UDENN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA processing factor 3 (PRP3)/Protein of unknown function (DUF1115), putative

Species:

Leishmania major

UniProt:

E9AC47_LEIMA

TriTrypDb:

LmjF.01.0560 , LMJLV39_010010900 , LMJSD75_010010900

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030532	small nuclear ribonucleoprotein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	11
GO:0097525	spliceosomal snRNP complex	4	11
GO:0097526	spliceosomal tri-snRNP complex	5	11
GO:0120114	Sm-like protein family complex	2	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

E9AC47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC47

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	560	564	PF00656	0.496
CLV_NRD_NRD_1	127	129	PF00675	0.621
CLV_NRD_NRD_1	191	193	PF00675	0.241
CLV_NRD_NRD_1	26	28	PF00675	0.665
CLV_NRD_NRD_1	332	334	PF00675	0.245
CLV_NRD_NRD_1	419	421	PF00675	0.244
CLV_NRD_NRD_1	441	443	PF00675	0.480
CLV_NRD_NRD_1	587	589	PF00675	0.266
CLV_NRD_NRD_1	87	89	PF00675	0.659
CLV_PCSK_KEX2_1	126	128	PF00082	0.602
CLV_PCSK_KEX2_1	191	193	PF00082	0.227
CLV_PCSK_KEX2_1	332	334	PF00082	0.266
CLV_PCSK_KEX2_1	419	421	PF00082	0.244
CLV_PCSK_KEX2_1	435	437	PF00082	0.425
CLV_PCSK_KEX2_1	441	443	PF00082	0.442
CLV_PCSK_KEX2_1	546	548	PF00082	0.271
CLV_PCSK_KEX2_1	554	556	PF00082	0.361
CLV_PCSK_KEX2_1	587	589	PF00082	0.266
CLV_PCSK_KEX2_1	87	89	PF00082	0.659
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.436
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.271
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.361
CLV_PCSK_PC7_1	83	89	PF00082	0.624
CLV_PCSK_SKI1_1	129	133	PF00082	0.747
CLV_PCSK_SKI1_1	239	243	PF00082	0.337
CLV_PCSK_SKI1_1	442	446	PF00082	0.451
CLV_PCSK_SKI1_1	546	550	PF00082	0.281
CLV_PCSK_SKI1_1	604	608	PF00082	0.431
DOC_CKS1_1	148	153	PF01111	0.643
DOC_CYCLIN_RxL_1	236	244	PF00134	0.448
DOC_CYCLIN_yClb5_NLxxxL_5	382	391	PF00134	0.441
DOC_MAPK_gen_1	126	132	PF00069	0.702
DOC_MAPK_gen_1	24	32	PF00069	0.547
DOC_MAPK_gen_1	518	527	PF00069	0.538
DOC_PP1_RVXF_1	126	133	PF00149	0.573
DOC_PP2B_LxvP_1	589	592	PF13499	0.572
DOC_PP4_MxPP_1	1	4	PF00568	0.725
DOC_USP7_MATH_1	116	120	PF00917	0.683
DOC_USP7_MATH_1	12	16	PF00917	0.627
DOC_USP7_MATH_1	153	157	PF00917	0.659
DOC_USP7_MATH_1	161	165	PF00917	0.531
DOC_USP7_MATH_1	227	231	PF00917	0.534
DOC_USP7_MATH_1	43	47	PF00917	0.730
DOC_USP7_MATH_1	590	594	PF00917	0.581
