	0.529
MOD_GSK3_1	645	652	PF00069	0.307
MOD_GSK3_1	673	680	PF00069	0.431
MOD_GSK3_1	714	721	PF00069	0.517
MOD_GSK3_1	75	82	PF00069	0.708
MOD_GSK3_1	780	787	PF00069	0.701
MOD_GSK3_1	899	906	PF00069	0.642
MOD_GSK3_1	945	952	PF00069	0.492
MOD_LATS_1	73	79	PF00433	0.484
MOD_N-GLC_1	768	773	PF02516	0.584
MOD_N-GLC_1	780	785	PF02516	0.672
MOD_N-GLC_2	125	127	PF02516	0.553
MOD_NEK2_1	12	17	PF00069	0.600
MOD_NEK2_1	157	162	PF00069	0.567
MOD_NEK2_1	388	393	PF00069	0.468
MOD_NEK2_1	397	402	PF00069	0.437
MOD_NEK2_1	455	460	PF00069	0.578
MOD_NEK2_1	497	502	PF00069	0.314
MOD_NEK2_1	556	561	PF00069	0.381
MOD_NEK2_1	650	655	PF00069	0.488
MOD_NEK2_1	800	805	PF00069	0.388
MOD_NEK2_1	846	851	PF00069	0.326
MOD_NEK2_1	949	954	PF00069	0.350
MOD_NEK2_2	945	950	PF00069	0.384
MOD_PIKK_1	268	274	PF00454	0.494
MOD_PIKK_1	761	767	PF00454	0.460
MOD_PK_1	912	918	PF00069	0.464
MOD_PK_1	961	967	PF00069	0.408
MOD_PKA_1	404	410	PF00069	0.363
MOD_PKA_1	470	476	PF00069	0.384
MOD_PKA_2	127	133	PF00069	0.439
MOD_PKA_2	218	224	PF00069	0.403
MOD_PKA_2	341	347	PF00069	0.528
MOD_PKA_2	435	441	PF00069	0.461
MOD_PKA_2	470	476	PF00069	0.491
MOD_PKA_2	479	485	PF00069	0.509
MOD_PKA_2	515	521	PF00069	0.672
MOD_PKA_2	567	573	PF00069	0.524
MOD_PKA_2	662	668	PF00069	0.682
MOD_PKA_2	74	80	PF00069	0.493
MOD_PKA_2	853	859	PF00069	0.371
MOD_Plk_1	138	144	PF00069	0.505
MOD_Plk_1	549	555	PF00069	0.390
MOD_Plk_1	753	759	PF00069	0.369
MOD_Plk_1	780	786	PF00069	0.669
MOD_Plk_1	800	806	PF00069	0.257
MOD_Plk_4	138	144	PF00069	0.419
MOD_Plk_4	168	174	PF00069	0.523
MOD_Plk_4	187	193	PF00069	0.316
MOD_Plk_4	211	217	PF00069	0.486
MOD_Plk_4	363	369	PF00069	0.363
MOD_Plk_4	596	602	PF00069	0.315
MOD_Plk_4	642	648	PF00069	0.508
MOD_Plk_4	650	656	PF00069	0.460
MOD_Plk_4	674	680	PF00069	0.387
MOD_Plk_4	853	859	PF00069	0.351
MOD_Plk_4	896	902	PF00069	0.584
MOD_Plk_4	945	951	PF00069	0.458
MOD_ProDKin_1	15	21	PF00069	0.694
MOD_ProDKin_1	243	249	PF00069	0.588
MOD_ProDKin_1	280	286	PF00069	0.476
MOD_ProDKin_1	299	305	PF00069	0.474
MOD_ProDKin_1	31	37	PF00069	0.754
MOD_ProDKin_1	352	358	PF00069	0.578
MOD_ProDKin_1	425	431	PF00069	0.649
MOD_ProDKin_1	534	540	PF00069	0.467
MOD_ProDKin_1	57	63	PF00069	0.599
MOD_ProDKin_1	735	741	PF00069	0.494
TRG_DiLeu_BaEn_1	211	216	PF01217	0.482
TRG_DiLeu_BaEn_1	418	423	PF01217	0.528
TRG_DiLeu_BaEn_1	484	489	PF01217	0.361
TRG_DiLeu_BaEn_1	689	694	PF01217	0.439
TRG_ENDOCYTIC_2	155	158	PF00928	0.523
TRG_ENDOCYTIC_2	169	172	PF00928	0.409
TRG_ENDOCYTIC_2	536	539	PF00928	0.287
TRG_ENDOCYTIC_2	593	596	PF00928	0.533
TRG_ENDOCYTIC_2	647	650	PF00928	0.335
TRG_ENDOCYTIC_2	723	726	PF00928	0.497
TRG_ENDOCYTIC_2	841	844	PF00928	0.497
TRG_ENDOCYTIC_2	920	923	PF00928	0.548
TRG_ER_diArg_1	435	437	PF00400	0.475
TRG_ER_diArg_1	54	57	PF00400	0.606
TRG_ER_diArg_1	796	799	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V6	Leptomonas seymouri	57%	92%
A0A1X0P2P9	Trypanosomatidae	28%	100%
A0A3S5IR38	Trypanosoma rangeli	29%	100%
A0A451EJB3	Leishmania donovani	89%	100%
A4H381	Leishmania braziliensis	66%	100%
A4HRI1	Leishmania infantum	89%	100%
C9ZXL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AJE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5AX28	Trypanosoma cruzi	30%	100%