POPLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC46_LEIMA

TriTrypDb:

LmjF.01.0550 , LMJLV39_010010800 , LMJSD75_010010800

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0005488	binding	1	5
GO:0008270	zinc ion binding	6	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.712
CLV_C14_Caspase3-7	36	40	PF00656	0.503
CLV_NRD_NRD_1	267	269	PF00675	0.494
CLV_NRD_NRD_1	52	54	PF00675	0.414
CLV_PCSK_FUR_1	209	213	PF00082	0.527
CLV_PCSK_KEX2_1	211	213	PF00082	0.694
CLV_PCSK_KEX2_1	226	228	PF00082	0.646
CLV_PCSK_KEX2_1	232	234	PF00082	0.602
CLV_PCSK_KEX2_1	267	269	PF00082	0.591
CLV_PCSK_KEX2_1	52	54	PF00082	0.423
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.694
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.646
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.602
CLV_PCSK_SKI1_1	53	57	PF00082	0.368
DEG_SPOP_SBC_1	243	247	PF00917	0.684
DOC_CDC14_PxL_1	173	181	PF14671	0.493
DOC_MAPK_gen_1	182	190	PF00069	0.449
DOC_MAPK_gen_1	52	59	PF00069	0.496
DOC_MAPK_MEF2A_6	182	190	PF00069	0.510
DOC_MAPK_MEF2A_6	52	59	PF00069	0.486
DOC_MAPK_NFAT4_5	52	60	PF00069	0.488
DOC_PP2B_LxvP_1	133	136	PF13499	0.623
DOC_PP4_FxxP_1	134	137	PF00568	0.625
DOC_SPAK_OSR1_1	63	67	PF12202	0.411
DOC_USP7_MATH_1	13	17	PF00917	0.729
DOC_USP7_MATH_1	138	142	PF00917	0.614
DOC_USP7_MATH_1	243	247	PF00917	0.660
DOC_USP7_MATH_1	25	29	PF00917	0.468
DOC_USP7_MATH_1	260	264	PF00917	0.720
DOC_USP7_MATH_1	33	37	PF00917	0.309
DOC_USP7_MATH_1	38	42	PF00917	0.361
DOC_USP7_MATH_1	96	100	PF00917	0.628
DOC_WW_Pin1_4	23	28	PF00397	0.510
DOC_WW_Pin1_4	244	249	PF00397	0.737
LIG_14-3-3_CanoR_1	275	281	PF00244	0.553
LIG_14-3-3_CanoR_1	52	56	PF00244	0.456
LIG_BRCT_BRCA1_1	169	173	PF00533	0.556
LIG_FHA_1	239	245	PF00498	0.741
LIG_FHA_2	127	133	PF00498	0.533
LIG_FHA_2	212	218	PF00498	0.651
LIG_FHA_2	232	238	PF00498	0.671
LIG_LIR_Apic_2	132	137	PF02991	0.611
LIG_LIR_Gen_1	122	133	PF02991	0.611
LIG_LIR_Gen_1	170	180	PF02991	0.519
LIG_LIR_Gen_1	39	47	PF02991	0.356
LIG_LIR_Nem_3	170	176	PF02991	0.519
LIG_LIR_Nem_3	26	32	PF02991	0.457
LIG_LIR_Nem_3	39	45	PF02991	0.255
LIG_LIR_Nem_3	54	59	PF02991	0.396
LIG_SH2_STAT5	178	181	PF00017	0.521
LIG_SH3_3	275	281	PF00018	0.571
LIG_SH3_3	7	13	PF00018	0.734
LIG_TRAF2_1	150	153	PF00917	0.734
LIG_TRAF2_1	98	101	PF00917	0.632
MOD_CK1_1	143	149	PF00069	0.723
MOD_CK2_1	211	217	PF00069	0.712
MOD_Cter_Amidation	230	233	PF01082	0.672
MOD_GlcNHglycan	101	105	PF01048	0.734
MOD_GlcNHglycan	145	148	PF01048	0.696
MOD_GlcNHglycan	15	18	PF01048	0.675
MOD_GlcNHglycan	190	193	PF01048	0.520
MOD_GlcNHglycan	200	203	PF01048	0.602
MOD_GlcNHglycan	262	265	PF01048	0.657
MOD_GlcNHglycan	70	73	PF01048	0.544
MOD_GSK3_1	13	20	PF00069	0.590
MOD_GSK3_1	139	146	PF00069	0.696
MOD_GSK3_1	167	174	PF00069	0.525
MOD_GSK3_1	227	234	PF00069	0.753
MOD_GSK3_1	238	245	PF00069	0.662
MOD_GSK3_1	47	54	PF00069	0.474
MOD_GSK3_1	96	103	PF00069	0.624
MOD_NEK2_1	1	6	PF00069	0.771
MOD_NEK2_1	171	176	PF00069	0.503
MOD_NEK2_1	198	203	PF00069	0.592
MOD_NEK2_1	47	52	PF00069	0.520
MOD_NEK2_1	59	64	PF00069	0.356
MOD_PIKK_1	140	146	PF00454	0.689
MOD_PIKK_1	96	102	PF00454	0.632
MOD_PKA_1	211	217	PF00069	0.746
MOD_PKA_2	211	217	PF00069	0.662
MOD_PKA_2	219	225	PF00069	0.649
MOD_PKA_2	51	57	PF00069	0.451
MOD_Plk_1	171	177	PF00069	0.491
MOD_Plk_1	38	44	PF00069	0.356
MOD_Plk_2-3	126	132	PF00069	0.535
MOD_Plk_4	25	31	PF00069	0.482
MOD_Plk_4	38	44	PF00069	0.356
MOD_ProDKin_1	23	29	PF00069	0.496
MOD_ProDKin_1	244	250	PF00069	0.736
TRG_ER_diArg_1	181	184	PF00400	0.404
TRG_ER_diArg_1	266	268	PF00400	0.511
TRG_ER_diArg_1	51	53	PF00400	0.405
TRG_ER_diArg_1	61	64	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P578	Leptomonas seymouri	45%	74%
A0A3R7NL08	Trypanosoma rangeli	31%	91%
A0A3S5H4V9	Leishmania donovani	85%	79%
A4HRH8	Leishmania infantum	89%	100%
E9AJE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	76%
V5BH18	Trypanosoma cruzi	30%	77%