DOC_USP7_MATH_1	7	11	PF00917	0.661
DOC_USP7_UBL2_3	24	28	PF12436	0.589
DOC_WW_Pin1_4	147	152	PF00397	0.709
DOC_WW_Pin1_4	15	20	PF00397	0.648
DOC_WW_Pin1_4	274	279	PF00397	0.465
DOC_WW_Pin1_4	591	596	PF00397	0.581
LIG_14-3-3_CanoR_1	254	260	PF00244	0.555
LIG_14-3-3_CanoR_1	381	389	PF00244	0.538
LIG_14-3-3_CanoR_1	441	450	PF00244	0.424
LIG_14-3-3_CanoR_1	521	526	PF00244	0.444
LIG_Actin_WH2_2	422	437	PF00022	0.602
LIG_Actin_WH2_2	595	611	PF00022	0.391
LIG_APCC_Cbox_2	423	429	PF00515	0.501
LIG_BRCT_BRCA1_1	531	535	PF00533	0.501
LIG_Clathr_ClatBox_2	250	255	PF01394	0.444
LIG_deltaCOP1_diTrp_1	250	255	PF00928	0.444
LIG_deltaCOP1_diTrp_1	503	512	PF00928	0.444
LIG_FHA_1	232	238	PF00498	0.485
LIG_FHA_1	278	284	PF00498	0.465
LIG_FHA_1	382	388	PF00498	0.538
LIG_FHA_1	402	408	PF00498	0.538
LIG_FHA_1	515	521	PF00498	0.446
LIG_FHA_2	576	582	PF00498	0.571
LIG_LIR_Apic_2	511	515	PF02991	0.467
LIG_LIR_Gen_1	36	43	PF02991	0.523
LIG_LIR_Gen_1	569	579	PF02991	0.457
LIG_LIR_Gen_1	593	602	PF02991	0.572
LIG_LIR_Nem_3	309	313	PF02991	0.554
LIG_LIR_Nem_3	36	42	PF02991	0.521
LIG_LIR_Nem_3	593	599	PF02991	0.447
LIG_Pex14_1	603	607	PF04695	0.537
LIG_PROFILIN_1	2	8	PF00235	0.628
LIG_SH2_CRK	262	266	PF00017	0.412
LIG_SH2_CRK	89	93	PF00017	0.660
LIG_SH2_STAP1	109	113	PF00017	0.652
LIG_SH2_STAP1	304	308	PF00017	0.444
LIG_SH2_STAT3	195	198	PF00017	0.500
LIG_SH2_STAT5	109	112	PF00017	0.642
LIG_SH2_STAT5	195	198	PF00017	0.538
LIG_SH2_STAT5	304	307	PF00017	0.511
LIG_SH2_STAT5	482	485	PF00017	0.545
LIG_SH3_3	1	7	PF00018	0.636
LIG_SH3_3	145	151	PF00018	0.763
LIG_SH3_3	272	278	PF00018	0.585
LIG_SH3_3	291	297	PF00018	0.387
LIG_SH3_3	393	399	PF00018	0.450
LIG_SH3_3	589	595	PF00018	0.575
LIG_SH3_4	24	31	PF00018	0.627
LIG_SUMO_SIM_anti_2	487	493	PF11976	0.457
LIG_SUMO_SIM_par_1	28	34	PF11976	0.598
LIG_TRAF2_1	578	581	PF00917	0.441
LIG_WW_2	6	9	PF00397	0.641
MOD_CK1_1	10	16	PF00069	0.669
MOD_CK1_1	18	24	PF00069	0.596
MOD_CK1_1	277	283	PF00069	0.454
MOD_CK1_1	372	378	PF00069	0.472
MOD_CK1_1	54	60	PF00069	0.661
MOD_CK1_1	594	600	PF00069	0.509
MOD_CK2_1	160	166	PF00069	0.561
MOD_CK2_1	575	581	PF00069	0.452
MOD_CMANNOS	252	255	PF00535	0.244
MOD_Cter_Amidation	552	555	PF01082	0.266
MOD_Cter_Amidation	85	88	PF01082	0.658
MOD_GlcNHglycan	10	13	PF01048	0.655
MOD_GlcNHglycan	14	17	PF01048	0.627
MOD_GlcNHglycan	141	144	PF01048	0.646
MOD_GlcNHglycan	151	154	PF01048	0.668
MOD_GlcNHglycan	183	186	PF01048	0.669
MOD_GlcNHglycan	215	218	PF01048	0.326
MOD_GlcNHglycan	267	270	PF01048	0.374
MOD_GlcNHglycan	371	374	PF01048	0.338
MOD_GlcNHglycan	38	42	PF01048	0.564
MOD_GlcNHglycan	45	48	PF01048	0.604
MOD_GlcNHglycan	459	462	PF01048	0.334
MOD_GlcNHglycan	53	56	PF01048	0.593
MOD_GSK3_1	149	156	PF00069	0.736
MOD_GSK3_1	15	22	PF00069	0.832
MOD_GSK3_1	161	168	PF00069	0.572
MOD_GSK3_1	227	234	PF00069	0.496
MOD_GSK3_1	261	268	PF00069	0.464
MOD_GSK3_1	33	40	PF00069	0.607
MOD_GSK3_1	360	367	PF00069	0.500
MOD_GSK3_1	368	375	PF00069	0.468
MOD_GSK3_1	43	50	PF00069	0.639
MOD_GSK3_1	590	597	PF00069	0.575
MOD_GSK3_1	7	14	PF00069	0.665
MOD_LATS_1	379	385	PF00433	0.538
MOD_LATS_1	545	551	PF00433	0.465
MOD_NEK2_1	165	170	PF00069	0.642
MOD_NEK2_1	279	284	PF00069	0.536
MOD_NEK2_1	369	374	PF00069	0.453
MOD_NEK2_1	391	396	PF00069	0.484
MOD_NEK2_2	531	536	PF00069	0.430
MOD_PIKK_1	165	171	PF00454	0.555
MOD_PIKK_1	302	308	PF00454	0.457
MOD_PIKK_1	66	72	PF00454	0.642
MOD_PK_1	261	267	PF00069	0.394
MOD_PK_1	28	34	PF00069	0.663
MOD_PK_1	521	527	PF00069	0.501
MOD_PKA_1	546	552	PF00069	0.481
MOD_PKA_2	107	113	PF00069	0.782
MOD_PKA_2	253	259	PF00069	0.525
MOD_PKA_2	380	386	PF00069	0.444
MOD_PKA_2	546	552	PF00069	0.436
MOD_Plk_1	33	39	PF00069	0.538
MOD_Plk_2-3	33	39	PF00069	0.567
MOD_Plk_4	233	239	PF00069	0.457
MOD_Plk_4	364	370	PF00069	0.432
MOD_Plk_4	392	398	PF00069	0.444
MOD_ProDKin_1	147	153	PF00069	0.709
MOD_ProDKin_1	15	21	PF00069	0.645
MOD_ProDKin_1	274	280	PF00069	0.465
MOD_ProDKin_1	591	597	PF00069	0.586
TRG_DiLeu_BaEn_3	580	586	PF01217	0.538
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.501
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.469
TRG_ENDOCYTIC_2	262	265	PF00928	0.412
TRG_ENDOCYTIC_2	310	313	PF00928	0.510
TRG_ENDOCYTIC_2	453	456	PF00928	0.459
TRG_ENDOCYTIC_2	89	92	PF00928	0.661
TRG_ER_diArg_1	126	128	PF00400	0.623
TRG_ER_diArg_1	586	588	PF00400	0.465
TRG_ER_diArg_1	87	89	PF00400	0.725
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXQ4	Leptomonas seymouri	56%	100%
A0A1X0P2M3	Trypanosomatidae	44%	100%
A0A3R7KZ00	Trypanosoma rangeli	40%	100%
A0A3S5H4W0	Leishmania donovani	92%	99%
A4H379	Leishmania braziliensis	75%	100%
A4HRH9	Leishmania infantum	92%	100%
C9ZXK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AJE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BLJ6	Trypanosoma cruzi	37%	100%